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Appropriate Evaluation and Treatment of Heart Failure Patients After Implantable Cardioverter-Defibrillator Discharge: Time to Go Beyond the Initial ShockEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multiple clinical trials support the use of implantable cardioverter-defibrillators (ICDs) for prevention of sudden cardiac death in patients with heart failure (HF). Unfortunately, several complicating issues have arisen from the universal use of ICDs in HF patients. An estimated 20% to 35% of HF patients who receive an ICD for primary prevention will experience an appropriate shock within 1 to 3 years of implant, and one-third of patients will experience an inappropriate shock. An ICD shock is associated with a 2- to 5-fold increase in mortality, with the most common cause being progressive HF. The median time from initi...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Joseph D. Mishkin, Sherry J. Saxonhouse, Gregory W. Woo, Thomas A. Burkart, William M. Miles, Jamie B. Conti, Richard S. Schofield, Samuel F. Sears, Juan M. Aranda Tags: State-of-the-Art Paper Source Type: journals

PACERONE (Amiodarone Hydrochloride) Tablet [Upsher-Smith Laboratories, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

Mortality and drug exposure in a 5-year cohort of patients with chronic liver disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Drug exposure in general was not associated with higher mortality except for a few categories. Mortality in patients with chronic liver disease was high and is associated with simple laboratory values. PMID: 19924579 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Hug BL, Lipsitz SR, Seger DL, Karson AS, Wright SC, Bates DW Tags: Swiss Med Wkly Source Type: journals

Impact of Implantable Cardioverter-Defibrillator, Amiodarone, and Placebo on the Mode of Death in Stable Patients With Heart Failure. Analysis From the Sudden Cardiac Death in Heart Failure Trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions-ICD therapy reduced cardiac mortality and sudden death presumed to be ventricular tachyarrhythmic in SCD-HeFT and had no effect on heart failure mortality. Amiodarone had no effect on all-cause mortality or its cause-specific components. Clinical Trial Registration Information-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00000609. PMID: 19917887 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - November 16, 2009 Category: Cardiology Authors: Packer DL, Prutkin JM, Hellkamp AS, Mitchell LB, Bernstein RC, Wood F, Boehmer JP, Carlson MD, Frantz RP, McNulty SE, Rogers JG, Anderson J, Johnson GW, Walsh MN, Poole JE, Mark DB, Lee KL, Bardy GH Tags: Circulation Source Type: journals

Review: Cardioversion of atrial fibrillation and the use of antiarrhythmic drugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Heart Area: News This review on the treatment of atrial fibrillation (AF) looks at the following: . Indications for cardioversion of AF . Anti-arrhythmic drugs used for cardioversion or prevention of AF recurrence (digoxin, beta-blockers, non-dihydropyridine calcium antagonists, quinidine, disopyramide, propafenone, procainamide, dofetilide, amiodarone, sotalol, flecainide, dronedarone) . Non-anti-arrhythmic agents . Optimal management of patients with AF requiring rhythm control The authors note that large RCTs have shown that a rhythm control strategy (using antiarrhythm...
Source: NeLM - Cardiovascular Medicine - November 12, 2009 Category: Cardiology Source Type: organizations

Ability of Amiodarone and Propranolol Alone or in Combination to Prevent Post-coronary Bypass Atrial FibrillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atrial fibrillation (AF) is the most common arrhythmia in coronary artery bypass grafting (CABG) patients. The purpose of this study was to determine the best prophylaxis for AF prior to CABG. In this double-blind randomized study, 240 consecutive patients underwent elective CABG. They were then divided randomly into three groups to receive propranolol (n = 80), amiodarone (n = 80), or both drugs (n = 80). All groups received their medications from preoperative day 7 to post-CABG day 5. The patients were well matched for age, sex, risk factors, comorbidities, ejection fraction, and cardioplegic technique. Post-CABG AF deve...
Source: Cardiovascular Therapeutics - November 9, 2009 Category: Cardiology Authors: Javad Kojuri, Yadollah Mahmoodi, Mansoor Jannati, Masih Shafa, Mohammad Ghazinoor, Mahammad Bagher Sharifkazemi Tags: RESEARCH Source Type: journals

Implementation of an amiodarone ambulatory care clinic.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19890081 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 7, 2009 Category: Drugs & Pharmacology Authors: Tafreshi J, Chui MA, Riley AB Tags: Am J Health Syst Pharm Source Type: journals

Prescriber compliance with black box warnings in older adult patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Administrative claims analysis identified low rates of prescriber compliance with BBWs in managing patients age >or=65 years. Claims analysis may be a cost-effective strategy to monitor prescriber compliance with BBWs in older patients at higher risk. PMID: 19895180 [PubMed - in process] (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - November 1, 2009 Category: Health Management Authors: Ricci JR, Coulen C, Berger JE, Moore MC, McQueen A, Jan SA Tags: Am J Manag Care Source Type: journals

Amiodarone: Hepatotoxicity in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Amiodarone use in therapeutic hypothermia following cardiac arrest due to ventricular tachycardia and ventricular fibrillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Europace)
Source: Europace - October 30, 2009 Category: Cardiology Authors: Khan, J. N., Prasad, N., Glancy, J. Tags: LETTERS TO THE EDITOR Source Type: journals

Dofetilide is safe and effective in preventing atrial fibrillation recurrences in patients accepted for catheter ablationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Dofetilide appears safe and effective in preventing AF in patients refractory to other AADs undergoing catheter ablation. (Source: Europace)
Source: Europace - October 30, 2009 Category: Cardiology Authors: Shamiss, Y., Khaykin, Y., Oosthuizen, R., Tunney, D., Sarak, B., Beardsall, M., Seabrook, C., Frost, L., Wulffhart, Z., Tsang, B., Verma, A. Tags: Ablation for Atrial Fibrillation Source Type: journals

Arrhythmic death in implantable cardioverter defibrillator patients: a long-term study over a 10 year implantation periodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In this unselected group of ICD recipients, at least 16% of patients died from arrhythmic causes. Risk factors associated with arrhythmic mortality were a history of spontaneous or inducible VT, higher NYHA class, and amiodarone use. (Source: Europace)
Source: Europace - October 30, 2009 Category: Cardiology Authors: Duray, G. Z., Schmitt, J., Richter, S., Israel, C. W., Hohnloser, S. H. Tags: ICD Source Type: journals

CORDARONE (Amiodarone Hydrochloride) Tablet [Wyeth Pharmaceuticals Company]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

Life-Threatening Cardiac Toxicity After Chewing Inverted Nut (Pinang-Wang)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 51-year-old man collapsed after chewing a pinang-wang due to curiosity. He was transported to our emergency department (ED) presenting with out-of-hospital cardiac arrest. Quick paddle look showed ventricular fibrillation and the patient received repetitive defibrillation, epinephrine, vasopressin, amiodarone, lidocaine and magnesium sulphate. After 20 minutes, it changed to wide QRS complex tachycardia. Intravenous sodium bicarbonate (1 mEq/kg, total dose: 70 mEq) was administered and the arrhythmia was successfully terminated. His blood pressure increased to 126/71 mmHg. Electrocardiogram showed ST segment elevation ov...
Source: Annals of Emergency Medicine - October 27, 2009 Category: Emergency Medicine Authors: Chun-Jen Chou, Ho-Ming Su, Hei-Hwa Lee, Ying-Chin Ko, Ping-Ho Chen, Bai-Hsiun Chen Tags: Correspondence Source Type: journals

Amiodarone: Hypothyroidism in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 26, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Risk prediction by heart rate turbulence and deceleration capacity in postinfarction patients with preserved left ventricular function retrospective analysis of 4 independent trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In postinfarction patients with preserved left ventricular function, SAF identifies a subgroup with increased mortality risk equivalent to patients with LVEF of 30% or less. (Source: Journal of Electrocardiology)
Source: Journal of Electrocardiology - October 24, 2009 Category: Cardiology Authors: Axel Bauer, Petra Barthel, Alexander Müller, Kurt Ulm, Heikki Huikuri, Marek Malik, Georg Schmidt Tags: Session VII: Heart Rate Dynamics, Turbulence, Deceleration Capacity - Co-Chairs: Georg Schmidt/Dirk Field Source Type: journals

Effect of tecarfarin, a novel vitamin K epoxide reductase inhibitor, on coagulation in beagle dogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions and implications: Overall, the data presented herein indicate that tecarfarin, via a vitamin K-dependent mechanism, causes changes in key parameters of haemostasis in beagle dogs that are consistent with effective anticoagulation. Compared to warfarin it has a decreased potential to interact metabolically with drugs that inhibit CYP450 enzymes and, therefore, may offer an improved safety profile for patients. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 19, 2009 Category: Drugs & Pharmacology Authors: A Choppin, I Irwin, L Lach, MG McDonald, AE Rettie, L Shao, C Becker, MP Palme, X Paliard, S Bowersox, DM Dennis, P Druzgala Source Type: journals

ACP Journal Club. Review: Amiodarone reduces risk for sudden cardiac death but not all-cause mortality in cardiomyopathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19841450 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - October 19, 2009 Category: Internal Medicine Authors: Homoud MK Tags: Ann Intern Med Source Type: journals

Cardiovascular safety in treatment of bronchial asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nowadays interdisciplinary problems become more and more important in medicine. Most, if not all the patients in real world are treated not on one isolated disease but two or more serious concomitant diseases. Therefore, it happens more and more often that medications used in treatment of one disease have adverse effects or are even harmful in the treatment of another disease. In the patients with cardiovascular and respiratory diseases medications acting on beta receptors are problematic. It is known that b-blockers, one of the main group of cardiac drugs, have beneficial effects on the heart but might cause bronchospasm ...
Source: Articles of Advances in Dermatology and Allergology - TERMEDIA publishing house - October 19, 2009 Category: Dermatology Source Type: journals

Amiodarone: Hypothyroidism leading to renal failure in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Drug-Induced Steatohepatitis Leading to Cirrhosis: Long-Term Toxicity of Amiodarone UseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Semin Liver Dis 2009; 29: 423-428DOI: 10.1055/s-0029-1240011ABSTRACTNonalcoholic steatosis/steatohepatitis is the most common cause for abnormal liver chemistries. Apart from metabolic syndrome, drugs may also lead to development of steatohepatitis that may, rarely, progress to cirrhosis and portal hypertension. We discuss a case of amiodarone-induced steatohepatitis with advanced fibrosis, presenting with hepatic decompensation and portal hypertension manifesting as ascites and recurrent esophageal variceal hemorrhage. Amiodarone is a lipophilic drug that concentrates in the liver and usually, over a period of time, leads...
Source: Seminars in Liver Disease - October 14, 2009 Category: Gastroenterology Tags: DIAGNOSTIC PROBLEMS IN HEPATOLOGY Source Type: journals

Amiodarone: Cirrhosis in elderly patients: 2 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 12, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Vanoxerine: Cellular Mechanism of a New AntiarrhythmicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Vanoxerine (1) is a potent blocker of cardiac hERG, Na and Ca channels; (2) block is strongly frequency-dependent especially for Na and Ca channels; and (3) transmural dispersion of ventricular repolarization is unaffected. The multichannel block and repolarization uniformity resemble the effects of amiodarone, the exemplar atrial fibrillation drug. Vanoxerine is a completely different chemical and has none of amiodarone's toxic effects. Vanoxerine has characteristics of a potentially effective and safe antiarrhythmic. (J Cardiovasc Electrophysiol, Vol. pp. 1[ndash]10) (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - October 7, 2009 Category: Cardiology Authors: ANTONIO E. LACERDA, YURI A. KURYSHEV, GAN-XIN YAN, ALBERT L. WALDO, ARTHUR M. BROWN Source Type: journals

Age-Related Increase in Atrial Fibrillation Induced by Transvenous Catheter-Based Atrial Burst Pacing: An In Vivo Rat Model of Inducible Atrial FibrillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Transvenous catheter-based AF is significantly longer in middle-aged than in young rats and is markedly reduced by treatment with antiarrhythmic drugs. This rat model of AF is simple, reproducible, and reliable for examining pharmacologic effects on AF and studying the process of atrial remodeling. (J Cardiovasc Electrophysiol, Vol. pp. 1[ndash]6) (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - October 7, 2009 Category: Cardiology Authors: DONGZHU XU, NOBUYUKI MURAKOSHI, HIROSHI TADA, MIYAKO IGARASHI, YUKIO SEKIGUCHI, KAZUTAKA AONUMA Source Type: journals

Cardiovascular Drugs Inducing QT Prolongation: Facts and Evidence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acquired QT syndrome is mainly caused by the administration of drugs that prolong ventricular repolarization. On the other hand, the risk of drug-induced torsades de pointes is increased by numerous predisposing factors, such as genetic predisposition, female sex, hypokalemia and cardiac dysfunction. This adverse reaction is induced by different chemical compounds used for the treatment of a variety of pathologies, including arrhythmias. As it is known, antiarrhythmic agents and other cardiovascular drugs can prolong the QT interval, causing this adverse reaction. Of the 20 most commonly reported drugs, 10 were cardiov...
Source: Current Drug Safety - October 6, 2009 Category: Drugs & Pharmacology Authors: Taira CA, Opezzo JA, Mayer MA, Höcht C Tags: Curr Drug Saf Source Type: journals

Amiodarone/ciprofloxacin/clarithromycin interaction: Prolonged QT interval and ventricular tachycardia in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Evaluation of the Effects of PM101, a Cyclodextrin-Based Formulation of Intravenous Amiodarone, on Blood Pressure in Healthy HumansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the results of this study demonstrate that PM101 is devoid of hypotension in healthy human subjects. The absence of a hypotensive effect of AIV in this population suggests that further evaluation is needed in a patient population with cardiac disease. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - October 5, 2009 Category: Cardiology Authors: Daniel J. Cushing, Michael P. Adams, Warren D. Cooper, Bing Zhang, Raymond J. Lipicky, Peter R. Kowey Tags: Cardiovascular Pharmacology Source Type: journals

Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Leishmaniasis is parasitic disease that is an important problem of public health worldwide. Intramuscular-administered glucantime and pentostam are the most common drugs used for treatment of this disease, but they have significant limitations due to toxicity and increasing resistance. A recent breakthrough has been the introduction of orally administered miltefosine for the treatment of visceral, cutaneous and muco-cutaneous leishmaniasis, but the relative high cost and concerns about teratogenicity have limited the use of this drug. Searching for alternative drugs, we have previously demonstrated that the antiarrhyth...
Source: Antimicrobial Agents and Chemotherapy - October 4, 2009 Category: Microbiology Authors: Serrano-Martín X, Payares G, De Lucca M, Martinez JC, Mendoza-León A, Benaim G Tags: Antimicrob Agents Chemother Source Type: journals

Amiodarone: Organising pneumonia and sinus arrest in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 30, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

The hypotensive effect of intravenous amiodarone is sustained throughout the maintenance infusion period.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY 1. Hypotension frequently occurs with use of intravenous amiodarone and is managed by slowing the rate of administration. This response has been attributed to the cosolvents in the formulation and is believed to be solely related to the initial loading dose. The present study was performed to determine whether intravenous amiodarone-induced hypotension persists beyond the loading dose and into the maintenance infusion period and also whether hypotension occurs with maintenance level dosing alone. 2. Anesthetized beagle dogs (n=7/group) were instrumented to assess hemodynamics. Animals were treated with the huma...
Source: Clinical and Experimental Pharmacology and Physiology - September 27, 2009 Category: Drugs & Pharmacology Authors: Cushing DJ, Cooper WD, Gralinski MR, Lipicky RJ Tags: Clin Exp Pharmacol Physiol Source Type: journals

Prediction of phospholipidosis-inducing potential of drugs by in vitro biochemical and physicochemical assays followed by multivariate analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An in vitro method to predict phospholipidosis-inducing potential of cationic amphiphilic drugs (CADs) was developed using biochemical and physicochemical assays. The following parameters were applied to principal component analysis, as well as physicochemical parameters: pKa and clogP; dissociation constant of CADs from phospholipid, inhibition of enzymatic phospholipid degradation, and metabolic stability of CADs. In the score plot, phospholipidosis-inducing drugs (amiodarone, propranolol, imipramine, chloroquine) were plotted locally forming the subspace for positive CADs; while non-inducing drugs (chlorpromazine, c...
Source: Toxicology in Vitro - September 24, 2009 Category: Toxicology Authors: Kuroda Y, Saito M Tags: Toxicol In Vitro Source Type: journals

Long QT syndrome and torsades de pointes induced by acute sulpiride poisoningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of long QT syndrome and torsades de pointes induced by ingestion of 1.5 g of sulpiride. Ventricular arrhythmia was initially treated with amiodarone, without success. Eventually, lidocaine and magnesium sulfate successfully terminated the ventricular arrhythmia. The patient was discharged uneventfully after 3 days of hospitalization. This case illustrates the fact that acute sulpiride poisoning may lead to life-threatening ventricular arrhythmia. Early recognition followed by effective therapy is crucial. Intensive cardiac monitoring is recommended for sulpiride poisoning. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - September 24, 2009 Category: Emergency Medicine Authors: Jia-How Chang, Te-I Weng, Cheng-Chung Fang Tags: Case Reports Source Type: journals

The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodaroneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to investigate acute effects of the class III antiarrhythmic drug amiodarone on human K2P3.1 channels. Potassium currents were recorded from Xenopus oocytes using the two-microelectrode voltage clamp technique. Amiodarone produced concentration-dependent inhibition of hK2P3.1 currents (IC50 = 0.40 µM) with maximum current reduction of 58.1%. Open rectification properties that are characteristic to hK2P3.1 currents were not altered by amiodarone. Channels were blocked in open and closed states in reverse frequency-dependent manner. hK2P3.1 channel inhibition was voltage-independen...
Source: Naunyn-Schmiedeberg's Archives of Pharmacology - September 24, 2009 Category: Drugs & Pharmacology Tags: Naunyn-Schmiedeberg's Archives of Pharmacology Source Type: journals

Treatment of new-onset atrial fibrillation in noncardiac intensive care unit patients: a systematic review of randomized controlled trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: The authors found insufficient evidence to make recommendations about standard treatment of noncardiac critically ill patients with new-onset atrial fibrillation. Despite some concerns about the risk of language and publication bias, this was generally a well-conducted review and the authors' conclusions were likely to be reliable. [The included studies compared procainamide, flecainide, magnesium, amiodarone, verapamil, diltiazem and esmolol with each other. ] CRD Commentary: The review question was clearly stated and inclusion criteria were specifie...
Source: NeLM - Cardiovascular Medicine - September 23, 2009 Category: Cardiology Source Type: organizations

Mixed Start to Planned MARVEL Trial of Post-MI Autologous Skeletal-Myoblast TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A pilot analysis suggests the cell therapy can improve functional capacity, but amiodarone may be needed to prevent ventricular arrhythmias; its investigators say they plan to switch gears on the remainder of the study. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 23, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Avloclor (chloroquine) Tablets - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.5 (interactions) has been updated. This section now contains the following information: If the patient is taking amiodarone then chloroquine and hydroxychloroquine may increase the risk of cardiac arrhythmias including ventricular arrhythmias, bradycardias and cardiac conduction defect. Concurrent use is contraindicated. Antacids (aluminium, calcium and magnesium salts) and adsorbents (e.g. kaolin) may reduce the absorption of chloroquine, so should be taken well separated from Avloclor (at least four hours apart). (Sou...
Source: NeLM - SPC Changes - September 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

Systematic review: Dronedarone vs. amiodarone for maintenance of sinus rhythm in patients with atrial fibrillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: J Am Coll Cardiol Area: News The efficacy and safety of dronedarone, a non-iodinated amiodarone congener, for the prevention of recurrent atrial fibrillation (AF) has been compared with that of amiodarone in a systematic review published in the J of the American College of Cardiology. The researchers identified 4 placebo-controlled trials of dronedarone, 4 placebo-controlled trials of amiodarone, and 1 trial of dronedarone versus amiodarone. The effect of amiodarone vs. dronedarone was summarised by the use of indirect comparison meta-analysis and normal logistic meta-regression models. The following fi...
Source: NeLM - Cardiovascular Medicine - September 17, 2009 Category: Cardiology Source Type: organizations

Dronedarone may reduce stroke risk in patients with AFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Circulation Area: News A post-hoc analysis of a controlled trial suggests that dronedarone may reduce the risk of stroke in patients with atrial fibrillation (AF), and thus controlled trials to investigate this are warranted. Patients with AF are at increased risk for stroke and are often treated with anti-thrombotic agents to reduce this risk. Studies with older anti-arrhythmic drugs have not shown any significant reduction in stroke risk despite reductions in arrhythmias. Dronedarone is a new drug related to amiodarone, and in the ATHENA trial was shown to reduce adverse cardiovascular outcomes compar...
Source: NeLM - Cardiovascular Medicine - September 16, 2009 Category: Cardiology Source Type: organizations

Dronedarone in Atrial Fib Trades Efficacy for Safety in Meta-AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The finding, based on eight randomized trials, supports the view that dronedarone is less effective than amiodarone at preventing the arrhythmia's recurrence but doesn't have the older drug's serious toxicities, as suggested by the DIONYSOS trial. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 14, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Comparative amiodarone, dronedarone benefits in AF remain uncertainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Indirect comparative meta-analysis results indicate that amiodarone is more effective than dronedarone for maintenance of sinus rhythm in patients with atrial fibrillation, but is associated with more adverse effects. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - September 12, 2009 Category: Cardiology Source Type: news

Dronedarone in atrial fib trades efficacy for safety in meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The finding, based on eight randomized trials, supports the view that dronedarone is less effective than amiodarone at preventing the arrhythmia's recurrence but doesn't have the older drug's serious toxicities, as suggested by the DIONYSOS trial. (Source: theHeart.org)
Source: theHeart.org - September 11, 2009 Category: Cardiology Source Type: info

Cut-off values and significance of Oil Red O-positive cells in bronchoalveolar lavage fluidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Significantly increased numbers of ORO-PM were associated with various lung pathologies. However, the higher numbers observed in HIV patients require further investigations. (Source: Cytopathology)
Source: Cytopathology - September 10, 2009 Category: Pathology Authors: C. Basset-Léobon, L. Lacoste-Collin, J. Aziza, J. C. Bes, S. Jozan, M. Courtade-Saïdi Source Type: journals

Comparative Efficacy of Dronedarone and Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial FibrillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Dronedarone is less effective than amiodarone for the maintenance of sinus rhythm, but has fewer adverse effects. For every 1,000 patients treated with dronedarone instead of amiodarone, we estimate approximately 228 more recurrences of AF in exchange for 9.6 fewer deaths and 62 fewer adverse events requiring discontinuation of drug. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - September 9, 2009 Category: Cardiology Authors: Jonathan P. Piccini, Vic Hasselblad, Eric D. Peterson, Jeffrey B. Washam, Robert M. Califf, David F. Kong Tags: Heart Rhythm Disorders Source Type: journals

Amiodarone or Dronedarone for Atrial Fibrillation: Too Early to Know the Winner?⁎Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atrial fibrillation (AF) is estimated to affect >10 million patients by 2050 in the U.S. () and is associated with significant rates of morbidity and an increased risk of mortality. Health care costs due to AF are enormous at >$2 billion annually. Restoration of sinus rhythm in patients with AF has been demonstrated to improve left ventricular ejection fraction, left atrial size, and quality of life both in patients with congestive heart failure and normal ejection fraction, even when optimal ventricular rate control during AF has been achieved (). Furthermore, many patients with AF are troubled by symptoms that persist de...
Source: Journal of the American College of Cardiology - September 9, 2009 Category: Cardiology Authors: Paul S. Chan, Brahmajee K. Nallamothu, Hakan Oral Tags: Heart Rhythm Disorders: Editorial Comment Source Type: journals

The role of negatively charged lipids in lysosomal phospholipase A2 function [Research Articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lysosomal phospholipase A2 (LPLA2) is characterized by increased activity toward zwitterionic phospholipid liposomes containing negatively charged lipids under acidic conditions. The effect of anionic lipids on LPLA2 activity was investigated. Mouse LPLA2 activity was assayed as C2-ceramide transacylation. Sulfatide incorporated into liposomes enhanced LPLA2 activity under acidic conditions and was weakened by NaCl or increased pH. Amiodarone, a cationic amphiphilic drug, reduced LPLA2 activity. LPLA2 exhibited esterase activity when p-nitro-phenylbutyrate (pNPB) was used as a substrate. Unlike the phospholipase A2 activit...
Source: The Journal of Lipid Research - September 7, 2009 Category: Lipidology Authors: Abe, A., Shayman, J. A. Tags: Research Articles Source Type: journals

Journal Scan: Comparative Efficacy of Dronedarone and Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation (J Am Coll Cardiol 2009;54:1089-1095.)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All randomized clinical trials (RCTs) that compared amiodarone or dronedarone to a placebo or amiodarone to dronedarone in patients with AF were subjected to meta-analysis. Indirect comparison meta-analysis was performed to compare amiodarone to dronedarone. (Source: Cardiosource)
Source: Cardiosource - September 7, 2009 Category: Cardiology Source Type: organizations

Association of Polymorphism at Position 49 in Exon 1 of the Cytotoxic T-Lymphocyte-Associated Factor 4 Gene with Graves' Disease Refractory to Medical Treatment, but Not with Amiodarone-Associated Thyroid DysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thyroid Sep 2009, Vol. 19, No. 9: 975-981. (Source: Thyroid)
Source: Thyroid - September 4, 2009 Category: Endocrinology Tags: article Source Type: journals

Effects of Intravenous Nifekalant as a Lifesaving Drug for Severe Ventricular Tachyarrhythmias Complicating Acute Coronary Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: An intravenous bolus injection and subsequent continuous infusion of NIF at a relatively low dosage were effective in treating severe ventricular tachyarrhythmias complicating ACS, reducing the potential risk of proarrhythmia. PMID: 19724153 [PubMed - as supplied by publisher] (Source: Circulation Journal)
Source: Circulation Journal - September 1, 2009 Category: Cardiology Authors: Yusu S, Ikeda T, Mera H, Miyakoshi M, Miwa Y, Abe A, Tsukada T, Ishiguro H, Shimizu H, Yoshino H Tags: Circ J Source Type: journals

AMIODARONE HYDROCHLORIDEtablet [TEVA Pharmaceuticals USA Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 1, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 1, 2009 Category: Drugs & Pharmacology Source Type: organizations

Med Sci Monit 2009; 15(9):CR494-498 "Statins and amiodarone improve freedom from recurrence of atrial fibrillation after successful cardioversion"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study shows that adding statins to amiodarone significantly decreases the recurrence rate of AF after successful EC in patients with persistent AF. Our findings urge for prospective randomized studies to be performed in order to confirm these results and elucidate the role of statins in AF prevention. (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 31, 2009 Category: Research Tags: Original article Source Type: journals