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Am J Pathol; +30 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2009/11/08PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - November 8, 2009 Category: Pathology Tags: Report Source Type: journals

Am J Pathol; +42 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2009/10/30PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - October 30, 2009 Category: Pathology Tags: Report Source Type: journals

Am J Pathol; +16 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2009/10/11PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - October 11, 2009 Category: Pathology Tags: Report Source Type: journals

Loss-of-Function FERMT1 Mutations in Kindler Syndrome Implicate a Role for Fermitin Family Homolog-1 in Integrin Activation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides evidence that fermitin family homolog-1 is implicated in integrin activation and demonstrates that lack of this protein leads to pathological changes beyond focal adhesions, with disruption of several hemidesmosomal components and reduced expression of keratinocyte stem cell markers. These findings collectively provide novel data on the role of fermitin family homolog-1 in skin and further insight into the pathophysiology of Kindler syndrome. PMID: 19762710 [PubMed - as supplied by publisher] (Source: Am J Pathol)
Source: Am J Pathol - September 16, 2009 Category: Pathology Authors: Lai-Cheong JE, Parsons M, Tanaka A, Ussar S, South AP, Gomathy S, Mee JB, Barbaroux JB, Techanukul T, Almaani N, Clements SE, Hart IR, McGrath JA Tags: Am J Pathol Source Type: journals

Role of CD11b+ Macrophages in Intraperitoneal Lipopolysaccharide-Induced Aberrant Lymphangiogenesis and Lymphatic Functionin the Diaphragm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lymphatic vessels in the diaphragm are essential for draining peritoneal fluid, but little is known about their pathological changes during inflammation. Here we characterized diaphragmatic lymphatic vessels in a peritonitis model generated by daily i.p. administration of lipopolysaccharide (LPS) in mice. Intraperitoneal LPS increased lymphatic density, branching, sprouts, connections, and network formation in the diaphragm in time- and dose-dependent manners. These changes were reversible on discontinuation of LPS administration. The LPS-induced lymphatic density and remodeling occur mainly through proliferation of ly...
Source: Am J Pathol - September 16, 2009 Category: Pathology Authors: Kim KE, Koh YJ, Jeon BH, Jang C, Han J, Kataru RP, Schwendener RA, Kim JM, Koh GY Tags: Am J Pathol Source Type: journals

Is Expression or Activation of Src Kinase Associated with Cancer-Specific Survival in ER, PR and HER2-Negative Breast Cancer Patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the current study was to assess the expression levels of c-Src and phosphorylated Src kinase in human breast cancers and to establish if these are linked to oestrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status or patient survival. Tissue microarray technology was used to analyze 314 breast cancer specimens. Immunohistochemistry was performed using antibodies to c-Src, Y419Src, and Y215Src, and expression was assessed using the weighted histoscore method. High cytoplasmic c-Src kinase and high membrane phosphorylated activated Y419Src kinase was associated with decrea...
Source: Am J Pathol - September 16, 2009 Category: Pathology Authors: Elsberger B, Tan BA, Mitchell TJ, Brown SB, Mallon EA, Tovey SM, Cooke TG, Brunton VG, Edwards J Tags: Am J Pathol Source Type: journals

An Inducible Cartilage Oligomeric Matrix Protein Mouse Model Recapitulates Human Pseudoachondroplasia Phenotype.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we achieved robust expression of human mutant (MT) or wild-type (WT) COMP in mice by using a tetracycline-inducible promoter. Normal growth plate distribution of ECM proteins was observed in 1-month-old WT-COMP and C57BL\\6 control mice. In contrast, the structure of the MT-COMP growth plate recapitulated the findings of human PSACH growth plate morphology, including (1) retention of ECM proteins, (2) intracellular matrix formation in the rER cisternae, and (3) increased chondrocyte apoptosis. Therefore, we have generated the first mouse model to show extensive intracellular retention of ECM proteins recapit...
Source: Am J Pathol - September 16, 2009 Category: Pathology Authors: Posey KL, Veerisetty AC, Liu P, Wang HR, Poindexter BJ, Bick R, Alcorn JL, Hecht JT Tags: Am J Pathol Source Type: journals

Role of MKP-1 in Osteoclasts and Bone Homeostasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone mass is maintained through the complementary activities of osteoblasts and osteoclasts; yet differentiation of either osteoblasts and osteoclasts engages the mitogen-activated protein kinase (MAPK) pathway. The MAPKs are negatively regulated by a family of dual-specificity phosphatases known as the MAPK phosphatases (MKPs). MKP-1 is a stress-responsive MKP that inactivates the MAPKs and plays a central role in macrophages; however, whether MKP-1 plays a role in the maintenance of bone mass has yet to be investigated. We show here, using a genetic approach, that mkp-1(-/-) female mice exhibited slightly reduced bon...
Source: Am J Pathol - September 16, 2009 Category: Pathology Authors: Carlson J, Cui W, Zhang Q, Xu X, Mercan F, Bennett AM, Vignery A Tags: Am J Pathol Source Type: journals

Kindlin-1 Is Required for RhoGTPase-Mediated Lamellipodia Formation in Keratinocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kindlin-1 is an epithelial-specific member of the novel kindlin protein family, which are regulators of integrin functions. Mutations in the gene that encodes Kindlin-1, FERMT1 (KIND1), cause the Kindler syndrome (KS), a human disorder characterized by mucocutaneous fragility, progressive skin atrophy, ulcerative colitis, photosensitivity, and propensity to skin cancer. Our previous studies indicated that loss of kindlin-1 resulted in abnormalities associated with integrin functions, such as adhesion, proliferation, polarization, and motility of epidermal cells. Here, we disclosed novel FERMT1 mutations in KS and used ...
Source: Am J Pathol - September 16, 2009 Category: Pathology Authors: Has C, Herz C, Zimina E, Qu HY, He Y, Zhang ZG, Wen TT, Gache Y, Aumailley M, Bruckner-Tuderman L Tags: Am J Pathol Source Type: journals

Am J Pathol; +17 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2009/09/06PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - September 6, 2009 Category: Pathology Tags: Report Source Type: journals

Am J Pathol; +18 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2009/08/26PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - August 26, 2009 Category: Pathology Tags: Report Source Type: journals

Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and Wound Healing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported previously that normal fibroblasts stimulated by transforming growth factor-ss showed rapid and transient induction of Egr-1. Moreover, we observed that tissue expression of Egr-1 was elevated in patients with scleroderma, which suggests that Egr-1 may be involved in tissue repair and fibrosis. Here, we investigated matrix remodeling and wound healing in mice harboring gain of function or loss of function mutations of Egr-1. Using the model of bleomycin-induced scleroderma, we found that the early influx of inflammatory cells into the skin and lungs, and the subsequent development of fibrosis in these organs, w...
Source: Am J Pathol - August 12, 2009 Category: Pathology Authors: Wu M, Melichian DS, de la Garza M, Gruner K, Bhattacharyya S, Barr L, Nair A, Shahrara S, Sporn PH, Mustoe TA, Tourtellotte WG, Varga J Tags: Am J Pathol Source Type: journals

Characterization of RAGE, HMGB1, and S100{beta} in Inflammation-Induced Preterm Birth and Fetal Tissue Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immune activation represents an adaptive reaction triggered by both noxious exogenous (microbes) and endogenous [high mobility group box-1 protein (HMGB1), S100 calcium binding proteins] inducers of inflammation. Cell stress or necrosis lead the release of HMGB1 and S100 proteins in the extracellular compartment where they act as damage-associated molecular pattern molecules (or alarmins) by engaging the receptor for advanced glycation end-products (RAGE). Although the biology of RAGE is dictated by the accumulation of damage-associated molecular pattern molecules at sites of tissue injury, the role of RAGE in mediatin...
Source: Am J Pathol - August 12, 2009 Category: Pathology Authors: Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA Tags: Am J Pathol Source Type: journals

Fenfluramine Disrupts the Mitral Valve Interstitial Cell Response to Serotonin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serotonin (5HT) receptor signaling and 5HT-related agents, such as the anorexogen fenfluramine (Fen), have been associated with heart valve disease. We investigated the hypothesis that Fen may disrupt mitral valve interstitial cell (MVIC) homeostasis through its effects on mitogenesis and extracellular matrix biosynthesis. Normal and myxomatous mitral valves, both human and canine, were harvested, and primary MVIC cultures were established. 5HT caused increased phosphorylation of extracellular signal-related kinase in MVIC; Fen alone did not. However, Fen combined with 5HT increased the level of MVIC extracellular sign...
Source: Am J Pathol - August 12, 2009 Category: Pathology Authors: Connolly JM, Bakay MA, Fulmer JT, Gorman RC, Gorman JH, Oyama MA, Levy RJ Tags: Am J Pathol Source Type: journals

A Novel Organotypic Model Mimics the Tumor Microenvironment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, a novel organotypic model based on human uterine leiomyoma tissue was established and characterized to create a more authentic environment for carcinoma cells. Human tongue squamous cell carcinoma cells (HSC-3) were cultured on top of either collagen or myoma. Organotypic sections were examined by immunohistochemistry and in situ hybridization. The maximal invasion depth of HSC-3 cells was markedly increased in myomas compared with collagen. In myomas, various cell types and ECM components were present, and the HSC-3 cells only expressed ECM molecules in the myoma model. Organotypic media were analyzed by ra...
Source: Am J Pathol - August 12, 2009 Category: Pathology Authors: Nurmenniemi S, Sinikumpu T, Alahuhta I, Salo S, Sutinen M, Santala M, Risteli J, Nyberg P, Salo T Tags: Am J Pathol Source Type: journals

Reduced Phosphoinositide 3-Kinase (p110{alpha}) Activation Increases the Susceptibility to Atrial Fibrillation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atrial fibrillation (AF) is the most common sustained arrhythmia presenting at cardiology departments. A limited understanding of the molecular mechanisms responsible for the development of AF has hindered treatment strategies. The purpose of this study was to assess whether reduced activation of phosphoinositide 3-kinase (PI3K, p110alpha) makes the compromised heart susceptible to AF. Risk factors for AF, including aging, obesity, and diabetes, have been associated with insulin resistance that leads to depressed/defective PI3K signaling. However, to date, there has been no link between PI3K(p110alpha) and AF. To addre...
Source: Am J Pathol - August 12, 2009 Category: Pathology Authors: Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, Medcalf RL, Ming Z, Head GA, Tan JW, Cemerlang N, Sadoshima J, Shioi T, Izumo S, Lukoshkova EV, Dart AM, Jennings GL, McMullen JR Tags: Am J Pathol Source Type: journals

Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute liver failure (ALF) remains a disease with poor patient outcome. Improved prognosis is associated with spontaneous liver regeneration, which supports the relevance of exploring 'regenerative' therapies. Therefore, the role of the Wnt/beta-catenin pathway in liver regeneration following ALF was investigated. ALF was induced in mice by acetaminophen overdose, which is also a leading cause of liver failure in patients. beta-catenin distribution was also studied in liver sections from acetaminophen-induced ALF patients. A nonlethal dose of acetaminophen, which induces liver regeneration, led to stabilization and acti...
Source: Am J Pathol - August 12, 2009 Category: Pathology Authors: Apte U, Singh S, Zeng G, Cieply B, Virji MA, Wu T, Monga SP Tags: Am J Pathol Source Type: journals

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid balance in the blood, ie, dyslipidemia, may affect the functional biology of lymphatic vessels. Here, we show that hypercholesterolemia occurring in apolipoprotein E-deficient (apoE(-/-)) mice is associated with tissue swelling, lymphatic leakiness, and decreased lymphatic transport of fluid and dendritic cells from tissue. Lymphatic dysfunction results in part from profound structural abnormalities in ...
Source: Am J Pathol - August 12, 2009 Category: Pathology Authors: Lim HY, Rutkowski JM, Helft J, Reddy ST, Swartz MA, Randolph GJ, Angeli V Tags: Am J Pathol Source Type: journals

Neuroendocrine Cancer-Specific Up-Regulating Mechanism of Insulin-Like Growth Factor Binding Protein-2 in Small Cell Lung Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we demonstrate that SCLC cells overexpress insulin-like growth factor binding protein (IGFBP)-2 via NeuroD, a neuroendocrine cell-specific transcription factor. Chromatin immunoprecipitation, electrophoretic mobility shift, and IGFBP-2 promoter assays all revealed that NeuroD binds to the E-box in the 5'-untranslated region of IGFBP-2. A NeuroD transgene in both airway epithelial and NSCLC cells up-regulated the transcription of IGFBP-2 and retarded cell growth. Recombinant IGFBP-2 repressed the growth of both airway epithelial and NSCLC cells in a dose-dependent manner. A NeuroD-specific small interfering R...
Source: Am J Pathol - August 12, 2009 Category: Pathology Authors: Yazawa T, Sato H, Shimoyamada H, Okudela K, Woo T, Tajiri M, Ogura T, Ogawa N, Suzuki T, Mitsui H, Ishii J, Miyata C, Sakaeda M, Goto K, Kashiwagi K, Masuda M, Takahashi T, Kitamura H Tags: Am J Pathol Source Type: journals

Am J Pathol; +42 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2009/07/16PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - July 16, 2009 Category: Pathology Tags: Report Source Type: journals

Am J Pathol; +165 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
165 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - June 27, 2009 Category: Pathology Tags: Report Source Type: journals

Am J Pathol; +32 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
32 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These PubMed results were generated on 2009/04/09PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - April 9, 2009 Category: Pathology Tags: Report Source Type: journals

Am J Pathol; +37 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
37 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These PubMed results were generated on 2009/03/26PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - March 26, 2009 Category: Pathology Tags: Report Source Type: journals

Am J Pathol; +16 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
16 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These PubMed results were generated on 2009/03/08PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - March 8, 2009 Category: Pathology Tags: Report Source Type: journals

Angiotensin II Induces Renal Plasminogen Activator Inhibitor-1 and Cyclooxygenase-2 Expression Posttranscriptionally via Activation of the mRNA-Stabilizing Factor Human-Antigen R.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiotensin (Ang) II-induced fibrosis of the kidney is characterized by the enhanced expression of profibrotic and proinflammatory genes, including the serine protease inhibitor plasminogen activator inhibitor-1 (PAI-1) and cyclooxygenase-2 (COX-2). In addition to transcriptional regulation, both genes are subject to posttranscriptional control by AU-rich destabilizing elements that reside within the 3' untranslated region of the mRNA. We demonstrated that the continuous infusion of AngII in rats induced fibrosis concomitant with a significant increase in glomerular PAI-1 and COX-2 expression levels. Using RNA pull-dow...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Doller A, Gauer S, Sobkowiak E, Geiger H, Pfeilschifter J, Eberhardt W Tags: Am J Pathol Source Type: journals

Mitogen-Activated Protein 3 Kinase 6 Mediates Angiogenic and Tumorigenic Effects via Vascular Endothelial Growth Factor Expression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genome-wide screening using a small interfering RNA (siRNA) library has revealed novel molecules that are involved in a wide range of physiological responses. The expression of vascular endothelial growth factor (VEGF) is increased under hypoxic conditions, and plays a crucial role in tumor angiogenesis and tissue responses to ischemia. Here, we used a siRNA expression vector library to elucidate molecules that modify VEGF expression. Screening using an siRNA library revealed that MAPKKK6 (MEKK6/MAP3K6) regulates VEGF expression under both normoxic and hypoxic conditions in vitro, although the biological function of MA...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M Tags: Am J Pathol Source Type: journals

Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, but not Tubulointerstitial Injury, in Diabetic eNOS Knockout Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study could provide insights into the pathogenesis of advanced diabetic nephropathy in the presence of endothelial dysfunction. PMID: 19246639 [PubMed - as supplied by publisher] (Source: Am J Pathol)
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Kosugi T, Heinig M, Nakayama T, Connor T, Yuzawa Y, Li Q, Hauswirth WW, Grant MB, Croker BP, Campbell-Thompson M, Zhang L, Atkinson MA, Segal MS, Nakagawa T Tags: Am J Pathol Source Type: journals

Large CTG Repeats Trigger p16-Dependent Premature Senescence in Myotonic Dystrophy Type 1 Muscle Precursor Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we show that these muscle precursor cells containing large CTG expansion sequences have not exhausted their proliferative capacity, but have entered into premature senescence. We demonstrate that an abnormal accumulation of p16 is responsible for this defect because the abolition of p16 activity overcomes early growth arrest and restores an extended proliferative capacity. Our results suggest that the accelerated telomere shortening measured in DM1 cells does not contribute to the aberrant induction of p16. We propose that a cellular stress related to the amplified CTG repeat promotes premature senescence m...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Bigot A, Klein AF, Gasnier E, Jacquemin V, Ravassard P, Butler-Browne G, Mouly V, Furling D Tags: Am J Pathol Source Type: journals

Immunoglobulin Expression in Non-Lymphoid Lineage and Neoplastic Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has traditionally been believed that the production of immunoglobulin (Ig) molecules is restricted to B lineage cells. However, immunoglobulin genes and proteins have been recently found in a variety of types of cancer cells, as well as some proliferating epithelial cells and neurons. The immunoglobulin molecules expressed by these cells consist predominantly of IgG, IgM, and IgA, and the light chains expressed are mainly kappa chains. Recombination activating genes 1 and 2, which are required for V(D)J recombination, are also expressed in these cells. Knowledge about the function of these non-lymphoid cell-derived ...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Chen Z, Qiu X, Gu J Tags: Am J Pathol Source Type: journals

{beta}-Glycoglycosphingolipid-Induced Alterations of the STAT Signaling Pathways Are Dependent on CD1d and the Lipid Raft Protein Flotillin-2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
beta-glucosylceramide has been shown to affect natural killer T cell function in models of inflammation. We, therefore, investigated the effects of different beta-glycosphingolipids, including beta-glucosylceramide, on STAT (signal transducers and activators of transcription) signaling pathways and determined whether these effects were mediated by lipid raft microdomains and/or CD1 days molecules. The effects of alpha- and beta-structured ligands on the lipid raft protein flotillin-2 were studied in both natural killer T hybridoma cells and leptin-deficient mice. To determine whether CD1 days was involved in the effect...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Lalazar G, Ya'acov AB, Livovsky DM, El Haj M, Pappo O, Preston S, Zolotarov L, Ilan Y Tags: Am J Pathol Source Type: journals

Oxidative Stress-Mediated Mitochondrial Dysfunction Contributes to Angiotensin II-Induced Nonalcoholic Fatty Liver Disease in Transgenic Ren2 Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Emerging evidence indicates that impaired mitochondrial fatty acid beta-oxidation plays a key role in liver steatosis. We have recently demonstrated that increased angiotensin (ANG) II causes progressive hepatic steatosis associated with oxidative stress; however, the underlying mechanisms remain unclear. We hypothesized that ANG II causes hepatic mitochondrial oxidative damage and impairs mitochondrial beta-oxidation, thereby leading to hepatic steatosis. We used the Ren2 rat with elevated endogenous ANG II levels to evaluate mitochondrial ultrastructural changes, gene expression levels, and beta-oxidation. Compared w...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Wei Y, Clark SE, Thyfault JP, Uptergrove GM, Li W, Whaley-Connell AT, Ferrario CM, Sowers JR, Ibdah JA Tags: Am J Pathol Source Type: journals

Specific Detection of CD56 (NCAM) Isoforms for the Identification of Aggressive Malignant Neoplasms with Progressive Development.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alternative splicing of transcripts from many cancer-associated genes is believed to play a major role in carcinogenesis as well as in tumor progression. Alternative splicing of one such gene, the neural cell adhesion molecule CD56 (NCAM), impacts the progression, inadequate therapeutic response, and reduced total survival of patients who suffer from numerous malignant neoplasms. Although previous investigations have determined that CD56 exists in three major isoforms (CD56(120kD), CD56(140kD), and CD56(180kD)) with individual structural and functional properties, neither the expression profiles nor the functional rele...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Gattenlöhner S, Stühmer T, Leich E, Reinhard M, Etschmann B, Völker HU, Rosenwald A, Serfling E, Bargou RC, Ertl G, Einsele H, Müller-Hermelink HK Tags: Am J Pathol Source Type: journals

Anti-Inflammatory and Renal Protective Actions of Stanniocalcin-1 in a Model of Anti-Glomerular Basement Membrane Glomerulonephritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the following parameters both at baseline and after anti-glomerular basement membrane antibody treatment: blood pressure; C3a levels; urine output; proteinuria; blood urea nitrogen; and kidney C3 deposition, fibrosis, histological changes, cytokine expression, and number of T cells and macrophages. Compared with wild-type mice, after anti-glomerular basement membrane treatment STC1 transgenic mice exhibited: i) diminished infiltration of inflammatory macrophages in the glomeruli; ii) marked reduction in crescent formation and sclerotic glomeruli; iii) decreased interstitial fibrosis; iv) preservation of kidney ...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Huang L, Garcia G, Lou Y, Zhou Q, Truong LD, Dimattia G, Lan XR, Lan HY, Wang Y, Sheikh-Hamad D Tags: Am J Pathol Source Type: journals

Senescent Peritoneal Mesothelial Cells Promote Ovarian Cancer Cell Adhesion. The Role of Oxidative Stress-Induced Fibronectin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adhesion of ovarian cancer cells to the peritoneal mesothelium is a key step in the malignant progression of the disease. In an in vitro study, we showed that the adherence of ovarian cancer cells (of the OVCAR-3, SKOV-3, and A2780 cell lines) to senescent human omentum-derived peritoneal mesothelial cells (HOMCs) was greater than to early passage cells. The process was mediated primarily by the increased interaction of the alpha5beta1 integrin on cancer cells with HOMC-associated fibronectin (FN). In comparison with early passage HOMCs, senescent cells exhibited increased FN mRNA expression levels and produced signifi...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Ksiazek K, Mikula-Pietrasik J, Korybalska K, Dworacki G, Jörres A, Witowski J Tags: Am J Pathol Source Type: journals

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in 12% of glioblastomas. We assessed IDH1 mutations in 321 gliomas of various histological types and biological behaviors. A total of 130 IDH1 mutations was detected, and all were located at amino acid residue 132. Of these, 91% were G-->A mutations (Arg-->His). IDH1 mutations were frequent in low-grade diffuse astrocytomas (88%) and in secondary glioblastomas that developed through progression from low-grade diffuse or anaplastic astrocytoma (82%). Similarly, high frequencies of IDH1 mutat...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Watanabe T, Nobusawa S, Kleihues P, Ohgaki H Tags: Am J Pathol Source Type: journals

Lymphotoxin-{alpha} and TNF Have Essential but Independent Roles in the Evolution of the Granulomatous Response in Experimental Leprosy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies identified an association between genetic variants in the lymphotoxin-alpha (LTalpha) gene and leprosy. To study the influence of LTalpha on the control of experimental leprosy, both low- and high-dose Mycobacterium leprae foot pad (FP) infections were evaluated in LTalpha-deficient chimeric (cLTalpha(-/-)) and control chimeric (cB6) mice. Cellular responses to low-dose infection in cLTalpha(-/-) mice were dramatically different, with reduced accumulation of CD4(+) and CD8(+) lymphocytes and macrophages and failure to form granulomas. Growth of M. leprae was contained for 6 months, but augmented late in ...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Hagge DA, Saunders BM, Ebenezer GJ, Ray NA, Marks VT, Britton WJ, Krahenbuhl JL, Adams LB Tags: Am J Pathol Source Type: journals

COP9-Associated CSN5 Regulates Exosomal Protein Deubiquitination and Sorting.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we show that the COP9 signalosome (CSN)-associated protein CSN5 quantitatively regulated proteins that were sorted into exosomes. Western blot analysis of exosomal proteins indicated that small interfering (si)RNA knockdown of CSN5 results in increased levels of both ubiquitinated and non-ubiquitinated exosomal proteins, including heat shock protein 70, in comparison with exosomes isolated from the supernatants of 293 cells transfected with scrambled siRNA. Furthermore, 293 cells transfected with JAB1/MPN/Mov34 metalloenzyme domain-deleted CSN5 produced exosomes with higher levels of ubiquitinated heat shock...
Source: Am J Pathol - February 26, 2009 Category: Pathology Authors: Liu Y, Shah SV, Xiang X, Wang J, Deng ZB, Liu C, Zhang L, Wu J, Edmonds T, Jambor C, Kappes JC, Zhang HG Tags: Am J Pathol Source Type: journals

Am J Pathol; +33 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
33 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These PubMed results were generated on 2009/02/20PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - February 20, 2009 Category: Pathology Tags: Report Source Type: journals

Am J Pathol; +35 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
35 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These PubMed results were generated on 2009/02/05PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - February 5, 2009 Category: Pathology Tags: Report Source Type: journals

Proepithelin Regulates Prostate Cancer Cell Biology by Promoting Cell Growth, Migration, and Anchorage-Independent Growth.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study supports the hypothesis that proepithelin may play a critical role as an autocrine growth factor in the establishment and initial progression of prostate cancer. Furthermore, proepithelin may prove to be a useful clinical marker for the diagnosis of prostate tumors. PMID: 19179604 [PubMed - as supplied by publisher] (Source: Am J Pathol)
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Monami G, Emiliozzi V, Bitto A, Lovat F, Xu SQ, Goldoni S, Fassan M, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A Tags: Am J Pathol Source Type: journals

Aortic Carboxypeptidase-Like Protein Is Expressed in Fibrotic Human Lung and its Absence Protects against Bleomycin-Induced Lung Fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we demonstrate that aortic carboxypeptidase-like protein (ACLP), a collagen-associated protein with a discoidin-like domain, is expressed at high levels in human fibrotic lung tissue and human fibroblasts, and that its expression increases markedly in the lungs of bleomycin-injured mice. Importantly, ACLP-deficient mice accumulated significantly fewer myofibroblasts and less collagen in the lung after bleomycin injury, as compared with wild-type controls, despite equivalent levels of bleomycin-induced inflammation. ACLP that is secreted by lung fibroblasts was retained on fibrillar collagen, and ACLP-deficie...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Schissel SL, Dunsmore SE, Liu X, Shine RW, Perrella MA, Layne MD Tags: Am J Pathol Source Type: journals

HMGA2 Maintains Oncogenic RAS-Induced Epithelial-Mesenchymal Transition in Human Pancreatic Cancer Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pancreatic cancer is a highly aggressive malignancy due to elevated mitotic activities and epithelial-mesenchymal transition (EMT). Oncogenic RAS and transforming growth factor-beta signaling are implicated in these malignant features. The mechanisms that underlie EMT need to be addressed since it promotes tissue invasion and metastasis. The high-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor that is primarily expressed in undifferentiated tissues and tumors of mesenchymal origin. However, its role in EMT in pancreatic cancer is largely unknown. Here we report that HMGA2 is involved in EMT mainten...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Watanabe S, Ueda Y, Akaboshi SI, Hino Y, Sekita Y, Nakao M Tags: Am J Pathol Source Type: journals

Ribozyme-Mediated Targeting of I{kappa}B{gamma} Inhibits Melanoma Invasion and Metastasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the consequences of targeting IkappaBgamma in melanoma cells using a hammerhead ribozyme. We developed stable transformant B16-F10 melanoma cell lines that express a ribozyme that targets mouse IkappaBgamma (IkappaBgamma-144-Rz). Tail-vein injection of B16-F10 cells that stably express IkappaBgamma-144-Rz into mice resulted in a significant reduction of the metastatic potential of these cells. IkappaBgamma-144-Rz-expressing B16 cells were shown to have increased transcriptional activity of nuclear factor-kappaB. We then showed that IkappaBgamma-144-Rz-expressing cells demonstrated both reduced invasion and incr...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Torabian SZ, de Semir D, Nosrati M, Bagheri S, Dar AA, Fong S, Liu Y, Federman S, Simko J, Haqq C, Debs RJ, Kashani-Sabet M Tags: Am J Pathol Source Type: journals

Prolactin-Growth Factor Crosstalk Reduces Mammary Estrogen Responsiveness Despite Elevated ER{alpha} Expression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Most breast cancers that occur in women express estrogen receptor alpha (ERalpha). However, a large subset of these cancers either does not initially respond to anti-estrogen therapy or develops resistance to such treatment modalities. One postulated mechanism of this failure is signaling cross talk between hormones and local growth factors. To examine these complex interactions in vivo, we assessed the effects of estrogen on transforming growth factor alpha (TGFalpha)- and prolactin (PRL)-induced mammary tumorigenesis in transgenic mice. Both PRL and estrogen reduced the latency of TGFalpha-induced oncogenesis, result...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Arendt LM, Grafwallner-Huseth TL, Schuler LA Tags: Am J Pathol Source Type: journals

Valproic Acid Activates the PI3K/Akt/mTOR Pathway in Muscle and Ameliorates Pathology in a Mouse Model of Duchenne Muscular Dystrophy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Duchenne muscular dystrophy is a lethal neuromuscular disease that currently has no effective therapy. Transgenic overexpression of the alpha7 integrin in mdx/utrn(-/-) mice, a model of Duchenne muscular dystrophy ameliorates the disease. We have isolated and used alpha7(+/-) muscle cells expressing beta-galactosidase, driven by the endogenous alpha7 promoter, to identify compounds that increase alpha7 integrin levels. Valproic acid (VPA) was found to enhance alpha7 integrin levels, induce muscle hypertrophy, and inhibit apoptosis in myotubes by activating the Akt/mTOR/p70S6K pathway. This activation of the Akt pathway...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Gurpur PB, Liu J, Burkin DJ, Kaufman SJ Tags: Am J Pathol Source Type: journals

Ezetimibe Is An Inhibitor of Tumor Angiogenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we used ezetimibe (Zetia), a specific, FDA-approved, cholesterol uptake-blocking drug, in combination with either a hyper- or hypocholesterolemic diet, to show that elevated circulating cholesterol levels promote, whereas a reduction in circulating cholesterol levels retard, the growth of human prostate cancer xenograft tumors in mice. Circulating cholesterol levels also modified tumor angiogenesis; higher cholesterol levels increased microvessel density and other indicators of vascularity. Consistent with these data, the reduction of cholesterol levels also increased the levels of the angiogenesis inhibitor...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Solomon KR, Pelton K, Boucher K, Joo J, Tully C, Zurakowski D, Schaffner CP, Kim J, Freeman MR Tags: Am J Pathol Source Type: journals

Dendritic Cell-Nerve Clusters Are Sites of T Cell Proliferation in Allergic Airway Inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interactions between T cells and dendritic cells in the airway mucosa precede secondary immune responses to inhaled antigen. The purpose of this study was to identify the anatomical locations where dendritic cell-T cell interactions occur, resulting in T cells activation by dendritic cells. In a mouse model of allergic airway inflammation, we applied whole-mount immunohistology and confocal microscopy to visualize dendritic cells and T cells together with nerves, epithelium, and smooth muscle in three dimensions. Proliferating T cells were identified by the detection of the incorporation of the nucleotide analogue 5-et...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Veres TZ, Shevchenko M, Krasteva G, Spies E, Prenzler F, Rochlitzer S, Tschernig T, Krug N, Kummer W, Braun A Tags: Am J Pathol Source Type: journals

Galectin-3 is Critical for the Development of the Allergic Inflammatory Response in a Mouse Model of Atopic Dermatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Galectin-3 belongs to a family of beta-galactoside-binding animal lectins expressed in several cell types, including epithelial and immune cells. To establish the role of galectin-3 in the development of allergic skin inflammation, we compared inflammatory skin responses of galectin-3-deficient (gal3(-/-)) and wild-type (gal3(+/+)) mice to epicutaneous sensitization with ovalbumin (OVA). OVA-treated gal3(-/-) mice exhibited markedly reduced epidermal thickening, lower eosinophil infiltration, and lower serum IgE levels compared with gal3(+/+) mice. The former evoked lower interleukin-4, but higher interferon-gamma, mRN...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Saegusa J, Hsu DK, Chen HY, Yu L, Fermin A, Fung MA, Liu FT Tags: Am J Pathol Source Type: journals

Critical Roles of Lysosomal Acid Lipase in T Cell Development and Function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lysosomal acid lipase (LAL) cleaves cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in lysosomes. In LAL gene-knockout (lal(-/-)) mice, blockage of cholesteryl ester and triglyceride metabolism led to abnormal organization of the thymus and spleen, as well as neutral lipid accumulation in these organs. LAL deficiency impaired T cell development in the thymus. Peripheral T cells were reduced dramatically in lal(-/-) mice, due largely to increased apoptosis and decreased proliferation of lal(-/-) T cells in the thymus and peripheral compartments. These lal(-/-) T cells lost the ability t...
Source: Am J Pathol - January 29, 2009 Category: Pathology Authors: Qu P, Du H, Wilkes DS, Yan C Tags: Am J Pathol Source Type: journals