American Journal of Medical Genetics Part B: Neuropsychiatric GeneticsThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Psychiatric syndromes in individuals with chromosome 18 abnormalitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study focuses on the presentations of psychiatric syndromes as they relate to specific chromosomal abnormalities of chromosome 18. Twenty-five subjects (13 with an 18q deletion, 9 with 18p tetrasomy, and 3 with an 18p deletion), were interviewed by psychiatrists (blind to specific chromosomal abnormality) using the DIGS (subjects 18 and older) or KSADS-PL (subjects under 18). A consensus best estimation diagnostic process was employed to determine psychiatric syndromes. Oligonucleotide Array Comparative Genomic Hybridization (Agilent Technologies) was utilized to define specific regions of chromosome 18 that were dele...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 19, 2009 Category: Genetics & Stem Cells Authors: Juan Zavala, Mercedes Ramirez, Rolando Medina, Patricia Heard, Erika Carter, AnaLisa Crandall, Daniel Hale, Jannine Cody, Michael Escamilla Source Type: journals

A systematic association mapping on chromosome 6q in bipolar affective disorder - evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Strong evidence of linkage between chromosomal region 6q16-q22 and bipolar affective disorder (BPAD) has previously been reported. We conducted a systematic association mapping of the 6q-linkage interval using 617 SNP markers in a BPAD case-control sample of German descent (cases = 330, controls = 325). In this screening step, 46 SNPs showed nominally significant BPAD-association (P-values between 0.0007 and 0.0484). Although none of the 46 SNPs survived correction for multiple testing, they were genotyped in a second and ethnically matched BPAD sample (cases = 328, controls = 397). At the melanin-concentrating-hormone-rec...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 19, 2009 Category: Genetics & Stem Cells Authors: Rami Abou Jamra, Thomas G. Schulze, Tim Becker, Felix F. Brockschmidt, Elaine Green, Margrieta A. Alblas, Jens R. Wendland, Mazda Adli, Detelina Grozeva, Jana Strohmeier, Alexander Georgi, Nick Craddock, Peter Propping, Marcella Rietschel, Markus M. Nöth Source Type: journals

Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The reported interaction between the length polymorphism (5HTTLPR) in the serotonin transporter gene (SLC6A4) and stressful life events on depression has led to many attempts to replicate but with inconsistent results. This inconsistency may reflect, in part, small sample size and the unknown contribution of the long allele SNP, rs25531. Using a large twin sample of 3,243 individuals from 2,230 families aged 18-95 years (mean = 32.3, SD = 13.6) we investigate the interaction between 5HTTLPR (subtyped with SNP rs25531) and stressful events on risk of depression and suicidality using both ordinal regressions and item respons...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 12, 2009 Category: Genetics & Stem Cells Authors: William L. Coventry, Michael R. James, Lindon J. Eaves, Scott D. Gordon, Nathan A. Gillespie, Leanne Ryan, Andrew C. Heath, Grant W. Montgomery, Nicholas G. Martin, Naomi R. Wray Source Type: journals

Association study of bromodomain-containing 1 gene with schizophrenia in Japanese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chromosome 22q13 region has been implicated in schizophrenia in several linkage studies. Genes within this locus are therefore promising genetic and biologic candidate genes for schizophrenia if they are expressed in the brain or predicted to have some role in brain development. A recent study reported that bromodomain-containing 1 gene (BRD1), located in 22q13, showed an association with schizophrenia in a Scottish population. Except for being a putative regulator of transcription, the precise function of BRD1 is not clear; however, expression analysis of BRD1 mRNA revealed widespread expression in mammalian brains. In ou...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 11, 2009 Category: Genetics & Stem Cells Authors: Itaru Kushima, Branko Aleksic, Masashi Ikeda, Yoshio Yamanouchi, Yoko Kinoshita, Yoshihito Ito, Yukako Nakamura, Toshiya Inada, Nakao Iwata, Norio Ozaki Source Type: journals

Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study assessed the relationship between hippocampal volume and psychological symptoms in carriers, both with and without FXTAS, and controls. Volumetric MRI measures, clinical staging, cognitive testing, molecular analysis, and measures of psychological symptoms were performed for female premutation carriers both with FXTAS (n = 16, age: 57.50 ± 12.46) and without FXTAS (n = 17, age: 44.94 ± 11.23), in genetically normal female controls (n = 8, age: 50.63 ± 11.43), male carriers with FXTAS (n = 34, age: 66.44 ± 6.77) and without FXTAS (n = 21, age: 52.38 ± 12.11), and genetically normal male controls (n = 30, age...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 11, 2009 Category: Genetics & Stem Cells Authors: P.E. Adams, J.S. Adams, D.V. Nguyen, D. Hessl, J.A. Brunberg, F. Tassone, W. Zhang, K. Koldewyn, S.M. Rivera, J. Grigsby, L. Zhang, C. DeCarli, P.J. Hagerman, R.J. Hagerman Source Type: journals

Mutation screening of the DTNBP1 exonic sequence in 669 schizophrenics and 710 controls using high-resolution melting analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we set out to perform a comprehensive assessment of DNA variation within the exonic sequence of DTNBP1. To achieve this we optimized a high-resolution melting analysis (HRMA) protocol and applied it to screen all 11 DTNBP1 exons for DNA variants in a sample of 669 cases and 710 controls from the UK. Despite identifying seven exonic variants with a minor allele frequency (MAF) >0.01, none was significantly associated with schizophrenia (minimum P = 0.054), showing that the strong association we previously reported in this sample is not the result of association to a common functional variant located within the...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 26, 2009 Category: Genetics & Stem Cells Authors: S. Dwyer, L. Carroll, K.K. Mantripragada, M.J. Owen, M.C. O'Donovan, N.M. Williams Source Type: journals

Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European AmericansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several previous genome-wide and targeted association studies revealed that variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 that encode the [alpha]5, [alpha]3, and [beta]4 subunits of the nicotinic acetylcholine receptors (nAChRs) are associated with nicotine dependence (ND) in European Americans (EAs) or others of European origin. Considering the distinct linkage disequilibrium patterns in European and other ethnic populations such as African Americans (AAs), it would be interesting to determine whether such associations exist in other ethnic populations. We performed a comprehensive asso...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 26, 2009 Category: Genetics & Stem Cells Authors: Ming D. Li, Qing Xu, Xiang-Yang Lou, Thomas J. Payne, Tianhua Niu, Jennie Z. Ma Source Type: journals

Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we hypothesized that genetic variation in the MPPE1 gene contributes to BPD. We tested this hypothesis by genotyping four SNPs (rs871044; rs3974590; rs593713; rs602201) in BPD patients (n = 570) and healthy controls (n = 725). Genotypes and allele frequencies were compared between groups using Chi square contingency analysis. Linkage disequilibrium (LD) between markers was calculated and estimated haplotype frequencies were compared between groups. Single marker analysis revealed an association of rs3974590 with BPD (P = 0.009; permutation corrected P = 0.046). Haplotype analysis did not show any significant...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 26, 2009 Category: Genetics & Stem Cells Authors: Falk W. Lohoff, Thomas N. Ferraro, Edward S. Brodkin, Andrew E. Weller, Paul J. Bloch Source Type: journals

Quantitative analysis of alternative transcripts of human PCDH11X/Y genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Protocadherin 11X/Y (PCDH11X/Y) gene pair has been proposed as a carrier of the variation relating to cerebral asymmetry and psychosis on the ground that the Y gene was generated by duplication at 6 million years (close to the chimpanzee-human separation) and there is a case for an X/Y determinant of cerebral asymmetry. The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes. Twelve alternative transcripts of PCDH11X/Y genes were presently identified by in silico analysis. To investigate the biological roles of alternative transcripts of PCDH11X/Y genes, the transcrip...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 26, 2009 Category: Genetics & Stem Cells Authors: Kung Ahn, Jae-Won Huh, Dae-Soo Kim, Hong-Seok Ha, Yun-Ji Kim, Ja-Rang Lee, Heui-Soo Kim Source Type: journals

Association of the SAT1 in/del polymorphism with suicide completionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several studies have observed decreased expression of spermidine/spermine N1-acetyltransferase (SAT1) in the brains of suicide completers, and we previously identified a single-nucleotide polymorphism in the promoter region of SAT1 which was associated with suicide completion and SAT1 expression in the brain. We recently characterized the haplotype structure of the SAT1 promoter region and identified an insertion/deletion (in/del) of 15 adenine residues. This variant appears to be a predictor of SAT1 expression, and we were thus interested in determining if the lower expressing deletion allele was found more frequently amo...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 21, 2009 Category: Genetics & Stem Cells Authors: Laura M. Fiori, Gustavo Turecki Source Type: journals

Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We performed a linkage analysis on 23 Finnish families with bipolar disorder and originating from the North-Eastern region of Finland, using the Illumina Linkage Panel IV (6K) Array with an average intermarker spacing of 0.65 cM across the genome. We detected genome-wide significant evidence for linkage of mood disorder (bipolar disorder type I, II, or not otherwise specified, manic type of schizoaffective psychosis, cyclothymia, or recurrent depression) to chromosomes 7q31 (LOD = 3.20) and 9p13.1 (LOD = 4.02). Analyzing the best markers on the complete set of 179 Finnish bipolar families supported the findings on chromoso...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 21, 2009 Category: Genetics & Stem Cells Authors: Outi M. Palo, Pia Soronen, Kaisa Silander, Teppo Varilo, Katja Tuononen, Tuula Kieseppä, Timo Partonen, Jouko Lönnqvist, Tiina Paunio, Leena Peltonen Source Type: journals

Relevance of perceived childhood neglect, 5-HTT gene variants and hypothalamus-pituitary-adrenal axis dysregulation to substance abuse susceptibilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hypotheses of (1) gene × environment interaction in the susceptibility to experiment with drugs and (2) hypothalamus-pituitary-adrenal (HPA) axis involvement in mediating the effects of early adverse experiences and gene variants affecting serotonin function on substance abuse vulnerability were tested by investigating in 187 healthy adolescents the possible relevance of 5-HTT "S" polymorphism, childhood parental neglect reported retrospectively and HPA axis function to the susceptibility to experiment with illicit drugs. Higher frequency of the 5-HTT SS genotype seems to be associated with an increased susceptibility...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 11, 2009 Category: Genetics & Stem Cells Authors: G. Gerra, A. Zaimovic, L. Castaldini, L. Garofano, M. Manfredini, L. Somaini, C. Leonardi, M.L. Gerra, C. Donnini Source Type: journals

Association study of SNAP25 and schizophrenia in Irish family and case-control samplesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SNAP25 occurs on chromosome 20p12.2, which has been linked to schizophrenia in some samples, and recently linked to latent classes of psychotic illness in our sample. SNAP25 is crucial to synaptic functioning, may be involved in axonal growth and dendritic sprouting, and its expression may be decreased in schizophrenia. We genotyped 18 haplotype-tagging SNPs in SNAP25 in a sample of 270 Irish high-density families. Single marker and haplotype analyses were performed in FBAT and PDT. We adjusted for multiple testing by computing q values. Association was followed up in an independent sample of 657 cases and 411 controls. We...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 4, 2009 Category: Genetics & Stem Cells Authors: A.H. Fanous, Z. Zhao, E.J.C.G. van den Oord, B.S. Maher, D.L. Thiselton, S.E. Bergen, B. Wormley, T. Bigdeli, R.L. Amdur, F.A. O'Neill, D. Walsh, K.S. Kendler, B.P. Riley Source Type: journals

Linkage analysis of Tourette syndrome in a large utah pedigreeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined a qualitative trait (TS1) where cases had a definitive diagnosis of TS as observed by a clinical interviewer (n = 66) and a quantitative phenotype based on the total Yale global motor and phonic tic severity scores (n = 102). Both parametric and non-parametric multipoint linkage analyses based on MCMC methods were performed using a 10 cM spaced micro-satellite autosomal marker set. Two regions of interest were identified under affecteds-only recessive models; a LOD score of 3.3 on chromosome 1p for Yale tic severity and a LOD score of 3.1 on chromosome 3p for the TS1 phenotype. Twenty-seven individuals shared l...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 22, 2009 Category: Genetics & Stem Cells Authors: Stacey Knight, Hilary Coon, Michael Johnson, Mark F. Leppert, Nicola J. Camp, William M. McMahon, Tourette Syndrome Association International Consortium for Genetics Source Type: journals

Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning levelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results implicate that genetic variation in the OXTR gene might be relevant in the etiology of autism on high-functioning level. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 22, 2009 Category: Genetics & Stem Cells Authors: Anne-Kathrin Wermter, Inge Kamp-Becker, Philipp Hesse, Gerd Schulte-Körne, Konstantin Strauch, Helmut Remschmidt Source Type: journals

The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole bloodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prior work using lymphoblast DNA prepared from 192 subjects from the Iowa Adoption Studies (IAS) demonstrated that decreased MAOA promoter methylation was associated with lifetime symptom count for nicotine dependence (ND) and provided suggestive evidence that the amount of methylation is genotype dependent. In the current investigation, we replicate and extend these prior findings in three ways using another 289 IAS subjects and the same methodologies. First, we show that methylation is dependent on current smoking status. Second, we introduce a factor analytic approach to DNA methylation, highlighting three distinct regi...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 22, 2009 Category: Genetics & Stem Cells Authors: Robert A. Philibert, Steven R.H. Beach, Tracy D. Gunter, Gene H. Brody, Anup Madan, Meg Gerrard Source Type: journals

Novel mutations in the calreticulin gene core promoter and coding sequence in schizoaffective disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have recently reported the first case of mutation in the core promoter sequence of the human calreticulin gene in a family case of schizoaffective disorder. Remarkably, this gene coincides with a region of suggested linkage at 19p13.2, identified in a whole genome scan [Hamshere et al. (2005); Arch Gen Psychiatry 62;1081-1088]. The identified mutation was located at the conserved position -48 from the transcription start site, and was shown to be of functional effect, resulting in the aberrant expression of the gene. Following screening of the gene in 60 independent cases of schizoaffective disorder, we report novel ger...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 15, 2009 Category: Genetics & Stem Cells Authors: M. Olad Nabi, A. Mirabzadeh, G. Feizzadeh, H.R. Khorram Khorshid, M. Karimlou, M. Zarif Yeganeh, A.M. Asgharian, H. Najmabadi, M. Ohadi Source Type: journals

G72 influences longitudinal change in frontal lobe volume in schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Schizophrenia is a neurodevelopmental psychiatric disorder characterized by a variety of structural brain abnormalities that appear to progress across the course of illness. Schizophrenia also is highly heritable, and one gene that has emerged as a possible susceptibility factor is G72. G72 influences brain development and activity by an as-yet unclear mechanism, and multiple studies have reported associations between G72 and schizophrenia. We were interested in linking these domains of investigation by determining whether G72 also influences the rate of longitudinal structural brain changes in individuals with schizophren...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 15, 2009 Category: Genetics & Stem Cells Authors: Sarah M. Hartz, Beng-Choon Ho, Nancy C. Andreasen, Amy Librant, Danielle Rudd, Eric A. Epping, Thomas H. Wassink Source Type: journals

No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Robust associations between the dysbindin gene (DTNBP1) and schizophrenia have been demonstrated in many but not all samples, and evidence that this gene particularly predisposes to negative symptoms in this illness has been presented. The current study sought to replicate the previously reported negative symptom associations in an Irish case-control sample. Association between dysbindin and schizophrenia has been established in this cohort, and a factor analysis of the assessed symptoms yielded three factors, Positive, Negative, and Schneiderian. The sequential addition method was applied using UNPHASED to assess the rela...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 15, 2009 Category: Genetics & Stem Cells Authors: Sarah E. Bergen, Ayman H. Fanous, Po-Hsiu Kuo, Brandon K. Wormley, F. Anthony O'Neill, Dermot Walsh, Brien P. Riley, Kenneth S. Kendler Source Type: journals

Association of CHRN genes with "dizziness" to tobaccoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The neuronal nicotinic receptor genes (CHRN) have been implicated in a variety of smoking-related behaviors. Here we tested for association between an early subjective response phenotype, "dizziness," and 226 single nucleotide polymorphisms (SNPs) in CHRN genes. The sample included 789 nicotine-dependent cases and 811 controls, where early "dizziness" reports were significantly associated with case/control status (P < 0.0001). Multiple SNPs in the putative promoter region of the CHRNB3 gene were nominally associated with "dizziness" experience from the first few cigarettes (P < 0.01). Cell culture studies were conducted to...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 15, 2009 Category: Genetics & Stem Cells Authors: Marissa A. Ehringer, Matthew B. McQueen, Nicole R. Hoft, Nancy L. Saccone, Jerry A. Stitzel, Jen C. Wang, Laura J. Bierut Source Type: journals

Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Different lines of evidence indicate that methylenetetrahydrofolate reductase (MTHFR) functional gene polymorphisms, causative in aberrant folate-homocysteine metabolism, are associated with increased vulnerability to several heritable developmental disorders. Opposing views are expressed considering the possible association between MTHFR and susceptibility for schizophrenia. In order to evaluate if age of onset could explain some of this discrepancy we investigated the relationship between two functional MTHFR gene polymorphisms and age at onset in this disorder. Scandinavian patients (n = 820) diagnosed with schizophreni...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 9, 2009 Category: Genetics & Stem Cells Authors: Maria Vares, Peter Saetre, Hong Deng, Guiqing Cai, Xiehe Liu, Thomas Hansen, Henrik B. Rasmussen, Thomas Werge, Ingrid Melle, Srdjan Djurovic, Ole A. Andreassen, Ingrid Agartz, Håkan Hall, Lars Terenius, Erik G. Jönsson Source Type: journals

Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 9, 2009 Category: Genetics & Stem Cells Authors: Marek K. Brandys, Annemarie A. van Elburg, Ruth J.F. Loos, Florianne Bauer, Judith Hendriks, Yvonne T. van der Schouw, Roger A.H. Adan Source Type: journals

The association of the dopamine transporter gene and the dopamine receptor 2 gene with delirium, a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Delirium is the most common neuropsychiatric syndrome in elderly ill patients. Previously, associations between delirium and the dopamine transporter gene (solute carrier family 6, member 3 (SLC6A3)) and dopamine receptor 2 gene (DRD2) were found. The aim of this study was to validate whether markers of the SLC6A3 and DRD2 genes are were associated with delirium in independent populations. Six European populations collected DNA of older delirious patients. Associations were determined per population and results were combined in a meta-analysis. In total 820 medical inpatients, 185 cardiac surgery patients, 134 non-cardiac ...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 7, 2009 Category: Genetics & Stem Cells Authors: Barbara C. van Munster, Sophia E.J.A. de Rooij, Mojgan Yazdanpanah, Pentti J. Tienari, Kaisu H. Pitkälä, Robert J. Osse, Dimitrios Adamis, Orla Smit, Marijke S. van der Steen, Miriam van Houten, Terhi Rahkonen, Raimo Sulkava, Jouko V. Laurila, Timo E. S Source Type: journals

Methylation at SLC6A4 is linked to family history of child abuse: An examination of the Iowa Adoptee sampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 7, 2009 Category: Genetics & Stem Cells Authors: Steven R.H. Beach, Gene H. Brody, Alexandre A. Todorov, Tracy D. Gunter, Robert A. Philibert Source Type: journals

Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serotonin-1A (5-HT1A) receptors are known to play a role in impulsivity-related behavior. The C(-1019)G functional polymorphism (rs6295) has been suggested to regulate the 5-HT1A receptor gene (HTR1A) expression in presynaptic raphe neurons, namely, increased receptor concentration and reduced neuronal firing could be associated with the G allele. Previous studies indicate that this polymorphism is associated with aggression, suicide, and several psychiatric disorders, yet its association with impulsivity has rarely been investigated. We studied the relationship between impulsivity and the C(-1019)G polymorphism of the HTR...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 31, 2009 Category: Genetics & Stem Cells Authors: Anita Benko, Judit Lazary, Eszter Molnar, Xenia Gonda, Laszlo Tothfalusi, Dorottya Pap, Zsuzsanna Mirnics, Tamas Kurimay, Diana Chase, Gabriella Juhasz, Ian M. Anderson, John F.W. Deakin, Gyorgy Bagdy Source Type: journals

Promoter variants of the cannabinoid receptor 1 gene (CNR1) in interaction with 5-HTTLPR affect the anxious phenotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, genetically determined serotonergic and endocannabinoid dysfunctions could lead to a vulnerability causing anxiety disorders and possibly depression. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 31, 2009 Category: Genetics & Stem Cells Authors: Judit Lazary, Aron Lazary, Xenia Gonda, Anita Benko, Eszter Molnar, Laszlo Hunyady, Gabriella Juhasz, Gyorgy Bagdy Source Type: journals

Support of association between BRD1 and both schizophrenia and bipolar affective disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided evidence suggesting a possible role for BRD1 in neurodevelopment. The present study reports an association analysis of BRD1 and the neighboring gene ZBED4 using a Caucasian case-control sample from Denmark and England (UK/DK sample: 490 patients with BPD, 527 patients with SZ, and 601 control individuals), and genotypes obtained from a BPD genome wide association (GWA) study of an overlapping English sample c...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 18, 2009 Category: Genetics & Stem Cells Authors: Mette Nyegaard, Jacob E. Severinsen, Thomas D. Als, Anne Hedemand, Steen Straarup, Merete Nordentoft, Andrew McQuillin, Nicholas Bass, Jacob Lawrence, Srinivasa Thirumalai, Ana C.P. Pereira, Radhika Kandaswamy, Gregory J. Lydall, Pamela Sklar, Edward Scol Source Type: journals

PER2 variantion is associated with depression vulnerabilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, genetic variation in PER2 is associated with depression vulnerability a Swedish population-based sample. More studies are needed to determine if this is the case also for NPAS2, ARNTL, and RORA. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 18, 2009 Category: Genetics & Stem Cells Authors: Catharina Lavebratt, Louise K. Sjöholm, Timo Partonen, Martin Schalling, Yvonne Forsell Source Type: journals

Sex-specific association of the reelin gene with bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated whether genetic variation in RELN is associated with BP in a large family sample. We genotyped 75 tagSNPs and 6 coding SNPs in 1,188 individuals from 318 nuclear families, including 554 affected offspring. Quality control measures, transmission-disequilibrium tests (TDTs), and empirical simulations were performed in PLINK. We found a significant overtransmission of the C allele of rs362719 to BP offspring (OR = 1.47, P = 5.9 × 10-4); this withstood empirical correction for testing of multiple markers (empirical P = 0.048). In a hypothesis-driven secondary analysis, we found that the associat...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 17, 2009 Category: Genetics & Stem Cells Authors: F.S. Goes, V.L. Willour, P.P. Zandi, P.L. Belmonte, D.F. MacKinnon, F.M. Mondimore, B. Schweizer, National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium, J.R. DePaulo Jr., E.S. Gershon, F.J. McMahon, J.B. Potash Source Type: journals

Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies showing the improvement of ADHD symptoms obtained with the highly selective noradrenergic reuptake inhibitor, atomoxetine, demonstrate that the noradrenergic system plays the role of pathophysiology in this disorder. It is revealed that the norepinephrine transporter gene (SLC6A2) is a possible candidate gene directly related to ADHD. To determine possible roles of the SLC6A2 as a susceptibility gene for ADHD, we performed the genetic association study for a functional -3081(A/T) polymorphism, located in the promoter region of SLC6A2. For the present study of association between ADHD and the SLC6A2, 103 male...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 13, 2009 Category: Genetics & Stem Cells Authors: Yoosook Joung, Chun-Hyung Kim, Jisook Moon, Won-Seok Jang, Jaewon Yang, Dongwon Shin, Soonyoung Lee, Kwang-Soo Kim Source Type: journals

Common origin of pure and interrupted repeat expansions in spinocerebellar ataxia type 2 (SCA2)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we found instability towards expansion in interrupted ATXN2 alleles and a shared ancestral ATXN2 haplotype for pure and interrupted expanded alleles; this finding has strong implications in mutation diagnosis and counseling. Our results indicate that interrupted alleles, below the pathological threshold, may be a reservoir of mutable alleles, prone to expansion in subsequent generations, leading to full disease mutation. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 11, 2009 Category: Genetics & Stem Cells Authors: Eliana Marisa Ramos, Sandra Martins, Isabel Alonso, Vanessa E. Emmel, Maria Luiza Saraiva-Pereira, Laura Bannach Jardim, Paula Coutinho, Jorge Sequeiros, Isabel Silveira Source Type: journals

Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although attention-deficit/hyperactivity disorder (ADHD) is associated both with brain alterations in attention and executive function (EF) circuitry and with genetic variations within the dopamine system (including the dopamine transporter gene [SLC6A3]), few studies have directly investigated how genetic variations are linked to brain alterations. We sought to examine how a polymorphism in the 3[prime] untranslated region (UTR) of SLC6A3, associated with ADHD in meta-analysis, might contribute to variation in dorsal anterior cingulate cortex (dACC) function in subjects with ADHD. We collected fMRI scans of 42 individuals...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 11, 2009 Category: Genetics & Stem Cells Authors: Ariel B. Brown, Joseph Biederman, Eve M. Valera, Alysa E. Doyle, George Bush, Thomas Spencer, Michael C. Monuteaux, Eric Mick, Susan Whitfield-Gabrieli, Nikos Makris, Peter S. LaViolette, Marlene Oscar-Berman, Stephen V. Faraone, Larry J. Seidman Source Type: journals

FKBP5 polymorphisms and antidepressant response in geriatric depressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genetic variation at the FKBP5 locus has been reported to affect clinical outcomes in patients treated with antidepressant medications in several studies. However, other reports have not confirmed this association. FKBP5 may regulate the sensitivity of the hypothalamic-pituitary-adrenal axis. We tested two FKBP5 single nucleotide polymorphisms (rs1360780 and rs3800373) in a sample of 246 geriatric patients treated for 8 weeks in a double-blind randomized comparison trial of paroxetine and mirtazapine. These two polymorphisms had previously been reported to predict efficacy in depressed patients treated with selective serot...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 11, 2009 Category: Genetics & Stem Cells Authors: Jane E. Sarginson, Laura C. Lazzeroni, Heather S. Ryan, Alan F. Schatzberg, Greer M. Murphy Jr. Source Type: journals

Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT alleleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The catechol-O-methyltransferase (COMT) gene is considered as a candidate gene in obsessive-compulsive disorder (OCD). Specifically, the COMT low-activity M158 allele has been suggested to be associated with OCD. However, there is no study reporting that COMT activity is decreased in OCD patients and that the decrease is mediated by the V158M polymorphism. Therefore, the purpose of our study was to assess COMT activity in OCD by measuring plasma levels of 3-O-methyl-dopa (3-OMD), which result from the methylation of levodopa by COMT, and to investigate the relationship between 3-OMD levels and the V158M polymorphism. We al...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 11, 2009 Category: Genetics & Stem Cells Authors: Richard Delorme, Catalina Betancur, Pauline Chaste, Solen Kernéis, Astrid Stopin, Marie-Christine Mouren, Corinne Collet, Thomas Bourgeron, Marion Leboyer, Jean-Marie Launay Source Type: journals

Interaction among genes influencing ethanol metabolism and sex is association with alcohol use disorders in a Tibet populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, ALDH2*2 and ADH1B*2 alleles were not only independently associated with AUDs but also demonstrated cumulative dosage effects. However the positive association between CYP2E1*c2 allele and AUDs might only exist in males homozygotic for ALDH2*1 and ADH1B*1. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 3, 2009 Category: Genetics & Stem Cells Authors: Wanjun Guo, Qiang Wang, Gongga Lanzi, Ouzhu Luobu, Xiaohong Ma, Yingcheng Wang, Puo Zhen, Yulin Ji, Geng Wei, Zheng Wang, Wei Deng, Basang Zhuoma, Xiaoming Shi, Chengyin Yan, Chan He, Xiehe Liu, Yuejing Wu, Hongrong Luo, David A Collier, David Ball, Tao L Source Type: journals

The P86L common allele of CALHM1 does not influence risk for Alzheimer disease in Japanese cohortsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A common P86L variant in CALHM1 was recently identified to increase susceptibility to Alzheimer disease (AD) in individuals of European-descent. To determine whether or not this association is also valid in a different ethnic population, we directly sequenced three nearby SNPs including P86L in more than 2,500 Japanese AD case-control samples. We found no association between CALHM1 P86L polymorphism and AD risk in Japanese individuals. We also found a small number of non-synonymous minor variants in both control and case populations, some of which are predicted to affect protein function, but are unlikely to increase this ...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 3, 2009 Category: Genetics & Stem Cells Authors: Ken Inoue, Noriko Tanaka, Fumio Yamashita, Yoshie Sawano, Takashi Asada, Yu-ichi Goto Source Type: journals

Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene-environment interplayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Early institutional deprivation is a risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms. However not all individuals are affected. We tested the hypothesis that this heterogeneity is influenced by gene x environment (GxE) interaction and that genetic polymorphisms involved in dopamine neurotransmission moderate the effects of severe early institutional deprivation on symptoms of ADHD (sADHD). Using a prospective-longitudinal design sADHD were measured at ages 6, 11, and 15 years in a sample of individuals who experienced severe institutional deprivation (up to 42 months of age) in Romanian orphanages ...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 3, 2009 Category: Genetics & Stem Cells Authors: Suzanne E. Stevens, Robert Kumsta, Jana M. Kreppner, Keeley J. Brookes, Michael Rutter, Edmund J. S. Sonuga-Barke Source Type: journals

Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addictionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genetic factors contribute to the overall risk of developing nicotine addiction, which is the major cause of preventable deaths in western countries. However, knowledge regarding specific polymorphisms influencing smoking phenotypes remains scarce. In the present study we provide evidence that a common single nucleotide polymorphism (SNP) in the 5[prime] untranslated region of CHRM2, the gene coding for the muscarinic acetylcholine receptor 2 is associated with nicotine addiction. CHRM2 was defined as a candidate gene for nicotine addiction based on previous evidence that linked variations in CHRM2 to alcohol and drug depe...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 29, 2009 Category: Genetics & Stem Cells Authors: A. Mobascher, D. Rujescu, K. Mittelstraß, I. Giegling, C. Lamina, B. Nitz, H. Brenner, C. Fehr, L.P. Breitling, J. Gallinat, D. Rothenbacher, E. Raum, H. Müller, A. Ruppert, A.M. Hartmann, H.J. Möller, A. Gal, Ch. Gieger, H.E. Wichmann, T. Illig, N. Da Source Type: journals

Behavioral phenotype in the 9q subtelomeric deletion syndrome: A report about two adult patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, the behavioral and neuropsychiatric characteristics of one male and one female middle-aged patient are described in whom the genetic diagnosis, interstitial and telomeric 9q deletion, respectively, was established recently. In both patients a remarkable sleep disturbance, characterized by frequent awakenings and daytime sleepiness, was present as well as a prominent apathy syndrome. The observed motor signs such as rigid flexure of the arms and finger stereotypies persisted over a period of many years and could therefore not be viewed as symptoms of catatonia. It is concluded that the proposed behavioral ph...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 28, 2009 Category: Genetics & Stem Cells Authors: Willem M.A. Verhoeven, Tjitske Kleefstra, Jos I.M. Egger Source Type: journals

Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Attention-deficit hyperactivity disorder (ADHD) is a multifactorial, neurodevelopmental disorder that often persists into adolescence and adulthood and is characterized by inattention, hyperactivity and impulsiveness. Before the advent of the first genome-wide association studies in ADHD, genetic research had mainly focused on candidate genes related to the dopaminergic and serotoninergic systems, although several other genes had also been assessed. Pharmacological data, analysis of animal models and association studies suggest that Brain-Derived Neurotrophic Factor (BDNF) is also a strong candidate gene for ADHD. Several ...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 13, 2009 Category: Genetics & Stem Cells Authors: C. Sánchez-Mora, M. Ribasés, J.A. Ramos-Quiroga, M. Casas, R. Bosch, A. Boreatti-Hümmer, M. Heine, C.P. Jacob, K-P. Lesch, O.B. Fasmer, P.M. Knappskog, J.J. Sandra Kooij, C. Kan, J.K. Buitelaar, E. Mick, P. Asherson, S.V. Faraone, B. Franke, S. Johanss Source Type: journals

Suggestive evidence for linkage of ADHD features in bipolar disorder to chromosome 10p14Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Higher rates of bipolar disorder amongst the first-degree relatives of probands with ADHD, and increased rates of ADHD in the relatives of bipolar probands have been reported in many studies. This suggests some commonality in the genetic basis for bipolar disorder and ADHD. We hypothesized that ADHD symptoms in bipolar disorder may access a quantitative subphenotype that is genetically less complex and therefore advantageous for mapping studies. The Wender Utah Rating Scale (WURS) was used to quantify ADHD features in 57 bipolar families collected for linkage studies. The factor structure of the WURS was first examined, an...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 13, 2009 Category: Genetics & Stem Cells Authors: Eun-Jeong Joo, Tiffany A. Greenwood, Nicholas Schork, Rebecca A. McKinney, A. Dessa Sadovnick, Ronald A. Remick, Paul E. Keck, Susan L. McElroy, John R. Kelsoe Source Type: journals

Variation in GRIN2B contributes to weak performance in verbal short-term memory in children with dyslexiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A multi-marker haplotype within GRIN2B, a gene coding for a subunit of the ionotropic glutamate receptor, has recently been found to be associated with variation in human memory performance [de Quervain and Papassotiropoulos, ]. The gene locus is located within a region that has been linked to a phonological memory phenotype in a recent genome scan in families with dyslexia [Brkanac et al., ]. These findings may indicate the involvement of GRIN2B in memory-related aspects of human cognition. Memory performance is one of the cognitive functions observed to be disordered in dyslexia patients. We therefore investigated whethe...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 8, 2009 Category: Genetics & Stem Cells Authors: Kerstin U. Ludwig, Darina Roeske, Stefan Herms, Johannes Schumacher, Andreas Warnke, Ellen Plume, Nina Neuhoff, Jennifer Bruder, Helmut Remschmidt, Gerd Schulte-Körne, Bertram Müller-Myhsok, Markus M. Nöthen, Per Hoffmann Source Type: journals

D10S1423 identifies a susceptibility locus for Alzheimer's disease (AD7) in a prospective, longitudinal, double-blind study of asymptomatic individuals: Results at 14 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes the prospective, longitudinal, double-blind assessment of the age-specific risk of AD encountered by 325 asymptomatic first-degree relatives of AD probands who carried the D10S1423 (AD7) 234 bp allele, the APOE E4 allele, or both, after 14 years of systematic follow-up. A total of 30 incident cases of AD were detected during the first 3752 subject-years of surveillance. The effects of carrying either or both of the D10S1423 234 bp and APOE E4 alleles on the age-specific risk of developing AD were determined using Kaplan-Meier survival analysis. The risk of developing AD was the greatest for individual...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 8, 2009 Category: Genetics & Stem Cells Authors: George S. Zubenko, Hugh B. Hughes III, Wendy N. Zubenko Source Type: journals

Association of reading disabilities with regions marked by acetylated H3 histones in KIAA0319Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, markers across the 6p region were tested for association with RD. Our strongest findings were for association with markers in KIAA0319, although with the opposite alleles compared with a previous study. We also found association with markers in VMP, but not with DCDC2. Current evidence indicates that differential regulation of KIAA0319 and DCDC2 contributes to RD, thus we used chromatin immunoprecipitation coupled with genomic tiling arrays (ChIP-chip) to map acetylated histones, a molecular marker for regulatory elements, across a 500 kb genomic region covering the RD locus on 6p. This approach identified s...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 7, 2009 Category: Genetics & Stem Cells Authors: Jillian M. Couto, Izzy Livne-Bar, Katherine Huang, Zhaodong Xu, Tasha Cate-Carter, Yu Feng, Karen Wigg, Tom Humphries, Rosemary Tannock, Elizabeth N. Kerr, Maureen W. Lovett, Rod Bremner, Cathy L. Barr Source Type: journals

Association and gene-gene interaction of SLC6A4 and ITGB3 in autismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study seeks to validate and clarify previous findings in an independent dataset taking into account sex, family-history (FH) and gene-gene effects. Family-based association analysis was performed within each gene. Gene-gene interactions were tested using extended multifactor dimensionality reduction (EMDR) and MDR-phenomics (MDR-P) using sex of affecteds and FH as covariates. No significant associations with individual SNPs were found in the datasets stratified by sex, but associations did emerge when we stratified by family history. While not significant in the overall dataset, nominally significant association was i...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 7, 2009 Category: Genetics & Stem Cells Authors: D.Q. Ma, R. Rabionet, I. Konidari, J. Jaworski, H.N. Cukier, H.H. Wright, R.K. Abramson, J.R. Gilbert, M.L. Cuccaro, M.A. Pericak-Vance, E.R. Martin Source Type: journals

Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were als...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 5, 2009 Category: Genetics & Stem Cells Authors: Chi-Un Pae, Antonio Drago, Martina Forlani, Ashwin A. Patkar, Alessandro Serretti Source Type: journals

Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: Convergent pathway analysis findings from two independent samplesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Schizophrenia (SCZ) and bipolar disorder (BPD) are polygenic disorders with many genes contributing to their etiologies. The aim of this investigation was to search for dysregulated molecular and cellular pathways for these disorders as well as psychosis. We conducted a blood-based microarray investigation in two independent samples with SCZ and BPD from San Diego (SCZ = 13, BPD = 9, control = 8) and Taiwan (SCZ = 11, BPD = 14, control = 16). Diagnostic groups were compared to controls, and subjects with a history of psychosis [PSYCH(+): San Diego (n = 6), Taiwan (n = 14)] were compared to subjects without such history [PS...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 5, 2009 Category: Genetics & Stem Cells Authors: Chad A. Bousman, Gursharan Chana, Stephen J. Glatt, Sharon D. Chandler, Ginger R. Lucero, Erick Tatro, Todd May, James B. Lohr, William S. Kremen, Ming T. Tsuang, Ian P. Everall Source Type: journals

A screen of SLC1A1 for OCD-related allelesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we conducted capillary electrophoresis single-strand conformation polymorphism (CE-SSCP) screen for all 12 identified exons, including all coding regions and [sim]50 bp of flanking introns of the human SLC1A1 in 378 OCD-affected individuals. Full sequencing was completed on samples that showed an aberrant SSCP tracing for identification of the underlying sequence variants. Our aim was to determine if there are differences in the frequencies of relatively common alleles, or rare functional alleles, in 378 OCD cases and 281 ethnically matched controls. We identified one nonsynonymous coding SNP (c.490A > G, T1...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - June 29, 2009 Category: Genetics & Stem Cells Authors: Y. Wang, A. Adamczyk, Y.Y. Shugart, J.F. Samuels, M.A. Grados, B.D. Greenberg, J.A. Knowles, J.T. McCracken, S.L. Rauch, D.L. Murphy, S.A. Rasmussen, B. Cullen, A. Pinto, A.J. Fyer, J. Piacentini, D.L. Pauls, O.J. Bienvenu, M. Riddle, K.Y. Liang, D. Valle Source Type: journals

Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neuritin 1 (NRN1), an activity-regulated gene with multiple roles in neurodevelopment and synaptic plasticity, is located within the 6p24-p25 interval on chromosome 6, previously identified as linked to a subtype of schizophrenia (SZ) characterized by pervasive cognitive deficit (CD). We have tested the effect of NRN1 sequence variation on susceptibility to SZ and on general cognitive ability in patients and non-psychiatric control subjects by re-sequencing the coding regions of NRN1 and its flanking sequences, and genotyping 19 single-nucleotide polymorphisms (SNPs) in 336 SZ patients and 172 healthy control individuals. ...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - June 29, 2009 Category: Genetics & Stem Cells Authors: David Chandler, Milan Dragovi[cacute], Matthew Cooper, Johanna C. Badcock, Benjamin H. Mullin, Deb Faulkner, Scott G. Wilson, Joachim Hallmayer, Sarah Howell, Daniel Rock, Lyle J. Palmer, Luba Kalaydjieva, Assen Jablensky Source Type: journals

Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deficits in prepulse inhibition (PPI) are a biological marker for psychiatric illnesses such as schizophrenia and bipolar disorder. To unravel PPI-controlling mechanisms, we previously performed quantitative trait loci (QTL) analysis in mice, and identified Fabp7, that encodes a brain-type fatty acid binding protein (Fabp), as a causative gene. In that study, human FABP7 showed genetic association with schizophrenia. FABPs constitute a gene family, of which members FABP5 and FABP3 are also expressed in the brain. These FABP proteins are molecular chaperons for polyunsaturated fatty acids (PUFAs) such as arachidonic and doc...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - June 23, 2009 Category: Genetics & Stem Cells Authors: Yoshimi Iwayama, Eiji Hattori, Motoko Maekawa, Kazuo Yamada, Tomoko Toyota, Tetsuo Ohnishi, Yasuhide Iwata, Kenji J. Tsuchiya, Genichi Sugihara, Mitsuru Kikuchi, Kenji Hashimoto, Masaomi Iyo, Toshiya Inada, Hiroshi Kunugi, Norio Ozaki, Nakao Iwata, Shinic Source Type: journals