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Prospective Evaluation of Waist Circumference and Visceral Adipose Tissue in Patients with Chronic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:104-109 (DOI:10.1159/000259896) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 16, 2009 Category: Neurology Source Type: journals

Anti-Glycation and Anti-Albuminuric Effects of GLY-230 in Human DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:110-116 (DOI:10.1159/000259897) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 16, 2009 Category: Neurology Source Type: journals

The Modifier Protein of Glyceraldehyde-3-Phosphate Dehydrogenase Reduces Free Radical-Mediated Renal Damage in a Rat Model of Acute Kidney InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:117-124 (DOI:10.1159/000259898) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 16, 2009 Category: Neurology Source Type: journals

JNK/ATF2 Pathway Is Involved in Iodinated Contrast Media-Induced ApoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:125-133 (DOI:10.1159/000259899) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 16, 2009 Category: Neurology Source Type: journals

Role of Cellular Cholesterol in Pharmacologic Preconditioning with Cyclosporine in Experimental Kidney TransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:134-140 (DOI:10.1159/000259900) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 16, 2009 Category: Neurology Source Type: journals

CYP3A4 and CYP3A5 Polymorphisms and Blood Pressure Response to Amlodipine among African-American Men and Women with Early Hypertensive Renal Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings suggest that blood pressure response to amlodipine among high-risk African-Americans appears to be determined by CYP3A4 genotypes, and sex specificity may be an important consideration. Clinical applications of CYP3A4 genotype testing for individualized treatment regimens warrant further study. PMID: 19907160 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 12, 2009 Category: Urology & Nephrology Authors: Bhatnagar V, Garcia EP, O'Connor DT, Brophy VH, Alcaraz J, Richard E, Bakris GL, Middleton JP, Norris KC, Wright J, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS Tags: Am J Nephrol Source Type: journals

Age- and Gender-Dependent Correlations between Body Composition and Chronic Kidney Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The associations between BMI, body composition and CKD differed according to age and gender stratifications. PMID: 19907158 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 11, 2009 Category: Urology & Nephrology Authors: Han SS, Heo NJ, Na KY, Chae DW, Kim YS, Kim S, Chin HJ Tags: Am J Nephrol Source Type: journals

The Death of John Paul Jones and Resurrection as 'Father of the US Navy'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
John Paul Jones, 'father of the US Navy', died under mysterious circumstances on July 18, 1792. Although his remains were resurrected and autopsied 113 years later, the cause of his death has yet to be explained fully. In this detailed review of his clinical history and autopsy findings, we conclude, as have others, that Jones died of kidney failure of undermined etiology. Although 'interstitial nephritis' was diagnosed by the prosectors who performed his autopsy, we believe glomerulopathy (possibly IgA nephropathy) was more likely responsible for his kidney failure and that his death was due to a cardiac arrhythmia or...
Source: American Journal of Nephrology - November 11, 2009 Category: Urology & Nephrology Authors: Weir MR, Bogle LL, Mackowiak PA Tags: Am J Nephrol Source Type: journals

Age- and Gender-Dependent Correlations between Body Composition and Chronic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:83-89 (DOI:10.1159/000258660) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 10, 2009 Category: Neurology Source Type: journals

The Death of John Paul Jones and Resurrection as 'Father of the US Navy'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:90-94 (DOI:10.1159/000258661) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 10, 2009 Category: Neurology Source Type: journals

Retraction Statement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19893299 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 5, 2009 Category: Urology & Nephrology Authors: Bakris GL Tags: Am J Nephrol Source Type: journals

Aldosterone Promotes Fibronectin Synthesis in Rat Mesangial Cells via ERK1/2-Stimulated Na-H(+) Exchanger Isoform 1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study suggests that NHE1 may play an important role in aldosterone-mediated fibronectin accumulation in rat mesangial cells via the ERK1/2 pathway. PMID: 19893300 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 5, 2009 Category: Urology & Nephrology Authors: Zhang M, Chen J, Lai L, You L, Lin S, Hao C, Gu Y Tags: Am J Nephrol Source Type: journals

Aldosterone Promotes Fibronectin Synthesis in Rat Mesangial Cells via ERK1/2-Stimulated Na + -H + Exchanger Isoform 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:75-82 (DOI:10.1159/000256665) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 4, 2009 Category: Neurology Source Type: journals

Retraction StatementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2009;30:563 (DOI:10.1159/000257391) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 4, 2009 Category: Neurology Source Type: journals

Estimating Glomerular Filtration Rate Using the New CKD-EPI Equation and Other Equations in Patients with Autosomal Dominant Polycystic Kidney Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: For estimating GFR in ADPKD patients the MDRD equation with cystatin C incorporated had the best performance. The CKD-EPI or the Cockcroft-Gault equations showed better performance compared to the 4-variable MDRD equation. PMID: 19887788 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 4, 2009 Category: Urology & Nephrology Authors: Orskov B, Borresen ML, Feldt-Rasmussen B, Ostergaard O, Laursen I, Strandgaard S Tags: Am J Nephrol Source Type: journals

Impact of Low Glucose Degradation Product Bicarbonate/Lactate-Buffered Dialysis Solution on the Epithelial-Mesenchymal Transition of Peritoneum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: GDPs found in PDF induce EMT of HPMCs, which is associated with peritoneal fibrosis and vascularization. Conversely, L-GDP PDF reduces EMT and peritoneal fibrosis. PMID: 19887789 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 4, 2009 Category: Urology & Nephrology Authors: Oh EJ, Ryu HM, Choi SY, Yook JM, Kim CD, Park SH, Chung HY, Kim IS, Yu MA, Kang DH, Kim YL Tags: Am J Nephrol Source Type: journals

TGF-beta1-Induced Epithelial-to-Mesenchymal Transition and Therapeutic Intervention in Diabetic Nephropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: TGF-beta-induced EMT is a key contributor to fibrotic scar formation as seen in DN, and novel routes for future therapeutic intervention are discussed. PMID: 19887790 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 4, 2009 Category: Urology & Nephrology Authors: Hills CE, Squires PE Tags: Am J Nephrol Source Type: journals

Estimating Glomerular Filtration Rate Using the New CKD-EPI Equation and Other Equations in Patients with Autosomal Dominant Polycystic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:53-57 (DOI:10.1159/000256657) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 3, 2009 Category: Neurology Source Type: journals

Impact of Low Glucose Degradation Product Bicarbonate/Lactate-Buffered Dialysis Solution on the Epithelial-Mesenchymal Transition of PeritoneumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:58-67 (DOI:10.1159/000256658) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 3, 2009 Category: Neurology Source Type: journals

TGF-b1-Induced Epithelial-to-Mesenchymal Transition and Therapeutic Intervention in Diabetic NephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:68-74 (DOI:10.1159/000256659) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 3, 2009 Category: Neurology Source Type: journals

Analysis of the Urine Proteome of Human Contrast-Induced Kidney Injury Using Two-Dimensional Fluorescence Differential Gel Electrophoresis/Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry/Liquid Chromatography Mass Spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The studies suggested that MBL may be associated with contrast-induced acute kidney injury. It leads to an attempt to define a new pathogenesis and a novel biomarker for CIN. PMID: 19887787 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 2, 2009 Category: Urology & Nephrology Authors: Wang L, Ni Z, Xie Z, Yang F, He B, Liu J, Dai H, Qian J, Jia M Tags: Am J Nephrol Source Type: journals

Tissue Expression of TRPC3 and TRPC6 in Hypertensive Munich Wistar Frömter Rats Showing Proteinuria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Altered TRPC expression pattern in kidney cortex is associated with kidney damage in MWF rats showing hypertension and albuminuria. PMID: 19887786 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 30, 2009 Category: Urology & Nephrology Authors: Liu Y, Thilo F, Kreutz R, Schulz A, Wendt N, Loddenkemper C, Jankowski V, Tepel M Tags: Am J Nephrol Source Type: journals

Tissue Expression of TRPC3 and TRPC6 in Hypertensive Munich Wistar Frömter Rats Showing ProteinuriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:36-44 (DOI:10.1159/000254060) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 29, 2009 Category: Neurology Source Type: journals

Phosphoproteomic Study of Human Tubular Epithelial Cell in Response to Transforming Growth Factor-Beta-1-Induced Epithelial-to-Mesenchymal Transition.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We demonstrate a TGF-beta1-mediated post-transcriptional regulation of EMT in tubular epithelial cells. Phosphorylation of moesin and HSP90alpha might play a role in TGF-beta-induced EMT. PMID: 19864886 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 28, 2009 Category: Urology & Nephrology Authors: Chen YX, Li Y, Wang WM, Zhang W, Chen XN, Xie YY, Lu J, Huang QH, Chen N Tags: Am J Nephrol Source Type: journals

Phosphoproteomic Study of Human Tubular Epithelial Cell in Response to Transforming Growth Factor-Beta-1-Induced Epithelial-to-Mesenchymal TransitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2010;31:24-35 (DOI:10.1159/000253865) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 27, 2009 Category: Neurology Source Type: journals

Adaptation and Validation of the Kidney Disease Quality of Life-Short Form Questionnaire in the Greek Language.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study shows that the Greek version of the KDQOL-SF questionnaire has high validity, reproducibility and internal consistency. Production of validated translations of the KDQOL-SF questionnaire in various languages will help promote health-related quality of life of end-stage renal disease patients all over the world. PMID: 19864884 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2009 Category: Urology & Nephrology Authors: Malindretos P, Sarafidis P, Spaia S, Sioulis A, Zeggos N, Raptis V, Kitos V, Koronis C, Kabouris C, Zili S, Grekas D Tags: Am J Nephrol Source Type: journals

Physical Activity Is a Determinant of Circadian Blood Pressure Variation in Chronic Kidney Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Physical activity is an independent determinant of circadian variation in BP. We speculate that among patients with CKD, a sedentary lifestyle, rather than non-dipping, mediates increased cardiovascular risk. PMID: 19864885 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2009 Category: Urology & Nephrology Authors: Agarwal R, Light RP Tags: Am J Nephrol Source Type: journals

Renal Protection by Ischemic Preconditioning Is Associated with p50/p50 Homodimers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, our investigation suggests that: (1) the general activity of NF-kappaB is attenuated in IPC kidneys, and (2) the remaining activation of NF-kappaB is dominated with p50/p50 homodimer. Both of these effects might subsequently downregulate IL-18 expression, as well as provide renal protective effects of IPC. Though we focused on the phenomenological observations in this study, the detailed mechanism is still to be determined. PMID: 19851061 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2009 Category: Urology & Nephrology Authors: Cao C, Wang S, Fan L, Wan X, Liu X, Chen X Tags: Am J Nephrol Source Type: journals

Circadian Blood Pressure Classification Scheme and the Health of Patients with Chronic Kidney Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Among patients with CKD, circadian BP profile described by either dipper-based or phase-based classification is related to the level of physical activity and the severity of kidney damage. The circadian BP profile is related to overall health and nutritional intake only when using the phase-based classification. The value of these classification schemes to profile circadian BP will require longitudinal studies. PMID: 19844085 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2009 Category: Urology & Nephrology Authors: Agarwal R, Kariyanna SS, Light RP Tags: Am J Nephrol Source Type: journals

Prognostic Value of Circadian Blood Pressure Variation in Chronic Kidney Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Among elderly veterans with or without CKD, circadian variation in BP is associated with mortality, but not ESRD. However, after accounting for common clinical risk factors, this association of circadian BP variation with mortality or ESRD is abolished. PMID: 19844086 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2009 Category: Urology & Nephrology Authors: Agarwal R, Kariyanna SS, Light RP Tags: Am J Nephrol Source Type: journals

Sex and Age Result in Differential Regulation of the Renal Thiazide-Sensitive NaCl Cotransporter and the Epithelial Sodium Channel in Angiotensin II-Infused Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Increased sensitivity to Ang II in aging and male mice may involve overactivity of NCC. PMID: 19844087 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2009 Category: Urology & Nephrology Authors: Tiwari S, Li L, Riazi S, Halagappa VK, Ecelbarger CM Tags: Am J Nephrol Source Type: journals

Circadian Blood Pressure Classification Scheme and the Health of Patients with Chronic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2009;30:536-546 (DOI:10.1159/000252774) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2009 Category: Neurology Source Type: journals

Prognostic Value of Circadian Blood Pressure Variation in Chronic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2009;30:547-553 (DOI:10.1159/000252775) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2009 Category: Neurology Source Type: journals

Sex and Age Result in Differential Regulation of the Renal Thiazide-Sensitive NaCl Cotransporter and the Epithelial Sodium Channel in Angiotensin II-Infused MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2009;30:554-562 (DOI:10.1159/000252776) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2009 Category: Neurology Source Type: journals

Prevalence and Cardiovascular Features of Japanese Hemodialysis Patients with Fabry Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Measurement of the alpha-galactosidase A activity and the results of a genetic analysis indicated that the prevalence of FD in our hemodialysis patients was 0.29% (0.16% in men and 0.5% in women). Furthermore, comprehensive examination detected cardiovascular abnormalities in Japanese hemodialysis patients with FD. PMID: 19844084 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 15, 2009 Category: Urology & Nephrology Authors: Fujii H, Kono K, Goto S, Onishi T, Kawai H, Hirata KI, Hattori K, Nakamura K, Endo F, Fukagawa M Tags: Am J Nephrol Source Type: journals

Protective Effect of Tonapofylline (BG9928), an Adenosine A(1) Receptor Antagonist, against Cisplatin-Induced Acute Kidney Injury in Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data support the involvement of A1Rs in CIS-induced AKI in rats. Tonapofylline may be useful in the clinical setting for the prevention of kidney failure induced by nephrotoxic agents such as CIS. PMID: 19828940 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 12, 2009 Category: Urology & Nephrology Authors: Gill A, Wortham K, Costa D, Davis W, Ticho B, Whalley E Tags: Am J Nephrol Source Type: journals

Mutagenicity of Immunosuppressive Medications among Renal Transplant Recipients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In patients with renal transplantation, immunosuppressive therapy intensifies the genotoxic damage of the preceding chronic renal failure. PMID: 19816013 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 4, 2009 Category: Urology & Nephrology Authors: Rath T, Oliveira-Frick V Tags: Am J Nephrol Source Type: journals

Genome-Wide Analysis of Histone H3 Lysine 4 Trimethylation in Peripheral Blood Mononuclear Cells of Minimal Change Nephrotic Syndrome Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our studies indicate that there are significant alterations of H3K4me3 in MCNS patients. These significant H3K4me3 candidates may help to explain the immunological disturbance involved in MCNS patients. PMID: 19797895 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2009 Category: Urology & Nephrology Authors: Zhang L, Dai Y, Peng W, Lu J, Zhang Y, Wang L Tags: Am J Nephrol Source Type: journals

Genome-Wide Analysis of Histone H3 Lysine 4 Trimethylation in Peripheral Blood Mononuclear Cells of Minimal Change Nephrotic Syndrome PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2009;30:505-513 (DOI:10.1159/000243811) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2009 Category: Neurology Source Type: journals

Effect of Community Characteristics on Familial Clustering of End-Stage Renal Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although select community measures of lower socioeconomic status may contribute to the familial clustering of ESRD, non-socioeconomic factors, potentially inherited, appear to be more important contributors to familial aggregation of the common forms of ESRD. PMID: 19797894 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 29, 2009 Category: Urology & Nephrology Authors: Song EY, McClellan WM, McClellan A, Gadi R, Hadley AC, Krisher J, Clay M, Freedman BI Tags: Am J Nephrol Source Type: journals

Effect of Community Characteristics on Familial Clustering of End-Stage Renal DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2009;30:499-504 (DOI:10.1159/000243716) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 29, 2009 Category: Neurology Source Type: journals

Hemoglobin Level Variability: Anemia Management among Variability Groups.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Anemia management protocols describing coordinated administration of ESAs and iron may help to increase the number of patients achieving target hemoglobin levels. PMID: 19786739 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 28, 2009 Category: Urology & Nephrology Authors: Gilbertson DT, Peng Y, Bradbury B, Ebben JP, Collins AJ Tags: Am J Nephrol Source Type: journals

Hemoglobin Level Variability: Anemia Management among Variability GroupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2009;30:491-498 (DOI:10.1159/000243565) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 28, 2009 Category: Neurology Source Type: journals

Modeling of Human Anti-GBM Antibody-alpha3(IV)NC1 Interactions Predicts Antigenic Cross-Linking through Contact of Both Heavy Chains with Repeating Epitopes on alpha3(IV)NC1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results suggest that the repetitive nature and relatedness of the alpha3(IV)NC1 antigenic epitopes facilitate cross-linking of pathogenic Ab, in vivo, by allowing both IgG Fab to bind to the basement membrane. This most likely accounts for the high-affinity Ab binding we and others observed among human anti-alpha3(IV)NC1 Ab. Based on these observations, we postulate that this interaction provides for the stability of the Ab interaction, resulting in a high-affinity interaction that serves as an ideal scaffold for optimal FcR engagement and complement activation, thereby accelerating inflammation and contri...
Source: American Journal of Nephrology - September 27, 2009 Category: Urology & Nephrology Authors: Meyers KE, Christensen M, Madaio MP Tags: Am J Nephrol Source Type: journals

Positive Feedback Loop between Plasminogen Activator Inhibitor-1 and Transforming Growth Factor-Beta1 during Renal Fibrosis in Diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Since TGF-beta1 is well known to stimulate the PAI-1 promoter, we suggest that TGF-beta1 and PAI-1 together constitute a positive feedback loop in the development of renal fibrosis in diabetes. PMID: 19786738 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 24, 2009 Category: Urology & Nephrology Authors: Seo JY, Park J, Yu MR, Kim YS, Ha H, Lee HB Tags: Am J Nephrol Source Type: journals

Positive Feedback Loop between Plasminogen Activator Inhibitor-1 and Transforming Growth Factor-Beta1 during Renal Fibrosis in DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Am J Nephrol 2009;30:481-490 (DOI:10.1159/000242477) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 24, 2009 Category: Neurology Source Type: journals

Urine Proteome Analysis in Murine Nephrotoxic Serum Nephritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Proteomic analysis of mouse urine remains challenging due to the abundance of a limited subset of proteins. iTRAQ analysis does not circumvent these challenges, but can provide information on post-translational processing of some proteins. Hepcidin is identified as a potential urinary marker of nephritis and its role in disease pathogenesis warrants further study. PMID: 19776558 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 23, 2009 Category: Urology & Nephrology Authors: Wenderfer SE, Dubinsky WP, Hernandez-Sanabria M, Braun MC Tags: Am J Nephrol Source Type: journals

Incidence, Predictors and Outcomes of Transplant Renal Artery Stenosis after Kidney Transplantation: Analysis of USRDS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TRAS is an important complication that predicts adverse patient and graft outcomes. Treatment strategies for TRAS warrant prospective investigation in clinical trials. PMID: 19776559 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 23, 2009 Category: Urology & Nephrology Authors: Hurst FP, Abbott KC, Neff RT, Elster EA, Falta EM, Lentine KL, Agodoa LY, Jindal RM Tags: Am J Nephrol Source Type: journals

Effect of Pioglitazone on Survival and Renal Function in a Mouse Model of Polycystic Kidney Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that pioglitazone may have a unique antihypertensive effect in polycystic kidney disease, and that such an effect may promote improved survival. PMID: 19776560 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 23, 2009 Category: Urology & Nephrology Authors: Raphael KL, Strait KA, Stricklett PK, Baird BC, Piontek K, Germino GG, Kohan DE Tags: Am J Nephrol Source Type: journals

Who Is Caring for Kidney Transplant Patients? Variation by Region, Transplant Center, and Patient Characteristics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Frequency of visits to transplant centers varied by center and region; most visits were to nephrologists. Patients from minority groups were less likely to visit transplant centers and nephrologists, with possibly significant public health implications. PMID: 19752531 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 14, 2009 Category: Urology & Nephrology Authors: Israni AK, Snyder JJ, Skeans MA, Tuomari AV, Maclean JR, Kasiske BL Tags: Am J Nephrol Source Type: journals