Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R
Amino Acids. 2024 Mar 21;56(1):25. doi: 10.1007/s00726-024-03386-6.ABSTRACTNowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the uptake of proteins, usually from alternatives to animal-based sources, by healthy volunteers. The data analysis is complex and requires many decisions on the part of the scientists involved. Such a process can be streamlined and made more objective and reproducible through bespoke software. This paper describes such a software package, aaresponse , for the R environment, available as open source. It feat...
Source: Amino Acids - March 21, 2024 Category: Biochemistry Authors: Ron Wehrens Jasper Engel Jurriaan Mes Aard de Jong Diederik Esser Source Type: research

Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R
Amino Acids. 2024 Mar 21;56(1):25. doi: 10.1007/s00726-024-03386-6.ABSTRACTNowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the uptake of proteins, usually from alternatives to animal-based sources, by healthy volunteers. The data analysis is complex and requires many decisions on the part of the scientists involved. Such a process can be streamlined and made more objective and reproducible through bespoke software. This paper describes such a software package, aaresponse , for the R environment, available as open source. It feat...
Source: Amino Acids - March 21, 2024 Category: Biochemistry Authors: Ron Wehrens Jasper Engel Jurriaan Mes Aard de Jong Diederik Esser Source Type: research

Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R
Amino Acids. 2024 Mar 21;56(1):25. doi: 10.1007/s00726-024-03386-6.ABSTRACTNowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the uptake of proteins, usually from alternatives to animal-based sources, by healthy volunteers. The data analysis is complex and requires many decisions on the part of the scientists involved. Such a process can be streamlined and made more objective and reproducible through bespoke software. This paper describes such a software package, aaresponse , for the R environment, available as open source. It feat...
Source: Amino Acids - March 21, 2024 Category: Biochemistry Authors: Ron Wehrens Jasper Engel Jurriaan Mes Aard de Jong Diederik Esser Source Type: research

Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R
Amino Acids. 2024 Mar 21;56(1):25. doi: 10.1007/s00726-024-03386-6.ABSTRACTNowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the uptake of proteins, usually from alternatives to animal-based sources, by healthy volunteers. The data analysis is complex and requires many decisions on the part of the scientists involved. Such a process can be streamlined and made more objective and reproducible through bespoke software. This paper describes such a software package, aaresponse , for the R environment, available as open source. It feat...
Source: Amino Acids - March 21, 2024 Category: Biochemistry Authors: Ron Wehrens Jasper Engel Jurriaan Mes Aard de Jong Diederik Esser Source Type: research

Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R
Amino Acids. 2024 Mar 21;56(1):25. doi: 10.1007/s00726-024-03386-6.ABSTRACTNowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the uptake of proteins, usually from alternatives to animal-based sources, by healthy volunteers. The data analysis is complex and requires many decisions on the part of the scientists involved. Such a process can be streamlined and made more objective and reproducible through bespoke software. This paper describes such a software package, aaresponse , for the R environment, available as open source. It feat...
Source: Amino Acids - March 21, 2024 Category: Biochemistry Authors: Ron Wehrens Jasper Engel Jurriaan Mes Aard de Jong Diederik Esser Source Type: research

An insight into role of amino acids as antioxidants via NRF2 activation
Amino Acids. 2024 Mar 20;56(1):23. doi: 10.1007/s00726-024-03384-8.ABSTRACTOxidative stress can affect the protein, lipids, and DNA of the cells and thus, play a crucial role in several pathophysiological conditions. It has already been established that oxidative stress has a close association with inflammation via nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway. Amino acids are notably the building block of proteins and constitute the major class of nitrogen-containing natural products of medicinal importance. They exhibit a broad spectrum of biological activities, including the ability to activate NR...
Source: Amino Acids - March 20, 2024 Category: Biochemistry Authors: Melford C Egbujor Olugbemi T Olaniyan Chigbundu N Emeruwa Sarmistha Saha Luciano Saso Paolo Tucci Source Type: research

Retraction Note: Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction
Amino Acids. 2024 Mar 20;56(1):24. doi: 10.1007/s00726-024-03390-w.NO ABSTRACTPMID:38506936 | PMC:PMC10954854 | DOI:10.1007/s00726-024-03390-w (Source: Amino Acids)
Source: Amino Acids - March 20, 2024 Category: Biochemistry Authors: Prasenjit Manna Mahua Sinha Parames C Sil Source Type: research

An insight into role of amino acids as antioxidants via NRF2 activation
Amino Acids. 2024 Mar 20;56(1):23. doi: 10.1007/s00726-024-03384-8.ABSTRACTOxidative stress can affect the protein, lipids, and DNA of the cells and thus, play a crucial role in several pathophysiological conditions. It has already been established that oxidative stress has a close association with inflammation via nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway. Amino acids are notably the building block of proteins and constitute the major class of nitrogen-containing natural products of medicinal importance. They exhibit a broad spectrum of biological activities, including the ability to activate NR...
Source: Amino Acids - March 20, 2024 Category: Biochemistry Authors: Melford C Egbujor Olugbemi T Olaniyan Chigbundu N Emeruwa Sarmistha Saha Luciano Saso Paolo Tucci Source Type: research

Retraction Note: Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction
Amino Acids. 2024 Mar 20;56(1):24. doi: 10.1007/s00726-024-03390-w.NO ABSTRACTPMID:38506936 | DOI:10.1007/s00726-024-03390-w (Source: Amino Acids)
Source: Amino Acids - March 20, 2024 Category: Biochemistry Authors: Prasenjit Manna Mahua Sinha Parames C Sil Source Type: research

Targeted metabolomic analysis of serum amino acids in heart failure patients
In conclusion, this study cannot only provide clinicians with an objective diagnostic approach for the early identification of HF, but also enhances comprehension of the underlying mechanisms involved in the pathogenesis of HF.PMID:38483649 | PMC:PMC10940394 | DOI:10.1007/s00726-024-03385-7 (Source: Amino Acids)
Source: Amino Acids - March 14, 2024 Category: Biochemistry Authors: Chunjing Yang Zhengyuan Shi Li Bao Xiqiao Xv Dechun Jiang Longtai You Source Type: research

Targeted metabolomic analysis of serum amino acids in heart failure patients
In conclusion, this study cannot only provide clinicians with an objective diagnostic approach for the early identification of HF, but also enhances comprehension of the underlying mechanisms involved in the pathogenesis of HF.PMID:38483649 | PMC:PMC10940394 | DOI:10.1007/s00726-024-03385-7 (Source: Amino Acids)
Source: Amino Acids - March 14, 2024 Category: Biochemistry Authors: Chunjing Yang Zhengyuan Shi Li Bao Xiqiao Xv Dechun Jiang Longtai You Source Type: research

Targeted metabolomic analysis of serum amino acids in heart failure patients
In conclusion, this study cannot only provide clinicians with an objective diagnostic approach for the early identification of HF, but also enhances comprehension of the underlying mechanisms involved in the pathogenesis of HF.PMID:38483649 | PMC:PMC10940394 | DOI:10.1007/s00726-024-03385-7 (Source: Amino Acids)
Source: Amino Acids - March 14, 2024 Category: Biochemistry Authors: Chunjing Yang Zhengyuan Shi Li Bao Xiqiao Xv Dechun Jiang Longtai You Source Type: research

Targeted metabolomic analysis of serum amino acids in heart failure patients
In conclusion, this study cannot only provide clinicians with an objective diagnostic approach for the early identification of HF, but also enhances comprehension of the underlying mechanisms involved in the pathogenesis of HF.PMID:38483649 | PMC:PMC10940394 | DOI:10.1007/s00726-024-03385-7 (Source: Amino Acids)
Source: Amino Acids - March 14, 2024 Category: Biochemistry Authors: Chunjing Yang Zhengyuan Shi Li Bao Xiqiao Xv Dechun Jiang Longtai You Source Type: research

Targeted metabolomic analysis of serum amino acids in heart failure patients
In conclusion, this study cannot only provide clinicians with an objective diagnostic approach for the early identification of HF, but also enhances comprehension of the underlying mechanisms involved in the pathogenesis of HF.PMID:38483649 | DOI:10.1007/s00726-024-03385-7 (Source: Amino Acids)
Source: Amino Acids - March 14, 2024 Category: Biochemistry Authors: Chunjing Yang Zhengyuan Shi Li Bao Xiqiao Xv Dechun Jiang Longtai You Source Type: research

GC-MS analysis of 4-hydroxyproline: elevated proline hydroxylation in metformin-associated lactic acidosis and metformin-treated Becker muscular dystrophy patients
Amino Acids. 2024 Mar 10;56(1):21. doi: 10.1007/s00726-024-03383-9.ABSTRACTMetformin (N,N-dimethylbiguanide), an inhibitor of gluconeogenesis and insulin sensitizer, is widely used for the treatment of type 2 diabetes. In some patients with renal insufficiency, metformin can accumulate and cause lactic acidosis, known as metformin-associated lactic acidosis (MALA, defined as lactate ≥ 5 mM, pH < 7.35, and metformin concentration > 38.7 µM). Here, we report on the post-translational modification (PTM) of proline (Pro) to 4-hydroxyproline (OH-Pro) in metformin-associated lactic acidosis and in metformin-treated pati...
Source: Amino Acids - March 10, 2024 Category: Biochemistry Authors: Svetlana Baskal Rene A Posma Alexander Bollenbach Willem Dieperink Stephan J L Bakker Maarten W Nijsten Daan J Touw Dimitrios Tsikas Source Type: research