American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones
Am J Physiol Heart Circ Physiol. 2024 Apr 12. doi: 10.1152/ajpheart.00116.2024. Online ahead of print.ABSTRACTCardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we investigated the impact of ADAM15 loss in female mice following cardiac pressure overload induced by transverse aortic constriction (TAC). Female Adam15-/-mice developed the same degree of cardiac hypertrophy, dilation and dysfunction as the parallel female wildtype ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Vidhya Krishnan Nikki Atanasova Preetinder K Aujla Devon Hupka Caroline A Owen Zamaneh Kassiri Source Type: research

The Association of Self-Reported Sleep and Circadian Measures with Glycemic Control and Diabetes Complications among Young Adults with Type 2 Diabetes
In conclusion, late bedtime on work/school days, rather than short sleep duration, daytime sleepiness, or poor sleep quality, was independently associated with loss of glycemic control in this longitudinal cohort of young adults with youth-onset type 2 diabetes.PMID:38607342 | DOI:10.1152/ajpheart.00550.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Dorit Koren Kristen L Knutson Brian K Burke Kimberly L Drews Fida Bacha Lorraine Katz Marsha D Marcus Siripoom McKay Kristen Nadeau Babak Mokhlesi Source Type: research

Tailoring Transfection for Cardiomyocyte Cell Lines: Balancing Efficiency and Toxicity in Lipid versus Polymer-Based Transfection Methods in H9c2 and HL-1 Cells
In this study, we introduce meticulously crafted protocols to enhance the culture and transfection of HL-1 and H9c2 cells, emphasizing the reduction of cytotoxic effects while improving transfection efficiency. Through the examination of polymer-based and lipid-based transfection methods, we offer a comparative analysis that underscores the heightened efficiency and reduced toxicity of these approaches. Our research provides an extensive array of step-by-step procedures designed to foster robust cell cultures and outlines troubleshooting practices to rectify issues of low transfection rates. We discuss the merits and drawb...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Flobater I Gawargi Hamid R Shahshahan Paras K Mishra Source Type: research

Unstrain my Heart: Can Cardiac Macrophages Reverse Remodel Fibrosis?
Am J Physiol Heart Circ Physiol. 2024 Apr 5. doi: 10.1152/ajpheart.00171.2024. Online ahead of print.NO ABSTRACTPMID:38578236 | DOI:10.1152/ajpheart.00171.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 5, 2024 Category: Physiology Authors: Koya Lumbao-Conradson Ronald J Vagnozzi Source Type: research

Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation and neointimal hyperplasia
CONCLUSION: Disturbed flow through the JAA correlates with rapid endothelial cell loss, thrombus formation, and JANIH; late endothelialization of the JAA channel correlates with late AVF patency. Early thrombus formation in the JAA may influence later development of JANIH.PMID:38578237 | DOI:10.1152/ajpheart.00054.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 5, 2024 Category: Physiology Authors: Hualong Bai M Alyssa Varsanik Carly Thaxton Yuichi Ohashi Luis Gonzalez Weichang Zhang Yukihiko Aoyagi Masaki Kano Bogdan Yatsula Zhuo Li Luka Pocivavsek Alan Dardik Source Type: research

Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion
Am J Physiol Heart Circ Physiol. 2024 Apr 5. doi: 10.1152/ajpheart.00025.2024. Online ahead of print.ABSTRACTGiven the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmation of zinc status, animal growth rates as well as plasma and urine zinc levels were evaluated. The accessible and cost-effective methodology outlined will increase scientific rigor, ensuring reproducibility in studies expl...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 5, 2024 Category: Physiology Authors: Tara-Yesomi Wenegieme Dalia Elased Kelia E McMichael Jananie Rockwood Khanzada Hasrat Adaku C Ume Andrea G Marshall Kit Neikirk Annet Kirabo Khalid M Elased Antentor Hinton Clintoria R Williams Source Type: research