American Journal of Clinical Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Use of the Afirma Xpression Atlas for cytologically indeterminate, Afirma Genomic Sequencing Classifier suspicious thyroid nodules: Clinicopathologic analysis with postoperative molecular testing
CONCLUSIONS: Afirma XA improved risk stratification of thyroid disease with a high risk of malignancy in Afirma GSC suspicious nodules. A negative Afirma XA result, however, should not be used as a rule-out test.PMID:38104250 | DOI:10.1093/ajcp/aqad169 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 17, 2023 Category: Pathology Authors: Carlos A Munoz-Zuluaga Jonas J Heymann James P Solomon Ami Patel Momin T Siddiqui Theresa Scognamiglio Hamza N Gokozan Source Type: research

HER2/ERBB2 copy number analysis by targeted next-generation sequencing in breast cancer
CONCLUSIONS: Copy number data from our NGS panel strongly correlate with HER2 status. Using a stringent cutoff, ERBB2 log2 ratio accurately predicts HER2 positivity with high specificity. The NGS CN assessment may have utility in determining HER2 status in certain clinical settings.PMID:38104247 | DOI:10.1093/ajcp/aqad167 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 17, 2023 Category: Pathology Authors: Daniel Xia Frank Kuo Melissa Hughes Neal Lindeman Danielle Manning Janet Files Sarah Strauss Greg Kirkner Ayesha Mohammed-Abreu Eric Winer Sara M Tolaney Nancy U Lin Deborah A Dillon Source Type: research

Analysis of hospital length of stay and cost savings with an in-house heparin-induced thrombocytopenia antibody assay at a midsized institution
CONCLUSIONS: We demonstrated a reduction in LOS following the introduction of an in-house HIT antibody assay that cannot be attributed to either systemwide initiatives or reduced patient acuity and was driven largely by patients with negative assays. This reduction was associated with significant estimated cost savings.PMID:38071967 | DOI:10.1093/ajcp/aqad152 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 10, 2023 Category: Pathology Authors: Caitlin Raymond Michael O'Rourke Liesel Dell'Osso Charles Golding Christopher Zahner Source Type: research

Digital and manual interfollicular Ki-67 are associated with a progression-free survival in patients with low-grade follicular lymphoma
CONCLUSIONS: Higher interfollicular Ki-67 by either digital or manual analysis is associated with a poorer PFS in patients with low-grade FL. These results suggest further validation of this marker is warranted to improve pathologic risk stratification at FL diagnosis. PD-L1 and LAG-3 were not associated with PFS or OS.PMID:38044670 | DOI:10.1093/ajcp/aqad161 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 4, 2023 Category: Pathology Authors: Aqsa Nasir Livia Hegerova Hira Yousaf Colleen L Forster Ryan Shanley Michael A Linden Veronika Bachanova Sophia Yohe Source Type: research