Am J Physiol Heart C...
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Am J Physiol Heart Circ Physiol; +63 new citations
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/11/13PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - November 13, 2009 Category: Cardiology Tags: Report Source Type: journals
Am J Physiol Heart Circ Physiol; +17 new citationsEmail this article to a colleague.
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/10/27PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - October 27, 2009 Category: Cardiology Tags: Report Source Type: journals
Am J Physiol Heart Circ Physiol; +43 new citationsEmail this article to a colleague.
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/10/11PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - October 11, 2009 Category: Cardiology Tags: Report Source Type: journals
Developmental regulation of cardiovascular function is dependent on both genotype and environment.Email this article to a colleague.
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DEVELOPMENTAL REGULATION OF CARDIOVASCULAR FUNCTION IS DEPENDENT ON BOTH GENOTYPE AND ENVIRONMENT.
Am J Physiol Heart Circ Physiol. 2009 Sep 25;
Authors: Knight BS, Sunn N, Pennell CE, Adamson SL, Lye SJ
Adverse developmental environments can increase the risk of adult cardiovascular disease but not all individuals are affected, suggesting the importance of genotype. Genetically distinct mouse strains allow genetic dissection of complex-traits; however, they have not been utilized to evaluate the developmental origins of adult cardiovascular disease. Our objective was to determine the effect of prenatal nutrien...
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Knight BS, Sunn N, Pennell CE, Adamson SL, Lye SJ Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Differential Regulation of Vascular Smooth Muscle and Endothelial Cell Proliferation In Vitro and In Vivo by cAMP/PKA-activated p85{alpha}PI3K.Email this article to a colleague.
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In conclusions, PKA-activated-p85alpha integrates cAMP/PKA signaling differently in VSMCs and ECs. By reducing neointimal hyperplasia without inhibiting endothelial regeneration, it exerts a protective effect against restenosis after balloon injury. Key words: Restenosis, smooth muscle cells, endothelial cells, cAMP.
PMID: 19783773 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Torella D, Gasparri C, Ellison GM, Curcio A, Leone A, Vicinanza C, Galuppo V, Mendicino I, Sacco W, Aquila I, Surace FC, Luposella M, Stillo G, Agosti V, Cosentino C, Avvedimento EV, Indolfi C Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes.Email this article to a colleague.
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Duchenne muscular dystrophy represents a severe inherited disease of striated muscle. It is caused by a mutation of the dystrophin gene and characterized by a progressive loss of skeletal muscle function. Most patients also develop a dystrophic cardiomyopathy resulting in dilated hypertrophy and heart failure, but cellular mechanisms leading to deterioration of cardiac function remain elusive. Here we tested whether defective excitation-contraction (EC) coupling contributes to impaired cardiac performance. "EC-coupling gain" was determined in cardiomyocytes from control and dystrophin-deficient mdx mice. To this end, C...
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Ullrich ND, Fanchaouy M, Gusev K, Shirokova N, Niggli E Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.Email this article to a colleague.
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Pulmonary arterial hypertension (PAH) is a chronic lung disease that leads to right ventricular hypertrophy (RVH), remodeling and failure. We tested treatment with bone marrow-derived mesenchymal stem cells (MSCs) obtained from donor rats with monocrotaline (MCT)-induced PAH to recipient rats with MCT-induced PAH on pulmonary artery pressure, lung pathology and RV function. This model was chosen to mimic autologous MSC therapy. At day 1, PAH was induced by MCT (60 mg/kg) in 20 female Wistar rats. At day 14, rats were treated with 10(6) MSCs i.v. (MCT+MSC) or saline (MCT60). MSCs were obtained from donor rats with PAH a...
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Umar S, de Visser YP, Steendijk P, Schutte CI, Laghmani EH, Wagenaar GT, Bax WH, Mantikou E, Pijnappels DA, Atsma DE, Schalij MJ, van der Wall EE, van der Laarse A Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Role of nitric oxide as a key mediator on cardiovascular actions of atrial natriuretic peptide in spontaneously hypertensive rats.Email this article to a colleague.
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Conclusions: In atria, ventricle and aorta, ANP interacts with NPR-C receptors, activating Ca-calmodulin eNOS through Gi protein. In ventricle and aorta, NOS activation also involves NPR-A/B. NOS response to ANP was impaired in heart and aorta of SHR. Impaired NO-system response to ANP in hypertensive animals, involving alterations in the signaling pathway, could participate in maintenance of high blood pressure in this model of hypertension. Key words: cardiovascular nitric oxide synthase, hypertension, aorta artery, heart.
PMID: 19783776 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Costa MA, Elesgaray R, Caniffi C, Fellet AL, Mac Laughlin M, Arranz C Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Additive Beneficial Effects of Lactotripeptide and Aerobic Exercise on Arterial Compliance in Postmenopausal Women.Email this article to a colleague.
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Central arterial compliance plays an important role in the functional abilities of the vasculature. Two active tripeptides, valine-proline-proline (Val-Pro-Pro) and isoleucine-Pro-Pro (Ile-Pro-Pro), were isolated from the sour milk and were referred to lactotripeptide (LTP). Because LTP appears to act as angiotensin-converting enzyme (ACE) inhibitor, it is plausible to hypothesize that LTP improves arterial compliance. We determined the effects of LTP ingestion alone or in combination with regular aerobic exercise on arterial compliance. A total of 55 postmenopausal women (50-65 years old) were randomly divided into fo...
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N, Ajisaka R, Tanaka H Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Structural adaptation of microvessel diameters in response to metabolic stimuli: Where are the oxygen sensors?Email this article to a colleague.
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Maintenance of functional vascular networks requires structural adaptation of vessel diameters in response to hemodynamic and metabolic conditions. The mechanisms by which diameters respond to the metabolic state are not known but may involve the release of vasoactive substances in response to low oxygen by tissue ("tissue signaling", e.g. CO2, adenosine), by vessel walls ("wall signaling", e.g. prostaglandins, adenosine) and/or by red blood cells, RBCs ("RBC signaling", e.g. ATP and NO). Here, the goal was to test the potential of each of these locations of oxygen-dependent signaling to control steady-state vascular d...
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Reglin B, Secomb TW, Pries AR Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Abnormal Nitric Oxide Production in Aged Rat Mesenteric Arteries is Mediated by NAD(P)H Oxidase-derived Peroxide.Email this article to a colleague.
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Previous work in our laboratory showed increased basal periarterial NO and H2O2 concentrations in the Spontaneously Hypertensive Rat (SHR), characterized by oxidant stress, as well as impaired flow-mediated NO production that was corrected by reduction of periarterial H2O2. Aging also is associated with an increase in vascular reactive oxygen species (ROS) and results in abnormal vascular function. The current study was designed to assess the role of H2O2 in regulating NO production during vascular aging. In vivo, real-time NO and H2O2 concentrations were measured by microelectrodes in mesenteric arteries of retired br...
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Zhou X, Bohlen HG, Unthank JL, Miller SJ Tags: Am J Physiol Heart Circ Physiol Source Type: journals
An Adaptive Transfer Function for Deriving the Aortic Pressure Waveform from a Peripheral Artery Pressure Waveform.Email this article to a colleague.
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We developed a new technique to mathematically transform a peripheral artery pressure (PAP) waveform distorted by wave reflections into the physiologically more relevant aortic pressure (AP) waveform. First, a transfer function relating PAP to AP is defined in terms of the unknown parameters of a parallel tube model of pressure and flow in the arterial tree. Then, the parameters are estimated from the measured PAP waveform along with a one-time measurement of the wave propagation delay time between the aorta and peripheral artery measurement site (which may be accomplished non-invasively) by exploiting pre-knowledge of...
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Swamy G, Xu D, Olivier NB, Mukkamala R Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.Email this article to a colleague.
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Although long term use of cyclooxygenase (COX)-2 inhibitors may be associated with increased cardiovascular risk, their effects on vascular reactivity in atherosclerosis has remained largely unexplored. The aim of the present study was to evaluate the role of COX-2 induced by an atherosclerotic process, in the local control of vascular tone. New Zealand White rabbits were fed 0.3% cholesterol and subjected to balloon injury of the abdominal aorta. After 2 weeks, the aorta was removed and used for organ bath experiments and immunohistochemistry, and the prostaglandins released were measured using enzyme immunoassays. Hy...
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Foudi N, Norel X, Rienzo M, Louedec L, Brink C, Michel JB, Back M Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Angiotensin II Effects on Ischemic Focal Ventricular Tachycardia are Predominantly Mediated Through Myocardial AT2 Receptor.Email this article to a colleague.
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Conclusions: AGII promotes only focal, mainly Purkinje ischemic VT. PD, but not losartan, preferentially blocked focal VT, which is likely due to triggered activity due to delayed afterdepolarizations in Purkinje. Key words: angiotensin II, AT2 receptor, focal ventricular tachycardia, triggered activity.
PMID: 19783782 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - September 24, 2009 Category: Cardiology Authors: Gopinathannair R, Chaudhary AK, Xing D, Ely D, Zheng W, Martins JB Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Am J Physiol Heart Circ Physiol; +39 new citationsEmail this article to a colleague.
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39 new pubmed citations were retrieved for your search.
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/09/22PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - September 22, 2009 Category: Cardiology Tags: Report Source Type: journals
Am J Physiol Heart Circ Physiol; +48 new citationsEmail this article to a colleague.
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48 new pubmed citations were retrieved for your search.
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/09/04PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - September 4, 2009 Category: Cardiology Tags: Report Source Type: journals
Nitrite Enhances RBC Hypoxic ATP Synthesis and the Release of ATP into the Vasculature: a new mechanism for nitrite induced vasodilation.Email this article to a colleague.
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In this study, we have delineated a mechanism for nitrite induced RBC vasodilation that does not require that NO be released from the cell. Instead we show that nitrite enhances the ATP release from RBCs, which is known to produce vasodilation by several different methods including the interaction with purinergic receptors on the endothelium that stimulate the synthesis of NO by endothelial NO synthase. This mechanism was established in vivo by measuring the decrease in blood pressure when injecting nitrite reacted RBCs into rats. The observed decrease in blood pressure was not observed if e-NOS was inhibited by N-omega-ni...
Source: Am J Physiol Heart C... - August 20, 2009 Category: Cardiology Authors: Cao Z, Bell JB, Mohanty JG, Nagababu E, Rifkind JM Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Experimental and Theoretical Ventricular Electrograms and their Relation to Electrophysiological Gradients in the Adult Rat Heart.Email this article to a colleague.
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In this study, optical mapping techniques have been applied to an in vitro left ventricular adult rat preparation to obtain patterns of conduction and action potential duration measurements from the epicardial surface. This information has been combined with previously published mathematical models of the rat ventricular myocyte to develop a bidomain model for action potential propagation and electrogram formation in the rat left ventricle. Important insights into the basis for the repolarization waveform in the ventricular electrogram of the adult rat have been obtained. Notably, our model demonstrated that the biphasic s...
Source: Am J Physiol Heart C... - August 20, 2009 Category: Cardiology Authors: Weber Dos Santos R, Nygren A, Otaviano Campos F, Koch H, Giles WR Tags: Am J Physiol Heart Circ Physiol Source Type: journals
A slowly-inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes.Email this article to a colleague.
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In conclusion, late INa can contribute to DD of atrial myocytes, and inhibition of this current suppresses atrial DD and spontaneous APs. Key words: Late sodium current, Atrial myocytes, Diastolic depolarization, Action potential.
PMID: 19700626 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - August 20, 2009 Category: Cardiology Authors: Song Y, Shryock JC, Belardinelli L Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Impaired Contractile Function and Calcium Handling in Hearts of Cardiac-specific Calcineurin b1-deficient Mice.Email this article to a colleague.
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To define the necessity of calcineurin (Cn) signaling for cardiac maturation and function, the postnatal phenotype of mice with cardiac-specific targeted ablation of the Cn B1 regulatory subunit (Ppp3r1) gene (csCnb1(-/-) mice) was characterized. csCnb1(-/-) mice develop a lethal cardiomyopathy characterized by impaired postnatal growth of the heart and combined systolic and diastolic relaxation abnormalities despite a lack of structural derangements. Notably, the csCnb1(-/-) hearts did not exhibit diastolic dilatation despite the severe functional phenotype. Myocytes isolated from the mutant mice exhibited reduced rat...
Source: Am J Physiol Heart C... - August 20, 2009 Category: Cardiology Authors: Schaeffer PJ, Desantiago J, Yang JH, Flagg TP, Kovacs A, Weinheimer C, Courtois MR, Leone TC, Nichols CG, Bers DM, Kelly DP Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Am J Physiol Heart Circ Physiol; +58 new citationsEmail this article to a colleague.
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58 new pubmed citations were retrieved for your search.
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/08/14PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - August 15, 2009 Category: Cardiology Tags: Report Source Type: journals
Am J Physiol Heart Circ Physiol; +16 new citationsEmail this article to a colleague.
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16 new pubmed citations were retrieved for your search.
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/08/12PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - August 13, 2009 Category: Cardiology Tags: Report Source Type: journals
Interleukin-1{alpha} Stimulates Pro-inflammatory Cytokine Expression in Human Cardiac Myofibroblasts.Email this article to a colleague.
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In conclusion, IL-1alpha stimulates human CMF to express IL-1beta, TNFalpha and IL-6 via specific signaling pathways; responses that are unaffected by IL-10 exposure. Key words: cardiac fibroblasts, inflammation, signal transduction, cytokines.
PMID: 19648252 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - July 30, 2009 Category: Cardiology Authors: Turner NA, Das A, Warburton P, O'Regan DJ, Ball SG, Porter KE Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Sphingosine 1-Phosphate is an Important Endogenous Cardioprtectant Released by Ischemic Pre- and Post-Conditioning.Email this article to a colleague.
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Exogenous sphingosine 1-phosphate (S1P) is an effective cardioprotectant against ischemic injury. We have investigated the hypothesis that S1P is also an important endogenous cardioprotectant released during both ischemic preconditioning (IPC) and ischemic postconditioning (IPOST). IPC of ex vivo rat hearts was instituted by 2 cycles of 3 min ischemia/5 min reperfusion prior to 40 min of index ischemia and then 40 min of reperfusion. IPC resulted in 70% recovery of left ventricular developed pressure (LVDP) upon reperfusion and a small infarct size (10%). VPC23019 (VPC), a specific antagonist of S1P1 and 3 G-protein co...
Source: Am J Physiol Heart C... - July 30, 2009 Category: Cardiology Authors: Vessey DA, Li L, Honbo N, Karliner JS Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Impact of ionic current variability on human ventricular cellular electrophysiology.Email this article to a colleague.
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This study provides quantitative insights into the sensitivity of preclinical biomarkers of arrhythmic risk to variations in ionic current properties in humans. Results show the importance of sensitivity analysis as a powerful method for in depth validation of mathematical models in cardiac electrophysiology. Key words: ionic current, biological variability, arrhythmia, computer simulation.
PMID: 19648254 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - July 30, 2009 Category: Cardiology Authors: Romero L, Pueyo E, Fink M, Rodriguez B Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Autonomic effects on the spectral analysis of heart rate variability after exercise.Email this article to a colleague.
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Although frequency domain analysis of heart rate variability (HRV) has been performed in the setting of exercise and recovery from exercise, the relationship of specific frequency components to sympathetic and parasympathetic inputs has not been validated in this setting. The aim of this study is to evaluate the relationship of frequency components of HRV to sympathetic and parasympathetic modulation in the setting of recovery after exercise using selective autonomic blockade. Normal subjects (N=27, 17 male, 53+/-7 years old) underwent bicycle stress testing on four separate days. On Day 1, a baseline study without aut...
Source: Am J Physiol Heart C... - July 30, 2009 Category: Cardiology Authors: Ng J, Sundaram S, Kadish AH, Goldberger JJ Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Spontaneous calcium release in tissue from the failing canine heart.Email this article to a colleague.
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Conclusions: TA in HF tissue is associated with abnormal calcium regulation and mediated by the spontaneous release of calcium from the SR in aggregates of myocardial cells (i.e. an SCR), but importantly it is the rate of SCR rise rather than amplitude that was associated with TA. Key words: heart failure, arrhythmia, spontaneous calcium release, delayed afterdepolarization.
PMID: 19648256 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - July 30, 2009 Category: Cardiology Authors: Hoeker GS, Katra RP, Wilson LD, Plummer BN, Laurita KR Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Am J Physiol Heart Circ Physiol; +36 new citationsEmail this article to a colleague.
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36 new pubmed citations were retrieved for your search.
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/07/19PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - July 20, 2009 Category: Cardiology Tags: Report Source Type: journals
Determinants of left ventricular shear strain.Email this article to a colleague.
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In this study, we used a finite element model of left ventricular (LV) mechanics to investigate sensitivity of midwall circumferential-radial shear strain Ecr to settings of parameters determining passive shear stiffness, cross-fiber active stress development, and transmural cross-over of myofibers. Simulated time courses of midwall LV Ecr were compared to time courses obtained in three healthy volunteers using MRT. Ecr as measured in the volunteers during the cardiac cycle was characterised by an amplitude of about 0.1. In the simulations, a realistic amplitude of the Ecr signal could be obtained by tuning either of the t...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Bovendeerd P, Kroon W, Delhaas T Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Focus on Carbon Monoxide: A Modulator of Neutrophil Oxidants and Elastase Spatial Localization?Email this article to a colleague.
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The protective roles of CO in various patho-physiological conditions are rapidly expanding. We are only beginning to understand how this gaseous signal molecule exerts such diverse cell and model specific effects. CO interacts in NO signaling, and is an activator of guanylate cyclase/PKG. However several downstream molecular signals mediated by CO (p38-MAPK, ERK1/2) may be oxidant dependent. How CO affects these and other signaling pathways in PMN is not well understood, but is of immense clinical interest. The present study by Mizoguchi et al. describes cell-specific roles of CORM-3 derived CO in protecting the lung a...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Ganta VC, Alexander JS Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Reduction of Repolarization Reserve Unmasks the Pro-arrhythmic Role of Endogenous Late Sodium Current in the Heart.Email this article to a colleague.
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Reduction of repolarization reserve increases the risk of arrhythmia. We hypothesized that inhibition of K(+) current (IK) to decrease repolarization reserve would unmask the pro-arrhythmic role of endogenous, physiological late Na(+) current (late INa). Monophasic action potentials (MAP) and 12-lead electrocardiogram were recorded from female rabbit isolated hearts. To block IK and reduce repolarization reserve, E-4031, 4-aminopyridine, and BaCl2 were used; to block endogenous late INa, tetrodotoxin (TTX) and ranolazine were used. E-4031 (1-60 nM) concentration-dependently prolonged MAP duration (MAPD90) and increased...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Wu L, Rajamani S, Li H, January CT, Shryock JC, Belardinelli L Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action.Email this article to a colleague.
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SENESCENCE, APOPTOSIS, AND STEM CELL BIOLOGY: THE RATIONALE FOR AN EXPANDED VIEW OF INTRACRINE ACTION.
Am J Physiol Heart Circ Physiol. 2009 Jul 10;
Authors: Re RN, Cook JL
Some extracellular signaling peptides also at times function within the intracellular space. We have termed these peptides intracrines and have argued that intracrine function is associated with a wide variety of peptides/proteins including hormones, growth factors, cytokines, enzymes, and DNA binding proteins among others. Here we consider the possibility that intracrines participate in the related phenomena of senescence, apoptosis, and st...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Re RN, Cook JL Tags: Am J Physiol Heart Circ Physiol Source Type: journals
The absence of gp130 in dopamine {beta} hydroxylase-expressing neurons leads to autonomic imbalance and increased reperfusion arrhythmias.Email this article to a colleague.
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Inflammatory cytokines that act through gp130 are elevated in the heart after myocardial infarction and in heart failure. These cytokines are potent regulators of neurotransmitter and neuropeptide production in sympathetic neurons, but are also important for the survival of cardiac myocytes following damage to the heart. To examine the effect of gp130 cytokines on cardiac nerves we used gp130(DBH-Cre/lox) mice, which have a selective deletion of the gp130 cytokine receptor in neurons expressing dopamine beta hydroxylase (DBH). Basal sympathetic parameters including norepinephrine (NE) content, tyrosine hydroxylase expr...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Parrish DC, Alston EN, Rohrer H, Hermes SM, Aicher SA, Nkadi P, Woodward WR, Stubbusch J, Gardner RT, Habecker BA Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Intermedin is a New Angiogenic Growth Factor.Email this article to a colleague.
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In this study, we evaluated the role of IMD in angiogenesis in the ischemic hindlimb. Adenovirus containing human IMD or control adenovirus (Ad.Null) was injected into adductor muscles of rats immediately after femoral artery ligation. Expression of human IMD was detected in the skeletal muscle 5 days after viral injection. Blood perfusion in the ischemic hindlimb was monitored by laser Doppler imaging from 1 to 3 weeks after gene delivery. Compared to animals receiving Ad.Null, IMD gene transfer resulted in a time-dependent increase in blood perfusion. IMD gene delivery also increased capillary and arteriole density in is...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Smith Jr RS, Gao L, Beldsoe G, Chao L, Chao J Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndrome.Email this article to a colleague.
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Metabolic syndrome (MetS) represents an increased risk of cardiovascular disease. Although its individual components adversely affect cardiac structure and function, the extent to which multiple components of MetS affect the cardiac extracellular matrix (ECM) has not been well characterized. Lysyl oxidase (LOX) is one of the cardiac ECM modifying enzymes that catalyzes the formation of collagen cross-linking. Our objective was to define the effect of diet-induced MetS on LOX enzyme. MetS was induced in male C57BL/6 mice by administrating a high-fat high-simple carbohydrate (HFHSC) diet for 6 months. Gene expression was...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Zibadi S, Vazquez R, Moore D, Larson DF, Watson RR Tags: Am J Physiol Heart Circ Physiol Source Type: journals
A1 adenosine receptor-mediated protein kinase C and p42/p44 mitogen-activated protein kinase signaling in mouse coronary artery smooth muscle cells.Email this article to a colleague.
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This study was performed in coronary artery smooth muscle cells (CASMC) isolated from mouse heart (A1WT and A1KO) to delineate the A1AR signaling through protein kinase C (PKC) pathway. In A1WT cells, treatment with ENBA (10(-5)M) increased A1AR expression by 150%, which was inhibited significantly by A1AR antagonist, DPCPX (10(-6)M) but not in A1KO CASMC. PKC isoforms were identified by western blotting in cytosolic and membrane fractions from cell homogenates of CASMC. In A1WT and A1KO cells, significant levels of basal PKCalpha were detected in cytosolic fractions. Treatment with A1AR agonist, ENBA (10-5M) translocated ...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Ansari HR, Teng B, Nadeem A, Roush KP, Martin KH, Schnermann JB, Mustafa SJ Tags: Am J Physiol Heart Circ Physiol Source Type: journals
The transport of LDL across the deformable arterial wall: the effect of endothelial cell turnover and intimal deformation under hypertension.Email this article to a colleague.
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A multilayered model of the aortic wall is introduced to investigate the transport of low-density lipoprotein (LDL) under hypertension, taking into account the influences of increased endothelial cell turnover and deformation of the intima at higher pressure. Meanwhile, the thickness and properties of the endothelium, intima, internal elastic lamina (IEL), and media are affected by the transmural pressure. The LDL macromolecules enter the intima through leaky junctions over the endothelium, which are created by dying or dividing cells. Water molecules enter the intima via the paracellular pathway through breaks in tigh...
Source: Am J Physiol Heart C... - July 9, 2009 Category: Cardiology Authors: Dabagh Meshin M, Jalali P, Tarbell JM Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Adipose-derived Stem Cells Are an Effective Cell Candidate for Treatment of Heart Failure - An MR Imaging Study of Rat Hearts.Email this article to a colleague.
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This study was to assess the potential therapeutic efficacy of adipose-derived stem cells (ASCs) on infarcted hearts. Myocardial infarction was induced in rat hearts by occlusion of the left anterior descending (LAD) artery. One week after LAD occlusion, the rats were divided to three groups and subjected to transplantation of ASCs, transplantation of cell-culture medium (CCM) or remained untreated. During one-month recovery period, magnetic resonance (MR) imaging showed that the ASC-treated hearts had a significantly greater left ventricular ejection fraction (LVEF) and LV wall thickening than did the CCM-treated and untr...
Source: Am J Physiol Heart C... - July 1, 2009 Category: Cardiology Authors: Wang L, Deng J, Tian W, Xiang B, Yang T, Li G, Wang J, Gruwel M, Kashour T, Rendell J, Glogowski M, Tomanek B, Freed D, Deslauriers R, Arora RC, Tian G Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Hemoglobin vesicles improve wound healing and tissue survival in critically ischemic skin in mice.Email this article to a colleague.
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Local hypoxia, as due to trauma, surgery or arterial occlusive disease, may severely jeopardize the survival of the affected tissue and its wound healing capacity. Initially developed to replace blood transfusions, artificial oxygen carriers have emerged as oxygen therapeutics in such conditions. The aim of this study was to target primary wound healing and survival in critically ischemic skin by systemic application of left-shifted liposomal hemoglobin vesicles (HbVs). This was tested in bilateral, cranially based dorsal skin flaps in mice treated with a HbV solution with an oxygen affinity that was increased to a P50...
Source: Am J Physiol Heart C... - July 1, 2009 Category: Cardiology Authors: Plock JA, Rafatmehr N, Sinovcic D, Schnider J, Sakai H, Tsuchida E, Banic A, Erni D Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Am J Physiol Heart Circ Physiol; +269 new citationsEmail this article to a colleague.
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269 new pubmed citations were retrieved for your search.
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Am J Physiol Heart Circ Physiol
These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - June 27, 2009 Category: Cardiology Tags: Report Source Type: journals
Patient-specific three-dimensional simulation of ldl accumulation in a human left coronary artery in its healthy and atherosclerotic states.Email this article to a colleague.
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PATIENT-SPECIFIC THREE-DIMENSIONAL SIMULATION OF LDL ACCUMULATION IN A HUMAN LEFT CORONARY ARTERY IN ITS HEALTHY AND ATHEROSCLEROTIC STATES.
Am J Physiol Heart Circ Physiol. 2009 Mar 27;
Authors: Olgac U, Poulikakos D, Saur SC, Alkadhi H, Kurtcuoglu V
We calculate low-density lipoprotein (LDL) transport from blood into arterial walls in a three-dimensional patient-specific model of a human left coronary artery. The in-vivo anatomy data are obtained from computed tomography (CT) images of a patient with coronary artery disease. Models of the artery anatomy in its healthy and diseased states are derived after seg...
Source: Am J Physiol Heart C... - March 27, 2009 Category: Cardiology Authors: Olgac U, Poulikakos D, Saur SC, Alkadhi H, Kurtcuoglu V Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Differences in Collagen Crosslinking Between the Four Valves of the Bovine Heart: A Possible Role in Adaptation to Mechanical Fatigue.Email this article to a colleague.
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Hydrothermal isometric tension (HIT) testing and high performance liquid chromatography (HPLC) were used to assess the molecular stability and crosslink population of collagen in the four valves of the adult bovine heart. Untreated and NaBH4-treated tissues under isometric tension were heated in a water bath to a 90 degrees C isotherm that was sustained for 5 hours. The denaturation temperature (Td), associated with hydrogen bond rupture and molecular stability, and the half-time of load decay (t1/2), associated with peptide bond hydrolysis and intermolecular crosslinking, were calculated from acquired load/temperature...
Source: Am J Physiol Heart C... - March 27, 2009 Category: Cardiology Authors: Aldous IG, Veres SP, Jahangir A, Lee JM Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Impact of Mitral Regurgitation on Left Ventricular Anatomic and Molecular Remodeling and Systolic Function: Implication for Outcome.Email this article to a colleague.
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Conclusion: Chronic MR leads to LV anatomic and cellular remodeling and impaired contractility. The time course of LV remodeling and function changes in the rat model of MR is similar to humans. Prediction of outcome may be achieved by assessments of early LV remodeling. Key words: mitral regurgitation, Molecular biology, left ventricular remodeling, left ventricular function.
PMID: 19329766 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - March 27, 2009 Category: Cardiology Authors: Pu M, Gao Z, Zhang X, Liao D, Pu DK, Brennan T, Davidson WR Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Venomotion Modulates Lymphatic Pumping in the Bat Wing.Email this article to a colleague.
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In skin, it is believed that lymph must be pumped by intrinsic contraction of lymphatic muscle, since investigators have not considered that cyclical dilation of adjacent venules could compress adjacent lymphatic microvessels. Because lymphatic vessels are sensitive to stretch, we hypothesized that venomotion not only can cause extrinsic pumping of lymph in nearby lymphatic vessels, but also can stimulate intrinsic contractions. Bat wing venules have pronounced venomotion and are in close proximity to lymphatic microvessels, and can be studied noninvasively without the confounding effects of anesthesia, surgical trauma...
Source: Am J Physiol Heart C... - March 27, 2009 Category: Cardiology Authors: Dongaonkar RM, Stewart RH, Laine GA, Davis MJ, Zawieja DC, Quick CM Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Myocardial oxygenation is critical for improving regeneration capacity.Email this article to a colleague.
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No abstract Key words: stem cell, myocardial infarction, ejection fraction, cellular cardiomyoplasty.
PMID: 19329768 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - March 27, 2009 Category: Cardiology Authors: Kaushal S, Bouchard CP, Wold LE Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Distributed modeling of osmotically driven fluid transport in peritoneal dialysis: theoretical and computational investigations.Email this article to a colleague.
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Based on a distributed model of peritoneal transport, a mathematical theory is presented to explain how the osmotic agent in the peritoneal dialysis solution that penetrates tissue induces osmotically driven flux out of the tissue. The relationships between phenomenological transport parameters (hydraulic permeability, reflection coefficient) and the respective specific transport parameters for the tissue and the capillary wall are separately described. Closed formulas for steady state flux across the peritoneal surface and for hydrostatic pressure at the opposite surface are obtained using an approximate description o...
Source: Am J Physiol Heart C... - March 27, 2009 Category: Cardiology Authors: Waniewski J, Stachowska-Pietka J, Flessner M Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Dose-response relationship of autonomic nervous system responses to individualized training impulse in marathon runners.Email this article to a colleague.
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DOSE-RESPONSE RELATIONSHIP OF AUTONOMIC NERVOUS SYSTEM RESPONSES TO INDIVIDUALIZED TRAINING IMPULSE IN MARATHON RUNNERS.
Am J Physiol Heart Circ Physiol. 2009 Mar 27;
Authors: Manzi V, Castagna C, Padua E, Lombardo M, D'Ottavio S, Massaro MC, Volterrani M, Iellamo F
In athletes exercise training induces autonomic nervous system (ANS) adaptations that could be used to monitor the training status. However, the relationship between training and ANS in athletes has been investigated without regard for individual training loads. We tested the hypothesis that in long-distance athletes changes in ANS parameters are do...
Source: Am J Physiol Heart C... - March 27, 2009 Category: Cardiology Authors: Manzi V, Castagna C, Padua E, Lombardo M, D'Ottavio S, Massaro MC, Volterrani M, Iellamo F Tags: Am J Physiol Heart Circ Physiol Source Type: journals
Am J Physiol Heart Circ Physiol; +28 new citationsEmail this article to a colleague.
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28 new PubMed citations were retrieved for your search.
Click on the search hyperlink below to display the complete search results:
Am J Physiol Heart Circ Physiol
These PubMed results were generated on 2009/03/20PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - March 20, 2009 Category: Cardiology Tags: Report Source Type: journals
Am J Physiol Heart Circ Physiol; +63 new citationsEmail this article to a colleague.
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63 new PubMed citations were retrieved for your search.
Click on the search hyperlink below to display the complete search results:
Am J Physiol Heart Circ Physiol
These PubMed results were generated on 2009/03/14PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950's.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...)
Source: Am J Physiol Heart C... - March 14, 2009 Category: Cardiology Tags: Report Source Type: journals
