American Journal of Physiology. Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mechanisms of spinophilin-dependent pancreas dysregulation in obesity
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00099.2023. Online ahead of print.ABSTRACTSpinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/-) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. We have corroborated and expanded upon previous studies to determine that Spino-/- mice have decre...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Kaitlyn C Stickel Nikhil R Shah Emily T Claeboe Kara S Orr Amber L Mosley Emma H Doud Teri L Belecky-Adams Anthony J Baucum Source Type: research

Advancements in Diabetic Kidney Disease Management: Integrating Innovative Therapies and Targeted Drug Development
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00026.2024. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a leading cause of chronic kidney disease and affects approximately 40% of diabetic individuals. Cases of DKD continue to rise globally as the prevalence of diabetes mellitus increases, with an estimated 415 million people living with diabetes in 2015 and a projected 642 million by 2040. DKD is associated with significant morbidity and mortality, representing 34% and 36% of all chronic kidney disease deaths in men and women, respectively. Common co-morbidities including hypertension an...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Shaarav Ghose Matthew Satariano Saichidroopi Korada Thomas Cahill Raghav Shah Rupesh Raina Source Type: research

Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevic Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-Wed Source Type: research

Corrigendum for Subramanian et al., volume 326, 2024, p. E182-E205
Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E545. doi: 10.1152/ajpendo.00278.2023_COR.NO ABSTRACTPMID:38619308 | DOI:10.1152/ajpendo.00278.2023_COR (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - April 15, 2024 Category: Physiology Source Type: research

Inhibition of Crif1 protects fatty acid-induced POMC neuron damage by increasing CPT-1 function
Am J Physiol Endocrinol Metab. 2024 Apr 10. doi: 10.1152/ajpendo.00420.2023. Online ahead of print.ABSTRACTHypothalamic proopiomelanocortin neurons are sensors of signals that reflect the energy stores in the body. Inducing mild stress in proopiomelanocortin neurons protect them from the damage promoted by the consumption of a high-fat diet, mitigating the development of obesity; however, the cellular mechanisms behind these effects are unknown. Here, we induced mild stress in a proopiomelanocortin neuron cell line by inhibiting Crif1. In proopiomelanocortin neurons exposed to high levels of palmitate, the partial inhibiti...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 10, 2024 Category: Physiology Authors: Lara Regina-Ferreira Fernando Valdivieso-Rivera Monara K S C Angelim Larissa Menezes Dos Reis Vanessa O de Oliveira Furino Joseane Morari Lizandra Maia de Souza Silvio R Consoni Carlos H Sponton Pedro M Moraes Vieira Licio A Velloso Source Type: research

Medium-Chain Triglycerides-Specific Appetite is Regulated by the β-oxidation of Medium-Chain Fatty Acids in the Liver
Am J Physiol Endocrinol Metab. 2024 Apr 10. doi: 10.1152/ajpendo.00031.2024. Online ahead of print.ABSTRACTMost studies on fat appetite have focused on long-chain triglycerides (LCTs) due to their obesogenic properties. Medium-chain triglycerides (MCTs), conversely, exhibit anti-obesogenic effects; however, the regulation of MCTs intake remains elusive. Here, we demonstrate that mice can distinguish between MCTs and LCTs, and the specific appetite for MCTs is governed by hepatic β-oxidation. We generated liver-specific medium-chain acyl-CoA dehydrogenase (MCAD)-deficient (MCADL-/-) mice and analyzed their preference for M...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 10, 2024 Category: Physiology Authors: Tsugunori Maruyama Sho Matsui Ryosuke Kobayashi Takuro Horii Yasuo Oguri Satoshi Tsuzuki Takahiro Horie Koh Ono Izuho Hatada Tsutomu Sasaki Source Type: research