Annals of Clinical BiochemistryThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Smith, K. Tags: Journal Watch Source Type: journals

Clinical Lipidology: A Companion to Braunwald's Heart DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: van Heyningen, C. Tags: Books Source Type: journals

Biology of DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Marshall, W. J Tags: Books Source Type: journals

Applying Evidence-based Laboratory Medicine - A Step-by-step GuideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Fox, J. Tags: Books Source Type: journals

Interpretation of internal quality control: time for a re-think?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Deacon, A. C Tags: Letters Source Type: journals

Stability of serum total N-terminal propeptide of type I collagenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Courtney, A P, Holloway, P, Fairney, A Tags: Letters Source Type: journals

The value of serum free light chains in a case of Waldenstrom's macroglobulinaemia that produces a type I cryoglobulinaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of lymphoplasmacytic lymphoma with type I cryoglobulinaemia that presented with clinical symptoms associated with hyperviscosity syndrome. Quantitation of the paraprotein was not possible using conventional serum protein electrophoresis due to the high serum viscosity, and therefore monitoring was carried out using serial serum free light chain measurements. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Pattenden, R. J, Davidson, K. L, Wenham, P. R Tags: Case Reports Source Type: journals

Depressive effect of an antidepressant: therapeutic failure of venlafaxine in a case lacking CYP2D6 activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Understanding the mechanisms of drug metabolism and interactions can help to prevent side-effects. Not only drug interactions, environmental factors, disease processes and ageing are factors in the inter-individual metabolic capacity variance but also genetic factors probably play an important role, as is illustrated in the case presented. Besides therapeutic drug monitoring, genotyping some important cytochrome P450 (CYP450) enzymes was of additional value in explaining why the patient developed severe adverse effects and, moreover, did not experience any therapeutical effect of venlafaxine. Results indicated that the pat...
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Wijnen, P A H M, Limantoro, I, Drent, M, Bekers, O, Kuijpers, P M J C, Koek, G H Tags: Case Reports Source Type: journals

An unusual case of profound hyponatraemia and bilateral adrenal calcificationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 65-year-old lady who presented with acute confusion and profound hyponatraemia (plasma sodium of 97 mmol/L). Five years earlier she had developed sepsis and was found to have hyponatraemia, thought to be due to syndrome of inappropriate antidiuretic hormone secretion. The patient was lost to follow-up. The patient was covered with steroids and investigations confirmed primary adrenal failure with flat response of cortisol to adrenocorticotropic hormone (ACTH) stimulation and very high level of ACTH. Adrenal auto-antibodies were negative and a computed tomography of the adrenals showed bilateral adrena...
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Cassar, C., Procter, R., Davidson, F., Collier, A., Malik, I. A, Ghosh, S., Elhadd, T. A Tags: Case Reports Source Type: journals

Unintentional silver intoxication following self-medication: an unusual case of corticobasal degenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 75-year-old man who had a history of self-medication with colloidal silver and presented with myoclonic seizures. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Stepien, K. M, Morris, R., Brown, S., Taylor, A., Morgan, L. Tags: Case Reports Source Type: journals

Critical difference calculations revised: inclusion of variation in standard deviation with analyte concentrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Replacing the usual assumption of similar total result SD for both measurements included in the CD calculation with a calculation of the SD at both analyte concentrations leads to an increase in the magnitude of the CD for rises in analyte concentration and a decrease for falls in analyte concentration. This change is proposed for all forms of CD calculations. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Jones, G. R. D. Tags: Short Reports Source Type: journals

Circulating ghrelin exists in both lipoprotein bound and free formsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The different binding patterns of AG and UAG may have significant implications for their biological effects, including roles in energy metabolism, the development of obesity and potentially in the modulation of cardiovascular disease. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Holmes, E, Davies, I, Lowe, G, Ranganath, L R Tags: Short Reports Source Type: journals

Fetuin-A serum concentrations in healthy childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Fetuin-A serum concentrations are independent of age and gender in a healthy paediatric population and are well comparable with those determined in adults with the same assay. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Wigger, M., Schaible, J., Muscheites, J., Kundt, G., Haffner, D., Fischer, D.-C. Tags: Short Reports Source Type: journals

A convenient enzyme-linked immunosorbent assay for rapid screening of anti-adeno-associated virus neutralizing antibodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This ELISA method may be useful for rapid screening of anti-AAV-2 neutralizing antibodies in candidates for gene therapy. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Ito, T., Yamamoto, S., Hayashi, T., Kodera, M., Mizukami, H., Ozawa, K., Muramatsu, S.-i. Tags: Short Reports Source Type: journals

Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenal axis reserve in patients with liver impairmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion When total cortisol alone is used to interpret SST in patients with liver impairment, 46% may have been classified as having adrenal insufficiency because of low CBG. FCI may be better for the evaluation of HPA axis insufficiency in patients with liver impairment. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Vincent, R. P, Etogo-Asse, F. E, Dew, T., Bernal, W., Alaghband-Zadeh, J., le Roux, C. W Tags: Short Reports Source Type: journals

Macroprolactin on the Advia Centaur: experience with 409 patients over a three-year periodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PEG screening is still needed for assays with low MPRL reactivity such as the Advia Centaur and this should be performed with a locally derived reference range for monomeric prolactin. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Jassam, N F, Paterson, A, Lippiatt, C, Barth, J H Tags: Short Reports Source Type: journals

Assessment of glomerular filtration rate by serum cystatin C in patients undergoing coronary artery bypass graftingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Cystatin C is a better marker for detecting small temporary changes of GFR in CABG patients. This may allow better identification of patients with renal impairment. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Wang, Q.-P., Gu, J.-W., Zhan, X.-H., Li, H., Luo, X.-H. Tags: Original Articles Source Type: journals

A rapid direct fluorescent assay for cell-free DNA quantification in biological fluidsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The direct SYBR® Gold assay proved to be an accurate and simple technique for measuring CFD in biological fluids. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Goldshtein, H., Hausmann, M. J, Douvdevani, A. Tags: Original Articles Source Type: journals

Acidification and urine calcium: is it a preanalytical necessity?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results suggest that the acidification of urine samples is not a preanalytical necessity for the measurement of urine calcium. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Sodi, R, Bailey, L B, Glaysher, J, Allars, L, Roberts, N B, Marks, E M, Fraser, W D Tags: Original Articles Source Type: journals

CSF levels of PSA and PSA-ACT complexes in Alzheimer's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PSA is locally produced in the human brain; however, brain PSA hardly contributes to the CSF levels of PSA. PSA and PSA–ACT levels in CSF are not suitable as a biomarker for AD. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Mulder, S. D, Heijst, J. A, Mulder, C., Martens, F., Hack, C E., Scheltens, P., Blankenstein, M. A, Veerhuis, R. Tags: Original Articles Source Type: journals

Protein and albumin-to-creatinine ratios in random urines accurately predict 24 h protein and albumin loss in patients with kidney diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions By careful choice of cut-offs, both PCR and ACR can be used in patients with kidney disease to rule in or rule out abnormal 24 h losses of protein and albumin. EMU and, importantly, random samples can be used as surrogates for 24 h urine collections. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Guy, M., Borzomato, J. K, Newall, R. G, Kalra, P. A, Price, C. P Tags: Original Articles Source Type: journals

Serum 99th centile values for two heart-type fatty acid binding protein assaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We have defined the 99th centile values for H-FABP in a population of primary and secondary care outpatients that can be used to risk stratify patients with ACS. We have confirmed that H-FABP increases with renal dysfunction and age, but have not confirmed the gender difference previously reported. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Bathia, D P, Carless, D R, Viswanathan, K, Hall, A S, Barth, J H Tags: Original Articles Source Type: journals

A deficiency of cholesteryl ester transfer protein whose serum remnant-like particle-triglyceride significantly increased, but serum remnant-like particle-cholesterol did not after an oral fat loadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The case subject was different from the common CETP deficient cases reported previously. Also, the results indicated that the metabolic pathways of RLP-C and RLP-TG formation in the postprandial state are controlled independently in CETP deficient cases. CETP deficiency itself may not be atherogenic, while one with elevated RLPs may be atherogenic. These cases may have raised the controversy of whether CETP deficiency is atherogenic or not. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Ai, M., Tanaka, A., Shimokado, K., Ohtani, R., Inazu, A., Kobayashi, J., Mabuchi, H., Nakano, T., Nakajima, K. Tags: Original Articles Source Type: journals

Oestradiol assays: fitness for purpose?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this review we discuss the analytical inadequacies of oestradiol assays in relation to the clinical requirements for performing them, and make recommendations for their improvement. The measurement of oestradiol can be requested in a number of clinical scenarios (precocious puberty, infertility, assisted conception, hormone replacement therapy). The very wide dynamic range of oestradiol concentrations is a huge challenge for routine assays, which they are unlikely to meet on theoretical as well as practical grounds. The EQA performance of oestradiol assays in terms of trueness, comparability, recovery and analytical sen...
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Middle, J. G, Kane, J. W Tags: Review Article Source Type: journals

Intravenous fluid therapy - an under-recognized patient safety opportunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inappropriate fluid regimens are rarely documented as being responsible for patient harm, although there is considerable circumstantial evidence to suggest that fluid overload may be a considerably under-estimated source of patient morbidity and mortality. The GIFTASUP fluid management guidelines published in 2008 offer a valuable opportunity to consider a more standardised approach to fluid management, possibly in the context of developing routine hospital services to support good practice. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Smellie, W S A Tags: Personal View Source Type: journals

Managing demand for pathology tests: financial imperative or duty of care?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Fryer, A. A, Hanna, F. W Tags: Editorial Source Type: journals

Use of a common standard improves the performance of liquid chromatography-tandem mass spectrometry methods for serum 25-hydroxyvitamin-DEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Tags: Erratum Source Type: journals

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(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Slack, S. Tags: Journal Watch Source Type: journals

Review: Lateral Flow ImmunoassayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Price, C. P Tags: Books Source Type: journals

Review: Prenatal Diagnosis (Methods in Molecular Biology 444)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Ball, S. Tags: Books Source Type: journals

Response to Heijboer et al. Ann Clin Biochem 2009;46(3):263-4Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: McKillop, D., Thompson, D., Sharpe, P. Tags: Letters Source Type: journals

Reliability of cystatin C in estimating renal function in rugby playersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Banfi, G., Del Fabbro, M., d'Eril, G. M., Melegati, G. Tags: Letters Source Type: journals

Troponin I and colonoscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: George, A T, Brain, A, Tovey, J Tags: Letters Source Type: journals

Salivary steroidsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Wood, P. Tags: Letters Source Type: journals

Thyroid stimulating hormone cut-off to define subclinical hypothyroidismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Ismail, A. A A Tags: Letters Source Type: journals

Thyrotoxic periodic paralysis due to excessive L-thyroxine replacement in a Caucasian manEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thyrotoxic periodic paralysis is a potentially fatal complication of hyperthyroidism, more common in Asian races, which is defined by a massive intracellular flux of potassium. This leads to profound hypokalaemia and muscle paralysis. Although the paralysis is temporary, it may be lethal if not diagnosed and treated rapidly, as profound hypokalaemia may induce respiratory muscle paralysis or cardiac arrest. The condition is often misdiagnosed in the west due to its comparative rarity in Caucasians; however it is now increasingly described in Caucasians and is also being seen with increasing frequency in western hospitals d...
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Hannon, M J, Behan, L A, Agha, A Tags: Case Reports Source Type: journals

Hypobetalipoproteinaemia secondary to chronic hepatitis C virus infection in a patient with familial hypercholesterolaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of HBL in a 43-year-old man with previously demonstrated marked hypercholesterolaemia who attended a lipid disorders clinic for FH cascade screening. Surprisingly, a lipid profile taken at that time showed low plasma LDL-cholesterol and apolipoprotein B concentrations of 1.6 mmol/L and 0.61 g/L, respectively. He was not on lipid-lowering therapy. DNA sequencing showed that he was heterozygous for the LDLR gene mutation (C677R) present in other affected family members. Of interest, his serum transaminases were increased by ~3-fold and hepatitis serology and genotyping confirmed a diagnosis of hepatitis C vi...
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Bima, A. I, Hooper, A. J, van Bockxmeer, F. M, Burnett, J. R Tags: Case Reports Source Type: journals

Design, implementation and results of the quality control program for the Australian government's point of care testing in general practice trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Results from QC testing indicate that PoCT in the GP trial met the analytical goals set for the trial, with the exception of HDL-C. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Shephard, M., Shephard, A., Watkinson, L., Mazzachi, B., Worley, P. Tags: Original Articles Source Type: journals

Serum free light chain assay reduces the need for serum and urine immunofixation electrophoresis in the evaluation of monoclonal gammopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The FLC ratio is a more sensitive method than uIFE in the detection of monoclonal light chains and may substantially reduce the need for onerous 24 h urine collections. Our proposed algorithm for the evaluation of monoclonal gammopathy incorporates the sFLC assay, resulting in a reduction in the performance of labour intensive sIFE and uEPG + uIFE while still increasing the detection of monoclonal proteins. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Fulton, R. B, Fernando, S. L Tags: Original Articles Source Type: journals

Measurement of immunoglobulin A in saliva by particle-enhanced nephelometric immunoassay: sample collection, limits of quantitation, precision, stability and reference rangeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Automated PENIA assay of s-IgA is precise and accurate. High stability of collected saliva samples and the ease and speed of the assay make this an ideal method for use in athletic and military training situations. The convenience of measuring albumin and IgA on the same analytical platform adds to the practicability of the test. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Booth, C. K, Dwyer, D. B, Pacque, P. F, Ball, M. J Tags: Original Articles Source Type: journals

Evaluation of redox statuses in patients with hepatitis B virus-associated hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our data suggest that the redox statuses in patients with HBV-associated HCC were elevated or decreased in certain parameters. However, the increased activities of antioxidant enzymes may be a compensatory up-regulation and the decrease antioxidant statuses were responses to the enhanced oxidative stress in those patients. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Tsai, S.-M., Lin, S.-K., Lee, K.-T., Hsiao, J.-K., Huang, J.-C., Wu, S.-H., Ma, H., Wu, S.-H., Tsai, L.-Y. Tags: Original Articles Source Type: journals

An audit of oral glucose tolerance tests at a large teaching hospital: indications, outcomes and confounding factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Only 55% of OGTTs had a previous FPG or RPG value warranting OGTT using current Australian DM guidelines. Other valid indications for OGTT were identified in the majority of the remainder. In addition, 41% were performed in the presence of confounding factors (such as acute illness or medications known to affect plasma glucose). Many of the OGTTs that are currently being performed are in the presence of confounding factors that could cause misleading results. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Ryan, J., Siriwardhana, D., Vasikaran, S. D Tags: Original Articles Source Type: journals

Biochemical and nutritional indices as cardiovascular risk factors among Iranian firefightersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Considering the high prevalence of overweight and obesity, high TC, TG and Lp(a) and low HDL-C concentrations among all firefighters, it seems necessary to provide fitness-promotion and nutritional education programs for the prevention of obesity-related chronic diseases such as CVD. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Azabdaftari, N., Amani, R., Taha Jalali, M. Tags: Original Articles Source Type: journals

Seasonal variation in liver function tests: a time-series analysis of outpatient dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The liver function tests were observed to show seasonal variations. These seasonal variations should therefore be taken into consideration when establishing either reference intervals or cut-off values, which are especially important regarding aminotransferases. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Miyake, K., Miyake, N., Kondo, S., Tabe, Y., Ohsaka, A., Miida, T. Tags: Original Articles Source Type: journals

Haemoglobin A1c: evaluation of a new HbA1c point-of-care analyser Bio-Rad in2it in comparison with the DCA 2000 and central laboratory analysersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The in2it is a suitable POCT analyser for HbA1c but its less than ideal precision performance and differences with the central laboratory analysers must be communicated to and noted by the users. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Yeo, C.-P., Tan, C. H.-C., Jacob, E. Tags: Original Articles Source Type: journals

Association of serum glycated albumin to haemoglobin A1C ratio with hepatic function tests in patients with chronic liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The G/H ratio correlates with hepatic function but not with plasma glucose levels. Therefore, CLD should be suspected for diabetic patients with an elevated G/H ratio. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Bando, Y., Kanehara, H., Toya, D., Tanaka, N., Kasayama, S., Koga, M. Tags: Original Articles Source Type: journals

The diagnosis and investigation of adrenal insufficiency in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is considerable variation in the methods used to diagnose and investigate adrenal insufficiency in clinical practice. These include a range of adrenocorticotropin (ACTH) stimulation and other dynamic testing protocols, serum cortisol cut-off values for diagnosis and tests used for differential diagnosis. With the introduction of modern cortisol and ACTH assays, the interpretation of tests used for diagnosis and differential diagnosis has become more complex and requires local validation. This review examines the basis of normal hypothalamic–pituitary–adrenal axis function and adrenal insufficiency states ...
Source: Annals of Clinical Biochemistry - August 30, 2009 Category: Biochemistry Authors: Wallace, I., Cunningham, S., Lindsay, J. Tags: Review Article Source Type: journals

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(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - July 13, 2009 Category: Biochemistry Tags: Piscator Source Type: journals