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(Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Tags: Frontmatter Source Type: journals

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We are writing to address the concerns raised by our colleagues, Pirouzian and associates, regarding our recently published manuscript. We want to thank Pirouzian and associates for bringing the following points to our attention. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: Yassine J. Daoud, Amy Hutchinson, David K. Wallace, Jonathan Song, Terry Kim Tags: Correspondence Source Type: journals

Refractive Surgery in ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the published Perspective article on “Refractive Surgery in Children” by Daoud and associates. We applaud the authors in undertaking a comprehensive investigative PubMed literature search-review on refractive surgery in children. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: Amir Pirouzian, Kenneth C. Ip, Huck Holz Tags: Correspondence Source Type: journals

Translation of Clinical Studies to Clinical Practice: Survey on the Treatment of Nonarteritic Anterior Ischemic Optic NeuropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Translational 2 or T2, research refers to the conversion of findings from clinical studies into actual practice. For example, a recent international survey on the management of optic neuritis showed that although clinical trials have changed the management of acute optic neuritis around the world, many neurologists and ophthalmologists still do not evaluate and treat acute isolated optic neuritis patients according to the best evidence. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: Edward J. Atkins, Beau B. Bruce, Nancy J. Newman, Valérie Biousse Tags: Correspondence Source Type: journals

Reporting Visual AcuitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The AJO encourages authors to report the visual acuity in the manuscript using the same nomenclature that was used in gathering the data provided they were recorded in one of the methods listed here. This table of equivalent visual acuities is provided to the readers as an aid to interpret visual acuity findings in familiar units. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Tags: Original Articles Source Type: journals

Reticular Macular DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: RMD is a single disease entity with stereotypical presentations in multiple imaging methods, of which RPD is one. Autofluorescence, infrared imaging, and indocyanine green angiography suggest that it involves the retinal pigment epithelium and choriocapillaris, whereas photographic patterns implicate the inner choroid. Infrared imaging, unlike other methods, can demonstrate RMD in the central macula. RMD is associated with progression to advanced age-related macular degeneration, perhaps on an inflammatory basis. RMD deserves wider recognition among clinicians caring for elderly patients. (Source: American Jou...
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: R. Theodore Smith, Mahsa A. Sohrab, Mihai Busuioc, Gaetano Barile Tags: Original Articles Source Type: journals

Angle-Closure Glaucoma–Simpler Answers to Complex Mechanisms: LXVI Edward Jackson Memorial LectureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Angle-closure and angle-closure glaucoma result from disturbed physiological mechanisms more than from simple anatomic measures, and future predictive testing can exploit knowledge of these factors. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: Harry A. Quigley Tags: Original Articles Source Type: journals

Risk Interpretation, Perception, and CommunicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a recent Statistics Editorial, I discussed the definition of a disease risk and various ways of comparing risks across groups. Beyond the necessary statistical tools to estimate and compare risk, as health professionals we need to understand how physicians, counselors, and the general public understand and interpret risk information. The success of scientific studies on risk factors and appropriate interventions depends on a researcher's skills in appropriately interpreting risk from data sources, communicating that risk effectively, and on consumers perceiving the information correctly. In passing, note that researcher...
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: Nicholas P. Jewell Tags: Series on Statistics Source Type: journals

The Perils of Glaucoma Surgical Outcome AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The “gold standard” for glaucoma incisional surgery has been trabeculectomy, a guarded filtration procedure that was introduced 40 years ago by Watson and Cairns. The operation has been modified over the years to improve success by utilizing antimetabolites and lowering complications by staged release of scleral flap sutures with releasable sutures or laser suture lysis. Also ushered in almost 30 years ago was the tube shunt for refractory glaucomas by Molteno. Modifications since the introduction of tube shunts have been the incorporation of a valve, using an internal and/or external tube ligature, and changing the re...
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: L. Jay Katz, Jonathan S. Myers, Scott J. Fudemberg Tags: Editorials Source Type: journals

Sympathetic Ophthalmia: What Have We Learned?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sympathetic ophthalmia (SO) is a rare bilateral granulomatous uveitis that occurs after ocular trauma or surgery to 1 eye. The eye sustaining the injury is referred to as the inciting eye and the fellow eye is called the sympathizing eye. The cause of SO has not been understood completely, but the underlying pathophysiologic feature is believed to be an autoimmune reaction against the exposed ocular antigens from the inciting eye. The time to development of SO varies from 2 weeks to 50 years, with the disease developing in approximately 90% of patients within 1 year of injury. Since MacKenzie and Fuchs' clinical descriptio...
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: H. Nida Sen, Robert B. Nussenblatt Tags: Editorials Source Type: journals

Deep Anterior Lamellar Keratoplasty: When Should it Replace Penetrating Keratoplasty?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For nearly a half century, penetrating keratoplasty (PKP) has been the surgical treatment of choice for visual rehabilitation of corneal blindness. Recently, endothelial keratoplasty (EK) techniques, which offer the advantages of preservation of relatively normal corneal stroma and architecture and rapid visual rehabilitation, have replaced PKP as the surgical treatment of choice in most cases of endothelial dysfunction. Conversely, deep anterior lamellar keratoplasty (DALK), which offers the advantages of preservation of the recipient endothelium and elimination of immune-mediated endothelial rejection, has been introduce...
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: John E. Sutphin, Kenneth M. Goins, Michael D. Wagoner Tags: Editorials Source Type: journals

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(Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Tags: Frontmatter Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Tags: Frontmatter Source Type: journals

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Media Type: Internet-based Synopsis: Purchase of this product allows access to an interactive website in which clinical cases are presented (often with clinical photographs), along with basic level questions regarding the cases, for which the user is asked to type in an answer. The site requires specific language to be entered as an answer to a question, but the menu of correct answers is limited, leading to imprecise responses from the website. The user may also encounter difficulty for some questions in accessing the list of ‘correct’ responses. Nevertheless, the Review is a potentially powerful learning tool. (Sour...
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: James D. Auran Tags: Book Reviews Source Type: journals

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Media Type: Textbook Synopsis: Laser in situ keratomileusis (LASIK) has been the patron of refractive surgery to allow people to eliminate their dependency on corrective lenses. Techniques to perform this procedure have been enhanced in order to produce safer results. One technique implements femtosecond lasers to create a corneal flap necessary for LASIK. “Femtodynamics: A Guide to Laser Settings and Procedure Techniques to Optimize Outcomes with Femtosecond Lasers” is a reference text that provides a very thorough explanation of utilizing this technique. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Emil Chynn, Elias Almeida, Lynnette Williams Young, Steve Zheng Tags: Book Reviews Source Type: journals

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Media Type: Textbook with DVD-ROM Synopsis: This textbook provides detailed authoritative guidance on many of the commonly performed vitreoretinal surgical procedures as well as a number of more complex procedures including surgery for retinopathy of prematurity and intraocular tumors. Written by experts in the field, well-illustrated, complemented with a DVD-ROM, it provides a level of detail that vitreoretinal fellows and ophthalmology trainees with a keen interest in vitreoretinal surgery will find extremely useful. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Petros E. Carvounis Tags: Book Reviews Source Type: journals

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The “event rate” of non-arteritic ischemic optic neuropathy (NION) reported in our study, and that Dr Tsertsvadze refers to as “absolute” rate, was not a standard epidemiologic incidence. This event-rate (which we expressed in patient-years) was a measure of how frequently NION and possible NION might be linked to phosphodiesterase (PDE)-5 inhibitor exposure in men enrolled in the Veterans Health Administration. It was intended to guide researchers planning a more definitive analytic study and never meant to describe disease incidence. The absolute rates of NION and possible NION that Dr Tsertsvadze refers to in hi...
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Curtis E. Margo, Dustin D. French Tags: Correspondence Source Type: journals

Rates of Non-Arteritic Ischemic Optic Neuropathy in Male Veterans Prescribed Phosphodiesterase-5 InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with interest the article by Margo and French that reported rates of non-arteritic ischemic optic neuropathy (NION) from a retrospective cohort study of veteran men 50 years or older with respect to their exposure to phosphodiesterase (PDE)-5 inhibitors (ie, dispensed prescriptions). This was a 2-year follow-up study based on the National Veterans Health Administration's pharmacy database. For men prescribed PDE-5 inhibitors, the study authors provided relative risks of 1.02 (95% confidence interval [CI], 0.92 to 1.12) and 1.34 (95% CI, 1.17 to 1.55) for NION and “possible” NION, respectively. (Source: American ...
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Alexander Tsertsvadze Tags: Correspondence Source Type: journals

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Our report emphasized that reversal of cupping, as recognized in clinical photographs, might represent both anterior movement of the lamina within the scleral canal and a change in prelaminar neural tissue volume unrelated to axonal regeneration. Drs Berdahl and Allingham have raised an important question about the mechanism of anterior laminar movement in those eyes that demonstrated this finding. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Crawford Downs, Claude F. Burgoyne, Richard K. Parrish, Joyce C. Schiffman, William J. Feuer Tags: Correspondence Source Type: journals

Cerebrospinal Fluid Pressure May Play a Role in Reversal of Cupping After Glaucoma SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The recent findings of the Collaborative Initial Glaucoma Treatment Study group showing a reversal of optic nerve cupping in 6.6% of patients is important and of great interest. The reversal of cupping was significantly associated with a lower postoperative intraocular pressure (IOP) but not improvement of visual acuity or visual field: an improvement of form but not function. The authors agree, stating, “We speculate that this unexpected 5-year finding is likely related to a mechanical deformation of the lamina cribrosa and prelaminar nerve fiber rather than to repair or regeneration of the retinal nerve fiber layer (RN...
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: John P. Berdahl, R. Rand Allingham Tags: Correspondence Source Type: journals

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We thank Dr Shimmyo for sharing his findings on the recovery of corneal hysteresis after surgical reduction in different types of glaucoma. We are in agreement with Dr Shimmyo's comments on how this phenomenon has occurred and hope this exchange will stimulate further research. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Lei Sun, Meixiao Shen, Jianhua Wang, Aiwu Fang, Aiqin Xu, Haizhen Fang, Fan Lu Tags: Correspondence Source Type: journals

Recovery of Corneal Hysteresis after Reduction of Intraocular Pressure in Chronic Primary Angle-Closure GlaucomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with great interest the article by Sun and associates. The authors reported recovery of corneal hysteresis (CH) after reduction in intraocular pressure (IOP) in chronic primary angle-closure glaucoma. I would like to add our retrospective observation of similar recovery of CH, from 6.4 ± 2.0 mm Hg before surgery to 9.6 ± 2.3 mm Hg after surgery (P < .001, analysis of variance t test, paired two-sample for means), after surgical reduction in IOP from 31.4 ± 8.8 mm Hg to 11.7 ± 6.5 mm Hg in 16 consecutive primary open-angle glaucoma eyes. Although the clinical types of the glaucoma may be different, the recovery i...
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Mitsugu Shimmyo Tags: Correspondence Source Type: journals

AJO History of Ophthalmology Series: Thomas Young and the OptometerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The first significant instrument used by modern eye doctors was probably the optometer invented by Thomas Young (1773 to 1829) and used by him to measure subjectively his own refraction and accommodation. (He was a myope of −4 diopters with astigmatism.) The optometer eventually evolved into the modern system of automatic refractors. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Tags: Original Articles Source Type: journals

Reporting Visual AcuitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The AJO encourages authors to report the visual acuity in the manuscript using the same nomenclature that was used in gathering the data provided they were recorded in one of the methods listed here. This table of equivalent visual acuities is provided to the readers as an aid to interpret visual acuity findings in familiar units. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Tags: Original Articles Source Type: journals

Risk ComparisonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We so often use the term risk of an event in both common language and technical articles that its meaning in any given context can be vague and misunderstood. The issue becomes even more complicated when we compare risks across groups or contrast different conditions for a single group, in part because there are multiple ways of quantifying the difference—or lack thereof—between two risks. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Nicholas P. Jewell Tags: Series on Statistics Source Type: journals

Thessaloniki Eye Study: The Importance of Recognizing PseudoexfoliationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From an interesting slit-lamp biomicroscopic finding that piques the interests of first year residents to an appreciation of a disease with a more pernicious course than primary open-angle glaucoma (POAG), the importance of pseudoexfoliation (PXE) as a important risk factor for glaucoma is now recognized. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Richard K. Parrish Tags: Editorials Source Type: journals

Fuchs Heterochromic Iridocyclitis—Syndrome, Disease, or Both?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ernst Fuchs, perhaps best known for his landmark “Textbook of Ophthalmology” first published in 1889, headed the Second Clinic of Ophthalmology at the University of Vienna from 1885 to 1915. During this period, Fuchs' extensive clinical and histopathologic studies provided the first detailed descriptions of more than a dozen ocular findings and conditions, including a series of 38 patients with complicated heterochromia, whom he characterized as having iris heterochromia, cyclitis, and cataract. Later studies have variously referred to this syndrome as Fuchs Heterochromic Cyclitis, Fuchs Heterochromic Iridocyclitis, Fu...
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Emmett T. Cunningham, Edoardo Baglivo Tags: Editorials Source Type: journals

Molecular Genetics and the Classification of the Corneal Dystrophies: What is Next?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Shakespeare said “a rose by any other name would smell as sweet.” The most popular interpretation of this often-repeated quotation explains that it means the substance of an object is more important than what it is called. Nevertheless, names still relay important information. While we expect a rose to smell sweet, even without additional knowledge, we would expect that a plant named stinkweed would have an offensive odor. In life and in medicine, nomenclature has significance. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - September 25, 2009 Category: Opthalmology Authors: Jayne S. Weiss Tags: Editorials Source Type: journals

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(Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Tags: Frontmatter Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Tags: Frontmatter Source Type: journals

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We thank Sakarya and associates for their comments regarding the pulse mode use of mitomycin C (MMC) in pterygium surgery. The authors state that to minimize the possible damage induced by the use of MMC, they apply a surgical sponge soaked with MMC 0.02% onto bare sclera for a total of 2 minutes divided into 4 sessions. The length of each session is 30 seconds with a 1-minute interval. In each interval, the sclera is irrigated with balanced salt solution. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Irit Bahar, Igor Kaiserman, Allan R. Slomovic Tags: Correspondence Source Type: journals

Pulse-Mode Mitomycin C Use in Pterygium SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with great interest the article entitled “Effect of Mitomycin C on Corneal Endothelium in Pterygium Surgery” by Bahar and associates. In this prospective, nonrandomized study, in the mitomycin C (MMC) group, a surgical sponge soaked with MMC 0.02% was placed on the exposed sclera for 2 minutes, with the conjunctival layer draped over the sponge. The authors reported that topical use of MMC 0.02% in pterygium surgery caused a decrease in the percentage of hexagonal corneal endothelium at 1 month. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Yasar Sakarya, Rabia Sakarya Tags: Correspondence Source Type: journals

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We thank Drs Byeon and Chu for their interest in our article. We appreciate their comment and insights and the issue they have raised. Their comment stimulated our interest about the microstructure of the fovea. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Hidetaka Matsumoto, Taku Sato, Shoji Kishi Tags: Correspondence Source Type: journals

Interpretation of Fovea Center Morphologic Features in Optical Coherence TomographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Congratulations to Dr Matsumoto and associates for their interesting findings concerning the central foveal thickness as a good indicator for photoreceptor cell damage (visual acuity) in central serous chorioretinopathy patients. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Suk Ho Byeon, Young Kwang Chu Tags: Correspondence Source Type: journals

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Downie and associates express ethical concerns about our clinical trial design investigating the light-adjustable lens (LAL). Specifically, they assert that by purposely targeting hyperopic refractive errors that could be adjusted after surgery, we intentionally created a suboptimal surgical outcome. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Arturo Chayet, Christian A. Sandstedt, Shiao H. Chang, Paul Rhee, Barbara Tsuchiyama, Daniel M. Schwartz Tags: Correspondence Source Type: journals

Ethical Issues When Conducting Trials of New Intraocular Lens TechnologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Advances in intraocular lens (IOL) technology require tissue culture, animal, human cadaveric, and eventually live human testing. Inevitably, this means that any new IOL must at some stage be tested for the first time in living human subjects. When this occurs, the investigators involved are obliged for reasons of ethics to perform any research procedures in a manner that minimizes risks and ensures that the interests of patients are not compromised by the interests of the investigation itself. We are writing to express concern about the conduct of such an experiment, which we believe may not have met these ethical standar...
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Lilian C. Downie, Anthony J. Hall, Paul A. Komesaroff Tags: Correspondence Source Type: journals

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We appreciate the comments of Dr Gorovoy and his interest in our article “Presoaking Donor Corneas Reduces Graft Detachment Rates in Descemet Stripping Endothelial Keratoplasty.” Dr Gorovoy makes the point that dislocation rates are multifactorial and that surgeon experience is an important factor. We agree. However, after we had become comfortable with the technique, we could not ignore the persistent elevated detachment rates that we encountered month after month. With detachment rates significantly lowered with presoaking, we look forward to improving attachment rates in cases where a retained air bubble is difficul...
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Jimmy K. Lee, Walter J. Stark, John D. Gottsch Tags: Correspondence Source Type: journals

Presoaking Donor Cornea Reduces Graft Detachment Rates in Descemet Stripping Endothelial KeratoplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with interest the article by Lee and associates, which concluded that presoaking the donor cornea in Balanced Salt Solution (BSS) Plus (Alcon Laboratories, Fort Worth, Texas, USA) eliminated the dislocation rate. My experience after 1,000 cases leads me to believe their conclusion may be premature. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Mark S. Gorovoy Tags: Correspondence Source Type: journals

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We appreciate the interest and comments of Drs Chen and Naseri concerning our article “Presoaking Donor Corneas Reduces Graft Detachment Rates in Descemet Stripping Endothelial Keratoplasty.” We agree with Drs Chen and Naseri that there is a learning curve with Descemet stripping endothelial keratoplasty. Although the technique is challenging, it is certainly well within the capabilities of experienced anterior segment surgeons. Thus, we were concerned that even after becoming comfortable with the surgical approach and managing seemingly uncomplicated cases, stubborn, and consistently elevated detachment rates continue...
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Jimmy K. Lee, Walter J. Stark, John D. Gottsch Tags: Correspondence Source Type: journals

Presoaking of Donor Corneas for the Reduction of Postoperative Dislocation after Descemet Stripping Endothelial KeratoplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with great interest Lee and associates' article describing their recent modification of Descemet stripping endothelial keratoplasty (DSEK) for the reduction of postoperative dislocation. In this technique, the donor tissue is pretreated by removing the storage media, Optisol GS (Chiron Ophthalmics, Irvine, California, USA), with room temperature balanced salt solution (BSS) Plus (Alcon Laboratories, Fort Worth, Texas, USA) for a period of 20 minutes, trephinated, and then replaced into a BSS Plus solution until the time of transplantation. In their 5 subgroups, of which only the last group was treated with presoaki...
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Edwin S. Chen, Ayman Naseri Tags: Correspondence Source Type: journals

Reporting Visual AcuitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The AJO encourages authors to report the visual acuity in the manuscript using the same nomenclature that was used in gathering the data provided they were recorded in one of the methods listed here. This table of equivalent visual acuities is provided to the readers as an aid to interpret visual acuity findings in familiar units. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Tags: Original Articles Source Type: journals

AJO History of Ophthalmology Series: The Ticho HouseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A beautiful landmark in Jerusalem, a museum known as the Ticho House, is the former hospital and residence of the ophthalmologist, Dr Albert Ticho (1883 to 1960) and his wife the artist, Anna Ticho (1894 to 1980). Born in what is now the Czech Republic, Albert Ticho trained in Vienna and immigrated to Palestine in 1912, soon followed by Anna. Ticho's early work included supervising the first American Hadassah nurses in fighting trachoma. Their work was reported at a historic conference in 1914 whose proceedings constituted the first modern medical book published in Hebrew. Ticho's career in ophthalmology spanned an intense...
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Tags: Original Articles Source Type: journals

Reflections of a Long-time Chair of an Academic Ophthalmology Department on Stepping DownEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As I was stepping down as Chairman of Ophthalmology at Northwestern University, a post I have held for more than 25 years, I was invited to participate in a course for new department chairs at the Association of University Professors in Ophthalmology meeting. We gave this course last year, but it had particular significance this year because it probably was my last Association of University Professors in Ophthalmology meeting. The search committee at Northwestern is active and is currently interviewing candidates for the new chair. The course was prepared for young chairs, but much of the wisdom dispensed is applicable to ...
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Lee M. Jampol Tags: Editorials Source Type: journals

Age-related Macular Degeneration and Cardiovascular Disease in the Era of Anti–Vascular Endothelial Growth Factor TherapiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The introduction of therapies blocking vascular endothelial growth factor (VEGF) represents a landmark in the management of neovascular age-related macular degeneration (AMD). It is now standard practice for clinicians to offer intravitreal injections of anti-VEGF agents, principally ranibizumab or bevacizumab, as the first-line treatment for neovascular AMD. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Tien Y. Wong Tags: Editorials Source Type: journals

Associations of Eye Diseases and Symptoms with Self-Reported Physical and Mental HealthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest an important link between visual symptoms and general HRQOL. The study extends the findings of prior research to show that both trouble seeing and blurred vision have independent, measurable associations with HRQOL, while the presence of specific eye diseases may not. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Paul P. Lee, William E. Cunningham, Terry T. Nakazono, Ron D. Hays Tags: Original Articles Source Type: journals

Safety Implications of Vascular Endothelial Growth Factor Blockade for Subjects Receiving Intravitreal Anti–Vascular Endothelial Growth Factor TherapiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We propose that highly sensitive methodologies be put into place for identifying low rate safety signals, including postmarketing clinical trials, chart reviews, electronic medical records, and various national and international registries and databases, to evaluate the systemic safety of antiangiogenic agents in ocular diseases such as neovascular age-related macular degeneration. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 26, 2009 Category: Opthalmology Authors: Karl Csaky, Diana V. Do Tags: Perspectives Source Type: journals

Peripheral Branching of Levator Superioris Muscle and Müller Muscle OriginEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The distal levator superioris muscle consisted of a branched structure, and the Müller muscle originated from the inferior branch of the levator superioris muscle. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 11, 2009 Category: Opthalmology Authors: Hirohiko Kakizaki, Venkatesh Prabhakaran, Thanuja Pradeep, Raman Malhotra, Dinesh Selva Tags: Original Articles Source Type: journals

Chronic Herpes Simplex Scleritis: Characterization of 9 Cases of an Underrecognized Clinical EntityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Unrecognized HSV infection can cause longstanding scleritis. Histopathologic features of HSV scleritis are varied and nonspecific; immunofluorescent demonstration of HSV protein can make a definitive diagnosis. Prolonged administration of acyclovir is required for effective therapy. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 11, 2009 Category: Opthalmology Authors: Pooja V. Bhat, Frederick A. Jakobiec, Kristina Kurbanyan, Tongzhen Zhao, C. Stephen Foster Tags: Original Articles Source Type: journals

Prevalence and Associations of Keratoconus in Rural Maharashtra in Central India: The Central India Eye and Medical StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Keratoconus defined as corneal refractive power of 48+ D has a prevalence of 2.3% ± 0.2% among Indians aged 30 years and above and living in the rural region of Central India. The prevalence of keratoconus was associated with lower body height, lower level of education, myopic refractive error, and thinner central cornea. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 11, 2009 Category: Opthalmology Authors: Jost B. Jonas, Vinay Nangia, Arshia Matin, Maithili Kulkarni, Krishna Bhojwani Tags: Original Articles Source Type: journals

Failed Descemet-Stripping Automated Endothelial Keratoplasty Grafts: A Clinicopathologic AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Most DSAEK failures are secondary to endothelial cell loss. Other contributing factors include interface fibrosis, retrocorneal membrane formation, retained host Descemet membrane, uneven trephination, epithelial ingrowth, graft rejection, and infection. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - August 11, 2009 Category: Opthalmology Authors: Julia Shulman, Mark Kropinak, David C. Ritterband, Henry D. Perry, John A. Seedor, Steven A. McCormick, Tatyana Milman Tags: Original Articles Source Type: journals