American Journal of Alzheimer's Disease and Other DementiasThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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News BriefsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Tags: Articles Source Type: journals

Hospice Access for Individuals With DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Involvement in a hospice program is important because it may allow individuals with dementia to delay or prevent institutionalization as well as provide psychosocial support for their families. Once used mostly by patients with a terminal cancer, now more than one half of the hospice patients have diagnoses other than cancer. Yet hospice is still underused for individuals dying with advanced dementia. We conducted a pilot study of hospice agencies to determine barriers and characteristics of dementia hospice enrollment. Using a mailed questionnaire and interview, we looked at demographics, accessibility, training, referral...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: McCarty, C. E., Volicer, L. Tags: Articles Source Type: journals

The Role of Caregiver Prosody in Conversations With Persons Who Have Alzheimer's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated whether aspects of family caregivers’ prosody (pitch and loudness) would be associated with successful or unsuccessful conversations with spouses who have Alzheimer’s disease (AD). Secondary analysis was conducted of 12 caregivers’ speech when interacting with spouses who have AD. Acoustic analyses were conducted to calculate the fundamental frequency (pitch) and intensity (loudness) of caregivers’ speech. The results showed no significant overall differences between the caregivers’ pitch or loudness in either successful or unsuccessful conversations. However, for 1 sub...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Small, J. A., Huxtable, A., Walsh, M. Tags: Articles Source Type: journals

Longitudinal Verbal Fluency in Normal Aging, Preclinical, and Prevalent Alzheimer's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Greater longitudinal declines in category compared to letter fluency are consistent with cross-sectional studies. Steeper declines on both fluency measures distinguish preclinical AD from cognitively unimpaired individuals. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Clark, L. J., Gatz, M., Zheng, L., Chen, Y.-L., McCleary, C., Mack, W. J. Tags: Articles Source Type: journals

Progranulin and {beta}-Amyloid Distribution: A Case Report of the Brain From Preclinical PS-1 Mutation CarrierEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This case report illustrates PGRN accumulation and Aβ aggregation in preclinical PS-1 AD case and raises the question whether this phenomenon coincides with or precedes Aβ aggregation. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Gliebus, G., Rosso, A., Lippa, C. F. Tags: Articles Source Type: journals

The Effect of Multisensory Stimulation on Persons Residing in an Extended Care FacilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The use of MSSE, as a non-pharmacological intervention, demonstrates the ability to decrease the number of incidences of disruptive or problematic behavior. The use of these interventions, where feasible, should be considered prior to the use of pharmacological methods. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Ward-Smith, P., Llanque, S. M., Curran, D. Tags: Articles Source Type: journals

Review: Obesity and Alzheimer's Disease: A Link Between Body Weight and Cognitive Function in Old AgeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity is now a global health hazard. It not only predisposes to an array of risk factors leading to increased morbidity and mortality amongst adults but it also has a major negative impact on children’s health. The deleterious effects of obesity on cardiovascular system have now been well acknowledged. It causes insulin resistance that in turn leads to diabetes, hypertension and cardiovascular abnormalities. The vascular effects of obesity may have a role in the development of a rapidly growing disease of late life, Alzheimer’s disease. The precise mechanisms of the association between adiposity and impairmen...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Naderali, E. K., Ratcliffe, S. H., Dale, M. C. Tags: Articles Source Type: journals

Review of Issue: Barriers to Hospice in Patients With AlzheimerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Lippa, C. F. Tags: Articles Source Type: journals

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(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Tags: Articles Source Type: journals

Elderspeak's Influence on Resistiveness to Care: Focus on Behavioral EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resistiveness to care (RTC) in older adults with dementia commonly disrupts nursing care. Research has found that elderspeak (infantilizing communication) use by nursing home (NH) staff increases the probability of RTC in older adults with dementia. The current analysis used general sequential querier (GSEQ) software to analyze behavior sequences of specific behavioral events. We found that older adults with dementia most frequently reacted to elderspeak communication by negative vocalizations (screaming or yelling, negative verbalizations, crying). Because negative vocalizations disrupt nursing care, reduction in elderspe...
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Authors: Herman, R. E., Williams, K. N. Tags: Articles Source Type: journals

The Northwestern Anagram Test: Measuring Sentence Production in Primary Progressive AphasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the Northwestern Anagram Test (NAT), a new clinical measure of sentence production. A total of 16 patients with PPA and their controls assembled single printed words to create sentences describing pictures. Northwestern Anagram Test performance was significantly correlated with a measure of sentence production and with aphasia severity but not with measures of naming, single word comprehension, object recognition, or motor speech. The NAT can be used to assess syntax competence when patients cannot be tested with measures that require intact speech production. (Source: American Journal of Alzheimer's...
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Authors: Weintraub, S., Mesulam, M.-M., Wieneke, C., Rademaker, A., Rogalski, E. J., Thompson, C. K. Tags: Articles Source Type: journals

Novel PSEN1 Mutation in a Bulgarian Patient With Very Early-Onset Alzheimer's Disease, Spastic Paraparesis, and Extrapyramidal SignsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the phenotype of a Bulgarian early-onset Alzheimer’s disease (EOAD) family with 3 affected patients in 3 generations. In the proband, a novel L381V mutation in the presenilin1 (PSEN1) gene was identified. In this patient, the first symptoms were noticed at the age of 32 years and she died at the age of 37 years. The EOAD phenotype caused by the novel L381V mutation in the PSEN1 gene presented clinically, by a very early onset in the proband, rapid progression of dementia, spastic paraparesis, and extrapyramidal signs, as atypical clinical signs in Alzheimer’s disease patients. (Source: American Jour...
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Authors: Dintchov Traykov, L., Mehrabian, S., Van den Broeck, M., Radoslavova Raycheva, M., Cruts, M., Kirilova Jordanova, A., Van Broeckhoven, C. Tags: Articles Source Type: journals

Computerized Cognitive Assessment of Mild Cognitive Impairment in Urban African AmericansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Few objective cognitive assessment tools have been validated for mild cognitive impairment (MCI) in African Americans despite higher prevalence of disease. This preliminary study evaluated discriminant validity of a computerized cognitive assessment battery for MCI in an urban African American cohort. Twenty-seven participants with MCI and 22 cognitively healthy individuals completed a multidomain battery (Mindstreams, NeuroTrax Corp, New Jersey). Mild cognitive impairment participants performed more poorly than cognitively healthy participants in all domains, with significant differences in memory (P = .003; d = 0.96), ex...
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Authors: Doniger, G. M., Jo, M.-Y., Simon, E. S., Crystal, H. A. Tags: Articles Source Type: journals

The Effect of Dementia Patient's Physical, Cognitive, and Emotional/ Behavioral Problems on Caregiver Well-Being: Findings From a Spanish-Speaking Sample From Colombia, South AmericaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The current study aims to (1) determine whether there is a relationship between the problems of patients with dementia and the psychosocial functioning of the caregiver, (2) determine whether these relationships exist independent of sociodemographic and caregiving-related variables, and (3) determine which type of problems of patients with dementia best predict the psychosocial functioning of the caregiver. In all, 73 family caregivers were recruited from Bogota, Colombia. The caregivers completed a checklist of problems presented by the person with dementia, Patient Health Questionnaire (PHQ-9), Zarit Burden Interview (ZB...
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Authors: Arango Lasprilla, J. C., Moreno, A., Rogers, H., Francis, K. Tags: Articles Source Type: journals

The Caregiver's Burden of Alzheimer Patients: Differences Between Live-In and Non-Live-InEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of our study was to describe the burden of a sample of 208 live-in/non-live-in caregivers of patients with Alzheimer’s disease (AD). We analyzed the statistical correlation between Caregiver Burden Inventory (CBI) and the live-in/non-live-in caregiver status, and between the ‘‘objective burden,’’ the cognitive deterioration, functional ability, and psychic and behavioral disorders. Using analysis of variance (ANOVA), the live-in groups of caregivers were compared to each subscale and to the total CBI. Living with a patient causes a bigger burden associated to the ‘‘de...
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Authors: Raccichini, A., Castellani, S., Civerchia, P., Fioravanti, P., Scarpino, O. Tags: Articles Source Type: journals

Cerebrospinal Immunoglobulin Level Changes and Clinical Response to Treatment of Hashimoto's EncephalopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 64-year-old male who presented with a 2-year history of behavioral and cognitive decline. Brain imaging showed nonenhancing hemispheric white matter lesions. Blood work revealed elevated thyroglobulin and thyroperoxidase antibody levels. Cerebrospinal fluid (CSF) analysis was largely negative, except for an elevated protein and immunoglobulin G (IgG) level. Because of the absence of stroke, central nervous system (CNS) tumor, or infection, this patient fits into criteria of Hashimoto’s encephalopathy. His Mini-Mental State Examination score improved from 10 to 29 after initial immunotherapy. The patient...
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Authors: Gliebus, G., Lippa, C. F. Tags: Articles Source Type: journals

Review of Issue: Primary Progressive Aphasia and Caregiver IssuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - October 2, 2009 Category: Geriatrics Authors: Lippa, C. F. Tags: Articles Source Type: journals

News BriefsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Tags: Article Source Type: journals

ApoE Genotype and Family History in Patients With Dementia and Cognitively Intact Spousal ControlsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In our sample of patients with Alzheimer dementia, approximately 3 of 4 (72.0%) were homozygous for the genotype Apo e4 when they had a positive family history. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Authors: Zintl, M., Schmitz, G., Hajak, G., Klunemann, H.-H. Tags: Article Source Type: journals

Apathy and Depressive Mood in Nursing Home Patients With Early-Onset DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The study explored whether apathy and depressive mood symptoms (DMS) are related to cognitive and functional features of dementia in 63 nursing home (NH) residents with early-onset dementia (EOD). All EOD residents from one NH (n = 41) and a random sample from another NH were assessed for depressive symptoms (Montgomery Asberg Depression Rating Scale [MADRS]), apathy (Neuropsychiatric Inventory [NPI]), global cognitive functions (Mini-Mental State Examination [MMSE]), activities of daily living (ADL, Minimum Data Set—Resident Assessment Instrument [MDS-RAI]), and overall dementia severity (Global Deterioration Scale ...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Authors: Leontjevas, R., van Hooren, S., Waterink, W., Mulders, A. Tags: Article Source Type: journals

Dementia-Friendly Architecture: Environments That Facilitate Wayfinding in Nursing HomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spatial disorientation is a prime reason for institutionalization. The autonomy of the residents and their quality of life, however, is strongly linked with their ability to reach certain places within their nursing home. The physical environment has a great potential for supporting a resident’s wayfinding abilities. For this study, data were collected from 30 German nursing homes. Skilled nurses rated the resident’s ability to perform 5 wayfinding tasks. The architectural characteristics of the homes were analyzed and their impact on the resulting scores was tested for statistical significance using the Mann-W...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Authors: Marquardt, G., Schmieg, P. Tags: Article Source Type: journals

Scheduled Medications and Falls in Dementia Patients Utilizing a Wander GardenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little has been reported about the relationship of a dementia wander garden with scheduled psychiatric medications in addition to changes in fall number and severity. The 28 participating residents of a dementia unit were divided into high (HUG) and low (LUG) wander garden user groups and assessed for the number and severity of falls. The type and dose of scheduled psychiatric medications were monitored for 12 months before and 12 months after the wander garden was opened. Results indicated that the residents experienced about a 30% decrease for the raw number of falls and fall severity scores. The HUG had a significant re...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Authors: Detweiler, M. B., Murphy, P. F., Kim, K. Y., Myers, L. C., Ashai, A. Tags: Article Source Type: journals

Visuospatial Function is a Significant Contributor to Functional Status in Patients With Alzheimer's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Visuospatial ability is one of the important contributors to functional status. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Authors: Fukui, T., Lee, E. Tags: Article Source Type: journals

What Are The Top-Circulating Magazines in the United States Telling Older Adults About Cognitive Health?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examines the content focused on cognitive health in 5 top—circulating magazines marketed to older people in the United States. All pages (29 881 pages) of each magazine published in 2006 and 2007 were searched. There were 84 articles on cognitive health. Few were by health or science writers. Of the 58 articles on prevention, the contents focused primarily on diet and multiple behaviors, with less on physical activity or social engagement. Less than 20% provided resources to help readers obtain further information. Articles focused on physical activity, with information directing readers to credible resour...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Authors: Mathews, A. E., Laditka, S. B., Laditka, J. N., Friedman, D. B. Tags: Article Source Type: journals

A Multicenter, Open-Label, 24-Week Follow-Up Study for Efficacy on Cognitive Function of Donepezil in Binswanger-Type Subcortical Vascular DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Donepezil-treated patients with Binswanger type subcortical vascular dementia demonstrated significant improvement in cognition compared with baseline, and donepezil was well tolerated. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Authors: Jay Cheol Kwon, , Eung Gyu Kim, , Jae Woo Kim, , Oh Dae Kwon, , Bong Goo Yoo, , Hyon Ah Yi, , Nack Cheon Choi, , Seon Young Ahn, , Byung Hwa Lee, , Myong Jin Kang, , Dae Seob Choi, , BKVD Study Group Tags: Article Source Type: journals

Review of Issue: The Media and Cognitive Health in Our Aging PopulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - August 3, 2009 Category: Geriatrics Authors: Lippa, C. F. Tags: Article Source Type: journals

News BriefsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Tags: Article Source Type: journals

Switching from Donepezil Tablets to Rivastigmine Transdermal Patch in Alzheimer's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Both switch strategies were safe and well tolerated. The majority of patients may be able to switch directly to rivastigmine patches without a withdrawal period. Appropriate clinical judgment should be used for patients with existing bradycardia or receiving β blockers. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Sadowsky, C. H., Dengiz, A., Olin, J. T., Koumaras, B., Meng, X., Brannan, S., US38 study group Tags: Article Source Type: journals

Eye Tracking During a Visual Paired Comparison Task as a Predictor of Early DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors present findings from a behavioral task (visual paired comparison) using infrared eye-tracking that could potentially be useful in predicting the onset of Alzheimer's disease. Delay intervals of 2 seconds and 2 minutes were used between the initial viewing of a picture and when the picture was displayed alongside a novel picture. Eye-tracking revealed that at the 2-second delay, 6 patients with mild cognitive impairment, 15 matched control participants (normal control), and 4 neurological control participants with Parkinson's disease performed comparably, viewing the novel picture greater than 71% of the time. ...
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Crutcher, M. D., Calhoun-Haney, R., Manzanares, C. M., Lah, J. J., Levey, A. I., Zola, S. M. Tags: Article Source Type: journals

Persons With Moderate Alzheimer's Disease Improve Activities and Mood via Instruction TechnologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that the approach reported may be a useful strategy for helping persons with Alzheimer's disease. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Lancioni, G. E., Singh, N. N., O'Reilly, M. F., Sigafoos, J., Pangrazio, M. T., Megna, M., Zonno, N., La Martire, M. L., Pinto,, K., Minervini, M. G. Tags: Article Source Type: journals

Preserving Cognition Through an Integrated Cognitive Stimulation and Training ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Blending computer-based with traditional cognitive stimulation activities shows promise in preserving cognitive function in elders. Future studies to explore efficacy in larger, more diverse samples are needed. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Eckroth-Bucher, M., Siberski, J. Tags: Article Source Type: journals

Treatment Characteristics of Patients With Dementia: Comparing Two Different Psychiatric Inpatient SettingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Data of this prospective study show that dementia patients were significantly restrained in cognitive and daily functioning along with high morbidity. Discharge to institutional care and discharge medication was reduced in patients of the special dementia care setting. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Haude, V., Ludeke, M., Dohse, H., Reiswig, S., Liebler, A., Assion, H.-J., Basilowski, M., Borner, I. Tags: Article Source Type: journals

Frontal-executive Versus Posterior-perceptual Mental Status Deficits in Early-onset DementiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although preliminary, this study indicates that mental status screening based on frontal versus posterior cortical functions may help clinicians diagnose EODs. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Mendez, M. F., McMurtray, A. M., Licht, E. A., Saul, R. E. Tags: Article Source Type: journals

A Framework for Managing Wandering and Preventing ElopementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of the Study: A framework aids choice of interventions to manage wandering and prevent elopement in consideration of associated risks and mobility needs of wanderers. Design and Methods: A literature review, together with research results, published wandering tools, clinical reports, author clinical experience, and consensus-based judgments was used to build a decision-making framework. Results: Referencing a published definition of wandering and originating a clinical description of problematic wandering, authors introduce a framework comprising (1) wandering and related behaviors; (2) goals of wandering-specific ...
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Moore, D. H., Algase, D. L., Powell-Cope, G., Applegarth, S., Beattie, E. R. A. Tags: Article Source Type: journals

The Effects of a Dementia Nurse Care Manager on Improving Caregiver Outcomes OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article defines the role of dementia nurse care management and shares the results of the outcomes measurements. The evaluation showed that caregivers assisted by nurse care managements were more likely to show improvement in their stress levels, endurance potential, and well-being. This improvement was consistent over time. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Specht, J., Bossen, A., Hall, G. R., Zimmerman, B., Russell, J. Tags: Article Source Type: journals

Review: Donepezil in Severe Alzheimer's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the severe stages of Alzheimer's disease, functional autonomy is lost, psychiatric and behavioral symptoms become increasingly troublesome, and cognitive deficits increase until most patients require complete care, usually in specialized nursing homes. Consequently, some health care professionals question the benefits of pharmacologic intervention during these later stages. Since primary care physicians are often first to see these patients, they have key roles in recognizing the benefits of treatment and initiating appropriate management and referral. Three prospective randomized clinical trials of donepezil in severe ...
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Winblad, B. Tags: Article Source Type: journals

Review of Issue: Strategies for Patient Diagnosis and ManagementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 23, 2009 Category: Geriatrics Authors: Lippa, C. F. Tags: Article Source Type: journals

News BriefsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Tags: Article Source Type: journals

An Itemized Approach to Assessing Behavioral and Psychological Symptoms in DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In an effort to obtain more detailed clinical information regarding behavioral and psychology symptoms in dementia, we submitted an existing, comprehensive measure of behavioral and psychology symptoms in dementia (Neuropsychiatric Inventory) to an alternate itemized scoring system. One hundred twenty-four caregivers of patients with dementia (mean Mini-Mental State Examination = 22.6) rated the frequency of individual symptoms across all domains of the measure. Internal reliability and factor structures for all domains were analyzed to assess the stability of this scoring approach. Internal consistency alphas for each dom...
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Gallo, J. L., Schmidt, K. S., Libon, D. J. Tags: Article Source Type: journals

Free Recall and Learning of Emotional Word Lists in Very Elderly People With and Without DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An emotional memory advantage has been found across the life span where recall is better for emotional (as opposed to neutral) stimuli. Our goal was to design emotionally valent word lists for easy use by practitioners and to test whether demented and healthy elderly participants showed an emotional memory advantage with these lists. Three new word lists (a positive, a negative, and a neutral list) were constructed. Thirty-eight controls, 37 with mild cognitive impairment and 20 Alzheimer's dementia participants' free recall was tested. Unsurprisingly, controls had better recall overall. Emotionally valent words were recal...
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Nieuwenhuis-Mark, R. E., Schalk, K., de Graaf, N. Tags: Article Source Type: journals

Examining Pauses in Alzheimer's DiscourseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This discussion examines how speaker pauses, both filled and silent, are keyed to functions within a conversation and to functions within narration. In Alzheimer's discourse, pause-fillers can be both placeholders and hesitation markers; they may be ohs and ums or longer formulaic phrases. Extracts from the speech of 4 older women from the United States and from New Zealand are reviewed for changes in syntactic complexity, for retention of story components, and for pauses. The extracts illustrate these functions for silent pauses: as word-finding; as planning at word, phrase, and narrative component levels; and as pragmati...
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Davis, B. H., Maclagan, M. Tags: Article Source Type: journals

Quetiapine Effective in Treatment of Inappropriate Sexual Behavior of Lewy Body Disease With Predominant Frontal Lobe SignsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report inappropriate sexual behaviors in a case of dementia of Lewy body disease, which improved rapidly after treatment with quetiapine. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Prakash, R., Pathak, A., Munda, S., Bagati, D. Tags: Article Source Type: journals

Development and Evaluation of a Computerized Test Battery for Alzheimer's Disease Screening in Community-based SettingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. We believe the battery is very useful for routine clinical and community-based settings. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Inoue, M., Jinbo, D., Nakamura, Y., Taniguchi, M., Urakami, K. Tags: Article Source Type: journals

Video Programming for Individuals With Dementia: Assessing Cognitive CongruenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect of cognitively congruent video programming on attentional engagement, as measured by the average look duration and the proportion of the video viewed, was examined among long-term care facility residents with Alzheimer's disease. Over a 2-week period, 24 residents viewed 4 cognitively congruent videos and 1 control video (ie, a recorded episode of a local news program) at least once. Level of attentional engagement was significantly higher for cognitively congruent video programs compared to the News. Neither history of television viewing nor cognitive status was related to engagement. The results suggest that v...
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Heller, R. B., Dobbs, B. M., Strain, L. A. Tags: Article Source Type: journals

Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience representative of the allied disciplines involved in research and patient care. After a foreword on epidemiology, genetics, and risk factors, the amyloid cascade model is introduced and the main neuropathological hallmarks are discussed. The progression of memory, language, visual processing, executive, attentional, and praxis deficits, and of behavioral symptoms is presented. After a summary on neuropsychological assessment, emerging biomarkers from cerebrospinal fluid assays, magnetic resonance imaging, nuclear medicine, and electrophy...
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Minati, L., Edginton, T., Grazia Bruzzone, M., Giaccone, G. Tags: Article Source Type: journals

Severe Psychological Stress in Elderly Individuals: A Proposed Model of Neurodegeneration and Its ImplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During clinical practice, degenerative diseases in some patients appear after exposure to a severe psychological stress. Several studies have suggested that the duration of exposure to corticosteroids or stress, the dose of corticosteroids and the vulnerability of the hippocampus, amygdala and prefrontal cortex areas targeted by elevated stress hormones, mediate the damaging effects of elevated corticosteroids. Although understanding what triggers the transition from adaptive plasticity to the maladaptive effects of stress in the elderly is important, one of the great challenges is to determine individual differences in vu...
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Tsolaki, M., Kounti, F., Karamavrou, S. Tags: Article Source Type: journals

Review of Issue: Clinical Characterization in Alzheimer DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - April 16, 2009 Category: Geriatrics Authors: Lippa, C. F. Tags: Article Source Type: journals

News BriefsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - February 12, 2009 Category: Geriatrics Tags: Article Source Type: journals

A Review of Telephone-Administered Screening Tests for Dementia DiagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dementia screening measures serve an important role in epidemiological research, clinical trials, identifying patients for more comprehensive assessment, and monitoring progression. Telephone-administered measures allow increased flexibility. Although there are several extant telephone-administered measures that offer the promise of efficient detection of cognitive impairment, research evidence supporting their use is limited. We review telephone-based cognitive screening instruments for detecting dementia or mild cognitive impairment, critically review the evidence for their validity, and make recommendations for future r...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 12, 2009 Category: Geriatrics Authors: Smith, M. M., Tremont, G., Ott, B. R. Tags: Article Source Type: journals

Neural Stem Cells and Alzheimer's Disease: Challenges and HopeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alzheimer's disease is characterized by degeneration and dysfunction of synapses and neurons in brain regions critical for learning and memory functions. The endogenous generation of new neurons in certain regions of the mature brain, derived from primitive cells termed neural stem cells, has raised hope that neural stem cells may be recruited for structural brain repair. Stem cell therapy has been suggested as a possible strategy for replacing damaged circuitry and restoring learning and memory abilities in patients with Alzheimer's disease. In this review, we outline the promising investigations that are raising hope, an...
Source: American Journal of Alzheimer's Disease and Other Dementias - February 12, 2009 Category: Geriatrics Authors: Zhongling Feng, , Gang Zhao, , Lei Yu, Tags: Article Source Type: journals