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Primary graft dysfunction: it's all the RAGE.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897768 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Wilkes DS Tags: Am J Respir Crit Care Med Source Type: journals

Searching for the tuberculosis "needle in the haystack": do we need a new approach to find tuberculosis in countries with a low burden of tuberculosis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897769 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Migliori GB, Weis S Tags: Am J Respir Crit Care Med Source Type: journals

Approaches to achieving universal health care in the United States: where should the American thoracic society stand?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897770 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Brown LK, Marcy TW, Kissner D, Douglas I, Tags: Am J Respir Crit Care Med Source Type: journals

Pro: single-payer health care: simple, fair, and affordable.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897771 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Day JA Tags: Am J Respir Crit Care Med Source Type: journals

Con: single-payer health care: why it's not the best answer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897772 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Diamond MA Tags: Am J Respir Crit Care Med Source Type: journals

Combined effects of obesity and chronic obstructive pulmonary disease on dyspnea and exercise tolerance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The combined mechanical effects of obesity and COPD reduced operating lung volumes at rest and throughout exercise with favorable influences on dyspnea perception and peak oxygen uptake during cycle ergometry. PMID: 19897773 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Ora J, Laveneziana P, Ofir D, Deesomchok A, Webb KA, O'Donnell DE Tags: Am J Respir Crit Care Med Source Type: journals

An official American thoracic society statement: position statement on ATS activities for the promotion of respiratory and sleep/wake health and the care of the critically ill in the United States.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The American Thoracic Society's Mission, Core Principles, and Vision provide clear guidance for the formulation of specific strategies that will serve to promote improved respiratory health and care of the critically ill in the United States. PMID: 19897774 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Brown LK, Angus DC, Marin MG, Balmes JR, Barker AF, Ewart G, Halbower AC, Lutz PO, Mularski RA, Nathanson IT, Sanders MH, Stewart GL, Upson DJ, Tags: Am J Respir Crit Care Med Source Type: journals

Rapid DNA methylation changes after exposure to traffic particles: the issue of spatio-temporal factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897775 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Patel MM, Miller RL Tags: Am J Respir Crit Care Med Source Type: journals

Simvastatin as a potential therapeutic for acute respiratory distress syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897776 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Fessler MB Tags: Am J Respir Crit Care Med Source Type: journals

Am J Respir Crit Care Med; +24 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Crit Care Med These pubmed results were generated on 2009/11/04PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 5, 2009 Category: Intensive Care Tags: Report Source Type: journals

Lung Pathology in Fatal Novel Human Influenza A (H1N1) Infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Autopsies have shown that the main pathological changes associated with S-OIV infection are localized to the lungs, where three distinct histological patterns can be identified. We also show evidence of ongoing pulmonary aberrant immune response. Our results reinforce the utility of autopsy in increasing the understanding of the novel human influenza A (H1N1) infection. PMID: 19875682 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Mauad T, Hajjar LA, Callegari GD, da Silva LF, Schout D, Galas FR, Alves VA, Malheiros DM, Auler Jr JO, Ferreira AF, Borsato MR, Bezerra SM, Gutierrez PS, Caldini ET, Pasqualucci CA, Dolhnikoff M, Saldiva PH Tags: Am J Respir Crit Care Med Source Type: journals

Pulmonary Hypertension and CT Measurement of Small Pulmonary Vessels in Severe Emphysema.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The %CSA<5 measured on CT images is significantly correlated to Ppa in severe emphysema, and can estimate the degree of pulmonary hypertension. PMID: 19875683 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Matsuoka S, Washko GR, Yamashiro T, San Jose Estepar R, Diaz A, Silverman EK, Hoffman E, Fessler HE, Criner GJ, Marchetti N, Scharf SM, Martinez FJ, Reilly JJ, Hatabu H Tags: Am J Respir Crit Care Med Source Type: journals

Hemodynamic and Gas Exchange Effects of Sildenafil in Patients with COPD and Pulmonary Hypertension.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In patients with COPD-associated PH, sildenafil improves pulmonary hemodynamics at rest and during exercise. This effect is accompanied by the inhibition of hypoxic vasoconstriction, which impairs arterial oxygenation at rest. The use of sildenafil in COPD should be done cautiously and under close monitoring of blood gases. PMID: 19875684 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Blanco I, Gimeno E, Munoz PA, Pizarro S, Rodriguez-Roisin R, Roca J, Barbera JA Tags: Am J Respir Crit Care Med Source Type: journals

Antibiotics in Addition to Systemic Corticosteroids for Acute Exacerbations of COPD.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: While equivalent to placebo on clinical success at day 30, doxycycline showed superiority on clinical success and clinical cure at day 10, microbiological success, the use of open label antibiotics and symptoms. (ClinicalTrials.gov #NCT00170222.). PMID: 19875685 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Daniels JM, Snijders D, de Graaff CS, Vlaspolder F, Jansen HM, Boersma WG Tags: Am J Respir Crit Care Med Source Type: journals

Resuscitation Promoting Factors Reveal an Occult Population of Tubercle Bacilli in Sputum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Smear-positive sputum samples are dominated by a population of Mtb cells that can only be grown in the presence of Rpfs. These intriguing proteins are therefore relevant to human infection. The Rpf-dependent population is invisible to conventional culture and is progressively enhanced in relative terms during chemotherapy, indicating a form of phenotypic resistance that may be significant for both chemotherapy and transmission. PMID: 19875686 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Mukamolova GV, Turapov O, Malkin J, Woltmann G, Barer MR Tags: Am J Respir Crit Care Med Source Type: journals

Reduction of Tumstatin in Asthmatic Airways Contributes to Angiogenesis, Inflammation and Hyperresponsiveness.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The observation that tumstatin is decreased in asthmatic airways and inhibits airway hyperresponsiveness and angiogenesis demonstrates the potential use of anti-angiogenic agents such as tumstatin as a therapeutic intervention in diseases which are characterized by aberrant angiogenesis and tissue remodeling, such as asthma. PMID: 19875687 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Burgess JK, Boustany S, Moir LM, Weckmann M, Lau JY, Grafton K, Baraket M, Hansbro PM, Hansbro NG, Foster PS, Black JL, Oliver BG Tags: Am J Respir Crit Care Med Source Type: journals

Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The preclinical anti-inflammatory effects of RWJ-355871 in these animal models of inflammation indicate that this dual inhibitor may have therapeutic utility for treating airway inflammatory diseases involving mechanisms that depend on cathepsin G and/or chymase. PMID: 19875688 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Maryanoff BE, de Garavilla L, Greco MN, Haertlein BJ, Wells GI, Andrade-Gordon P, Abraham WM Tags: Am J Respir Crit Care Med Source Type: journals

Recovery of Multipotent Progenitors from the Peripheral Blood of Patients Requiring ECMO Support.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Hematopoietic, mesenchymal and epithelial progenitors were mobilized into the circulation of patients on ECMO. This may reflect a response to severe cardiopulmonary injury, blood-foreign surface interactions with the ECMO circuit and/or hemodilution. PMID: 19875689 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Bui KC, Senadheera D, Wang X, Hendrickson B, Friedlich P, Lutzko C Tags: Am J Respir Crit Care Med Source Type: journals

Selected Medical Errors in the ICU: Results of the IATROREF Study (Parts I and II).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The impact of medical errors on mortality indicates an urgent need for developing prevention programs. We have planned a study to assess a program based on our results. PMID: 19875690 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 29, 2009 Category: Intensive Care Authors: Garrouste Orgeas M, Timsit JF, Vesin A, Schwebel C, Arnodo P, Lefrant JY, Souweine B, Tabah A, Charpentier J, Gontier O, Fieux F, Mourvillier B, Troché G, Reignier J, Dumay MF, Azoulay E, Reignier B, Carlet J, Soufir L Tags: Am J Respir Crit Care Med Source Type: journals

{beta}2-Adrenergic Receptor Gene Polymorphism is Associated with Mortality in Septic Shock.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The AA genotype of ADRB2 rs1042717, identifying homozygotes for the CysGlyGln haplotype, was associated with increased mortality and more organ dysfunction in septic shock. PMID: 19850944 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 21, 2009 Category: Intensive Care Authors: Nakada TA, Russell JA, Boyd JH, Aguirre-Hernandez R, Thain KR, Thair SA, Nakada E, McConechy M, Walley KR Tags: Am J Respir Crit Care Med Source Type: journals

In utero Smoke Exposure and Maternal and Infant GST Genes on Airway Responsiveness and Lung Function In Infancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: GST genes may be especially important during fetal development as they may modify, through proficient detoxification, the effects of in utero maternal smoke exposure on AR in infants. PMID: 19850945 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 21, 2009 Category: Intensive Care Authors: Murdzoska J, Devadason SG, Khoo SK, Landau LI, Young S, Goldblatt J, Zang G, Le Souef PN, Hayden CM Tags: Am J Respir Crit Care Med Source Type: journals

Role of Epidermal Growth Factor Inhibition in Experimental Pulmonary Hypertension.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The partial therapeutic efficacy of the EGFR antagonists in animal models of pulmonary hypertension and the absence of significant alteration in EGFR expression in the lungs from IPAH patients suggest that the EGFR do not represent a promising target for the treatment of pulmonary hypertension. PMID: 19850946 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 21, 2009 Category: Intensive Care Authors: Dahal BK, Cornitescu T, Tretyn A, Pullamsetti SS, Kosanovic D, Dumitrascu R, Ghofrani HA, Weissmann N, Voswinckel R, Banat GA, Seeger W, Grimminger F, Schermuly RT Tags: Am J Respir Crit Care Med Source Type: journals

Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The development of lung fibrosis in the setting of type II cell injury in our model provides evidence for a causal link between the epithelial defects seen in IPF and the corresponding areas of scarring. PMID: 19850947 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 21, 2009 Category: Intensive Care Authors: Sisson TH, Mendez M, Choi K, Subbotina N, Courey A, Cunningham A, Dave A, Engelhardt JF, Liu X, White ES, Thannickal VJ, Moore BB, Christensen PJ, Simon RH Tags: Am J Respir Crit Care Med Source Type: journals

HIV Co-infection in Multidrug- and Extensively Drug-resistant Tuberculosis Results in High Early Mortality.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Mortality from MDR and XDR TB in this high HIV-prevalence region is extraordinarily high, particularly within the first 30 days. Efforts to reduce mortality must focus on earlier diagnosis and early initiation of second-line TB and antiretroviral therapy. PMID: 19833824 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 14, 2009 Category: Intensive Care Authors: Gandhi NR, Shah NS, Andrews JR, Vella V, Moll AP, Scott M, Weissman D, Marra C, Lalloo UG, Friedland GH Tags: Am J Respir Crit Care Med Source Type: journals

Surfactant Protein-B 121ins2 Heterozygosity, Reduced Pulmonary Function and COPD in Smokers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Surfactant protein-B 121ins2 heterozygosity is associated with reduced lung function and increased risk for COPD among smokers. PMID: 19833825 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 14, 2009 Category: Intensive Care Authors: Bækvad-Hansen M, Dahl M, Tybjærg-Hansen A, Nordestgaard BG Tags: Am J Respir Crit Care Med Source Type: journals

Gene Profiling of Clinical Routine Biopsies and Prediction of Survival in Non-Small Cell Lung Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Integration of functional genomics from small bronchoscopic biopsies allows molecular tumor classification and prediction of survival in NSCLC and might become a powerful adjunct for the daily clinical practice. PMID: 19833826 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 14, 2009 Category: Intensive Care Authors: Baty F, Facompré M, Kaiser S, Schumacher M, Pless M, Bubendorf L, Savic S, Marrer E, Budach W, Buess M, Kehren J, Tamm M, Brutsche MH Tags: Am J Respir Crit Care Med Source Type: journals

Transcriptomic Analysis of Human Lung Development.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study extends our knowledge of key gene expression patterns and bioâontologic attributes underlying early human lung developmental processes. The data also suggest the existence of molecular phases of lung development. PMID: 19815808 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 7, 2009 Category: Intensive Care Authors: Kho AT, Bhattacharya S, Tantisira KG, Carey VJ, Gaedigk R, Leeder JS, Kohane IS, Weiss ST, Mariani TJ Tags: Am J Respir Crit Care Med Source Type: journals

Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma: A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: BT in subjects with severe asthma improves asthma-specific quality of life with a reduction in severe exacerbations and healthcare utilization in the post-treatment period. PMID: 19815809 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 7, 2009 Category: Intensive Care Authors: Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Ja Tags: Am J Respir Crit Care Med Source Type: journals

Specific CD8 T Cells in Ige-mediated Allergy Correlate with Allergen Dose and Allergic Phenotype.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Allergen-specific CD8(+) T cells seem to protect from allergic inflammation in the lungs; their number which is dependent on the sensitization dose, appears to be a critical predictor for the severity of the allergic phenotype. PMID: 19815810 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 7, 2009 Category: Intensive Care Authors: Aguilar-Pimentel JA, Alessandrini F, Huster KM, Jakob T, Schulz H, Behrendt H, Ring J, Hrabé de Angelis M, Busch DH, Mempel M, Ollert M Tags: Am J Respir Crit Care Med Source Type: journals

Am J Respir Crit Care Med; +32 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
32 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Crit Care Med These pubmed results were generated on 2009/10/02PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 2, 2009 Category: Intensive Care Tags: Report Source Type: journals

A Functional Polymorphism in IL-18 is Associated with Severity of Bronchial Asthma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although the association results need to be replicated by other studies, IL-18 variants are significantly associated with asthma severity, and the rs5744247 variant reflects higher transcriptional activity and higher expression of IL-18 in LPS-stimulated monocytes and a higher serum IL-18 level. PMID: 19745201 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2009 Category: Intensive Care Authors: Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Taniguchi M, Higashi N, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M Tags: Am J Respir Crit Care Med Source Type: journals

Days of Delirium are Associated with 1-year Mortality in an Older Intensive Care Unit Population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Number of days of ICU delirium was associated with higher 1-year mortality after adjustment for relevant covariates in an older ICU population. Investigations should be undertaken to reduce the number of days of ICU delirium and to study the impact of this reduction on important health outcomes including mortality and functional and cognitive status. PMID: 19745202 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2009 Category: Intensive Care Authors: Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH Tags: Am J Respir Crit Care Med Source Type: journals

Impaired Vascular Regulation in Patients with Obstructive Sleep Apnea: Effects of CPAP Treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Vasodilator responses to chemical stimuli in the cerebral circulation and the forearm are impaired in many patients with OSA. Some of these impairments can be improved with continuous positive airway pressure. PMID: 19745203 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2009 Category: Intensive Care Authors: Reichmuth KJ, Dopp JM, Barczi SR, Skatrud JB, Wojdyla P, Hayes Jr D, Morgan BJ Tags: Am J Respir Crit Care Med Source Type: journals

Lung Volume Reference Values for Women and Men Aged 65 to 85.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results underscore the importance of using prediction equations appropriate to the origin, age and height characteristics of the subjects being studied. PMID: 19745204 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2009 Category: Intensive Care Authors: Garcia-Rio F, Dorgham A, Pino JM, Villasante C, Garcia-Quero C, Alvarez-Sala R Tags: Am J Respir Crit Care Med Source Type: journals

Ambient Metals, Elemental Carbon, and Wheeze and Cough in New York City Children through Age 24 Months.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results suggest that exposure to ambient metals and elemental carbon from heating oil and/or traffic at levels characteristic of urban environments may be associated with respiratory symptoms among very young children. PMID: 19745205 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2009 Category: Intensive Care Authors: Patel MM, Hoepner L, Garfinkel R, Chillrud S, Reyes A, Quinn JW, Perera F, Miller RL Tags: Am J Respir Crit Care Med Source Type: journals

Exposure to Traffic-Related Particles and Endotoxin During Infancy Is Associated With Wheezing At Age Three.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The association between traffic-related particle exposure and persistent wheezing at age 36 months is modified by exposure to endotoxin. This finding supports prior toxicological studies demonstrating a synergistic production of ROS after co-exposure to DEP and endotoxin. The effect of early versus later exposure to traffic-related particles, however, remains to be studied due to the high correlation between exposure throughout the first three years of life. PMID: 19745206 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2009 Category: Intensive Care Authors: Ryan PH, Bernstein DI, Lockey J, Reponen T, Levin L, Grinshpun S, Villareal M, Khurana Hershey GK, Burkle J, Lemasters G Tags: Am J Respir Crit Care Med Source Type: journals

HIV Infection does not Affect Active Case Finding of Tuberculosis in South African Gold Miners.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In a population of gold miners who undergo regular radiological screening, the addition of chest radiography to symptom screening substantially improved the sensitivity and positive predictive value. HIV infection did not alter the sensitivity of the screening tool. PMID: 19745207 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 9, 2009 Category: Intensive Care Authors: Lewis JJ, Charalambous S, Day JH, Fielding KL, Grant AD, Hayes RJ, Corbett EL, Churchyard GJ Tags: Am J Respir Crit Care Med Source Type: journals

Am J Respir Crit Care Med; +17 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Crit Care Med These pubmed results were generated on 2009/09/04PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 5, 2009 Category: Intensive Care Tags: Report Source Type: journals

Exhaled Breath Profiling Enables Discrimination of Chronic Obstructive Pulmonary Disease and Asthma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Molecular profiling of exhaled air can distinguish patients with COPD, asthma, and controls. Our data demonstrate a potential of electronic noses in the differential diagnosis of obstructive airway diseases and in the risk assessment in asymptomatic smokers. Clinical Trials Registry Information: ID# NTR 1282 registered at www.trialregister.nl. PMID: 19713445 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 26, 2009 Category: Intensive Care Authors: Fens N, Zwinderman AH, van der Schee MP, de Nijs SB, Dijkers E, Roldaan AC, Cheung D, Bel EH, Sterk PJ Tags: Am J Respir Crit Care Med Source Type: journals

Effects of Exposure to Intermittent Hypoxia on Oxidative Stress and Acute Hypoxic Ventilatory Response in Humans.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Chronic intermittent hypoxia increases oxidative stress by increasing production of reactive oxygen species (ROS) without a compensatory increase in anti-oxidant activity. Furthermore, this human study shows that ROS over-production modulates increased AHVR. These mechanisms may be responsible for increased AHVR in patients with OSA. PMID: 19713446 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 26, 2009 Category: Intensive Care Authors: Pialoux V, Hanly PJ, Foster GE, Brugniaux JV, Beaudin AE, Hartmann SE, Pun M, Duggan CT, Poulin MJ Tags: Am J Respir Crit Care Med Source Type: journals

Bone Marrow Stromal Cells Attenuate Lung Injury in a Murine Model of Neonatal Chronic Lung Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: BMSCs act in a paracrine manner via the release of immunomodulatory factors to ameliorate the parenchymal and vascular injury of BPD in vivo. Our study suggests that BMSCs and factor(s) they secrete offer new therapeutic approaches for lung diseases currently lacking effective treatment. PMID: 19713447 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 26, 2009 Category: Intensive Care Authors: Aslam M, Baveja R, Liang OD, Fernandez-Gonzalez A, Lee C, Mitsialis SA, Kourembanas S Tags: Am J Respir Crit Care Med Source Type: journals

Use of Intensive Care Services During Terminal Hospitalizations in England and the United States.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Despite similar overall hospitalization rates in England and the US, there were marked differences in terminal hospitalizations, with far greater use of intensive care services in the US, especially among medical patients and the elderly. PMID: 19713448 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 26, 2009 Category: Intensive Care Authors: Wunsch H, Linde-Zwirble WT, Harrison DA, Barnato AE, Rowan K, Angus DC Tags: Am J Respir Crit Care Med Source Type: journals

Airway Delivery of Mesenchymal Stem Cells Prevents Arrested Alveolar Growth in Neonatal Lung Injury in Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. BMSCs prevent arrested alveolar and vascular growth in part through a paracrine activity. Stem cell-based therapies may offer new therapeutic avenues for lung diseases that currently lack efficient treatments. PMID: 19713449 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 26, 2009 Category: Intensive Care Authors: van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, Bouchentouf M, Rey-Parra GJ, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thebaud B Tags: Am J Respir Crit Care Med Source Type: journals

Influence of Ambient Air Pollutant Sources on Clinical Encounters for Infant Bronchiolitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Air pollutants from several sources may increase infant bronchiolitis requiring clinical care. Traffic, local point source emissions and woodsmoke may contribute to this disease. PMID: 19713450 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 26, 2009 Category: Intensive Care Authors: Karr CJ, Demers PA, Koehoorn MW, Lencar CC, Tamburic L, Brauer M Tags: Am J Respir Crit Care Med Source Type: journals

Exogenous Natural Surfactant for Treatment of Acute Lung Injury and the Acute Respiratory Distress Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In this study, large bolus of exogenous natural porcine surfactant HL 10 into patients with acute lung injury and ARDS did not improve outcome and showed a trend towards increased mortality and adverse effects. Clinical Trials Registry Information: ID# 00742482 registered at www.clinicaltrials.gov. PMID: 19713451 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 26, 2009 Category: Intensive Care Authors: Kesecioglu J, Beale R, Stewart TE, Findlay GP, Rouby JJ, Holzapfel L, Bruins P, Steenken EJ, Jeppesen OK, Lachmann B Tags: Am J Respir Crit Care Med Source Type: journals

Am J Respir Crit Care Med; +21 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Crit Care Med These pubmed results were generated on 2009/08/26PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 26, 2009 Category: Intensive Care Tags: Report Source Type: journals

Impaired IL-10-dependent Induction of Tolerogenic Dendritic Cells by CD4+CD25hiCD127lo/- Natural Regulatory T Cells In Human Allergic Asthma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results provided the first evidences of impaired induction of tolerogenic dendritic cells mediated by natural regulatory T cells in human allergic asthma. PMID: 19679691 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 12, 2009 Category: Intensive Care Authors: Nguyen KD, Vanichsarn C, Nadeau KC Tags: Am J Respir Crit Care Med Source Type: journals

The Triterpenoid CDDO-Imidazolide Confers Potent Protection Against Hyperoxic Acute Lung Injury in Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results suggest that upregulation of Nrf2 signaling by CDDO-Im or its analogs may provide a novel therapeutic strategy to minimize the adverse effects of hyperoxia. PMID: 19679692 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 12, 2009 Category: Intensive Care Authors: Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP Tags: Am J Respir Crit Care Med Source Type: journals

Borderline Pulmonary Arterial Pressure is Associated with Decreased Exercise Capacity in Scleroderma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Mean pulmonary arterial pressure and resistance in the upper normal range at rest and moderate exercise are associated with decreased exercise capacity and may indicate early pulmonary vasculopathy in systemic sclerosis. Investigations on the prognostic and therapeutic implications of such borderline findings are warranted. Clinical Trial Registration Information: http://www.clinicaltrials.gov ID: NCT00609349. PMID: 19679693 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 12, 2009 Category: Intensive Care Authors: Kovacs G, Maier R, Aberer E, Brodmann M, Scheidl S, Tröster N, Hesse C, Salmhofer W, Graninger W, Gruenig E, Rubin LJ, Olschewski H Tags: Am J Respir Crit Care Med Source Type: journals

Increasing Proportions of Advanced Pulmonary Tuberculosis in the United States: Are Delays in Diagnosis on the Rise?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study highlights the need for tuberculosis diagnosis at early stages of the disease to minimize APT and decrease the risk of transmission. Additional efforts should concentrate on reducing time to treatment initiation in low-incidence areas and among groups traditionally seen as being at low-risk for tuberculosis disease. PMID: 19679694 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - August 12, 2009 Category: Intensive Care Authors: Wallace RM, Kammerer JS, Iademarco MF, Althomsons SP, Winston CT, Navin TR Tags: Am J Respir Crit Care Med Source Type: journals