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Binding hot spots and amantadine orientation in the influenza a virus m2 proton channel.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Structures of truncated versions of the influenza A virus M2 proton channel have been determined recently by x-ray crystallography in the open conformation of the channel, and by NMR in the closed state. The structures differ in the position of the bound inhibitors. The x-ray structure shows a single amantadine molecule in the middle of the channel, whereas in the NMR structure four drug molecules bind at the channel's outer surface. To study this controversy we applied computational solvent mapping, a technique developed for the identification of the most druggable binding hot spots of proteins. The method moves molec...
Source: Biophysical Journal - November 18, 2009 Category: Physics Authors: Chuang GY, Kozakov D, Brenke R, Beglov D, Guarnieri F, Vajda S Tags: Biophys J Source Type: journals

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition [Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Influenza A virus M2 (A/M2) and the influenza B virus BM2 are both small integral membrane proteins that form proton-selective... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 3, 2009 Category: Science Authors: Ohigashi, Y., Ma, C., Jing, X., Balannick, V., Pinto, L. H., Lamb, R. A. Tags: Microbiology Source Type: journals

Original paper Does amantadine have favourable effects on fatigue in Persian patients suffering from multiple sclerosis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings demonstrate a significant drop on the fatigue severity scale in MS patients after treatment with amantadine; nevertheless, more studies on a larger scale with longer duration are needed to confirm this finding. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)
Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house - October 30, 2009 Category: Neurosurgery Source Type: journals

Use of the MDRD Study Equation for Drug DosingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We appreciated the excellent article by Stevens et al on the comparison of drug dosing recommendations based on measured glomerular filtration rate– and kidney function–estimating equations. Although the study reflected a diverse population, it failed to provide detailed information about subgroups, including the elderly. Several studies have compared drug dosing recommendations based on the Cockcroft-Gault (CG) and the Modification of Diet in Renal Disease (MDRD) Study equations, finding higher values for glomerular filtration rate estimated using the MDRD Study equation and subsequently higher dosing recommendations....
Source: American Journal of Kidney Diseases - October 22, 2009 Category: Urology & Nephrology Authors: Maha Saad, Manouchkathe Cassagnol Tags: Correspondence Source Type: journals

Estimated GFR vs Creatinine Clearance for Drug DosingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stevens et al suggest that the Modification of Diet in Renal Disease (MDRD) Study equation for estimated glomerular filtration rate (GFR) is an acceptable substitute for estimated or measured creatinine clearance (CCr) as an index for adjusting drug doses in patients with chronic kidney disease and acute kidney injury. However, others have raised concerns that injudicious use of estimated GFR as a substitute for CCr could result in significant dosing errors and toxicity, especially for drugs with narrow therapeutic indices. Further, their conclusion is not supported by results of 4 studies that showed that using the MDRD S...
Source: American Journal of Kidney Diseases - October 22, 2009 Category: Urology & Nephrology Authors: Thomas C. Dowling, Gary R. Matzke, John E. Murphy Tags: Correspondence Source Type: journals

Amantadine: Corneal oedema and postkeratoplasty graft failure: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophilsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Receptor signaling is integral for adhesion, emigration, phagocytosis, and reactive oxygen species production in polymorphonuclear neutrophils (PMNs). Priming is an important part of PMN emigration, but it can also lead to PMN-mediated organ injury in the host. Platelet-activating factor (PAF) primes PMNs through activation of a specific G protein-coupled receptor. We hypothesize that PAF priming of PMNs requires clathrin-mediated endocytosis (CME) of the PAF receptor (PAFr), and, therefore, amantadine, known to inhibit CME, significantly antagonizes PAF signaling. PMNs were isolated by standard techniques to >98% purit...
Source: AJP: Cell Physiology - October 1, 2009 Category: Cytology Authors: Eckels, P. C., Banerjee, A., Moore, E. E., McLaughlin, N. J. D., Gries, L. M., Kelher, M. R., England, K. M., Gamboni-Robertson, F., Khan, S. Y., Silliman, C. C. Tags: RECEPTORS AND SIGNAL TRANSDUCTION Source Type: journals

Changes in prescribing of antiviral medications for influenza associated with new treatment guidelines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined changes in prescribing practices resulting from this recommendation and found that prescribing of adamantanes declined nationwide, with these drugs accounting for approximately 40% of the antivirals prescribed for influenza from 2000 to 2005 and only 2% in 2006. This finding provides evidence of a rapid change in clinical practice associated with the dissemination of treatment guidelines. Evaluating the effectiveness with which public health recommendations are translated into practice is important given the ongoing emergence of resistance to antiviral drugs and a novel H1N1 influenza virus. PMID: 19797750 ...
Source: American Journal of Public Health - September 30, 2009 Category: Global & Universal Authors: Hersh AL, Maselli JH, Cabana MD Tags: Am J Public Health Source Type: journals

Potentiometric determination of trace amounts of amantadine using a modified carbon-paste electrode.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A chemically modified carbon-paste electrode has been described for the sensitive and selective determination of amantadine. Beta-cyclodextrin was used as modifier. The electrode shows a sub-Nernstian response of 51.0 +/- 1.0 mV decade(-1) for amantadine in the concentration range of 6.3 x 10(-10)-7.1 x 10(-7) M at 25 degrees C. The optimum pH value was maintained at 4.5 using a 0.02 M acetate buffer. The limit of detection of the electrode was 6.3 x 10(-10) M of amantadine. The electrode responded very rapidly (<60 s) to changes in the concentration of amantadine, and its lifetime was more than three months. The re...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 30, 2009 Category: Chemistry Authors: Jalali F, Maghooli R Tags: Anal Sci Source Type: journals

Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxis--North Carolina, 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: Initial testing of the 2009 pandemic influenza A (H1N1) virus found it susceptible to neuraminidase inhibitors (oseltamivir and zanamivir) and resistant to adamantanes (amantadine and rimantadine). Neuraminidase inhibitors have been used widely for treatment and chemoprophylaxis of 2009 pandemic influenza A (H1N1); however, sporadic cases of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection have been reported worldwide, including nine U.S. cases identified as of September 4. On July 14, CDC was contacted by a physician at a summer camp in North Carolina regarding two cases of influenza-l...
Source: MMWR Morb Mortal Wkl... - September 10, 2009 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: journals

Amantadine: Syndrome of inappropriate antidiuretic hormone secretion in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 7, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

AMANTADINE HYDROCHLORIDEcapsule [Sandoz Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 3, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 3, 2009 Category: Drugs & Pharmacology Source Type: organizations

NMR studies of p7 protein from hepatitis C virus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The p7 protein of hepatitis C virus (HCV) plays an important role in the viral lifecycle. Like other members of the viroporin family of small membrane proteins, the amino acid sequence of p7 is largely conserved over the entire range of genotypes, and it forms ion channels that can be blocked by a number of established channel-blocking compounds. Its characteristics as a membrane protein make it difficult to study by most structural techniques, since it requires the presence of lipids to fold and function properly. Purified p7 can be incorporated into phospholipid bilayers and micelles. Initial solid-state nuclear magn...
Source: European Biophysics Journal : EBJ - September 1, 2009 Category: Physics Authors: Cook GA, Opella SJ Tags: Eur Biophys J Source Type: journals

Effect of repeated co-treatment with fluoxetine and amantadine on the behavioral reactivity of the central dopamine and serotonin system in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study we found that repeated co-treatment with fluoxetine and amantadine for 14 days (but not for 7 days) enhanced the hyperactivity induced by amphetamine or quinpirole (a dopamine D(2/3) agonist), compared to treatment with either drug alone. Whereas repeated co-treatment with fluoxetine and amantadine for 7 days more potently inhibited the behavioral syndrome evoked by the 5-hydroxytryptamine (5-HT)(1A) receptor agonist (+/-)-8-hydroxy-2(di-n-propylamino)-tetralin hydrobromide (8-OH-DPAT), it did not change the action of the 5-HT(2) receptor agonist (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane ...
Source: Pharmacological Reports - September 1, 2009 Category: Drugs & Pharmacology Authors: Rogóz Z, Skuza G Tags: Pharmacol Rep Source Type: journals

Novel Use of Amantadine: To Treat HiccupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a complex clinical case of intractable hiccups in a patient with cancer of the pancreas and Parkinson's disease and some of the problems encountered when attempting symptom control. We also discuss a potential therapeutic response to a novel agent, amantadine, unlicensed in the treatment of hiccups. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - August 31, 2009 Category: Palliative Care Authors: Sarah K. Wilcox, Anne Garry, Miriam J. Johnson Tags: Palliative Care Rounds Source Type: journals

Amantadine withdrawal: Neuroleptic malignant syndrome: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Amantadine-resistant influenza A viruses isolated in South Korea from 2003 to 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To investigate the frequency of amatadine resistance among influenza A viruses isolated in Korea during the 2003-2009 seasons, 369 (16.8%) 2,199 A/H1N1 viruses and 780 (14.8%) of 5,263 A/H3N2 viruses were randomly selected. The M2 and HA1 genes of each isolate were amplified by reverse transcription-polymerase chain reaction and followed by nucleotide sequencing. The results showed that the resistance rate to amantadine among A/H1N1 viruses increased significantly from 2004-2005 (33.3%) to 2007-2008 (97.8%) and then decreased dramatically in 2008-2009 (1.9%). The A/H1N1 isolates recently detected in 2008-2009 turned am...
Source: Antiviral Research - August 27, 2009 Category: Virology Authors: Choi WY, Kim S, Lee N, Kwon M, Yang I, Kim MJ, Cheong SG, Kwon D, Lee JY, Oh HB, Kang C Tags: Antiviral Res Source Type: journals

CKS Topic Minibite: Seasonal influenzaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: CKS Area: Evidence > Guidelines This Topic Minibite from the Clinical Knowledge Service (CKS) covers the management of seasonal influenza and post-exposure prophylaxis of seasonal influenza. It is based on two technology appraisals published by the National Institute for Health and Clinical Excellence (NICE): . Guidance number 158: Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza, and . Guidance (number 168): Amantadine, oseltamivir and zanamivir for the treatment of influenza (Source: NeLM - Guidelines)
Source: NeLM - Guidelines - August 24, 2009 Category: UK Health Source Type: organizations

If You Have Chronic Fatigue, You Might Just Need L-CarnitineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Nearly everyone experiences fatigue at one time or another, but when that fatigue goes on for long periods of time or when it accompanies another health problem, it can be devastating. While there ARE many medical reasons for it, often those with persistent fatigue are left without a diagnosis, without answers and without hope. For many, however, the amino acid supplement L-Carnitine COULD just offer some hope for a normal life again.L-Carnitine is an 'essential' amino acid, meaning that it must be supplied in the diet in order to meet the body's needs. While the majority of amino acids are used for protein s...
Source: NaturalNews.com - August 21, 2009 Category: Consumer Health Advice Source Type: news

Rapid spread of drug-resistant influenza A viruses in the Basque Country, northern Spain, 2000-1 to 2008-9.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A worldwide increase of adamantane-resistant influenza A(H3N2) and oseltamivir-resistant influenza A(H1N1) viruses has been observed in recent years. The aim of this study was to analyse the prevalence of antiviral drug-resistant influenza A in a region of northern Spain. Resistance to adamantanes was detected in 45.3% (68/150) of influenza AH3 viruses analysed for the period from 2000-1 to 2008-9. Adamantane-resistance was absent in our region during the 2000-1 to 2002-3 influenza seasons. However, after the first adamantane-resistant virus (characterised as A/Fujian/411/2002) was detected in the 2003-4 season, a rapi...
Source: Euro Surveill - August 20, 2009 Category: Infectious Diseases Authors: Vicente D, Cilla G, Montes M, Mendiola J, Pérez-Trallero E Tags: Euro Surveill Source Type: journals

Amantadine/memantine interaction: First report of an interaction, leading to psychosis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 10, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Large-Scale Sequence Analysis of M Gene of Influenza A Viruses from Different Species: Mechanisms for Emergence and Spread of Amantadine Resistance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Influenza A virus infects many species and amantadine is used as an antiviral agent. Recently, a substantial increase in amantadine-resistant strains has been reported, most of which have a substitution at amino acid position 31 in the M2 gene. Understanding the mechanism responsible for the emergence and spread of antiviral resistance is important for developing a treatment protocol for seasonal influenza and in deciding a policy for antiviral stockpiling for pandemic influenza. The present study was conducted to identify the existence of drug pressure on the emergence and spread of amantadine-resistant influenza A vi...
Source: Antimicrobial Agents and Chemotherapy - August 2, 2009 Category: Microbiology Authors: Furuse Y, Suzuki A, Oshitani H Tags: Antimicrob Agents Chemother Source Type: journals

AMANTADINE HYDROCHLORIDEsolution [Qualitest Pharmaceuticals]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jul 29, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - July 29, 2009 Category: Drugs & Pharmacology Source Type: organizations

Effects of amantadine on the dynamics of membrane-bound influenza A M2 transmembrane peptide studied by NMR relaxation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The molecular motions of membrane proteins in liquid-crystalline lipid bilayers lie at the interface between motions in isotropic liquids and in solids. Specifically, membrane proteins can undergo whole-body uniaxial diffusion on the microsecond time scale. In this work, we investigate the (1)H rotating-frame spin-lattice relaxation (T (1rho)) caused by the uniaxial diffusion of the influenza A M2 transmembrane peptide (M2TMP), which forms a tetrameric proton channel in lipid bilayers. This uniaxial diffusion was proved before by (2)H, (15)N and (13)C NMR lineshapes of M2TMP in DLPC bilayers. When bound to an inhibitor...
Source: Journal of Bimolecular NMR - July 24, 2009 Category: Biomedical Science Authors: Cady SD, Hong M Tags: J Biomol NMR Source Type: journals

Triple combination of oseltamivir, amantadine, and ribavirin displays synergistic activity against multiple influenza virus strains in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report demonstrates that a triple combination of antivirals was highly synergistic against influenza A. Importantly, the synergy of the triple combination was 2- to 13-fold greater than the synergy of any double combination, depending on the influenza subtype. These data support the investigation of a novel combination of oseltamivir, amantadine, and ribavirin as an effective treatment for both seasonal and pandemic influenza, allowing efficient use of the existing drug supplies. PMID: 19620324 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - July 19, 2009 Category: Microbiology Authors: Nguyen JT, Hoopes JD, Smee DF, Prichard MN, Driebe EM, Engelthaler DM, Le MH, Keim PS, Spence RP, Went GT Tags: Antimicrob Agents Chemother Source Type: journals

AMANTADINE HYDROCHLORIDEcapsule [Sandoz Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jun 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - June 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

Amantadine-resistant influenza A (H3N2) viruses in Iran.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adamantanes have been used for the prophylaxis and treatment of Influenza A virus (IAV) infections worldwide. However, they have limited use because of increasing number of resistant viruses during recent years. In investigating the frequency of amantadine-resistant IAVs (H3N2) circulating in Iran in 2005-2008, we found that M2 sequences of recently circulating viruses that were amantadine-resistant contained a Ser31Asn mutation. Thus, adamantanes should not be used for treatment or prophylaxis of recent IAVs (H3N2) infections. In future, their potential use will depend on the resistance of circulating viruses. Keyword...
Source: Acta Virologica - June 27, 2009 Category: Infectious Diseases Authors: Yavarian J, Mokhtari Azad T, Shafiei Jandaghi NZ, Nategh R Tags: Acta Virol Source Type: journals

AMANTADINE (Amantadine Hydrochloride) Capsule, Gelatin Coated [UPSHER-SMITH LABORATORIES, INC.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - June 23, 2009 Category: Drugs & Pharmacology Source Type: organizations

Structural and evolutionary characteristics of HA, NA, NS and M genes of clinical influenza A/H3N2 viruses passaged in human and canine cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data suggest that (i) clinical influenza viruses can be isolated from respiratory tract of humans more effectively in human than in canine cells; (ii) heterologous virus population circulates during one influenza outbreak; (iii) increasing numbers of glycosylation sites on HA and NA and stalk shortening of NA take place during virus evolution in humans. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 21, 2009 Category: Virology Authors: O.P. Zhirnov, I.V. Vorobjeva, O.A. Saphonova, S.V. Poyarkov, A.V. Ovcharenko, D. Anhlan, N.A. Malyshev Tags: Full length articles Source Type: journals

Aripiprazole in l-dopa-induced dyskinesias: a one-year open-label pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Aripiprazole is a novel antipsychotic medication characterized by partial agonism at the D2 and 5-HT1A receptors and by antagonism at the 5-HT2A receptor. The aim of the present study was to evaluate, in an open-label pilot study, the effects and safety of very small doses of aripiprazole on l-dopa-induced dyskinesia of a group of PD patients who did not show a significant clinical benefit by pharmacological treatment with amantadine and mirtazapine. Twelve PD patients with peak-dose LID were enrolled in a period of 1 year. Aripiprazole dosage was of 0.625 mg/day. The ten patients who cont...
Source: Journal of Neural Transmission - June 17, 2009 Category: Neurology Tags: Journal of Neural Transmission Source Type: journals

Plasma amantadine concentrations in patients with Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We determined plasma amantadine concentrations in patients with Parkinson's disease (PD) in daily clinical practice and investigated the relationship between plasma concentration and adverse reactions to clarify the safe therapeutic range. Seventy-eight consecutive PD patients on stable amantadine treatment were recruited. Plasma concentration of amantadine was measured 3h after the administration of morning amantadine dose. Serum creatinine was measured to estimate renal function. The mean daily dose of amantadine was 135.1±62.3mg/day, and the mean plasma amantadine concentration was 812.5±839.5ng/ml (range, 9...
Source: Parkinsonism and Related Disorders - June 1, 2009 Category: Neurology Authors: N. Nishikawa, M. Nagai, T. Moritoyo, H. Yabe, M. Nomoto Tags: Papers Source Type: journals

Amantadine-associated Corneal EdemaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Jeng et al report on 3 patients with acute onset bilateral diffuse corneal edema associated with systemic amantadine use. If there is indeed a causal relationship, this article has potentially serious clinical implications, particularly for patients with Parkinson's disease receiving long-term therapy. The authors refer to French and Margo's report on 13137 patients who were dispensed amantadine and also were diagnosed with corneal edema or Fuchs' dystrophy in 36 patients (0.27%). However, the specific keratopathy associated with pseudoexfoliation (PEX) syndrome, caused by direct involvement of the corneal endothelium ...
Source: Ophthalmology - June 1, 2009 Category: Opthalmology Authors: Gottfried O.H. Naumann, Ursula Schlötzer-Schrehardt Tags: Letters to the Editor Source Type: journals

Author replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We thank Drs. Naumann and Schlötzer-Schrehardt for their interest in our paper. It is clear that the potential mechanism of action of amantadine on the corneal endothelium is unknown at this time, and we agree that a definitive determination cannot be made as to whether amandatine causes corneal decompensation, or if it merely accelerates an underlying corneal endothelial process. However, given the sizable number of individuals who are taking amantadine systemically who have not developed corneal decompensation, we have to believe that certain eyes are, for some reason, susceptible to damage from amantadine. Given the wi...
Source: Ophthalmology - June 1, 2009 Category: Opthalmology Authors: Bennie H. Jeng, David M. Meisler, Roger H.S. Langston, Joe G. Hollyfield, Lynn Schoenfield, James T. McMahon, Michael S. Lee, Anat Galor Tags: Letters to the Editor Source Type: journals

Case files of the program in medical toxicology at brown university: amantadine withdrawal and the neuroleptic malignant syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19415596 [PubMed - in process] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - May 31, 2009 Category: Toxicology Authors: Brantley E, Cohn J, Babu K Tags: J Med Toxicol Source Type: journals

Clinical trial: a randomized trial of pegylated-interferon-α-2a plus ribavirin with or without amantadine in treatment-naïve or relapsing chronic hepatitis C patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This large study definitely excludes the role of amantadine in addition of conventional combination therapy in the treatment of chronic hepatitis C patients. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - May 25, 2009 Category: Drugs & Pharmacology Authors: P. LANGLET, F. D'HEYGERE, J. HENRION, M. ADLER, J. DELWAIDE, H. VAN VLIERBERGHE, J. P. MULKAY, L. LASSER, R. BRENARD, Y. HORSMANS, P. MICHIELSEN, A. LAUREYS, F. NEVENS Tags: Clinical trial Source Type: journals

Rapid spread of drug-resistant influenza A viruses in the Basque Country, northern Spain, 2000-1 to 2008-9Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A worldwide increase of adamantane-resistant influenza A(H3N2) and oseltamivir-resistant influenza A(H1N1) viruses has been observed in recent years. The aim of this study was to analyse the prevalence of antiviral drug-resistant influenza A in a region of northern Spain. Resistance to adamantanes was detected in 45.3% (68/150) of influenza AH3 viruses analysed for the period from 2000-1 to 2008-9. Adamantane-resistance was absent in our region during the 2000-1 to 2002-3 influenza seasons. However, after the first adamantane-resistant virus (characterised as A/Fujian/411/2002) was detected in the 2003-4 season, a rapid in...
Source: Eurosurveillance latest news - May 21, 2009 Category: Infectious Diseases Source Type: journals

AMANTADINE HYDROCHLORIDEsyrup [Qualitest Pharmaceuticals]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: May 13, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - May 13, 2009 Category: Drugs & Pharmacology Source Type: organizations

Amantadine: Corneal oedema leading to vision loss: 2 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - May 7, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

The trouble with TamifluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The companies behind the two leading anti-flu drugs are making millions out of the crisis. But just how effective are their products? Sarah Boseley reportsIt was a sight that would have gladdened the heart of Dr Severin Shwan, chief executive of Roche, one of the biggest drug companies in the world. A long line of well-heeled parents assembled on a bank holiday weekend at a British private school, Alleyn's in south London, patiently waiting their turn to receive a packet of Roche's drug Tamiflu from staff. Five pupils had been diagnosed with swine flu and the school had been closed. The pills were intended to stave off inf...
Source: Guardian Unlimited Science - May 6, 2009 Category: Science Authors: Sarah Boseley Tags: Swine flu Drugs Pharmaceuticals industry Science Business GlaxoSmithKline Health Society World news Infectious diseases & wellbeing Life and style The Guardian Editorial Source Type: news

Amantadine: Corneal oedema leading to vision loss: 2 case reports.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 7 (Source: Reactions Weekly)
Source: Reactions Weekly - May 3, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

CDC MMWR: Update: Swine Influenza A (H1N1) Infection in Two Children --- Southern California, March--April 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report briefly describes the two cases and the investigations currently under way. Although this is not a new subtype of influenza A in humans, concern exists that this new strain of swine influenza A (H1N1) is substantially different from human influenza A (H1N1) viruses, that a large proportion of the population might be susceptible to infection, and that the seasonal influenza vaccine H1N1 strain might not provide protection. The lack of known exposure to pigs in the two cases increases the possibility that human-to-human transmission of this new influenza virus has occurred. Clinicians should consider animal as we...
Source: PandemicFlu.gov RSS Feed for News Releases - May 2, 2009 Category: American Health Source Type: news

Update: drug susceptibility of swine-origin influenza A (H1N1) viruses, April 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: Since April 21, 2009, CDC has reported cases of respiratory infection with a swine-origin influenza A (H1N1) virus (S-OIV) that is being spread via human-to-human transmission. As of April 28, the total number of confirmed S-OIV cases in the United States was 64; these cases occurred in California (10 cases), Kansas (two), New York (45), Ohio (one), and Texas (six). The viruses contain a unique combination of gene segments that had not been reported previously among swine or human influenza viruses in the United States or elsewhere. Viruses from 13 (20%) of 64 patients have been tested for resistance to anti...
Source: MMWR Morb Mortal Wkl... - April 30, 2009 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: journals

Oseltamivir- and Amantadine-Resistant Influenza Viruses (H1N1), P.K.C. Cheng et al.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - April 30, 2009 Category: Infectious Diseases Source Type: journals

H1N1 Swine Flu Susceptible to Oseltamivir and ZanamivirEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The swine-origin influenza A virus H1N1 is susceptible to both neuraminidase inhibitors oseltamivir and zanamivir, but is resistant to the M2 ion channel blockers amantadine and rimantadine, according to a dispatch on April 28 from the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report. (Source: Modern Medicine)
Source: Modern Medicine - April 29, 2009 Category: Journals (General) Source Type: info

Amantadine: Obstructive renal failure, with urinary retention, and seizures in an elderly patient: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 4 (Source: Reactions Weekly)
Source: Reactions Weekly - April 29, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Is Aripiprazole Useful to Refrain From Cocaine Use After Detoxification (Avoiding Relapses)?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cocaine abuse/addiction is a recidivist, chronic disturbance and it represents a crucial issue of public health, because of physical and psychic disturbances, associated to the use of this substance. Nowadays, no specific drug has been approved by the Food and Drugs Administration for the treatment of cocaine addiction. In the treatment of cocaine abuse/addiction, both agonist dopaminergic drugs (ropinirole, amantadine, pergolide, and psychostimulants), and antagonist action drugs (traditional antipsychotics) have been proposed. Aripiprazole is an atypical antipsychotic, marketing in the USA since 2003 for the treatment of...
Source: Addictive Disorders & Their Treatment - April 28, 2009 Category: Addiction Tags: Case Report: PDF Only Source Type: journals

CDC Releases Recommendations for Antiviral Drugs and Swine InfluenzaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are four influenza antiviral drugs approved for use in the United States (oseltamivir, zanamivir, amantadine and rimantadine). The swine influenza A (H1N1) viruses that have been detected in humans in the United States and Mexico are resistant to amantadine and rimantadine so these drugs will not work against these swine influenza viruses. Laboratory testing on these swine influenza A (H1N1) viruses so far indicate that they are susceptible (sensitive) to oseltamivir and zanamivir. (Source: PandemicFlu.gov RSS Feed for News Releases)
Source: PandemicFlu.gov RSS Feed for News Releases - April 27, 2009 Category: American Health Source Type: news

Amantadine: Obstructive renal failure, with urinary retention, and seizures in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - April 26, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Swine Flu Outbreak Beyond Containment; Deaths Mount in Mexico, California, TexasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) A virulent new strain combining elements of swine flu, human flu and avian flu has leapfrogged past containment measures and is now circulating "in the wild" in Mexico, California and Texas. Up to 60 deaths may have already occurred from the new viral strain called H1N1. Over 1,000 people may have been infected. The CDC does not really know how many are infected, as it's still very early in the spread of the viral strain and reliable data isn't yet available.Importantly, just as I warned NaturalNews readers many times over the last several years, there is no vaccine for this swine flu. Vaccines are virtually ...
Source: NaturalNews.com - April 24, 2009 Category: Consumer Health Advice Source Type: news

Swine influenza A (H1N1) infection in two children--Southern California, March-April 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report briefly describes the two cases and the investigations currently under way. Although this is not a new subtype of influenza A in humans, concern exists that this new strain of swine influenza A (H1N1) is substantially different from human influenza A (H1N1) viruses, that a large proportion of the population might be susceptible to infection, and that the seasonal influenza vaccine H1N1 strain might not provide protection. The lack of known exposure to pigs in the two cases increases the possibility that human-to-human transmission of this new influenza virus has occurred. Clinicians should consider animal as we...
Source: MMWR Morb Mortal Wkl... - April 23, 2009 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: journals