Skeletal muscle fiber type and TMS-induced muscle relaxation in unfatigued and fatigued knee-extensor muscles
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 25. doi: 10.1152/ajpregu.00174.2023. Online ahead of print.ABSTRACTThe force drop after transcranial magnetic stimulation (TMS) delivered to the motor cortex during voluntary muscle contractions could inform about muscle relaxation properties. Because of the physiological relation between skeletal muscle fiber type distribution and size and muscle relaxation, TMS could be a non-invasive index of muscle relaxation in humans. By combining a non-invasive technique to record muscle relaxation in vivo (TMS) with the gold standard technique for muscle tissue sampling (muscle biops...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 25, 2024 Category: Physiology Authors: Chiara Barbi John Temesi Gaia Giuriato Fabio Giuseppe Laginestra Camilla Martignon Tatiana Moro Federico Schena Massimo Venturelli Gianluca Vernillo Source Type: research

Skeletal muscle fiber type and TMS-induced muscle relaxation in unfatigued and fatigued knee-extensor muscles
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 25. doi: 10.1152/ajpregu.00174.2023. Online ahead of print.ABSTRACTThe force drop after transcranial magnetic stimulation (TMS) delivered to the motor cortex during voluntary muscle contractions could inform about muscle relaxation properties. Because of the physiological relation between skeletal muscle fiber type distribution and size and muscle relaxation, TMS could be a non-invasive index of muscle relaxation in humans. By combining a non-invasive technique to record muscle relaxation in vivo (TMS) with the gold standard technique for muscle tissue sampling (muscle biops...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 25, 2024 Category: Physiology Authors: Chiara Barbi John Temesi Gaia Giuriato Fabio Giuseppe Laginestra Camilla Martignon Tatiana Moro Federico Schena Massimo Venturelli Gianluca Vernillo Source Type: research

Skeletal muscle fiber type and TMS-induced muscle relaxation in unfatigued and fatigued knee-extensor muscles
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 25. doi: 10.1152/ajpregu.00174.2023. Online ahead of print.ABSTRACTThe force drop after transcranial magnetic stimulation (TMS) delivered to the motor cortex during voluntary muscle contractions could inform about muscle relaxation properties. Because of the physiological relation between skeletal muscle fiber type distribution and size and muscle relaxation, TMS could be a non-invasive index of muscle relaxation in humans. By combining a non-invasive technique to record muscle relaxation in vivo (TMS) with the gold standard technique for muscle tissue sampling (muscle biops...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 25, 2024 Category: Physiology Authors: Chiara Barbi John Temesi Gaia Giuriato Fabio Giuseppe Laginestra Camilla Martignon Tatiana Moro Federico Schena Massimo Venturelli Gianluca Vernillo Source Type: research

Reply to Francescato and Cettolo
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 1;326(4):R331-R332. doi: 10.1152/ajpregu.00028.2024.NO ABSTRACTPMID:38518073 | DOI:10.1152/ajpregu.00028.2024 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 22, 2024 Category: Physiology Authors: Michele Girardi Chiara Gattoni William W Stringer Harry B Rossiter Richard Casaburi Carrie Ferguson Carlo Capelli Source Type: research

Is the current definition of ventilation congruent with the alveolar gas exchange?
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 1;326(4):R330. doi: 10.1152/ajpregu.00289.2023.NO ABSTRACTPMID:38518074 | DOI:10.1152/ajpregu.00289.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 22, 2024 Category: Physiology Authors: Maria Pia Francescato Valentina Cettolo Source Type: research

Reply to Francescato and Cettolo
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 1;326(4):R331-R332. doi: 10.1152/ajpregu.00028.2024.NO ABSTRACTPMID:38518073 | DOI:10.1152/ajpregu.00028.2024 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 22, 2024 Category: Physiology Authors: Michele Girardi Chiara Gattoni William W Stringer Harry B Rossiter Richard Casaburi Carrie Ferguson Carlo Capelli Source Type: research

Is the current definition of ventilation congruent with the alveolar gas exchange?
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 1;326(4):R330. doi: 10.1152/ajpregu.00289.2023.NO ABSTRACTPMID:38518074 | DOI:10.1152/ajpregu.00289.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 22, 2024 Category: Physiology Authors: Maria Pia Francescato Valentina Cettolo Source Type: research

Reply to Francescato and Cettolo
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 1;326(4):R331-R332. doi: 10.1152/ajpregu.00028.2024.NO ABSTRACTPMID:38518073 | DOI:10.1152/ajpregu.00028.2024 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 22, 2024 Category: Physiology Authors: Michele Girardi Chiara Gattoni William W Stringer Harry B Rossiter Richard Casaburi Carrie Ferguson Carlo Capelli Source Type: research

Is the current definition of ventilation congruent with the alveolar gas exchange?
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 1;326(4):R330. doi: 10.1152/ajpregu.00289.2023.NO ABSTRACTPMID:38518074 | DOI:10.1152/ajpregu.00289.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 22, 2024 Category: Physiology Authors: Maria Pia Francescato Valentina Cettolo Source Type: research

Nerve transfer for restoration of lower motor neuron-lesioned bladder, urethral and anal sphincter function. Part 4: Effectiveness of the motor reinnervation
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00248.2023. Online ahead of print.ABSTRACTIn pilot work we showed that somatic nerve transfers can restore motor function in long-term decentralized dogs. We continue to explore the effectiveness of motor reinnervation in 30 female dogs. After anesthesia, 12 underwent bilateral transection of coccygeal and sacral (S) spinal roots, dorsal roots of lumbar (L)7, and hypogastric nerves. Twelve months post-decentralization, 8 underwent transfer of obturator nerve branches to pelvic nerve vesical branches, and sciatic nerve branches to pudendal nerves, fol...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Ekta Tiwari Danielle S Porreca Alan S Braverman Lewis Holt-Bright Nagat A Frara Justin M Brown Benjamin R Johnston Stanley F Bazarek Brendan A Hilliard Michael Mazzei Michel A Pontari Daohai Yu Michael R Ruggieri Mary F Barbe Source Type: research

Sex differences in the purinergic 2 receptor mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00010.2024. Online ahead of print.ABSTRACTWe investigated the role played by ATP sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ~72 hours to induce simulated peripheral artery disease (PAD). We hypothesized that PPADS (P2 receptor antagonist, 10 mg i.v.) would reduce the pressor response to four minutes of treadmill exercise (15 m×min-1, 1° incline) and steady-state exercise plasma norepinephrine (NE) values in male and femal...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Alec L E Butenas Joseph S Flax Raimi J Carroll C Shane Chuwonganant Ashley M Baranczuk Steven W Copp Source Type: research

Stimulatory effect of methylglyoxal on capsaicin-sensitive lung vagal afferents in rats: role of TRPA1
In conclusion, these results suggest that MG exerts a stimulatory effect on CSLV afferents, inducing pulmonary chemoreflexes, and such stimulation is mediated through the TRPA1 activation.PMID:38497128 | DOI:10.1152/ajpregu.00297.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: You Shuei Lin Nai-Ju Chan Pei-Yu Xiao Ching Jung Lai Source Type: research

Nerve transfer for restoration of lower motor neuron-lesioned bladder, urethral and anal sphincter function. Part 4: Effectiveness of the motor reinnervation
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00248.2023. Online ahead of print.ABSTRACTIn pilot work we showed that somatic nerve transfers can restore motor function in long-term decentralized dogs. We continue to explore the effectiveness of motor reinnervation in 30 female dogs. After anesthesia, 12 underwent bilateral transection of coccygeal and sacral (S) spinal roots, dorsal roots of lumbar (L)7, and hypogastric nerves. Twelve months post-decentralization, 8 underwent transfer of obturator nerve branches to pelvic nerve vesical branches, and sciatic nerve branches to pudendal nerves, fol...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Ekta Tiwari Danielle S Porreca Alan S Braverman Lewis Holt-Bright Nagat A Frara Justin M Brown Benjamin R Johnston Stanley F Bazarek Brendan A Hilliard Michael Mazzei Michel A Pontari Daohai Yu Michael R Ruggieri Mary F Barbe Source Type: research

Sex differences in the purinergic 2 receptor mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00010.2024. Online ahead of print.ABSTRACTWe investigated the role played by ATP sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ~72 hours to induce simulated peripheral artery disease (PAD). We hypothesized that PPADS (P2 receptor antagonist, 10 mg i.v.) would reduce the pressor response to four minutes of treadmill exercise (15 m×min-1, 1° incline) and steady-state exercise plasma norepinephrine (NE) values in male and femal...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Alec L E Butenas Joseph S Flax Raimi J Carroll C Shane Chuwonganant Ashley M Baranczuk Steven W Copp Source Type: research

Stimulatory effect of methylglyoxal on capsaicin-sensitive lung vagal afferents in rats: role of TRPA1
In conclusion, these results suggest that MG exerts a stimulatory effect on CSLV afferents, inducing pulmonary chemoreflexes, and such stimulation is mediated through the TRPA1 activation.PMID:38497128 | DOI:10.1152/ajpregu.00297.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: You Shuei Lin Nai-Ju Chan Pei-Yu Xiao Ching Jung Lai Source Type: research