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Definitions of the phenotypic manifestations of sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides an overview of the process and describes 12 body system categories and the most prevalent or severe complications within these categories. A detailed Appendix provides standardized definitions for all complications identified within each system. This report proposes use of these definitions for studies of SCD complications, so future studies can be comparably robust and treatment efficacy measured. Use of these definitions will support greater accuracy in genotype-phenotype studies, thereby achieving a better understanding of SCD pathophysiology. This should nevertheless be viewed as a dynamic rather ...
Source: American Journal of Hematology - November 10, 2009 Category: Hematology Authors: Samir K. Ballas, Susan Lieff, Lennette J. Benjamin, Carlton D. Dampier, Matthew M. Heeney, Carolyn Hoppe, Cage S. Johnson, Zora R. Rogers, Kim Smith-Whitley, Winfred C. Wang, Marilyn J. Telen, on Behalf of the Investigators at the Comprehensive Sickle Cel Source Type: journals

On being metachromatic: Mystique and misunderstanding in mastocytosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - November 7, 2009 Category: Hematology Authors: Jason Gotlib Source Type: journals

Reality of complementary and alternative medicine in lymphoma patients: Hope, hype, or help?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - November 6, 2009 Category: Hematology Authors: Alka Mallik, John P. Leonard Source Type: journals

Estimating platelet production in patients with HIV-related thrombocytopenia using the immature platelet fractionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - November 4, 2009 Category: Hematology Authors: Brian Garibaldi, Rupal Malani, Hsin-Chieh Yeh, Evan Lipson, Deborah Michell, Mosi Bennett, Alison Moliterno, Michael A. McDevitt, Thomas S. Kickler Source Type: journals

Patients have a "CAM" knowledge gap - But who will fill it?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - October 29, 2009 Category: Hematology Authors: Kimball C. Atwood IV Source Type: journals

When yellow jackets attack: Recurrent and severe anaphylactic reactions to insect bites and stingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - October 28, 2009 Category: Hematology Authors: Daniel A. Pollyea, Tracy I. George, Christopher Corless, Jason Gotlib Source Type: journals

Identification of molecular targets associated with transformed diffuse large B cell lymphoma using highly purified tumor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Follicular lymphoma (FL) frequently transforms into the more aggressive diffuse large B cell lymphoma (DLBCL-tr), but no protein biomarkers have been identified for predictive or early diagnosis. Gene expression analyses have identified genes changing on transformation but have failed to be reproducible in different studies, reflecting the heterogeneity within the tumor tissue and between tumor samples. Gene expression analyses on Affymetrix Human Genome U133 Plus 2.0 arrays were performed, using flow cytometry sorted tumor cells derived from FL and transformed DLBCL. To identify molecular targets associated with the trans...
Source: American Journal of Hematology - October 20, 2009 Category: Hematology Authors: Ulrika Andréasson, Michael Dictor, Mats Jerkeman, Mattias Berglund, Christer Sundström, Johan Linderoth, Richard Rosenquist, Carl A. K. Borrebaeck, Sara Ek Source Type: journals

Idiotype-pulsed antigen presenting cells following autologous transplantation for multiple myeloma may be associated with prolonged survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the results of a phase II trial of the immunotherapeutic, APC8020 (MylovengeTM), given after ASCT for MM. We compared the results with that of other patients with MM who underwent ASCT at Mayo Clinic during the same time period. Twenty-seven patients were enrolled on the trial between July, 1998 and June, 2001, and the outcomes were compared to that of 124 consecutive patients transplanted during the same period, but not enrolled on the trial. The median (range) follow-up for patients still alive from the vaccine trial is 6.5 (2.9-8 years), and 7.1 (6-8 years) in the control group. The median age was 57.4 range (...
Source: American Journal of Hematology - October 9, 2009 Category: Hematology Authors: Martha Q. Lacy, Sumithra Mandrekar, Angela Dispenzieri, Suzanne Hayman, Shaji Kumar, Francis Buadi, David Dingli, Mark Litzow, Peter Wettstein, Douglas Padley, Brian Kabat, Dennis Gastineau, S. Vincent Rajkumar, Morie A. Gertz Source Type: journals

Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytoreductive therapy in systemic mastocytosis (SM) includes several drugs whose individual merit has not been well characterized. We retrospectively studied 108 Mayo Clinic patients who met the 2008 WHO diagnostic criteria for SM and received at least one cytoreductive drug. The numbers of patients who were evaluable for response to treatment with interferon-alpha with or without prednisone (IFN-[alpha]), hydroxyurea (HU), imatinib mesylate (IM) or 2-chlorodeoxyadenosine (2-CdA) were 40, 26, 22, and 22, respectively. The corresponding overall (major) response rates, according to recently published consensus criteria, were...
Source: American Journal of Hematology - October 9, 2009 Category: Hematology Authors: Ken H. Lim, Animesh Pardanani, Joseph H. Butterfield, Chin-Yang Li, Ayalew Tefferi Source Type: journals

Outcome of 93 patients with relapse or progression following allogeneic hematopoietic cell transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the subsequent clinical outcome was overviewed in 292 patients with leukemia/myelodysplastic syndrome who received allo-HCT. Among them, 93 (32%) showed relapse/progression. Cohort 1 was chosen to receive no interventions with curative intent (n = 25). Cohort 2 received reinduction chemotherapy and/or donor lymphocyte infusion (n = 48), and Cohort 3 underwent a second allo-HCT (n = 20). Sixty-three patients received reinduction chemotherapy, and 27 (43%) achieved subsequent complete remission (CR). The incidence of nonrelapse mortality (NRM) was similar among the three cohorts (4, 15, and 5%). The 1-year ove...
Source: American Journal of Hematology - October 8, 2009 Category: Hematology Authors: Saiko Kurosawa, Takahiro Fukuda, Kinuko Tajima, Bungo Saito, Shigeo Fuji, Hiroki Yokoyama, Sung-Won Kim, Shin-Ichiro Mori, Ryuji Tanosaki, Yuji Heike, Yoichi Takaue Source Type: journals

Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drug metabolizing genes are involved in the detoxification of chemical carcinogens. Polymorphisms in drug-metabolizing genes affect the risk of some forms of cancer. We analyzed six polymorphisms to evaluate their association with risk for non-Hodgkin lymphoma (NHL), and to examine whether smoking modifies these associations in population-based study in Korea (713 cases and 1,700 controls). The GSTP1 rs1695 AG and the combined AG/GG genotypes were associated with decreased risk of NHL (odds ratio (OR)AG = 0.67, 95% confidence interval (CI) = 0.55-0.82; ORAG/GG = 0.66, 95% CI = 0.54-0.80) and DLBCL (ORAG = 0.63, 95% CI = 0....
Source: American Journal of Hematology - October 8, 2009 Category: Hematology Authors: Hee Nam Kim, Nan Young Kim, Li Yu, Yeo-Kyeoung Kim, Il-Kwon Lee, Deok-Hwan Yang, Je-Jung Lee, Min-Ho Shin, Kyeong-Soo Park, Jin-Su Choi, Hyeoung-Joon Kim Source Type: journals

Complementary and alternative medicine use among long-term lymphoma survivors: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No published survey has specifically addressed the beliefs, knowledge, and usage of complementary and alternative medicine (CAM) in long-term (5-20 years) lymphoma survivors alone. In this pilot project, 95 subjects were randomly selected from a population of 2,475 long-term lymphoma survivors and mailed a questionnaire. The median time from lymphoma diagnosis to completion of the questionnaire was 11 years (range 6-20). Overall, 68% (95% CI: 54-80%) of the long-term lymphoma survivors reported that they have used CAM, a rate higher than the estimated usage rate reported for the general population The most commonly used mo...
Source: American Journal of Hematology - October 8, 2009 Category: Hematology Authors: Thomas M. Habermann, Carrie A. Thompson, Betsy R. LaPlant, Brent A. Bauer, Carol A. Janney, Matthew M. Clark, Teresa A. Rummans, Matthew J. Maurer, Jeff A. Sloan, Susan M. Geyer, James R. Cerhan Source Type: journals

Relapsed or refractory nongastric marginal zone B-cell lymphoma: Multicenter retrospective analysis of 92 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we conducted a retrospective analysis to identify the clinical features and outcomes of relapsed or refractory MZL. From 1995 to 2008, a total of 92 patients with relapsed MZL were retrospectively analyzed. The median age of our subjects was 53.5 years (range: 23-82 years). The most common primary sites of involvement were the orbit and ocular adnexa (28.3%) followed by the lymph node and lymphatic organs (23.9%), and multiple mucosa-associated lymphoid tissue (MALT) sites (13.0%). The median time to relapse from initial diagnosis was 25.5 months. Of the 53 patients with Stage I or II at diagnosis, 42 patien...
Source: American Journal of Hematology - October 8, 2009 Category: Hematology Authors: Sung Yong Oh, Won Seog Kim, Seok Jin Kim, Jin Seok Kim, Sung-Hyun Kim, Dae Ho Lee, Jong-Ho Won, In Gyu Hwang, Min Kyoung Kim, Soon Il Lee, Jong Gwang Kim, Deok-Hwan Yang, Hye Jin Kang, Chul Won Choi, Jinny Park, Young Jin Choi, Hyo Jung Kim, Jung Hye Kwon Source Type: journals

Severe iron overload in Blackfan-Diamond anemia: A case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a retrospective analysis of iron overload, and its related complications in 31 transfusion-dependent Italian DBA patients whose records included one or more evaluation of liver iron concentration (LIC) by means of noninvasive magnetic liver susceptometry with a superconductive quantum interference device (SQUID). This cohort is also matched with a group of transfusion-dependent [beta]-thalassemia major patients to look for differences. A severe iron overload was observed in 54% patients, especially among those inadequately chelated. The DBA patients displayed a significantly higher LIC than the regularly chelat...
Source: American Journal of Hematology - October 6, 2009 Category: Hematology Authors: Simona Roggero, Paola Quarello, Tiziana Vinciguerra, Filomena Longo, Antonio Piga, Ugo Ramenghi Source Type: journals

Salvage therapy for acute myeloid leukemia with fludarabine, cytarabine, and idarubicin with or without gemtuzumab ozogamicin and with concurrent or sequential G-CSFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The current salvage therapies for relapsed/refractory acute myeloid leukemia (AML) are unsatisfactory. Over the past 7 years, we have used two salvage regimens: fludarabine, cytarabine, and idarubicin with (FLAG-IM) or without gemtuzumab ozogamicin (GO) (9 mg/m2 on Day 8) (FLAG-I) in relapsed/refractory AML. Three-quarters of patients also received concurrent G-CSF. Seventy-one patients were treated, 23 with FLAG-I and 48 with FLAG-IM. The median duration of follow-up was 30.6 months. The treatment groups were well balanced with median ages of 48 years (range 18-70) and 47 years (range 20-68), unfavorable cytogenetics in 5...
Source: American Journal of Hematology - October 5, 2009 Category: Hematology Authors: Mike G. Martin, Kristan M. Augustin, Geoffrey L. Uy, John S. Welch, Lindsay Hladnik, Sagun Goyal, Divya Tiwari, Ryan S. Monahan, Richard M. Reichley, Amanda F. Cashen, Keith Stockerl-Goldstein, Peter Westervelt, Camille N. Abboud, John F. DiPersio, Ravi V Source Type: journals

Unexpected immune hemolytic anemia in an intensive care ward patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - October 2, 2009 Category: Hematology Authors: Barbara J. Bain, Andrew Innes Source Type: journals

C/[beta]0 thalassemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 29, 2009 Category: Hematology Authors: Barbara J. Bain Source Type: journals

Bisphosphonates associated osteonecrosis of the jaw: A long-term follow-up of a series of 35 cases observed by GISL and evaluation of its frequency over timeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 29, 2009 Category: Hematology Authors: Samantha Pozzi, Raffaella Marcheselli, Simona Falorio, Luciano Masini, Caterina Stelitano, Antonietta Falcone, Giovanni Quarta, Luisa Ponchio, Vincenzo Pitini, Stefano Luminari, Luca Baldini, on behalf of Gruppo Italiano Studio Linfomi (GISL) Source Type: journals

Hemoglobin H-constant spring in North America: An alpha thalassemia with frequent complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 28, 2009 Category: Hematology Authors: Sylvia Titi Singer, Hae-Young Kim, Nancy F. Olivieri, Janet L. Kwiatkowski, Thomas D. Coates, Susan Carson, Ellis Neufeld, Melody J. Cunningham, Patricia J. Giardina, Brigitta U. Mueller, Charles T. Quinn, Ellen Fung, Elliott Vichinsky, for the Thalassemi Source Type: journals

Retrospective comparison of mobilization methods for autologous stem cell transplantation in multiple myelomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The combination of cyclophosphamide and granulocyte-colony stimulating factor (G-CSF) has widely been used to mobilize hematopoietic stem cells (HSCs) for autologous stem cell transplantation (ASCT) for multiple myeloma (MM). Recently, however, alternative approaches such as G-CSF alone or etoposide followed by G-CSF have been investigated. We, therefore, retrospectively analyzed the effects of these mobilization methods on collection yield and disease outcome in ASCT for MM. We reviewed 146 MM patients from whom we intended to collect stem cells. For mobilization, 67, 58, and 21 patients received cyclophosphamide and G-CS...
Source: American Journal of Hematology - September 28, 2009 Category: Hematology Authors: Hideki Nakasone, Yoshinobu Kanda, Tomoki Ueda, Kenji Matsumoto, Naomi Shimizu, Jiro Minami, Rika Sakai, Maki Hagihara, Akira Yokota, Kumi Oshima, Yuiko Tsukada, Takayoshi Tachibana, Chiaki Nakaseko, Shin Fujisawa, Shingo Yano, Hiroyuki Fujita, Satoshi Tak Source Type: journals

Erythrocytapheresis in the prevention of recurrent myocardial infarction in sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 15, 2009 Category: Hematology Authors: Zohya Khalique, Jiri Pavlu, David Lefroy, Mark Layton Source Type: journals

Successful combination treatment of clofarabine, cytarabine, and gemtuzumab-ozogamicin in adult refractory B-acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 15, 2009 Category: Hematology Authors: Cristina Papayannidis, Enrico Derenzini, Ilaria Iacobucci, Antonio Curti, Stefania Paolini, Daniela Cilloni, Michele Baccarani, Giovanni Martinelli Source Type: journals

Management of hematological malignancies during pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The management of hematological malignancies during pregnancy is a challenging endeavor, which not only requires technical skills and knowledge by the clinicians but also requires sound clinical judgment and compassion, keeping in mind the patient and family preferences and, ultimately, the wellbeing of the neonate. The incidence of hematological malignancies during pregnancy is rare, ranging from 1 in 1,000 to 1 in 10,000 deliveries, impeding the design and execution of large prospective studies. The purpose of this review is to evaluate the limited existing data and make useful suggestions in the management of acute and ...
Source: American Journal of Hematology - September 15, 2009 Category: Hematology Authors: Tina Rizack, Anthony Mega, Robert Legare, Jorge Castillo Source Type: journals

The course and correlates of high hospital utilization in sickle cell disease: Evidence from a large, urban Medicaid managed care organizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although most patients with sickle cell disease (SCD) are hospitalized infrequently and manage painful crises at home, a small subpopulation is frequently admitted to emergency departments and inpatient units. This small group accounts for the majority of health care expenses for patients with SCD. Using inpatient claims data from a large, urban Medicaid MCO for 5 consecutive years, this study sought to describe the course of high inpatient utilization (averaging four or more admissions enrolled per year for at least 1 year) in members with a diagnosis of SCD and a history of hospitalizations for vaso-occlusive crisis. Hig...
Source: American Journal of Hematology - September 9, 2009 Category: Hematology Authors: C. Patrick Carroll, Carlton Haywood Jr., Peter Fagan, Sophie Lanzkron Source Type: journals

A pediatric case series of acute hemolysis after administration of intravenous immunoglobulinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 8, 2009 Category: Hematology Authors: David J. Gordon, Steven R. Sloan, Jill L.O. de Jong Source Type: journals

Retreatment with bortezomib alone or in combination for patients with multiple myeloma following an initial response to bortezomibEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This clinical trial was conducted to determine the safety and efficacy of bortezomib retreatment in patients with multiple myeloma (MM) who had previously responded to bortezomib. Patients with progressive MM who had previously tolerated bortezomib as a single agent or in combination with other drugs, with a minimum of partial response (PR; [ge]50% M-protein reduction) for [ge]4 months, who had not received intervening MM therapy, were retreated with bortezomib (days 1, 4, 8, and 11 of a 21-day cycle) with a starting dose being the dose at which the patient ended the initial treatment. Patients were allowed to receive bort...
Source: American Journal of Hematology - September 3, 2009 Category: Hematology Authors: Raman Sood, Harry Carloss, Robert Kerr, Jose Lopez, Martin Lee, Mark Druck, Ian B. Walters, Stephen J. Noga Source Type: journals

Prodromal myeloproliferative neoplasms: The 2008 WHO classificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The concept of prodromal chronic myeloproliferative neoplasms has been endorsed by the WHO classification implicating a stepwise evolution of disease. Histology of the bone marrow (BM) and borderline to mildly expressed clinical features play a pivotal role for diagnosing prefibrotic-early primary myelofibrosis. By lowering the platelet count for essential thrombocythemia and regarding BM morphology, early manifestations are tackled. Pre-polycythemic stages of polycythemia vera with a low hemoglobin level at onset are diagnosed by positive JAK2V617F mutation status, a low erythropoietin value, and characteristic BM feature...
Source: American Journal of Hematology - September 2, 2009 Category: Hematology Authors: Hans Michael Kvasnicka, Juergen Thiele Source Type: journals

Acute monoblastic leukemia with abnormal granules and disseminated intravascular coagulation: Diagnostic pitfallsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 2, 2009 Category: Hematology Authors: Rebecca Pohlmann, Parul Bhargava Source Type: journals

Venous thrombosis associated with gene deletion of tissue factor pathway inhibitorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - September 2, 2009 Category: Hematology Authors: Alex Kentsis, Gary Bradwin, David T. Miller, Cameron C. Trenor III Source Type: journals

Atypical presentations of Sweet's syndrome in patients with MDS/AML receiving combinations of hypomethylating agents with histone deacetylase inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 31, 2009 Category: Hematology Authors: Cristina Alencar, Matthew Abramowtiz, Samir Parekh, Ira Braunshweig, Mark Jacobson, Lewis Silverman, Amit Verma Source Type: journals

Need for comparative effectiveness research to address clinical questions in hematologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 27, 2009 Category: Hematology Authors: Jodi B. Segal Source Type: journals

Expression of CD117 by proerythroblastsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 24, 2009 Category: Hematology Authors: Barbara J. Bain, E. Mary Thompson Source Type: journals

Production of [beta]-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous [beta]039 thalassemia patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study strongly suggests that ribosomal readthrough should be considered a strategy for developing experimental strategies for the treatment of [beta]0-thalassemia caused by stop codon mutations. Am. J. Hematol., 2009. © 2009 Wiley-Liss, Inc. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 24, 2009 Category: Hematology Authors: Francesca Salvatori, Giulia Breveglieri, Cristina Zuccato, Alessia Finotti, Nicoletta Bianchi, Monica Borgatti, Giordana Feriotto, Federica Destro, Alessandro Canella, Eleonora Brognara, Ilaria Lampronti, Laura Breda, Stefano Rivella, Roberto Ga Source Type: journals

Recurrent acute thrombocytopenia in the hospitalized patient: Sepsis, DIC, HIT, or antibiotic-induced thrombocytopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 24, 2009 Category: Hematology Authors: Talla A. Rousan, Ibrahim T. Aldoss, Benjamin D. Cowley Jr., Brian R. Curtis, Daniel W. Bougie, Richard H. Aster, James N. George Source Type: journals

Functional capacity in children and young adults with sickle cell disease undergoing evaluation for cardiopulmonary diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although cardiopulmonary disease is associated with decreased functional capacity among adults with sickle cell disease (SCD), its impact on functional capacity in children with SCD is unknown. We evaluated 6-min walk (6MW) distance in 77 children and young adults with SCD undergoing screening for cardiopulmonary disease. Of 30 subjects who also underwent cardiopulmonary exercise testing, we found evidence for decreased exercise capacity in a significant proportion. Exercise capacity was related to baseline degree of anemia and was significantly lower in subjects with a history of recurrent acute chest syndrome. We found t...
Source: American Journal of Hematology - August 24, 2009 Category: Hematology Authors: Robert I. Liem, Mary A. Nevin, Adrienne Prestridge, Luciana T. Young, Alexis A. Thompson Source Type: journals

Blast phase of essential thrombocythemia: A single center studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study includes 19patients with post-ET BP diagnosed and followed in a single institution. At BP, 63% of patients had leukocytosis (white blood cell count >10 × 109/L), 74% had anemia (hemoglobin value (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 18, 2009 Category: Hematology Authors: Francesco Passamonti, Elisa Rumi, Luca Arcaini, Chiara Elena, Carlo Castagnola, Patrizia Zappasodi, Paolo Bernasconi, Daniela Pietra, Cristiana Pascutto, Mario Cazzola, Mario Lazzarino Source Type: journals

Crystal-storing histiocytosis in plasma cell myelomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2009 Category: Hematology Authors: Yusong Yang, Leonas G. Bekeris, Dan T. Vogl, Adam Bagg Source Type: journals

A novel missense mutation causing abnormal LMAN1 in a Japanese patient with combined deficiency of factor V and factor VIIIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Combined deficiency of coagulation factor V (FV) and factor VIII (FVIII) (F5F8D) is an inherited bleeding disorder characterized by a reduction in plasma concentrations of FV and FVIII. F5F8D is genetically linked to mutations in either LMAN1 or MCFD2. Here, we investigated the molecular basis of F5F8D in a Japanese patient, and identified a novel missense mutation (p.Trp67Ser, c.200G>C) in the LMAN1, but no mutation in the MCFD2. The amount of LMAN1 in Epstein-Barr virus-immortalized lymphoblasts from the patient was found to be almost the same as that in cells from a normal individual. Interestingly, an anti-MCFD2 antibo...
Source: American Journal of Hematology - August 17, 2009 Category: Hematology Authors: Takayuki Yamada, Yuta Fujimori, Atsuo Suzuki, Yuhri Miyawaki, Akira Takagi, Takashi Murate, Masayuki Sano, Tadashi Matsushita, Hidehiko Saito, Tetsuhito Kojima Source Type: journals

Help with HELLPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2009 Category: Hematology Authors: Barbara J. Bain, John Riches Source Type: journals

Cytology of systemic mastocytosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 17, 2009 Category: Hematology Authors: Barbara J. Bain, A. J. Marks Source Type: journals

The revival of clinical wisdom: The case of oral anticoagulation managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 12, 2009 Category: Hematology Authors: Francesco Rodeghiero Source Type: journals

Secondary clonal cytogenetic abnormalities following successful treatment of acute promyelocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify patients who developed secondary clonal cytogenetic aberrations (CCA) following therapy for acute promyelocytic leukemia (APL), we retrospectively analyzed cytogenetic results from 123 patients diagnosed with APL between 1995 and 2007, who had ongoing cytogenetic analysis undertaken in our laboratory. During follow-up for APL we identified 12 patients (9.8%) who developed CCA, not detected at diagnosis of APL and unrelated to their original APL karyotype. All patients had received all-trans retinoic acid (ATRA) and chemotherapy and were in complete remission for APL when secondary CCA were identified. The media...
Source: American Journal of Hematology - August 10, 2009 Category: Hematology Authors: Crisoula Batzios, Lachlan A. Hayes, Simon Z. He, Hang Quach, Zoe K. McQuilten, Meaghan Wall, Lynda J. Campbell Source Type: journals

Modification of gene expression: Help to detect doping with erythropoiesis-stimulating agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 10, 2009 Category: Hematology Authors: Emmanuelle Varlet-Marie, Michel Audran, Michael Ashenden, Marie-Thérèse Sicart, David Piquemal Source Type: journals

Monocytes from patients with myelodysplastic syndromes are more resistant to inhibition by thalidomideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 10, 2009 Category: Hematology Authors: Stef Meers, Louis Boon, Gregor Verhoef, Michel Delforge Source Type: journals

Treatment with hydroxyurea in a patient compound heterozygote for a high oxygen affinity hemoglobin and [beta]-thalassemia minorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 10, 2009 Category: Hematology Authors: Pierre-Olivier Gaudreau, Xiaoduan Weng, Ghislain Cournoyer, Louise Robin, Carmen Gagnon, Denis Soulières Source Type: journals

KIR and HLA-Cw genotypes of donor-recipient pairs influence the rate of CMV reactivation following non-T-cell deleted unrelated donor hematopoietic cell transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 10, 2009 Category: Hematology Authors: Xiaojin Wu, Jun He, Depei Wu, Xiaojing Bao, Qiaocheng Qiu, Xiaoni Yuan, Yue Han, Ainig Sun, Guanghua Chen, Yang Xu Source Type: journals

HFE, SLC40A1, HAMP, HJV, TFR2, and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We sought to identify mutations that could explain iron phenotype heterogeneity in adults with previous HFE genotyping to detect C282Y and H63D. HEIRS Study participants genotyped for C282Y and H63D were designated as high transferrin saturation (TS) and/or serum ferritin (SF) (high TS/SF), low TS/SF, or controls. We grouped 191 C282Y homozygotes as high TS/SF, low TS/SF, or controls, and 594 other participants by race/ethnicity as high TS/SF or controls. Using denaturing high-performance liquid chromatography (DHPLC), we screened 20 regions of HFE, SLC40A1, HAMP, HJV, TFR2, and FTL in each participant. DHPLC analyses were...
Source: American Journal of Hematology - August 10, 2009 Category: Hematology Authors: James C. Barton, Susie A. LaFreniere, Catherine Leiendecker-Foster, Honggui Li, Ronald T. Acton, Richard D. Press, John H. Eckfeldt Source Type: journals

Outcomes of inpatients with and without sickle cell disease after high-volume surgical proceduresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined differences in inpatient costs, length of stay, and in-hospital mortality between hospitalizations for patients with and without sickle cell disease (SCD) undergoing high-volume surgical procedures. We used Clinical Classification Software (CCS) codes to identify discharges in the 2002-2005 Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project for patients who had undergone either cholecystectomy or hip replacement. We limited the non-SCD cohort to hospitals where patients with SCD had undergone the same procedure. We compared inpatient outcomes using summary statistics and g...
Source: American Journal of Hematology - August 9, 2009 Category: Hematology Authors: Michaela A. Dinan, Chia-Hung Chou, Bradley G. Hammill, Felicia L. Graham, Kevin A. Schulman, Marilyn J. Telen, Shelby D. Reed Source Type: journals

Possible graft-versus-host disease involving the central nervous system soon after cord blood transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 9, 2009 Category: Hematology Authors: Hisashi Yamamoto, Naoyuki Uchida, Kazuya Ishiwata, Hideki Araoka, Shinsuke Takagi, Masanori Tsuji, Daisuke Kato, Yoshiko Matsuhashi, Sachiko Seo, Naofumi Matsuno, Kazuhiro Masuoka, Atsushi Wake, Akiko Yoneyama, Shigeyoshi Makino, Shuichi Taniguchi Source Type: journals

Profound neutropenia resulting from metyrapone-induced adrenal crisisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 9, 2009 Category: Hematology Authors: James K. Mangan, J. Eric Russell Source Type: journals