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Second-line treatments of advanced non-small-cell lung cancer: new evidence for clinical practice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19920059 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 17, 2009 Category: Cancer & Oncology Authors: Tassinari D, Drudi F, Lazzari-Agli L, Tombesi P, Sartori S Tags: Ann Oncol Source Type: journals

Prognostic models for diffuse large B-cell lymphoma in the rituximab era: a never-ending story.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A new model on the basis of significant variables in the rituximab era and built on a large database of patients treated with rituximab is urgently needed. As prognostic models are changing with the efficacy and mechanisms of action of treatment utilized, looking for a new prognostic score is a never-ending story in which researchers are trying to hit a continuously moving target. PMID: 19920060 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 17, 2009 Category: Cancer & Oncology Authors: Bari A, Marcheselli L, Sacchi S, Marcheselli R, Pozzi S, Ferri P, Balleari E, Musto P, Neri S, Aloe Spiriti MA, Cox MC Tags: Ann Oncol Source Type: journals

Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The regimen of docetaxel and PI-88 is active in CRPC but associated with significant haematologic toxicity. Further evaluation of different scheduling and dosing of PI-88 and docetaxel may be warranted to optimise efficacy with a more manageable safety profile. PMID: 19917571 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 16, 2009 Category: Cancer & Oncology Authors: Khasraw M, Pavlakis N, McCowatt S, Underhill C, Begbie S, de Souza P, Boyce A, Parnis F, Lim V, Harvie R, Marx G Tags: Ann Oncol Source Type: journals

Long-term follow-up of an age-adapted C5R protocol followed by radiotherapy in 99 newly diagnosed primary CNS lymphomas: a prospective multicentric phase II study of the Groupe d'Etude des Lymphomes de l'Adulte (GELA).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The C5R protocol was feasible in the multicentric setting with favorable long-term survival in patients younger than 60 years. Despite dose adaptation, results in older patients were disappointing. PMID: 19914958 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 13, 2009 Category: Cancer & Oncology Authors: Ghesquières H, Ferlay C, Sebban C, Perol D, Bosly A, Casasnovas O, Reman O, Coiffier B, Tilly H, Morel P, Van den Neste E, Colin P, Haioun C, Biron P, Blay JY Tags: Ann Oncol Source Type: journals

Phase II trial of single-agent oral vinorelbine in elderly (>=70 years) patients with advanced non-small-cell lung cancer and poor performance status.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Single-agent oral vinorelbine is extremely safe in elderly patients with advanced NSCLC and ECOG PS of two or more and may represent a valid option in this very special population. PMID: 19914959 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 13, 2009 Category: Cancer & Oncology Authors: Camerini A, Valsuani C, Mazzoni F, Siclari O, Puccetti C, Donati S, Rondini M, Tartarelli G, Puccinelli P, Di Costanzo F, Amoroso D Tags: Ann Oncol Source Type: journals

Prognostic value of 18F-FDG PET/CT before and after radiotherapy for locally advanced nasopharyngeal carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: (18)F-FDG uptake, as measured by the SUV(max) before radiotherapy and metabolic response after radiotherapy, may predict the prognosis in locally advanced NPC. High (18)F-FDG uptake before and after radiotherapy may be useful for identifying patients requiring more aggressive treatment. PMID: 19914960 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 13, 2009 Category: Cancer & Oncology Authors: Xie P, Yue JB, Fu Z, Feng R, Yu JM Tags: Ann Oncol Source Type: journals

Long-term follow-up of chemonaive patients with asymptomatic metastatic colorectal cancer treated with enzastaurin in a window of opportunity phase II study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19914961 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 13, 2009 Category: Cancer & Oncology Authors: Glimelius B, Spindler KL, Frödin JE, Berglund A, Byström P, Qvortrup C, Jakobsen A, Pfeiffer P Tags: Ann Oncol Source Type: journals

Absence of transforming growth factor-{beta} type II receptor is associated with poorer prognosis in HER2-negative breast tumours.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: To the best of our knowledge, this is the first report indicating the relevance of HER2 status in discriminating TGF-betaRII as a prognostic marker for DFS and OS in human BC. These data indicate that TGF-betaRII protein analysis in tumour cells could be introduced in clinical practice as additional prognostic biomarker in HER2-negative BC. PMID: 19914962 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 13, 2009 Category: Cancer & Oncology Authors: Paiva CE, Drigo SA, Rosa FE, Moraes Neto FA, Caldeira JR, Soares FA, Domingues MA, Rogatto SR Tags: Ann Oncol Source Type: journals

Hodgkin's lymphoma in remission after first-line therapy: which patients need FDG-PET/CT for follow-up?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Asymptomatic patients without morphological residues and an early stage of disease do not need a routine FDG-PET/CT for follow-up. Asymptomatic patients with morphological residues should receive routine follow-up FDG-PET/CT for the first 24 months. Only patients with advanced initial stage do need a routine follow-up FDG-PET/CT beyond 24 months. PMID: 19914963 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 13, 2009 Category: Cancer & Oncology Authors: Petrausch U, Samaras P, Veit-Haibach P, Tschopp A, Soyka JD, Knuth A, Hany TF, Mischo A, Renner C, Schaefer NG Tags: Ann Oncol Source Type: journals

Ann Oncol; +34 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
34 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2009/11/11PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Ann Oncol)
Source: Ann Oncol - November 11, 2009 Category: Cancer & Oncology Tags: Report Source Type: journals

Ann Oncol; +26 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2009/11/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Ann Oncol)
Source: Ann Oncol - November 7, 2009 Category: Cancer & Oncology Tags: Report Source Type: journals

Statin-independent prognosis of patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results indicate that statins do not influence the clinical prognosis of DLBCL treated with RCHOP. Further studies with larger numbers of patients are warranted to confirm the prognostic significance of statins for patients with DLBCL receiving rituximab-containing chemotherapy. PMID: 19884246 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 2, 2009 Category: Cancer & Oncology Authors: Ennishi D, Asai H, Maeda Y, Shinagawa K, Ikeda K, Yokoyama M, Terui Y, Takeuchi K, Yoshino T, Matsuo K, Hatake K, Tanimoto M Tags: Ann Oncol Source Type: journals

Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19884247 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 2, 2009 Category: Cancer & Oncology Authors: Martin-Castillo B, Dorca J, Vazquez-Martin A, Oliveras-Ferraros C, Lopez-Bonet E, Garcia M, Del Barco S, Menendez JA Tags: Ann Oncol Source Type: journals

Where is the future of endometrial cancer therapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19861581 [PubMed - in process] (Source: Ann Oncol)
Source: Ann Oncol - October 29, 2009 Category: Cancer & Oncology Authors: McMeekin DS Tags: Ann Oncol Source Type: journals

Incidence and risk factors for central nervous system relapse in patients with diffuse large B-cell lymphoma: the impact of the addition of rituximab to CHOP chemotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The use of R-CHOP appears to reduce the overall risk of CNS relapse in patients with DLBCL particularly in patients who achieve a complete response. PMID: 19861575 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 27, 2009 Category: Cancer & Oncology Authors: Villa D, Connors JM, Shenkier TN, Gascoyne RD, Sehn LH, Savage KJ Tags: Ann Oncol Source Type: journals

Aromatase inhibition in male breast cancer patients: biological and clinical implications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: AIs are active in MBC patients. This activity is correlated with a significant reduction in E(2) levels. Secondary resistance is in part related to a deleterious feedback loop resulting in a significant increase in substrate for aromatization. PMID: 19861576 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 27, 2009 Category: Cancer & Oncology Authors: Doyen J, Italiano A, Largillier R, Ferrero JM, Fontana X, Thyss A Tags: Ann Oncol Source Type: journals

Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The CTC count before and during treatment independently predicts PFS and OS in ACC patients treated with chemotherapy plus targeted agents and provides additional information to CT imaging. PMID: 19861577 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 27, 2009 Category: Cancer & Oncology Authors: Tol J, Koopman M, Miller MC, Tibbe A, Cats A, Creemers GJ, Vos AH, Nagtegaal ID, Terstappen LW, Punt CJ Tags: Ann Oncol Source Type: journals

MACOP-B regimen in the treatment of adult Langerhans cell histiocytosis: experience on seven patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: MACOP-B regimen seems to be very active in the treatment of adult MS or SS-m LCH, with long-lasting responses in five of seven patients. PET scan merits further evaluation in the initial staging and in the evaluation of the response to chemotherapy. PMID: 19861578 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 27, 2009 Category: Cancer & Oncology Authors: Derenzini E, Fina MP, Stefoni V, Pellegrini C, Venturini F, Broccoli A, Gandolfi L, Pileri S, Fanti S, Lopci E, Castellucci P, Agostinelli C, Baccarani M, Zinzani PL Tags: Ann Oncol Source Type: journals

Outcomes after repeated resection for recurrent pulmonary metastases from colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Repeated resection after initial metastasectomy can be carried out safely and provides long-term survival in patients with recurrent pulmonary metastasis from colorectal cancer. Our findings indicate that close follow-up for the early detection of recurrence and parenchyma-saving resection can improve the results after repeated resection. PMID: 19861579 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 27, 2009 Category: Cancer & Oncology Authors: Park JS, Kim HK, Choi YS, Kim K, Shim YM, Jo J, Lee WY, Chun HK, Park YS, Kang WK, Kim J Tags: Ann Oncol Source Type: journals

The impact of carcinoembryonic antigen flare in patients with advanced colorectal cancer receiving first-line chemotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Compared with patients with rising CEA, flare was an independent favourable predictive and prognostic factor for tumour response and survival. PMID: 19861580 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 27, 2009 Category: Cancer & Oncology Authors: Strimpakos AS, Cunningham D, Mikropoulos C, Petkar I, Barbachano Y, Chau I Tags: Ann Oncol Source Type: journals

Acute aortic dissection during sorafenib-containing therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19858082 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Serrano C, Suárez C, Andreu J, Carles J Tags: Ann Oncol Source Type: journals

Management of occult invasive cervical cancer found after simple hysterectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although RP and RT/CCRT had similar therapeutic efficacy, the lower rate of late complications observed with RP makes it preferable to RT/CCRT. PMID: 19858083 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Park JY, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH Tags: Ann Oncol Source Type: journals

Subcutaneous 'lipoma-like' B-cell lymphoma associated with HCV infection: a new presentation of primary extranodal marginal zone B-cell lymphoma of MALT.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our observations expand the spectrum of HCV-associated lymphomas to include a subset of extranodal MZL characterized by a novel primary 'lipoma-like' subcutaneous presentation and indolent clinical course. PMID: 19858084 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Paulli M, Arcaini L, Lucioni M, Boveri E, Capello D, Passamonti F, Merli M, Rattotti S, Rossi D, Riboni R, Berti E, Magrini U, Bruno R, Gaidano G, Lazzarino M Tags: Ann Oncol Source Type: journals

Characteristics of cancer patients using homeopathy compared with those in conventional care: a cross-sectional study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Homeopathic treatment is sought by cancer patients at a different phase during the course of the disease, which has particular implications for research. However, expectancies toward the benefit of the treatment as well as QoL data are similar. PMID: 19858085 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Guethlin C, Walach H, Naumann J, Bartsch HH, Rostock M Tags: Ann Oncol Source Type: journals

Increasing incidence rates of soft tissue sarcomas? A population-based epidemiologic study and literature review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study has analyzed the most recent data from a European population in comparison with seven international studies. An increase, as postulated elsewhere, could not be confirmed. The incidence rate of STS in Austria ranges in the lower half of the international incidence rates (1.8-5.0 per 100 000 per year). Different inclusion criteria (Kaposi's sarcoma and dermatofibrosarcoma) and classifications in the various studies explain the increase of incidence in some studies rather than true increase of STS due to new or accumulated risk factors. PMID: 19858086 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Wibmer C, Leithner A, Zielonke N, Sperl M, Windhager R Tags: Ann Oncol Source Type: journals

Low-dose tamoxifen in the treatment of breast ductal intraepithelial neoplasia: results of a large observational study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: High ER and especially high PgR expression is a significant adverse prognostic indicator of DIN, and low-dose tamoxifen appears to be an active treatment. Women with low-expression ER or PgR DIN do not seem to benefit from tamoxifen. A definitive clinical trial is warranted. PMID: 19858087 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Guerrieri-Gonzaga A, Botteri E, Lazzeroni M, Rotmensz N, Goldhirsch A, Varricchio C, Serrano D, Cazzaniga M, Bassi F, Luini A, Bagnardi V, Viale G, Mora S, Bollani G, Albertazzi E, Bonanni B, Decensi A Tags: Ann Oncol Source Type: journals

Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A significant number of patients show discordant quantitative expression of molecular markers between primary and nodal disease. Appropriately measured, lymph node receptor status could be a more accurate measurement for guiding adjuvant therapy, which requires testing in a clinical trial. PMID: 19858088 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Aitken SJ, Thomas JS, Langdon SP, Harrison DJ, Faratian D Tags: Ann Oncol Source Type: journals

Reversibility of capillary density after discontinuation of bevacizumab treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Bevacizumab-induced decrease in capillary density is reversible. Noninvasive assessment of capillary density during treatment with antiangiogenic drugs may be useful as a marker of treatment efficacy. PMID: 19854721 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 23, 2009 Category: Cancer & Oncology Authors: Steeghs N, Rabelink TJ, Op 't Roodt J, Batman E, Cluitmans FH, Weijl NI, de Koning E, Gelderblom H Tags: Ann Oncol Source Type: journals

A phase II trial of capecitabine and docetaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (FEC) as preoperative treatment in women with stage II/III breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These data indicate that the sequential combination of XT followed by FEC is a well-tolerated, effective neoadjuvant treatment of stage II/III breast cancer. PMID: 19854722 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 23, 2009 Category: Cancer & Oncology Authors: Jinno H, Sakata M, Hayashida T, Takahashi M, Mukai M, Ikeda T, Kitagawa Y Tags: Ann Oncol Source Type: journals

EGF61A>G polymorphism as predictive marker of clinical outcome to first-line capecitabine and oxaliplatin in metastatic colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Polymorphism analysis of a simple blood sample is a feasible approach to biomarker analysis and the EGF61A>G polymorphism may influence the effect of first-line XELOX. Consequently, this marker deserves further investigation. PMID: 19850635 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Spindler KL, Andersen RF, Jensen LH, Ploen J, Jakobsen A Tags: Ann Oncol Source Type: journals

When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Despite extranodal NK/T-cell lymphoma frequently involves paranasal sinus, a routine CNS evaluation and prophylaxis do not seem to be necessary in NKPI group I or II patients due to a very low incidence. Nevertheless, CNS prophylaxis should be considered in NKPI groups III and IV. PMID: 19850636 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Kim SJ, Oh SY, Hong JY, Chang MH, Lee DH, Huh J, Ko YH, Ahn YC, Kim HJ, Suh C, Kim K, Kim WS Tags: Ann Oncol Source Type: journals

Incidence of brain metastases in renal cell carcinoma treated with sorafenib.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In this subpopulation, sorafenib may reduce the occurrence of brain metastases. Antiangiogenic therapy, such as sorafenib, could be an effective preventive therapy for brain metastases in advanced RCC. PMID: 19850637 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Massard C, Zonierek J, Gross-Goupil M, Fizazi K, Szczylik C, Escudier B Tags: Ann Oncol Source Type: journals

Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The current prognostic model successfully stratified patients with NK cell neoplasms with different outcomes. PMID: 19850638 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Suzuki R, Suzumiya J, Yamaguchi M, Nakamura S, Kameoka J, Kojima H, Abe M, Kinoshita T, Yoshino T, Iwatsuki K, Kagami Y, Tsuzuki T, Kurokawa M, Ito K, Kawa K, Oshimi K, Tags: Ann Oncol Source Type: journals

Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Detection of >/=1 CTC/7.5 ml before neoadjuvant chemotherapy can accurately predict OS. Our findings may change the clinical management of nonmetastatic breast cancer and indicate that the metastatic efficiency of CTC could be higher than previously reported. PMID: 19850639 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Bidard FC, Mathiot C, Delaloge S, Brain E, Giachetti S, de Cremoux P, Marty M, Pierga JY Tags: Ann Oncol Source Type: journals

High dose intensity doxorubicin in aggressive non-Hodgkin's lymphoma: a literature-based meta-analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: High DI doxorubicin based should be considered in patients with aggressive NHL. PMID: 19850640 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Azim HA, Santoro L, Bociek RG, Gandini S, Malek RA, Azim HA Tags: Ann Oncol Source Type: journals

Components of the metabolic syndrome in 500 adult long-term survivors of childhood cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Adult survivors of childhood cancer, especially those treated with cranial irradiation, are at increased risk of developing the metabolic syndrome. PMID: 19850641 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: van Waas M, Neggers SJ, Pieters R, van den Heuvel-Eibrink MM Tags: Ann Oncol Source Type: journals

Decreasing incidence of gastric MALT lymphomas in the era of anti-Helicobacter pylori interventions: results from a population-based study on extranodal marginal zone lymphomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This population-based study provides new insights into recent changes in the epidemiology of EN-MZL, mainly represented by the sharp reduced incidence of HP-positive g-MALT lymphomas. PMID: 19850642 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Luminari S, Cesaretti M, Marcheselli L, Rashid I, Madrigali S, Maiorana A, Federico M Tags: Ann Oncol Source Type: journals

Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Further understanding of treatment resistance and interactions between bortezomib and docetaxel may provide novel approaches in managing HNSCC. PMID: 19850643 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Chung CH, Aulino J, Muldowney NJ, Hatakeyama H, Baumann J, Burkey B, Netterville J, Sinard R, Yarbrough WG, Cmelak AJ, Slebos RJ, Shyr Y, Parker J, Gilbert J, Murphy BA Tags: Ann Oncol Source Type: journals

Primary cardiac lymphoma: B- and T-cell cases at a specialist UK centre.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: All six cases illustrate the wide spectrum of clinical presentation of lymphomas presenting primarily in the heart and emphasise that histology of all mass lesions is essential. Other series are small like ours highlighting the rarity of these tumours in the heart with the emphasis on imaging, early diagnosis and treatment. PMID: 19846467 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 20, 2009 Category: Cancer & Oncology Authors: Patel J, Melly L, Sheppard MN Tags: Ann Oncol Source Type: journals

A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: GLMLE appears to be a well-tolerated compound in this setting. There appears to be no objective benefit. However, grade 3/4 hepatic toxicity noted in two patients is of concern and should be considered while evaluating patients taking GLMLE or while designing studies with this agent. PMID: 19846468 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 20, 2009 Category: Cancer & Oncology Authors: Sukumaran S, Pittman KB, Patterson WK, Dickson J, Yeend S, Townsend A, Broadbridge V, Price TJ Tags: Ann Oncol Source Type: journals

Breast cancer brain metastases: differences in survival depending on biological subtype, RPA RTOG prognostic class and systemic treatment after whole-brain radiotherapy (WBRT).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HER2-positive and triple-negative breast cancers have special predilection for metastases to the brain. Survival from brain metastases depended on performance status and the use of systemic treatment. PMID: 19840953 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 18, 2009 Category: Cancer & Oncology Authors: Niwinska A, Murawska M, Pogoda K Tags: Ann Oncol Source Type: journals

Analysis of local and regional recurrences in breast cancer after conservative surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Local and regional recurrences after breast-conserving surgery are rare events. They are markers of tumor aggressiveness and indicators of an increased likelihood of distant metastases. PMID: 19833817 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 14, 2009 Category: Cancer & Oncology Authors: Botteri E, Bagnardi V, Rotmensz N, Gentilini O, Disalvatore D, Bazolli B, Luini A, Veronesi U Tags: Ann Oncol Source Type: journals

Impact of p53 expression and microsatellite instability on stage III colon cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our observations indicate that MSI status and p53 expression may influence the impact of oxaliplatin on adjuvant treatment of stage III colon cancer patients. PMID: 19833818 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 14, 2009 Category: Cancer & Oncology Authors: Zaanan A, Cuilliere-Dartigues P, Guilloux A, Parc Y, Louvet C, de Gramont A, Tiret E, Dumont S, Gayet B, Validire P, Fléjou JF, Duval A, Praz F Tags: Ann Oncol Source Type: journals

A randomized, phase III multicenter trial of gemcitabine in combination with carboplatin or paclitaxel versus paclitaxel plus carboplatin in patients with advanced or metastatic non-small-cell lung cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Non-platinum and non-paclitaxel gemcitabine-containing doublets demonstrate similar overall survival and RR compared with the standard PC regimen. However, the treatment arms had distinct toxicity profiles. PMID: 19833819 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 14, 2009 Category: Cancer & Oncology Authors: Treat JA, Gonin R, Socinski MA, Edelman MJ, Catalano RB, Marinucci DM, Ansari R, Gillenwater HH, Rowland KM, Comis RL, Obasaju CK, Belani CP, Tags: Ann Oncol Source Type: journals

Cost-effectiveness of CT and PET-CT for determining the need for adjuvant neck dissection in locally advanced head and neck cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Adjuvant ND reserved for patients with RD on PET-CT is the dominant and cost-effective strategy. PMID: 19833820 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 14, 2009 Category: Cancer & Oncology Authors: Sher DJ, Tishler RB, Annino D, Punglia RS Tags: Ann Oncol Source Type: journals

Efficacy of radionuclide treatment DOTATATE Y-90 in patients with progressive metastatic gastroenteropancreatic neuroendocrine carcinomas (GEP-NETs): a phase II study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: DOTATATE Y-90 therapy is effective and relatively safe in patients with GEP-NET. Standard doses of DOTATATE Y-90 result in a relatively low risk of myelotoxicity. However, due to ongoing risk of renal toxicity, careful monitoring of the kidney is recommended. PMID: 19833821 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 14, 2009 Category: Cancer & Oncology Authors: Cwikla JB, Sankowski A, Seklecka N, Buscombe JR, Nasierowska-Guttmejer A, Jeziorski KG, Mikolajczak R, Pawlak D, Stepien K, Walecki J Tags: Ann Oncol Source Type: journals

Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause. PMID: 19828559 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 13, 2009 Category: Cancer & Oncology Authors: Mar Fan HG, Houédé-Tchen N, Chemerynsky I, Yi QL, Xu W, Harvey B, Tannock IF Tags: Ann Oncol Source Type: journals

Lack of prophylaxis before the onset of acute venous thromboembolism among hospitalized cancer patients: the SWIss Venous ThromboEmbolism Registry (SWIVTER).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although most hospitalized cancer patients were at high risk, 40% did not receive any prophylaxis before the onset of acute VTE. There is a need to improve thromboprophylaxis in cancer patients, particularly in the presence of recent or ongoing chemotherapy. PMID: 19828560 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 13, 2009 Category: Cancer & Oncology Authors: Kucher N, Spirk D, Baumgartner I, Mazzolai L, Korte W, Nobel D, Banyai M, Bounameaux H Tags: Ann Oncol Source Type: journals

Prognostic and predictive factors in a randomized phase III trial comparing cisplatin-pemetrexed versus cisplatin-gemcitabine in advanced non-small-cell lung cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: NSCLC histology significantly predicts efficacy outcomes for patients receiving pemetrexed. Several other factors are prognostic for the overall study population as well as a subset of patients with advanced nonsquamous NSCLC. PMID: 19828561 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 13, 2009 Category: Cancer & Oncology Authors: Syrigos KN, Vansteenkiste J, Parikh P, von Pawel J, Manegold C, Martins RG, Simms L, Sugarman KP, Visseren-Grul C, Scagliotti GV Tags: Ann Oncol Source Type: journals

Phase II study of S-1 plus leucovorin in patients with metastatic colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: S-1 combined with LV therapy demonstrated promising efficacy and acceptable safety in chemotherapy-naive patients with mCRC without the concurrent use of irinotecan, oxaliplatin, or molecular-targeted drugs. PMID: 19828562 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 13, 2009 Category: Cancer & Oncology Authors: Koizumi W, Boku N, Yamaguchi K, Miyata Y, Sawaki A, Kato T, Toh Y, Hyodo I, Nishina T, Furuhata T, Miyashita K, Okada Y Tags: Ann Oncol Source Type: journals