Annales d'EndocrinologieThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Etiological diagnosis of hyperprolactinemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are numerous etiologies of hyperprolactinemia, a common reason for consultation. Diagnostic measures must be capable of identifying the tumors, the most frequent of which are prolactin adenomas. Hypothalamic-pituitary MRI is the reference morphological examination. In clinical practice, it is usually performed very early, following the discovery of increased plasma concentrations of PRL. This approach is warranted for marked increase in PRL in the absence of drugs with hyperprolactinemic effects (>10 x upper limit of normal) since a diagnosis of PRL adenoma is extremely likely under such circumstances. When hy...
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Cortet-Rudelli C, Sapin R, Bonneville JF, Brue T Tags: Ann Endocrinol (Paris) Source Type: journals

[Recent advances in familial hypercholesterolemia]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 17512894 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Bruckert E Tags: Ann Endocrinol (Paris) Source Type: journals

Prolactinoma surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surgery is generally used as second-line treatment in prolactinomas. For microprolactinomas, it may be indicated in cases of resistance or intolerance to dopamine agonists or where patients prefer definitive cure to lifelong drug treatment. In highly trained hands, selective adenomectomy results in normalization of prolactin levels in 75-90% of cases with little morbidity and no mortality. However, subsequent relapse is possible in up to 20% of cases. In macroprolactinoma, a definitive cure is unlikely due to the frequency of invasive tumor extension. A transsphenoidal or, less frequently, a transfrontal surgical appro...
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Jan M, Dufour H, Brue T, Jaquet P Tags: Ann Endocrinol (Paris) Source Type: journals

[Susceptibility markers in Tunisian first-degree relatives of patients with type 1 diabetes]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this observational study confirms in a Tunisian population known epidemiological data and demonstrates the usefulness of follow-up to determine the predictive value of studied markers. PMID: 17512892 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Laadhar L, Gassara A, Mahfoudh N, Ben Hadj hmida Y, Kamoun T, Ben Ayed M, Rekik N, Mahfoudh A, Rebai A, Makni H, Abid M, Hachicha M, Masmoudi H Tags: Ann Endocrinol (Paris) Source Type: journals

[The Prader-Willi syndrome]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prader-Willi syndrome is a rare genetic disorder, affecting 1 out of 25,000 births, in which a critical region of chromosome 15, the 15q11-q13 region, is affected. At birth, PWS infants exhibit severe hypotonia that partially improves, explaining in part suckling and swallowing troubles and the delay in psychomotor development. Characteristic facial features (dysmorphic syndrome) and very small hands and feet are frequently observed at this age. After this initial phase, the most striking signs appear: hyperphagia and absence of satiety often leading to severe obesity in affected children as young as two years. The sit...
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Diene G, Postel-Vinay A, Pinto G, Polak M, Tauber M Tags: Ann Endocrinol (Paris) Source Type: journals

[After the LDL receptor and apolipoprotein B, autosomal dominant hypercholesterolemia reveals its third protagonist: PCSK9]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The genes encoding the low-density lipoproteins receptor and its ligand apolipoprotein B, have been the only two genes classically implicated in autosomal dominant hypercholesterolemia. We have identified in 2003, the third gene implicated in this disease: PCSK9 (Proprotein Convertase Subtilin Kexin 9). Several mutations (p.S127R, p.F216L, p.D374Y...) of this gene have been reported to cause hypercholesterolemia by a gain of function leading to a reduction of LDL receptor levels. Other variations of PCSK9 are conversely associated with hypocholesterolemia particularly the non-sense p.Y142X and p.C679X mutations found i...
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Abifadel M, Rabès JP, Boileau C, Varret M Tags: Ann Endocrinol (Paris) Source Type: journals

Recent advances in treatment of medullary thyroid carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medullary thyroid carcinoma accounts for 5-10% of all thyroid cancers. It is sporadic in 75% of cases and familial in 25% of cases. Germ-line REarranged during transfection (RET) proto-oncogene mutations are detected in more than 95% of patients with familial medullary carcinoma whereas somatic RET mutations are detected in 40-70% of sporadic medullary carcinomas. Surgery is the only curative treatment and should consist of total thyroidectomy with central and ipsilateral or bilateral lateral lymph node dissection. Surgery provides successful cure in almost 100% of patients when tumor size measures a few millimeters, i...
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Vezzosi D, Bennet A, Caron P Tags: Ann Endocrinol (Paris) Source Type: journals

[A Multiple endocrine neoplasia type-1 observatory in a French-speaking area. A tool from the Endocrine Tumor study Group (GTE)]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the way to diagnose a new MEN1 case and to register it. Procedures for participating in a new study are presented. Some original results are quoted. PMID: 17379178 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Goudet P, Bonithon C, Costa A, Cadiot G, Baudin E, Murat A, Delemer B, Tabarin A, Lecomte P, Calender A, Tags: Ann Endocrinol (Paris) Source Type: journals

[Diagnostic procedures and more particularly, place of scintigraphy in neuroendocrine tumors, example of vipoma in MEN 1]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a symptomatic neuroendocrine tumor in a 27-year old woman. The identification of the nature of the neuroendocrine tumors was difficult despite the use of a wide range of diagnostic procedures. This case is interesting in many ways: this is an exceptional illustration of MEN 1 with vipoma associated with calcitonin secretion and it is also a good example of the benefits and limitations of each diagnostic procedure in the heterogeneous group of neuroendocrine tumors. PMID: 17292846 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - June 1, 2007 Category: Endocrinology Authors: Rigabert J, De Clermont H Tags: Ann Endocrinol (Paris) Source Type: journals

[Turner syndrome]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Turner syndrome occurs in 1:5000 live births (1:2,500 females) and is caused not only by X-chromosome monosomy, but also in a large degree, by the presence of a mosaicism (45,X) and/or an abnormal X or Y chromosome (deletion, isochromosome X, dicentric chromosome). Clinical features are heterogeneous and typical physical anomalies are often mild or absent. In all cases, patients are short but final height has been improved by growth hormone therapy. Ovarian failure, with variable onset depending on the chromosomal anomalies, is frequent. Others visceral diseases (bone anomalies, lymphedema, deafness, and cardiovascular...
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Cabrol S Tags: Ann Endocrinol (Paris) Source Type: journals

[Primary lipodystrophies]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary lipodystrophies represent a heterogeneous group of very rare diseases with a prevalence of less than 1 case for 100.000, inherited or acquired, caracterized by a loss of body fat either generalized or localized (lipoatrophy). In some forms, lipoatrophy is associated with a selective hypertrophy of other fat depots. Clinical signs of insulin resistance are often present: acanthosis nigricans, signs of hyperandrogenism. All lipodystrophies are associated with dysmetabolic alterations with insulin resistance, altered glucose tolerance or diabetes and hypertriglyceridemia leading to a risk of acute pancreatitis. Ch...
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Capeau J, Magré J, Lascols O, Caron M, Béréziat V, Vigouroux C Tags: Ann Endocrinol (Paris) Source Type: journals

Ageing and reproduction: is polycystic ovary syndrome an exception?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These clinical observations suggest improved fertility in some PCOS ageing women. The positive impact of ageing on cycle regularisation in PCOS has recently been claimed but the fertility outcome was not evaluated. Ovary ageing results in diminution of the follicular cohort in both normal and PCOS women, associated with decreased inhibin B and anti-müllerian hormone (AMH) levels. Lower inhibin B levels induce FSH enhancement, with a rise in FSH rate per follicle which may determine better follicle maturation, regular and ovulatory cycles in PCOS ageing women. The best proof of this improved fertility was ...
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Vulpoi C, Lecomte C, Guilloteau D, Lecomte P Tags: Ann Endocrinol (Paris) Source Type: journals

Diagnosis and management of hyperprolactinemia: expert consensus - French Society of Endocrinology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 17316545 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Brue T, Delemer B, Tags: Ann Endocrinol (Paris) Source Type: journals

Effects of non-steroid immunosuppressive drugs on insulin secretion in transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Post-transplantation diabetes (PTD) is a serious complication in organ transplantation: not only does it increase the risk of graft dysfunction; it also increases cardiovascular morbidity and mortality. PTD incidence is correlated with age, non-Caucasian ethnic background, a family history of diabetes, excess weight, hepatitis C infection and steroid boluses for potential rejection. Different mechanisms might explain post-transplantation glucose metabolism disorders: ischemia-reperfusion disorders, whether renal, hepatic or cardiac, are responsible for insulin-resistance, which is increased by post-transplantation ster...
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Vantyghem MC, Marcelli-Tourvielle S, Pattou F, Noël C Tags: Ann Endocrinol (Paris) Source Type: journals

The use of intravenous catheterisation with a rest period is useful for determination of plasma cortisol levels but not plasma prolactin levels.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results don't justify intravenous catheterisation with a rest period for plasma prolactin determination in contrast with plasma cortisol determination. PMID: 17316543 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Briet C, Saraval M, Loric S, Topolinski-Duyme H, Fendri S, Desailloud R Tags: Ann Endocrinol (Paris) Source Type: journals

[Malignant struma ovarii: false positive PET image for suspected metastasis due to sarcoidosis]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first use of (18)F-fluorodeoxyglucose positron emission tomography (PET) in the follow-up of malignant struma ovarii with persistently elevated serum thyroglobulin level and negative diagnostic iodine 131 whole body scan after thyroidectomy and four courses of 131 iodine. Hilar and mediastinal lymph node uptake was detected but histological verification concluded that there was a false-positive localization corresponding to sarcoidosis lesions without malignant aspect. PMID: 17313936 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Kunstmann L, Bständig B, Brucker-Davis F, Mouroux J, Rigot P, Fenichel P Tags: Ann Endocrinol (Paris) Source Type: journals

[Nelson's syndrome: course of aggressive pituitary corticotroph adenoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nelson's syndrome was defined in 1958 as the association of an expanding pituitary tumor with high ACTH secretion after bilateral adrenalectomy for Cushing's disease. Pituitary MRI and ACTH measurements led to the definition of Nelson's syndrome as the proliferation of a corticotrophic microadenoma or an aggressive and highly proliferative tumor residue induced by the decreased glucocorticoid inhibition after bilateral adrenalectomy. Now, the problem is not the definition of Nelson's syndrome but rather the identification of markers predictive of tumor growth. Based on a typical case and a review of the literature, we ...
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Mounier C, Pasquet F, Trouillas J, Perrin G, Jouanneau E, Borson-Chazot F, Colle B Tags: Ann Endocrinol (Paris) Source Type: journals

[A case of hyperthyroidism due to functioning metastasis of differentiated thyroid carcinoma. Discussion and literature review]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a very rare case of hyperthyroidism due to multiple autonomously functioning bone metastasis of papillary thyroid cancer in a 79-year-old woman. This situation remains extremely uncommon, as shown by our review of the literature; only 47 similar cases have been published from 1946 to 2005. The pathogenic mechanism remains largely unknown in spite of several hypotheses (conjunction in volume and differentiation, auto-antibodies). Hyperthyroidism can be severe, and often T3 levels are markedly more elevated than T4 levels. Apart from hyperthyroidism caused by the hormone-production, clinical features are similar...
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Tardy M, Tavernier E, Sautot G, Nove-Josserand R, Bournaud C, Houzard C, Borson-Chazot F Tags: Ann Endocrinol (Paris) Source Type: journals

[Graves' disease and autoimmune thrombocytopenic purpura: distinct outcomes of the two diseases]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of idiopathic thrombocytopenic purpura associated with Graves' disease, in which the two diseases had distinct outcomes. Thus, the hypothesis of cross-reaction between antithyroid antibodies and platelet epitopes, which has been proposed to explain the association, seems unlikely. PMID: 17292844 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - February 1, 2007 Category: Endocrinology Authors: Cohen Aubart F, Jublanc C, Bruckert E Tags: Ann Endocrinol (Paris) Source Type: journals

[Adrenal gland hemangioma: a case report]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of adrenal gland hemangioma diagnosed in a 55-year-old woman who presented a cervical neoplasm. The non-specific imaging features, the tumor size and the clinical context led to mandatory surgical resection. The pathological examination established the diagnosis of adrenal gland hemangioma. PMID: 17194976 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Harzallah L, Zouari L, Ben Chérifa L, Harzallah F, Sriha B, Bakir D, Kraiem Ch Tags: Ann Endocrinol (Paris) Source Type: journals

[Langerhans cell histiocytosis of the thyroid]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Langerhans histiocytosis is a disease with a very diverse clinical spectrum and a very varied prognosis. The thyroid localization is relatively rare, and raises diagnostic and therapeutic difficulties. Diagnosis often requires recourse to clinical, radiological and pathological confrontation. Combined medical and surgical treatment is indicated and requires close multidisciplinary cooperation. On the basis of a new observation and data in the literature, we present a progress report on the clinical and therapeutic options preferred by various authors. PMID: 17194975 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Oudidi A, Hachimi H, El Alami MN Tags: Ann Endocrinol (Paris) Source Type: journals

[Hypoparathyroidism associated with systemic lupus erythematosus: a case]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: The combined diagnosis lupus-hypoparathyroidism has very rarely been reported. We suggest there may be a common underlying pathological process linking the two diseases. The occurrence of these diseases in the same individual may be related to an underlying genetic predisposition or secondary to the generalized autoimmune disease process. PMID: 17194974 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Hassikou H, Safi S, Tabache F, Hadri L Tags: Ann Endocrinol (Paris) Source Type: journals

[Contribution of ultrasonography to the diagnosis of non-hormonal acquired clitoromegalia: a case report]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 30-year-old woman, consulting for a painful clitoromegaly which developed progressively and rapidly. The gyneco-endocrinological assessment ruled out hyperandrogenism. Ultrasound examination of the clitoris revealed the presence of a clitoral cyst. Acquired clitoromegaly is a symptom which occurs in severe hyperandrogenism. Other organic etiologies include clitoral cysts of various nature and solid tumors. An ultrasonographic examination should be included in the diagnostic work-up for acquired clitoromegaly. PMID: 17194973 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Robin G, Marcelli F, Agbetra N, Guerin Du Masgenet B, Goeusse P Tags: Ann Endocrinol (Paris) Source Type: journals

[MRI pituitary stalk abnormalities: etiology aspects in 11 patients]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Newer techniques of magnetic resonance imaging (MRI) describe more accurately pituitary stalk abnormalities such as infections, infiltrative lesions and tumors. In absence of all the above mentioned etiological factors, genetics defects are suspected, mainly when other malformations are equally present. We attempt to show through 11 observations the variability of pathologies involving the pituitary stalk with their respective clinical and radiological features and associated endocrine abnormalities. This is a retrospective study of 7 men (67%) and 4 women (33%), mean age of 28 year (range: 15 to 53) in whom pituitary ...
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Trabelsi L, Mnif M, Rekik N, Kaffel N, Charfi N, Mnif J, Kchaow MS, Abid M Tags: Ann Endocrinol (Paris) Source Type: journals

HLA class II distribution in Congolese with hyperthyroidism: preliminary results.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HLA-DR2, HLA-DQB1*0602 and DR2/DR2-DQB1*0.602 would play a protective role against the hyperthyroidism, while DR3 allele, allele group DR11,13,14 and haplotype HLA-DR3/DR11,13,14 would predispose to this disease or to Graves' exophtalmopathy. A large and profound study is needed to confirm our preliminary results. PMID: 17194971 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Bidingija M, Galgani A, Buzzetti R, Ditu M Tags: Ann Endocrinol (Paris) Source Type: journals

[Epidemiologic study of autoimmune thyroid disease in south Tunisia]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to study incidence and prevalence of autoimmune thyroid diseases (AITDs), we studied a retrospective cohort of 1,079 patients explored in the department of Endocrinology of Sfax (south of Tunisia). The overall incidence of AITDs was 9.9%. Mean age was 39.6+15 years; sex ratio 5 F/1M. Graves' disease was the most frequent (45%). Atrophic thyroiditis was present in 32.2% of patients and Hashimoto's thyroiditis in 22.8%. The incidence of AITDs increased from 1990 to 2000 and by 2003 it had fallen to 67 cases per year. TPO antibody was present in two-thirds of patients with Hashimoto thyroiditis, and half of those...
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Chabchoub G, Mnif M, Maalej A, Charfi N, Ayadi H, Abid M Tags: Ann Endocrinol (Paris) Source Type: journals

[Prevalence of diabetes-related autoantibodies in celiac disease]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The risk to develop diabetes seems to be the same in celiac patients and in healthy subjects thus screening of diabetes-related autoantibodies is not justified in celiac patients. PMID: 17194969 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Laadhar L, Ben Hariz M, Zitouni M, Sellami-Kallel M, Toumi A, Mehrezi A, Makni S Tags: Ann Endocrinol (Paris) Source Type: journals

Contribution of genetic analysis in screening for MEN1 among patients with sporadic disease and one or more typical manifestation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant hereditary syndrome (OMIM 131100) due to MEN1 gene mutations, predisposing to the development of hyperplasic and tumoral lesions of neuroendocrine tissues. Since the identification of the gene in 1997, more than 400 different mutations of MEN1 have been registered. Genotypic analysis of MEN1 remains fastidious and must be reserved to targeted situations. If the lesions appear in a familial assessed context, there is a strong argument to search for MEN1 mutation. This is not the case in a sporadic context. With experience acquired in our laboratory, we ...
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Odou MF, Cardot-Bauters C, Vantyghem MC, Carnaille B, Leteurtre E, Pigny P, Verier-Mine O, Desailloud R, Porchet N Tags: Ann Endocrinol (Paris) Source Type: journals

[Skin and menopause]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Important changes related to declining level of several hormones occur during menopause: vasomotor instability, bone loss, anxiety, sexual dysfunction, skin aging... Our objective was a review of the literature concerning the histological and clinical changes seen in post menopausal skin, and also an analysis of the effect of hormonal replacement therapy in slowing down the aging process. Decline in progesterone increases the impact of androgen on the sebaceous glands and hair. Decreased estrogen slows down mitotic activity in the epidermal basal layer, reduces the synthesis of collagen and contributes to thickening of...
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Bensaleh H, Belgnaoui FZ, Douira L, Berbiche L, Senouci K, Hassam B Tags: Ann Endocrinol (Paris) Source Type: journals

Anti-mullerian hormone: clinical relevance in assisted reproductive therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anti-Müllerian Hormone (AMH) is a member of the transforming Growth Factor-B (TGF-B) family synthesized exclusively by the gonads of both sexes. Over the last four years, numerous studies have examined the clinical usefulness of serum AMH levels as a predictor of ovarian response and pregnancy in assisted reproductive technology cycles. Assessment of ovarian reserve in women undergoing assisted reproduction is useful in optimising the treatment protocol. Availability of a reliable measure of ovarian reserve is essential. Currently, serum AMH level seems to be more strongly related to the ovarian reserve and to be ...
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Fréour T, Mirallié S, Colombel A, Bach-Ngohou K, Masson D, Barrière P Tags: Ann Endocrinol (Paris) Source Type: journals

[Premature ovarian failure]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Premature ovarian failure (POF) is defined by at least four months of amenorrhea with elevated gonadotropins (usually above 40 UI/L) detected on two occasions a few weeks apart, in a woman before the age of 40. It occurs in 1 out of 10,000 in women below the age of 20, 1/1,000 below 30 and 1% in women before the age of 40. In 80% of POF cases, the etiology is unknown, except for Turner syndrome. The different etiologies identified are 1) iatrogenic following chemotherapy and/or radiotherapy, 2) autoimmune, 3) viral, 4) genetic (RFSH, FOXL2, FRAXA, BMP15, GDF9, GALT, 17 hydroxylase...). Management of these patients incl...
Source: Annales d'Endocrinologie - December 1, 2006 Category: Endocrinology Authors: Christin-Maitre S, Pasquier M, Donadille B, Bouchard P Tags: Ann Endocrinol (Paris) Source Type: journals

Abstracts of WorldMEN 2006 Workshop, Marseille, France, September 7-10, 2006.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 17396282 [PubMed - indexed for MEDLINE]
Source: Annales d'Endocrinologie - September 1, 2006 Category: Endocrinology Tags: Ann Endocrinol (Paris) Source Type: journals

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