Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Neuroimmunophysiology of the Gastrointestinal Tract
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00075.2024. Online ahead of print.NO ABSTRACTPMID:38626403 | DOI:10.1152/ajpgi.00075.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Derek M McKay Manon Defaye Sruthi Rajeev Wallace K MacNaughton Yasmin Nasser Keith A Sharkey Source Type: research
Biomechanical Increase in Cervical Esophageal Wall Tension during Peristalsis
CONCLUSION: We conclude that there is a significant CTE increase, independent of laryngeal elevation or esophageal muscle contraction, which occurs during esophageal peristalsis. This response is a biomechanical process caused by esophageal shortening that occurs during esophageal longitudinal contraction of esophageal peristalsis.PMID:38626405 | DOI:10.1152/ajpgi.00049.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Ivan M Lang Bidyut K Medda Reza Shaker Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Neuroimmunophysiology of the Gastrointestinal Tract
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00075.2024. Online ahead of print.NO ABSTRACTPMID:38626403 | DOI:10.1152/ajpgi.00075.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Derek M McKay Manon Defaye Sruthi Rajeev Wallace K MacNaughton Yasmin Nasser Keith A Sharkey Source Type: research
Biomechanical Increase in Cervical Esophageal Wall Tension during Peristalsis
CONCLUSION: We conclude that there is a significant CTE increase, independent of laryngeal elevation or esophageal muscle contraction, which occurs during esophageal peristalsis. This response is a biomechanical process caused by esophageal shortening that occurs during esophageal longitudinal contraction of esophageal peristalsis.PMID:38626405 | DOI:10.1152/ajpgi.00049.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Ivan M Lang Bidyut K Medda Reza Shaker Source Type: research
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation
In conclusion, SCAP N-glycosylation aggravates inflammation and lipid accumulation through enhancing ACSS2-mediated H3K27ac in hepatocytes.PMID:38591127 | DOI:10.1152/ajpgi.00273.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Xuemei Li Xiaoqin Tang Yue Xiang Zhibo Zhao Yanping Li Qiuying Ding Linkun Zhang Jingyuan Xu Lei Zhao Yao Chen Source Type: research
High-Energy Pacing Inhibits Slow Wave Dysrhythmias in the Small Intestine
This study assessed the use of pacing to suppress glucagon-induced slow wave dysrhythmias in the small intestine. Slow waves in the jejunum were mapped in vivo using a high-resolution surface-contact electrode array in pigs (n=7). Glucagon was intravenously administered to induce hyperglycemia. Slow wave propagation patterns were categorized into antegrade, retrograde, collision, pacemaker and uncoupled activity. Slow wave characteristics such as period, amplitude and speed were also quantified. Post-glucagon infusion, pacing was applied at 4 mA and 8 mA and the resulting slow waves were quantified spatiotemporally. Antegr...
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Nipuni D Nagahawatte Recep Avci Niranchan Paskaranandavadivel Leo K Cheng Source Type: research
Milk and < em > Lacticaseibacillus casei < /em > BL23 effects on intestinal responses in a murine model of colitis
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 9. doi: 10.1152/ajpgi.00259.2023. Online ahead of print.ABSTRACTProbiotic-containing fermented dairy foods have the potential to benefit human health, but the importance of the dairy matrix for efficacy remains unclear. We investigated the capacity of Lacticaseibacillus casei BL23 in phosphate-buffered saline (BL23-PBS), BL23-fermented milk (BL23-milk), and milk to modify intestinal and behavioral responses in a Dextran Sodium Sulfate (DSS, 3% w/v) mouse model of colitis. Significant sex-dependent differences were found such that female mice exhibited more severe colitis, g...
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Glory Bui Cristina Torres-Fuentes Matteo M Pusceddu Melanie G Gareau Maria L Marco Source Type: research
Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial
Conclusions: At the doses used in this study, oral tryptophan supplementation in humans induces microbial indole and host kynurenine metabolic pathways in the small intestine, known to be immunomodulatory. The results should prompt tryptophan intervention strategies in inflammatory conditions of the small intestine where the AhR pathway is impaired.PMID:38591144 | DOI:10.1152/ajpgi.00306.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Gaston H Rueda Natalia Causada-Calo Rajka Borojevic Andrea Nardelli Maria Ines Pinto-Sanchez Marco Constante Josie Libertucci Vidhyalakshmi Mohan Philippe Langella Linda M P Loonen Jerry M Wells Harry Sokol Elena F Verdu Premysl Bercik Source Type: research
StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis
CONCLUSIONS: StarD5's downregulation with hepatic lipid excess is a previously unappreciated physiologic function appearing to promote lipid storage for future needs. Conversely, StarD5's lingering downregulation with prolonged lipid/cholesterol excess accelerates fatty liver's transition to fibrosis; mediated via dysregulation in the oxysterol signaling pathway.PMID:38591148 | DOI:10.1152/ajpgi.00024.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Genta Kakiyama Kei Minowa Nanah Bai-Kamara Taishi Hashiguchi William M Pandak Daniel Rodriguez-Agudo Source Type: research
LPA < sub > 5 < /sub > -Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 9. doi: 10.1152/ajpgi.00269.2023. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) is a bioactive lipid molecule that regulates a wide array of cellular functions, including proliferation, differentiation, and survival, via activation of cognate receptors. The LPA5 receptor is highly expressed in the intestinal epithelium, but its function in restoring intestinal epithelial integrity following injury has not been examined. Here, we use a radiation-induced injury model to study the role of LPA5 in regulating intestinal epithelial regeneration. Control mice (Lpar5f/f...
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Beth B McConnell Zhongxing Liang Chad Xu Yiran Han C Chris Yun Source Type: research
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation
In conclusion, SCAP N-glycosylation aggravates inflammation and lipid accumulation through enhancing ACSS2-mediated H3K27ac in hepatocytes.PMID:38591127 | DOI:10.1152/ajpgi.00273.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Xuemei Li Xiaoqin Tang Yue Xiang Zhibo Zhao Yanping Li Qiuying Ding Linkun Zhang Jingyuan Xu Lei Zhao Yao Chen Source Type: research
High-Energy Pacing Inhibits Slow Wave Dysrhythmias in the Small Intestine
This study assessed the use of pacing to suppress glucagon-induced slow wave dysrhythmias in the small intestine. Slow waves in the jejunum were mapped in vivo using a high-resolution surface-contact electrode array in pigs (n=7). Glucagon was intravenously administered to induce hyperglycemia. Slow wave propagation patterns were categorized into antegrade, retrograde, collision, pacemaker and uncoupled activity. Slow wave characteristics such as period, amplitude and speed were also quantified. Post-glucagon infusion, pacing was applied at 4 mA and 8 mA and the resulting slow waves were quantified spatiotemporally. Antegr...
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Nipuni D Nagahawatte Recep Avci Niranchan Paskaranandavadivel Leo K Cheng Source Type: research
Milk and < em > Lacticaseibacillus casei < /em > BL23 effects on intestinal responses in a murine model of colitis
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 9. doi: 10.1152/ajpgi.00259.2023. Online ahead of print.ABSTRACTProbiotic-containing fermented dairy foods have the potential to benefit human health, but the importance of the dairy matrix for efficacy remains unclear. We investigated the capacity of Lacticaseibacillus casei BL23 in phosphate-buffered saline (BL23-PBS), BL23-fermented milk (BL23-milk), and milk to modify intestinal and behavioral responses in a Dextran Sodium Sulfate (DSS, 3% w/v) mouse model of colitis. Significant sex-dependent differences were found such that female mice exhibited more severe colitis, g...
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Glory Bui Cristina Torres-Fuentes Matteo M Pusceddu Melanie G Gareau Maria L Marco Source Type: research
