Two lateral flow assays for detection of anti-coccidioidal antibodies show similar performance to immunodiffusion in dogs with coccidioidomycosis
Am J Vet Res. 2024 Mar 25:1-8. doi: 10.2460/ajvr.23.12.0272. Online ahead of print.ABSTRACTOBJECTIVE: To compare 2 point-of-care lateral flow assays (LFAs) with immunodiffusion (ID) IgG results for anti-coccidioidal antibody detection in dogs with coccidioidomycosis. A further aim was to compare the quantifiable output of 1 of the LFAs to ID antibody titers.SAMPLE: Serum banked from 73 client-owned dogs diagnosed with pulmonary or disseminated coccidioidomycosis.METHODS: ID was used to determine antibody presence and titer against a coccidioidal antigen preparation. All sera were subsequently tested on an LFA based on reco...
Source: American Journal of Veterinary Research - March 26, 2024 Category: Veterinary Research Authors: Francisca J Grill Jared A Jaffey Thomas E Grys Laura H Rayhel Douglas F Lake Source Type: research

Myxomatous mitral valve disease and associated pulmonary hypertension might increase serum angiopoietin-2 in dogs
Am J Vet Res. 2024 Mar 30:1-9. doi: 10.2460/ajvr.23.12.0289. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the relationships between the severity of myxomatous mitral valve disease (MMVD) and pulmonary hypertension (PH) and serum angiopoietin (Ang)-1 and Ang-2 concentrations in dogs with MMVD.ANIMALS: 74 dogs (control, n = 12; MMVD, n = 62) were included.METHODS: Serum Ang-1 and Ang-2 concentrations were estimated using the canine-specific ELISA kit. The concentrations were compared between dogs with MMVD and healthy dogs, and they were analyzed according to the severity of MMVD and PH.RESULTS: The median serum Ang-...
Source: American Journal of Veterinary Research - March 26, 2024 Category: Veterinary Research Authors: Hogeun Yu Dohee Lee Yeon Chae Minseok Choi Yelim Lee Taesik Yun Byeong-Teck Kang Mhan-Pyo Yang Hakhyun Kim Source Type: research

Prevalence of elbow dysplasia in 13 dog breeds in France: a retrospective radiographic study (2002-2022)
This study included 17,861 records for 13 dog breeds: American Akita, Alaskan Malamute, Old German Shepherd (Altdeutscher Schäferhund), American Staffordshire Terrier, Australian Shepherd, Belgian Shepherd, White Swiss Shepherd, Bernese Mountain Dog, Cane Corso, Czechoslovakian Wolfdog, Rhodesian Ridgeback, Rottweiler, and Dogue de Bordeaux. The overall prevalence of ED was 11.4%, ranging from 1.1% in the Czechoslovakian Wolfdog to 32.2% in the Dogue de Bordeaux. The Dogue de Bordeaux, Rottweiler, Bernese Mountain Dog, and Cane Corso breeds were most commonly affected by ED. The prevalence of ED was significantly higher i...
Source: American Journal of Veterinary Research - March 22, 2024 Category: Veterinary Research Authors: Jos éphine Roels Jean-Pierre Genevois Mathilde Fostier-Humbert Charles Porsmoguer Margaux Blondel Guillaume Chanoit Didier Fau Thibaut Cachon Source Type: research

Prevalence of elbow dysplasia in 13 dog breeds in France: a retrospective radiographic study (2002-2022)
This study included 17,861 records for 13 dog breeds: American Akita, Alaskan Malamute, Old German Shepherd (Altdeutscher Schäferhund), American Staffordshire Terrier, Australian Shepherd, Belgian Shepherd, White Swiss Shepherd, Bernese Mountain Dog, Cane Corso, Czechoslovakian Wolfdog, Rhodesian Ridgeback, Rottweiler, and Dogue de Bordeaux. The overall prevalence of ED was 11.4%, ranging from 1.1% in the Czechoslovakian Wolfdog to 32.2% in the Dogue de Bordeaux. The Dogue de Bordeaux, Rottweiler, Bernese Mountain Dog, and Cane Corso breeds were most commonly affected by ED. The prevalence of ED was significantly higher i...
Source: American Journal of Veterinary Research - March 22, 2024 Category: Veterinary Research Authors: Jos éphine Roels Jean-Pierre Genevois Mathilde Fostier-Humbert Charles Porsmoguer Margaux Blondel Guillaume Chanoit Didier Fau Thibaut Cachon Source Type: research

Prevalence of elbow dysplasia in 13 dog breeds in France: a retrospective radiographic study (2002-2022)
This study included 17,861 records for 13 dog breeds: American Akita, Alaskan Malamute, Old German Shepherd (Altdeutscher Schäferhund), American Staffordshire Terrier, Australian Shepherd, Belgian Shepherd, White Swiss Shepherd, Bernese Mountain Dog, Cane Corso, Czechoslovakian Wolfdog, Rhodesian Ridgeback, Rottweiler, and Dogue de Bordeaux. The overall prevalence of ED was 11.4%, ranging from 1.1% in the Czechoslovakian Wolfdog to 32.2% in the Dogue de Bordeaux. The Dogue de Bordeaux, Rottweiler, Bernese Mountain Dog, and Cane Corso breeds were most commonly affected by ED. The prevalence of ED was significantly higher i...
Source: American Journal of Veterinary Research - March 22, 2024 Category: Veterinary Research Authors: Jos éphine Roels Jean-Pierre Genevois Mathilde Fostier-Humbert Charles Porsmoguer Margaux Blondel Guillaume Chanoit Didier Fau Thibaut Cachon Source Type: research

Serial injections of 4% polyacrylamide hydrogel have no detrimental effects in equine joints following clinical, histologic, and synovial biomarker evaluation
The objectives of this study were to evaluate the clinical, histologic, and synovial fluid biomarker effects following serial administration of 4% PAHG in normal equine fetlock joints.ANIMALS: 8 healthy horses.METHODS: In a blinded, controlled in vivo study, horses received serial intra-articular injections of 4% PAHG (Noltrex Vet; Nucleus ProVets LLC) and contralateral 0.9% saline control on days 0, 45, 90, and 135. Treatment and control joints were randomly assigned. Synovial fluid was collected before administration of 4% PAHG or 0.9% saline on day 0 and at study completion for cellular and biomarker evaluation. Serial ...
Source: American Journal of Veterinary Research - March 21, 2024 Category: Veterinary Research Authors: Scott R McClure Maggie D Peitzmeier Bradley R Jackman Richard B Evans Courtney L Ziegler Charan K Ganta Source Type: research

Serial injections of 4% polyacrylamide hydrogel have no detrimental effects in equine joints following clinical, histologic, and synovial biomarker evaluation
The objectives of this study were to evaluate the clinical, histologic, and synovial fluid biomarker effects following serial administration of 4% PAHG in normal equine fetlock joints.ANIMALS: 8 healthy horses.METHODS: In a blinded, controlled in vivo study, horses received serial intra-articular injections of 4% PAHG (Noltrex Vet; Nucleus ProVets LLC) and contralateral 0.9% saline control on days 0, 45, 90, and 135. Treatment and control joints were randomly assigned. Synovial fluid was collected before administration of 4% PAHG or 0.9% saline on day 0 and at study completion for cellular and biomarker evaluation. Serial ...
Source: American Journal of Veterinary Research - March 21, 2024 Category: Veterinary Research Authors: Scott R McClure Maggie D Peitzmeier Bradley R Jackman Richard B Evans Courtney L Ziegler Charan K Ganta Source Type: research

Doppler ultrasound is more accurate than pulse oximeter plethysmography in the measurement of systolic arterial pressure from the median caudal artery in anesthetized dogs
Am J Vet Res. 2024 Mar 23:1-7. doi: 10.2460/ajvr.23.11.0263. Online ahead of print.ABSTRACTOBJECTIVE: To compare the accuracy of doppler ultrasound (DOP) and pulse oximeter plethysmography (POP) in the measurement of systolic arterial pressure (SAP) to invasive blood pressure (IBP) in anesthetized dogs.ANIMALS: 40 client-owned healthy dogs > 10 kg.METHODS: Dogs were anesthetized for surgical procedures in dorsal recumbency. Invasive blood pressure was measured from a dorsal pedal artery. DOP and POP device probes were placed over the median caudal artery with a flow-occluding cuff for noninvasive blood pressure measurem...
Source: American Journal of Veterinary Research - March 19, 2024 Category: Veterinary Research Authors: John H Whittaker Nathaniel Kapaldo Eduarda M Bortoluzzi David C Rankin Source Type: research

Doppler ultrasound is more accurate than pulse oximeter plethysmography in the measurement of systolic arterial pressure from the median caudal artery in anesthetized dogs
Am J Vet Res. 2024 Mar 23:1-7. doi: 10.2460/ajvr.23.11.0263. Online ahead of print.ABSTRACTOBJECTIVE: To compare the accuracy of doppler ultrasound (DOP) and pulse oximeter plethysmography (POP) in the measurement of systolic arterial pressure (SAP) to invasive blood pressure (IBP) in anesthetized dogs.ANIMALS: 40 client-owned healthy dogs > 10 kg.METHODS: Dogs were anesthetized for surgical procedures in dorsal recumbency. Invasive blood pressure was measured from a dorsal pedal artery. DOP and POP device probes were placed over the median caudal artery with a flow-occluding cuff for noninvasive blood pressure measurem...
Source: American Journal of Veterinary Research - March 19, 2024 Category: Veterinary Research Authors: John H Whittaker Nathaniel Kapaldo Eduarda M Bortoluzzi David C Rankin Source Type: research

Doppler ultrasound is more accurate than pulse oximeter plethysmography in the measurement of systolic arterial pressure from the median caudal artery in anesthetized dogs
Am J Vet Res. 2024 Mar 23:1-7. doi: 10.2460/ajvr.23.11.0263. Online ahead of print.ABSTRACTOBJECTIVE: To compare the accuracy of doppler ultrasound (DOP) and pulse oximeter plethysmography (POP) in the measurement of systolic arterial pressure (SAP) to invasive blood pressure (IBP) in anesthetized dogs.ANIMALS: 40 client-owned healthy dogs > 10 kg.METHODS: Dogs were anesthetized for surgical procedures in dorsal recumbency. Invasive blood pressure was measured from a dorsal pedal artery. DOP and POP device probes were placed over the median caudal artery with a flow-occluding cuff for noninvasive blood pressure measurem...
Source: American Journal of Veterinary Research - March 19, 2024 Category: Veterinary Research Authors: John H Whittaker Nathaniel Kapaldo Eduarda M Bortoluzzi David C Rankin Source Type: research

Equine gamma herpesvirus presence and viral load are not associated with equine glandular gastric disease
Am J Vet Res. 2024 Mar 18:1-9. doi: 10.2460/ajvr.23.12.0282. Online ahead of print.ABSTRACTOBJECTIVE: To investigate the role of equine herpesvirus-2 (EHV-2) and equine herpesvirus-5 (EHV-5) in equine glandular gastric disease (EGGD) by visualizing and quantifying these gamma herpesviruses in EGGD-affected and normal glandular gastric mucosa of horses. A secondary objective was to describe the histopathological abnormalities in the equine gastric glandular mucosa in horses with EGGD.ANIMALS: 29 horses (n = 21 postmortem and 8 gastroscopy) categorized as normal (11), EGGD (12), or both EGGD and equine squamous gastric disea...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Rachelle N Thompson Erin Pearson Sean P McDonough Helenrose Iannitti Gerlinde R Van de Walle Heidi Banse Gillian A Perkins Joy E Tomlinson Source Type: research

Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses
Am J Vet Res. 2024 Mar 18:1-8. doi: 10.2460/ajvr.24.01.0022. Online ahead of print.ABSTRACTOBJECTIVE: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.ANIMALS: 8 horses owned by North Carolina State University.METHODS: Four liters of heparinized whole blood was collected from...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Kallie J Hobbs Jennifer L Davis Bethanie L Cooper Yu Ueda Megan J Burke M Katie Sheats Source Type: research

Equine gamma herpesvirus presence and viral load are not associated with equine glandular gastric disease
Am J Vet Res. 2024 Mar 18:1-9. doi: 10.2460/ajvr.23.12.0282. Online ahead of print.ABSTRACTOBJECTIVE: To investigate the role of equine herpesvirus-2 (EHV-2) and equine herpesvirus-5 (EHV-5) in equine glandular gastric disease (EGGD) by visualizing and quantifying these gamma herpesviruses in EGGD-affected and normal glandular gastric mucosa of horses. A secondary objective was to describe the histopathological abnormalities in the equine gastric glandular mucosa in horses with EGGD.ANIMALS: 29 horses (n = 21 postmortem and 8 gastroscopy) categorized as normal (11), EGGD (12), or both EGGD and equine squamous gastric disea...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Rachelle N Thompson Erin Pearson Sean P McDonough Helenrose Iannitti Gerlinde R Van de Walle Heidi Banse Gillian A Perkins Joy E Tomlinson Source Type: research

Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses
Am J Vet Res. 2024 Mar 18:1-8. doi: 10.2460/ajvr.24.01.0022. Online ahead of print.ABSTRACTOBJECTIVE: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.ANIMALS: 8 horses owned by North Carolina State University.METHODS: Four liters of heparinized whole blood was collected from...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Kallie J Hobbs Jennifer L Davis Bethanie L Cooper Yu Ueda Megan J Burke M Katie Sheats Source Type: research

Equine gamma herpesvirus presence and viral load are not associated with equine glandular gastric disease
Am J Vet Res. 2024 Mar 18:1-9. doi: 10.2460/ajvr.23.12.0282. Online ahead of print.ABSTRACTOBJECTIVE: To investigate the role of equine herpesvirus-2 (EHV-2) and equine herpesvirus-5 (EHV-5) in equine glandular gastric disease (EGGD) by visualizing and quantifying these gamma herpesviruses in EGGD-affected and normal glandular gastric mucosa of horses. A secondary objective was to describe the histopathological abnormalities in the equine gastric glandular mucosa in horses with EGGD.ANIMALS: 29 horses (n = 21 postmortem and 8 gastroscopy) categorized as normal (11), EGGD (12), or both EGGD and equine squamous gastric disea...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Rachelle N Thompson Erin Pearson Sean P McDonough Helenrose Iannitti Gerlinde R Van de Walle Heidi Banse Gillian A Perkins Joy E Tomlinson Source Type: research