American Heart Journal
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(Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Editorial BoardEmail this article to a colleague.
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(Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
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(Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Response to, "Atrial fibrillation and quality of life"Email this article to a colleague.
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Thank you for your interest in our recent publication. We fully agree that atrial fibrillation is not a benign condition. However, its effect on health-related quality of life (HRQOL) can vary significantly from asymptomatic patients unaware of their arrhythmia to those whose symptoms are difficult to control despite optimal medical care. In this analysis of an older (mean age, 73 years) cohort undergoing pacemaker placement, atrial fibrillation was associated with a decrement in functional status as measured by the Specific Activity Scale but was not a major driver of overall HRQOL as measured by the SF-36. In this respec...
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Kirsten E. Fleischmann, Gervasio A. Lamas, Carol M. Mangione, Lee Goldman Tags: Letters to the Editor Source Type: journals
Atrial fibrillation and quality of lifeEmail this article to a colleague.
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Fleischmann et al have analyzed serial quality of life (QOL) measures using a Short Form-36, Specific Activity Scale, time trade-off in patients who had atrial fibrillation after pacemaker implantation. They have also concluded that in elderly patients, AF was not a major determinant of QOL. Authors argue that previous studies were small in size and used of invalidated measures to determine the QOL. However, the major reason for treating patients with AF is to reduce the frequency of AF and also to decrease the disabling symptoms associated with its severity. There is documentation that QOL of patients with AF is poor comp...
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Radhakrishnan Ramaraj Tags: Letters to the Editor Source Type: journals
Mortality associated with adult congenital heart disease: Trends in the US population from 1979 to 2005Email this article to a colleague.
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Conclusions: Patients with congenital heart disease are living longer. Arrhythmia remains the primary contributing cause of death for those with cyanotic lesions. Myocardial infarction is now the leading contributing cause for adults with noncyanotic congenital heart disease consistent with late survival and an increasing impact of acquired heart disease. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Priya Pillutla, Kanaka D. Shetty, Elyse Foster Tags: Valvular and Congenital Heart Disease Source Type: journals
Low- and high-density lipoprotein cholesterol goal attainment in dyslipidemic women: The Lipid Treatment Assessment Project (L-TAP) 2Email this article to a colleague.
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Background: Differences between women and men have been documented for both diagnostic testing and treatment in cardiology. This analysis evaluates whether low-density lipoprotein cholesterol (LDL-C) success rates according to current guidelines and high-density lipoprotein cholesterol (HDL-C) levels differ by gender in the L-TAP 2 population.Methods: Patients aged ≥20 years with dyslipidemia on stable lipid-lowering therapy were assessed in 9 countries between September 2006 and April 2007. Low-density lipoprotein cholesterol goal attainment by cardiovascular risk level and region and determinants of low HDL-C were comp...
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Raul D. Santos, David D. Waters, Lisa Tarasenko, Michael Messig, J. Wouter Jukema, Jean Ferrières, Juan Verdejo, Cheng-Wen Chiang, on behalf of the L-TAP 2 Investigators Tags: Prevention and Rehabilitation Source Type: journals
Achieving routine sub 30 minute door-to-balloon times in a high volume 24/7 primary angioplasty center with autonomous ambulance diagnosis and immediate catheter laboratory accessEmail this article to a colleague.
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Conclusions: Interhospital transfer remains slow even with rapid institutional door-to-balloon times. With autonomous ambulance diagnosis and open access direct to the catheter laboratory, a median door-to-balloon time of 95% of patients were reperfused within 1 hour. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Miles Dalby, Rajesh Kharbanda, Gopal Ghimire, Jon Spiro, Phil Moore, Michael Roughton, Rebecca Lane, Mohammad Al-Obaidi, Molly Teoh, Elizabeth Hutchison, Mark Whitbread, David Fountain, Richard Grocott-Mason, Andrew Mitchell, Mark Mason, Charles Ilsley Tags: Interventional Cardiology Source Type: journals
Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney disease and diabetes mellitus undergoing coronary angiographic proceduresEmail this article to a colleague.
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Conclusions: In the present study, the overall rate of CIN in patients with chronic kidney disease and DM undergoing coronary angiographic procedures was 10.5%. There was no significant difference between iodixanol and iopamidol in either peak increase in SCr or risk of CIN. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Warren Laskey, Peter Aspelin, Charles Davidson, Michael Rudnick, Pierre Aubry, Sreenivas Kumar, Frank Gietzen, Marcus Wiemer, on behalf of the DXV405 Study Group Tags: Interventional Cardiology Source Type: journals
Transradial versus transfemoral percutaneous coronary intervention in acute myocardial infarction: Systematic overview and meta-analysisEmail this article to a colleague.
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Conclusions: Transradial PCI reduces the risk of periprocedural major bleeding and major adverse events in the STEMI setting. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: András Vorobcsuk, Attila Kónyi, Dániel Aradi, Iván G. Horváth, Imre Ungi, Yves Louvard, András Komócsi Tags: Interventional Cardiology Source Type: journals
Prognostic significance and magnetic resonance imaging findings in aborted myocardial infarction after primary angioplastyEmail this article to a colleague.
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Conclusion: The proven prognostic relevance of aborted MI makes it a meaningful end point and therapeutic target in future MI studies. MRI can further distinguish between true aborted MI with absence of myocardial scar and aborted MI with scar formations. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Ingo Eitel, Steffen Desch, Mahdi Sareban, Georg Fuernau, Matthias Gutberlet, Gerhard Schuler, Holger Thiele Tags: Interventional Cardiology Source Type: journals
Patterns of management of atrial fibrillation complicating coronary artery bypass grafting: Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT-IV) TrialEmail this article to a colleague.
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Conclusion: Although a rhythm control strategy was used in most of the patients in this trial and the overall rate of use of warfarin was low, the significance of these findings is uncertain because of the lack of data from randomized clinical trials. The substantial variations in the management of post-CABG AF across sites are likely because of definitive data on the most effective therapies, highlighting the need for clinical trials on rate versus rhythm control and on anticoagulation for AF in this setting. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Sana M. Al-Khatib, Gail Hafley, Robert A. Harrington, Michael J. Mack, Thomas Bruce Ferguson, Eric D. Peterson, Robert M. Califf, Nicholas T. Kouchoukos, John H. Alexander Tags: Electrophysiology Source Type: journals
Does intensity of rate control influence outcome in persistent atrial fibrillation? Data of the RACE studyEmail this article to a colleague.
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Background: Large trials have demonstrated that rate control is an acceptable alternative for rhythm control. However, optimal heart rate during atrial fibrillation (AF) remains unknown. Aim of this analysis was to compare outcome between rate control ≥80 and (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Hessel F. Groenveld, Harry J.G.M. Crijns, Michiel Rienstra, Maarten P. Van den Berg, Dirk J. Van Veldhuisen, Isabelle C. Van Gelder, for the RACE investigators Tags: Electrophysiology Source Type: journals
The relation between platelet reactivity and glycemic control in diabetic patients with cardiovascular disease on maintenance aspirin and clopidogrel therapyEmail this article to a colleague.
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Background: High platelet reactivity (HPR) during aspirin and clopidogrel therapy in patients with diabetes has been reported and may affect outcomes. However, the relation of platelet reactivity to glycemic control is less studied in patients on dual antiplatelet therapy.Methods: Platelet aggregation (PA) in response to 5 and 20 μmol/L adenosine diphosphate (ADP) was compared in type 2 diabetic (n = 36) and nondiabetic patients (n = 35) undergoing elective stenting on aspirin and clopidogrel maintenance therapy. The relation of glycosylated hemoglobin (HbA1c) 46% for 5 μmol/L ADP-induced and >59% for 20 μmol/L ADP-indu...
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Anand Singla, Mark J. Antonino, Kevin P. Bliden, Udaya S. Tantry, Paul A. Gurbel Tags: Diabetes and Metabolism Source Type: journals
Prognostic value of B-type natriuretic peptide for cardiovascular events independent of left ventricular end-diastolic pressureEmail this article to a colleague.
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Background: B-type natriuretic peptide (BNP) correlates with left ventricular (LV) end-diastolic pressure (LVEDP) and predicts cardiovascular events. We sought to determine whether BNP has prognostic value independent of LVEDP.Methods: Eligible patients were referred for coronary angiography between March 15, 2002, and April 30, 2008, at a single institution. Inclusion criteria were having BNP, LV ejection fraction (EF), and LVEDP measured within 24 hours of the angiogram. The predictive value of BNP for events independent of LVEDP, EF, and other confounders was determined.Results: The study population (n = 1,059) was foll...
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Robert Kevin Rogers, Heidi T. May, Jeffrey L. Anderson, J. Brent Muhlestein Tags: Congestive Heart Failure Source Type: journals
Cardiac resynchronization therapy in patients with ischemic versus non-ischemic heart failure: Differential effect of optimizing interventricular pacing intervalEmail this article to a colleague.
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Conclusions: Optimized sequential biventricular pacing further increased LV systolic performance as compared to simultaneous stimulation, particularly in ischemic patients where the presence of a large scar was correlated with a larger LV preactivation. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Nina Ajmone Marsan, Gabe B. Bleeker, Rutger J. Van Bommel, Jan Willem Borleffs, Matteo Bertini, Eduard R. Holman, Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax Tags: Congestive Heart Failure Source Type: journals
Comparative trends in guidelines adherence among patients with non–ST-segment elevation acute coronary syndromes treated with invasive versus conservative management strategies: Results from the CRUSADE quality improvement initiativeEmail this article to a colleague.
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Conclusions: Improvements in the use of guidelines-recommended therapies were seen among all patients with NSTE ACS in CRUSADE over a 4-year period regardless of management strategy, and the trajectory of improvement in acute care was greatest in patients managed conservatively. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Ezra A. Amsterdam, Eric D. Peterson, Fang-Shu Ou, L. Kristin Newby, Charles V. Pollack, W. Brian Gibler, E. Magnus Ohman, Matthew T. Roe Tags: Acute Ischemic Heart Disease Source Type: journals
High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation: A randomized controlled trial evaluating the relationship to endothelial function and inflammationEmail this article to a colleague.
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Conclusions: Regular high-intensity interval exercise training was associated with a significant reduction in late luminal loss in the stented coronary segment. This effect was associated with increased aerobic capacity, improved endothelium function, and attenuated inflammation. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Peter S. Munk, Eva M. Staal, Noreen Butt, Kjetil Isaksen, Alf I. Larsen Tags: Trial Design Source Type: journals
Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepositoryEmail this article to a colleague.
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Conclusions: We have established a biorepository and clinical database composed of patients with electrophysiologic diseases. EPGEN will seek to (1) improve risk stratification, (2) elucidate mechanisms of arrhythmogenesis, and (3) identify novel pharmacologic targets for the treatment of heart rhythm disorders. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Jason I. Koontz, Daniel Haithcock, Valerie Cumbea, Anthony Waldron, Kristie Stricker, Amy Hughes, Kent Nilsson, Albert Sun, Jonathan P. Piccini, William E. Kraus, Geoffrey S. Pitt, Svati H. Shah, Patrick Hranitzky Tags: Trial Design Source Type: journals
Design and rationale of the WOEST trial: What is the Optimal antiplatElet and anticoagulant therapy in patients with oral anticoagulation and coronary StenTing (WOEST)Email this article to a colleague.
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Conclusions: No prospective randomized study has yet addressed the issue of optimal antiplatelet therapy in patients with chronic oral anticoagulant therapy undergoing coronary stenting. Therefore, the WOEST trial will help to define new guidelines for patients with indication for chronic anticoagulation who need coronary stenting. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Willem Dewilde, Jurriën Ten Berg Tags: Trial Design Source Type: journals
Management of ST-segment elevation myocardial infarction: Comparison of the updated guidelines from North America and EuropeEmail this article to a colleague.
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The American College of Cardiology/American Heart Association and the European Society of Cardiology each recently published updated guidelines for management of patients with acute ST elevation myocardial infarction. In this article, we highlight the most important new recommendations, review their supporting data, and describe differences between the guidelines.Key aspects of these updates include detailed guidance regarding the selection of a reperfusion strategy and the incorporation of newer adjunctive antithrombotic agents. Both new guidelines suggest caution in the administration of intravenous β-blockers, avoidanc...
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Deepak Thomas, Robert P. Giugliano Tags: Curriculum in Cardiology Source Type: journals
Incremental value of 2-dimensional speckle tracking strain imaging to wall motion analysis for detection of coronary artery disease in patients undergoing dobutamine stress echocardiographyEmail this article to a colleague.
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Conclusion: Longitudinal strain analysis had higher diagnostic accuracy than circumferential and radial strains and was comparable to WMSI for detection of significant coronary artery disease. However, combination longitudinal strain and WMSI resulted in significant incremental increase in diagnostic accuracy. (Source: American Heart Journal)
Source: American Heart Journal - October 4, 2009 Category: Cardiology Authors: Arnold C.T. Ng, Marta Sitges, Phuong N. Pham, Da T. Tran, Victoria Delgado, Matteo Bertini, Gaetano Nucifora, Jane Vidaic, Christine Allman, Eduard R. Holman, Jeroen J. Bax, Dominic Y. Leung Tags: Imaging and Diagnostic Testing Source Type: journals
Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutationsEmail this article to a colleague.
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Conclusion: Myofilament-positive HC does not appear to represent a distinct clinical phenotypic entity as evidenced by specific histologic characteristics and septal shape. (Source: American Heart Journal)
Source: American Heart Journal - October 4, 2009 Category: Cardiology Authors: Christopher J. McLeod, J. Martijn Bos, Jeanne L. Theis, William D. Edwards, Bernard J. Gersh, Steve R. Ommen, Michael J. Ackerman Tags: Genetics Source Type: journals
Addition of inspiratory muscle training to aerobic training improves cardiorespiratory responses to exercise in patients with heart failure and inspiratory muscle weaknessEmail this article to a colleague.
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Background: This small clinical trial tested the hypothesis that the addition of inspiratory muscle training (IMT) to aerobic exercise training (AE) results in further improvement in cardiorespiratory responses to exercise than those obtained with AE in patients with chronic heart failure (CHF) and inspiratory muscle weakness (IMW).Methods: Twenty-four patients with CHF and IMW (maximal inspiratory pressure (Source: American Heart Journal)
Source: American Heart Journal - October 4, 2009 Category: Cardiology Authors: Eliane R. Winkelmann, Gaspar R. Chiappa, Camila O.C. Lima, Paulo R.N. Viecili, Ricardo Stein, Jorge P. Ribeiro Tags: Congestive Heart Failure Source Type: journals
Contribution of angiographic and electrocardiographic parameters of reperfusion to prediction of mortality and morbidity after acute ST-elevation myocardial infarction: Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trialEmail this article to a colleague.
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Background: Reperfusion with primary percutaneous intervention (PCI) in ST-segment elevation myocardial infarction leads to improved clinical outcomes. The contribution angiographic vs electrocardiographic reperfusion parameters confer on prognosis is unclear.Methods: A prespecified subset of the APEX-AMI trial patients was analyzed by independent angiographic and electrocardiographic core laboratories (n = 1,018). Angiographic reperfusion after PCI and electrocardiogram 30 minutes post-PCI were assessed.Results: Of the 941 patients in the angiographic substudy, 796 (85%) attained post-PCI Thrombolysis In Myocardial Infarc...
Source: American Heart Journal - October 4, 2009 Category: Cardiology Authors: Sorin J. Brener, Cynthia M. Westerhout, Yuling Fu, Thomas G. Todaro, David J. Moliterno, Galen S. Wagner, Christopher B. Granger, Paul W. Armstrong, for the APEX-AMI Investigators Tags: Acute Ischemic Heart Disease Source Type: journals
Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) trialEmail this article to a colleague.
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Conclusion: The EMINENCE trial will assess the safety and feasibility of M118 as an anticoagulant in the setting of PCI and will provide important information to determine the appropriate therapeutic range of activated clotting time for M118 and the appropriate dose or doses to be explored in a phase 3 clinical trial. (Source: American Heart Journal)
Source: American Heart Journal - September 30, 2009 Category: Cardiology Authors: Chiara Melloni, Ian Fier, James Roach, Andrzej S. Kosinski, Samuel Broderick, Kristina Sigmon, Shelley Myles, Richard C. Becker, Sunil V. Rao, on behalf of the EMINENCE Investigators Tags: Trial Design Source Type: journals
Barriers to participation in cardiac rehabilitationEmail this article to a colleague.
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Conclusions: Several clinical and psychosocial factors are associated with decreased participation in cardiac rehabilitation programs after MI in the community. As many are modifiable, addressing them may improve participation and outcomes. (Source: American Heart Journal)
Source: American Heart Journal - September 29, 2009 Category: Cardiology Authors: Shannon M. Dunlay, Brandi J. Witt, Thomas G. Allison, Sharonne N. Hayes, Susan A. Weston, Ellen Koepsell, Véronique L. Roger Tags: Prevention and Rehabilitation Source Type: journals
Reporting and representation of race/ethnicity in published randomized trialsEmail this article to a colleague.
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Conclusion: Although reporting the race/ethnic composition of study populations is increasing over time, two thirds of all RCTs supporting a recent American Heart Association () guideline failed to publish any information on race. A necessary first requirement in translating RCT evidence to patients of all races is information regarding racial demographics. Such information should be strongly encouraged in future publications. (Source: American Heart Journal)
Source: American Heart Journal - September 29, 2009 Category: Cardiology Authors: Jeffrey S. Berger, Chiara Melloni, Tracy Y. Wang, Rowena J. Dolor, Camille G. Frazier, Zainab Samad, Eric D. Peterson, Daniel B. Mark, L. Kristin Newby Tags: Acute Ischemic Heart Disease Source Type: journals
Self-reported anxiety and the risk of clinical events and atherosclerotic progression among patients with Coronary Artery Bypass Grafts (CABG)Email this article to a colleague.
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Conclusions: Anxiety symptoms are associated with increased risk of death or MI among patients with saphenous vein grafts, but this risk does not appear to be mediated by more extensive atherosclerotic progression. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Joshua I. Rosenbloom, Gregory A. Wellenius, Kenneth J. Mukamal, Murray A. Mittleman Tags: Surgery Source Type: journals
Additional prognostic value of physical examination, exercise testing, and arterial ultrasonography for coronary risk assessment in primary preventionEmail this article to a colleague.
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Conclusion: Physical examination, exercise testing, and arterial ultrasonography provide incremental information on the risk of coronary event in asymptomatic adults. Exercise testing and femoral ultrasonography also improve the accuracy of the risk stratification. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Maxime Cournot, Dorota Taraszkiewicz, Jean-Pierre Cambou, Michel Galinier, Henri Boccalon, Hélène Hanaire-Broutin, Bernard Chamontin, Didier Carrié, Jean Ferrières Tags: Prevention and Rehabilitation Source Type: journals
Magnitude and consequences of missing the acute infarct-related circumflex arteryEmail this article to a colleague.
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Emergent reperfusion strategies are integral to providing optimal patient outcomes in the setting of acute coronary artery occlusion. ST-segment elevation on the surface 12-lead electrocardiogram, although specific as a surrogate marker, is insensitive to acute posterior circulation coronary artery occlusion. Studies of non–ST-segment elevation acute coronary syndrome consistently identify patients who have epicardial vessel occlusion at the time of initial angiography, which is usually delayed for hours or days after the initial presentation. In addition, studies of ST-segment elevation myocardial infarction often divul...
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Amar Krishnaswamy, A. Michael Lincoff, Venu Menon Tags: Curriculum in Cardiology Source Type: journals
Information for ReadersEmail this article to a colleague.
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(Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Editorial BoardEmail this article to a colleague.
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(Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
ContentsEmail this article to a colleague.
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(Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Characterization and outcomes of women and men with non–ST-segment elevation myocardial infarction and nonobstructive coronary artery disease: Results from the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelines (CRUSADE) Quality Improvement InitiativeEmail this article to a colleague.
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Conclusions: Among NSTE ACS patients undergoing coronary angiography, absence of obstructive CAD is more common in women than men. Although nonobstructive CAD was twice as common among women with NSTEMI, sex differences in characteristics and outcomes were similar to those found with obstructive CAD. Unadjusted in-hospital outcomes of NSTEMI patients with nonobstructive CAD are favorable in both sexes. Whether the underlying pathophysiology of NSTE ACS without documentation of obstructive CAD is different between women and men requires further study. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Erika R. Gehrie, Harmony R. Reynolds, Anita Y. Chen, Brian H. Neelon, Matthew T. Roe, W. Brian Gibler, E. Magnus Ohman, L. Kristin Newby, Eric D. Peterson, Judith S. Hochman Tags: Acute Ischemic Heart Disease Source Type: journals
Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct arteryEmail this article to a colleague.
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Conclusions: The SBP, creatinine clearance, and number of vasopressors are significant predictors of mortality in patients with persistent vasopressor-dependent cardiogenic shock following acute MI despite a patent infarct artery. These prognostic variables may be useful for risk-stratification and in selecting patients for investigation of additional therapies. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Jason N. Katz, Amanda L. Stebbins, John H. Alexander, Harmony R. Reynolds, Karen S. Pieper, Witold Ruzyllo, Karl Werdan, Alexander Geppert, Vladimir Dzavik, Frans Van de Werf, Judith S. Hochman, for the TRIUMPH Investigators Tags: Acute Ischemic Heart Disease Source Type: journals
Treatment of stable angina pectoris by ivabradine in every day practice: The REDUCTION StudyEmail this article to a colleague.
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Conclusion: Ivabradine reduces the HR and is highly effective and well tolerated in the treatment of patients with symptomatic coronary artery disease. The results confirm the findings of controlled clinical trials in a broad patient population in everyday routine practice. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Ralf Köster, Jan Kaehler, Thomas Meinertz, for the REDUCTION Study Group Tags: Coronary Artery Disease Source Type: journals
Prevalence and prognostic significance of incidental cardiac troponin T elevation in ambulatory patients with stable coronary artery disease: Data from The Heart and Soul StudyEmail this article to a colleague.
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Conclusions: In ambulatory patients with stable CAD, the prevalence of cTnT elevation was 6.2%. Cardiac troponin T elevation detected using the conventional troponin assay was associated with increased risk of adverse cardiovascular outcomes, but its prognostic value was not incremental over N-terminal pro–B-type natriuretic peptide and echocardiographic evidence of cardiac abnormalities. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Bill P.C. Hsieh, Adam M. Rogers, Beeya Na, Alan H.B. Wu, Nelson B. Schiller, Mary A. Whooley Tags: Coronary Artery Disease Source Type: journals
CorrectionEmail this article to a colleague.
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The letter “Response to ‘Heparin/PF4 antibodies formation after heparin treatment: Temporal aspects and long-term follow-up’” (Am Heart J 2009;158:e19) should have been listed in the print table of contents of the July 2009 issue. It was mistakenly excluded. Please find the article online on page e19 of the July 2009 issue. We apologize for any confusion or inconvenience this has caused. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Tags: Congestive Heart Failure Source Type: journals
Blood transfusion for acute decompensated heart failure—friend or foe?Email this article to a colleague.
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Background: In acute coronary syndromes (ACSs), blood transfusion (BT) has been associated with worse outcomes. The impact of BT among patients with acute decompensated heart failure (ADHF) remains unknown.Methods: Propensity score analysis of patients with ADHF with and without BT in a national heart failure (HF) survey was used in this study.Results: Of the 4,102 enrolled patients, 2,335 had ADHF, of whom 166 (7.1%) received BT. These patients were older (75.6% vs 73.6%, P = .04), more likely to be females (54.8% vs 43.9%, P = .007), more likely to have diabetes (59.0% vs 51.1%, P = .04) and renal dysfunction (59.0% vs 4...
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Moshe Garty, Eytan Cohen, Alexander Zuchenko, Solomon Behar, Valentina Boyko, Zaza Iakobishvili, Moshe Mittelman, Alexander Battler, Avraham Shotan, Shmuel Gottlieb, Avraham Caspi, David Hasdai, for the Heart Failure Survey in ISrael (HFSIS) Investigators Tags: Congestive Heart Failure Source Type: journals
Characteristics and in-hospital outcomes for nonadherent patients with heart failure: Findings from Get With The Guidelines-Heart Failure (GWTG-HF)Email this article to a colleague.
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Conclusions: Nonadherence is a common precipitant for HF admission. Despite a higher risk profile, nonadherent patients had lower in-hospital mortality and LOS, suggesting that it may be easier to stabilize nonadherent patients by reinstituting sodium and/or fluid restriction and resuming medical therapy. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Amrut V. Ambardekar, Gregg C. Fonarow, Adrian F. Hernandez, Wenqin Pan, Clyde W. Yancy, Mori J. Krantz, for the Get With the Guidelines Steering Committee and Hospitals Tags: Congestive Heart Failure Source Type: journals
Drug-eluting versus bare-metal stents for treating saphenous vein graftsEmail this article to a colleague.
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Conclusions: Although DES showed a trend toward a lower primary end point when compared with BMS post-2003, this association was no longer present when DES was compared to pre-2003 BMS. These results are consistent with the preponderance of available data and indicate that unobserved bias in observational registries may explain the reported benefit of DES over BMS for treating SVG. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Mehdi H. Shishehbor, Riem Hawi, Inder M. Singh, E. Murat Tuzcu, Deepak L. Bhatt, Stephen G. Ellis, Samir R. Kapadia Tags: Congestive Heart Failure Source Type: journals
Close bidirectional relationship between chronic kidney disease and atrial fibrillation: The Niigata preventive medicine studyEmail this article to a colleague.
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Background: Atrial fibrillation (AF) and chronic kidney disease share risk factors and pathophysiologic mechanisms, suggesting that two conditions have close relationships.Methods: This is a prospective community-based observational cohort study including 235,818 subjects based upon a voluntary annual health check-up program in Japan. We studied the association of kidney dysfunction at entry with subsequent new-onset AF and the association of AF at entry with the development of kidney disease.Results: During a follow-up of 5.9 ± 2.4 years, AF developed in 2947 subjects (1.3%). Baseline serum creatinine and estimated glome...
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Hiroshi Watanabe, Toru Watanabe, Shigeru Sasaki, Kojiro Nagai, Dan M. Roden, Yoshifusa Aizawa Tags: Electrophysiology Source Type: journals
Electrocardiographic predictors of atrial fibrillationEmail this article to a colleague.
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Conclusions: Several ECG markers are independently predictive of future onset of AF. The P index, a measurement of disorganized atrial depolarization, is one of the strongest predictors of AF. The ECG contains valuable prognostic information that can identify patients at risk of AF. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Marco V. Perez, Frederick E. Dewey, Rachel Marcus, Euan A. Ashley, Amin A. Al-Ahmad, Paul J. Wang, Victor F. Froelicher Tags: Electrophysiology Source Type: journals
Insertion/deletion polymorphism in α2-adrenergic receptor gene is a genetic risk factor for sudden cardiac deathEmail this article to a colleague.
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Conclusions: The genetic polymorphism of the α2B-adrenoreceptor is genetic risk predictor for sudden cardiac death. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Jari A. Laukkanen, Timo H. Mäkikallio, Jussi Kauhanen, Sudhir Kurl Tags: Genetics Source Type: journals
Cardiac amyloidosis in African Americans: Comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosisEmail this article to a colleague.
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Conclusions: ATTR V122I and AL are equally prevalent as the cause of cardiomyopathy in African Americans referred for a diagnosis of amyloidosis. Available therapy for AL underscores the need for early and accurate determination of amyloid type. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Lawreen H. Connors, Tatiana Prokaeva, Amareth Lim, Roger Théberge, Rodney H. Falk, Gheorghe Doros, Alan Berg, Catherine E. Costello, Carl O'Hara, David C. Seldin, Martha Skinner Tags: Genetics Source Type: journals
Practice patterns, outcomes, and end-organ dysfunction for patients with acute severe hypertension: The Studying the Treatment of Acute hyperTension (STAT) RegistryEmail this article to a colleague.
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Conclusion: This study highlights heterogeneity in care, BP control, and outcomes of patients hospitalized with acute severe hypertension. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Jason N. Katz, Joel M. Gore, Alpesh Amin, Frederick A. Anderson, Joseph F. Dasta, James J. Ferguson, Kurt Kleinschmidt, Stephan A. Mayer, Alan S. Multz, W. Frank Peacock, Eric Peterson, Charles Pollack, Gene Yong Sung, Andrew Shorr, Joseph Varon, Allison Tags: Hypertension Source Type: journals
Benefits of drug-eluting stents as compared to bare metal stent in ST-segment elevation myocardial infarction: Four year results of the PaclitAxel or Sirolimus-Eluting stent vs bare metal stent in primary angiOplasty (PASEO) randomized trialEmail this article to a colleague.
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Conclusions: This study shows that among patients with STEMI undergoing primary angioplasty, both SES and PES are safe and associated with significant benefits in terms of TLR up to 4 years' follow-up, as compared to BMS. Thus, until the results of further large randomized trials with long-term follow-up become available, DES may be considered among patients with STEMI undergoing primary angioplasty. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Emilio Di Lorenzo, Rosario Sauro, Attilio Varricchio, Michele Capasso, Tonino Lanzillo, Fiore Manganelli, Ciro Mariello, Francesco Siano, Maria Rosaria Pagliuca, Giovanni Stanco, Giuseppe Rosato, Giuseppe De Luca Tags: Interventional Cardiology Source Type: journals
Timing of clopidogrel loading before percutaneous coronary intervention in clopidogrel-naive patients with stable or unstable angina: A comparison of two strategiesEmail this article to a colleague.
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Background: Clopidogrel-naive patients subjected to coronary angiography may be candidates for percutaneous coronary intervention (PCI). Clopidogrel loading with 600 mg at least 2 hours before the procedure is advised for such patients. However, there is no direct evidence that delaying PCI for 2 hours after clopidogrel loading is superior to ad hoc PCI.Methods: After coronary angiography, clopidogrel-naive patients (N = 199) with stable or unstable angina, candidates for PCI, were loaded with 900 mg of clopidogrel and then randomized to ad hoc PCI (ad hoc group, n = 103) or delayed PCI 2 hours after loading (delayed group...
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: Periklis A. Davlouros, Aggelos Arseniou, George Hahalis, John Chiladakis, Andreas Mazarakis, Anastasia Damelou, Marina Karakantza, Fotini Paliogianni, Nikolaos Karogiannis, Dimitrios Alexopoulos Tags: Interventional Cardiology Source Type: journals
Drug-eluting stents: A study of international practiceEmail this article to a colleague.
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Conclusion: Adoption and use of DES showed wide variation in four countries. The determinants of use are complex, and it is likely that nonclinical factors predominate. Recent reductions in use may be as a consequence of publicity and concerns regarding late stent thrombosis. The optimum application of DES in clinical practice is unclear and is reflected in the degree of international variation demonstrated. (Source: American Heart Journal)
Source: American Heart Journal - September 24, 2009 Category: Cardiology Authors: David Austin, Keith G. Oldroyd, David R. Holmes, Charanjit S. Rihal, P. Diane Galbraith, William A. Ghali, Victor Legrand, Yves Taeymans, Alex McConnachie, Jill P. Pell, on behalf of the APPROACH Investigators, Belgian Working Group on Invasive Cardiology Tags: Interventional Cardiology Source Type: journals
