Comparison of HER2 status determination methods in HER2 (2+) patients: Manual fluorescent in situ hybridization (FISH) vs. dual silver enhanced in situ hybridization (SISH)
HER2 amplification has been demonstrated in 15 –25% of invasive breast carcinomas and can be assessed using immunohistochemical and in situ hybridization methods. Here, we compared the accuracy of dual SISH to manual FISH in HER2 (2+) breast carcinoma and evaluated the feasibility of dual SISH method in routine practice. Sixty HER2 (2+) consec utive tumor samples diagnosed between January 2009 and February 2013 were selected. Demographic, histological and immunohistochemical features and FISH results were recruited from patient records and compared to dual SISH results. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 26, 2017 Category: Pathology Authors: Burcin Pehlivanoglu, Gurdeniz Serin, Levent Yeniay, Osman Zekioglu, Erhan Gokmen, Necmettin Ozdemir Source Type: research
Phenotypic alterations in breast cancer associated with neoadjuvant chemotherapy: A comparison with baseline rates of change
Several studies have documented phenotypic alterations in breast cancer associated with neoadjuvant chemotherapy [NACT], but many of these studies are limited by the fact that they did not account for the baseline rate of expected phenotypic change between biopsies and resections in the absence of NACT. Herein, we assess whether the NACT-associated rate of phenotypic change is significantly different than would be expected in a control population of patients that did not receive NACT. From a pathologic database, we documented the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-...
Source: Annals of Diagnostic Pathology - June 16, 2017 Category: Pathology Authors: Nosaibah Hariri, Andres A. Roma, Farnaz Hasteh, Vighnesh Walavalkar, Oluwole Fadare Source Type: research
Oral Lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma
Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. The pathogenesis of the condition is unclear, although reports dating back to 1997 suggest that at least a subset of EUOM represents CD30 positive lymphoproliferative disorder (LPD30). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 16, 2017 Category: Pathology Authors: Ziv Schwartz, Morton Coleman, Jennifer P. Toyohara, Paul D. Freedman, Cynthia M. Magro Source Type: research
Role of angiogenesis in colorectal carcinomas using VEGF and BCl2: An IHC study
Colorectal cancer is one of the leading causes of malignancies afflicting the general population worldwide. This is emphasized by the fact that 10% and 9.4% of total cancer cases worldwide, in males and females respectively are attributed to colorectal malignancies. Though the incidence rate of colorectal cancer in the Indian population (7.7 in males, 5.1 in females) is relatively low in comparison to worldwide statistics, recent studies have highlighted an increasing trend [1,2]. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 15, 2017 Category: Pathology Authors: Anjaneyulu Vasala, Haripreetha Nair, T. Subramanyeshwar Rao, S. Sudha Murthy, Ravindranath Tagore, Faiq Ahmed Source Type: research
Lymphocytic Thrombophilic arteritis: A distinct inflammatory type I interferon and C5b-9 mediated subcutaneous Endovasculitis
Lymphocytic thrombophilic arteritis is a recently recognized subcuticular larger vessel vasculitis characterized by striking vascular luminal thrombosis. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 14, 2017 Category: Pathology Authors: Cynthia M. Magro, Jad Saab Source Type: research
Editorial Board
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 1, 2017 Category: Pathology Source Type: research
Masthead
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 1, 2017 Category: Pathology Source Type: research
Table of Contents
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 1, 2017 Category: Pathology Source Type: research
Instructions to Authors
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 1, 2017 Category: Pathology Source Type: research
Three cases of adrenocortical tumors mistaken for hepatocellular carcinomas/diagnostic pitfalls and differential diagnosis
We report 3 cases of adrenal cortical tumors that were misdiagnosed as hepatocellular carcinoma in the preoperative state. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 29, 2017 Category: Pathology Authors: Won Young Park, Hyung Il Seo, Kyung Un Choi, Ahrong Kim, Young Keum Kim, So Jeong Lee, Chang Hun Lee, Gi Yeong Huh, Do Youn Park Source Type: research
Beta-catenin and p53 expression in topographic compartments of colorectal cancer and its prognostic value following surgery
Colorectal cancer (CRC) is the third most prevalent neoplasm worldwide and the fourth cause of cancer-related death. From Vogelstein's initial model, new molecular knowledge has been incorporated which includes an elevated number of genetic mutations, many of them located in the Wnt pathway, which affect its principle effector: β-catenin. Additionally, it is necessary to keep the heterogeneity of CRCs in mind, both in terms of morphology and biology. The aim of this work is to study the interaction between the Wnt molecular pathway, by means of immunoexpression of β-catenin, in CRC and other molecular mechanisms, such as...
Source: Annals of Diagnostic Pathology - May 27, 2017 Category: Pathology Authors: Juan Daniel Prieto, Martina Álvarez, María Isabel Hierro, Isabel García, Luis Vicioso Source Type: research
Establishing Fascin over-expression as a strategic regulator of neoplastic aggression and lymph node metastasis in oral squamous cell carcinoma tumor microenvironment
Oral squamous cell carcinoma (OSCC) has an aggressive behaviour with high incidence of nodal metastasis, even in the early stages, leading to poor prognosis. For progression and metastasis of cancers, the dominant element considered is cell motility. Fascin, an actin-binding protein has emerged as a protein of general importance for a diverse set of cell protrusions with functions in cell adhesion, cell interactions, and cell migration. The role of Fascin in various carcinomas, including aggressive behaviour in OSCC has been documented, but its role as a key regulator in lymph nodes metastasis is yet to be validated. (Sour...
Source: Annals of Diagnostic Pathology - May 26, 2017 Category: Pathology Authors: Samapika Routray, Supriya Kheur, Hemlata M. Chougule, Neeta Mohanty, Rupesh Dash Source Type: research
IMP3 contributes to poor prognosis of patients with metaplastic breast carcinoma: A clinicopathological study
Metaplastic breast carcinoma (MBC) is a rare type of tumor with heterogenous histological patterns. We investigated the immunohistochemical expression of IMP3, an oncofetal protein, in 31 MBC patients in association with histological subtypes and clinical outcomes. The cohort consisted of spindle cell carcinoma (SPC) (n=11), squamous cell carcinoma (SCC) (n=14), matrix-producing carcinoma (MPC) (n=4), carcinoma with osteocartilaginous elements (COC) (n=1), and low grade adenosquamous cell carcinoma (ASC) (n=1). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 26, 2017 Category: Pathology Authors: Ryuji Ohashi, Maoka Sangen, Shigeki Namimatsu, Hiroyuki Takei, Zenya Naito Source Type: research
Immunohistochemical expression of p53 and c-Myc at the invasive front of oral squamous cell carcinoma and its relation with clinicopathologic characteristics
The invasive tumor front (ITF) is the most progressed part of the tumor which consists of three to six tumor cell layers or detached tumor cell groups at the advancing edge of the oral squamous cell carcinoma (OSCC) [1]. It frequently shows a lower degree of differentiation and a higher grade of cellular dissociation in comparison with other parts of the tumor. It is believed that the integral prognostic information about the tumor's invasive and metastatic capacity can be deduced from ITF, where the deepest and presumably aggressive cells reside [2,3]. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 18, 2017 Category: Pathology Authors: Pragati Rai, Swetha Acharya, Amsavardani Tayaar, Jyoti Kale, Kaveri Hallikeri Source Type: research
Histological, immunohistochemical features and pathogenesis of pseudoangiosarcomatous urothelial carcinoma
Urothelial carcinoma (UC) cases make up the majority of bladder cancers and histologically contain very different variants and patterns. About 10 variants and many entities reported in recent years which were not included the former classification have been described in the 2016 World Health Organization (WHO) classification [1,2]. Pseudoangiosarcomatous UC is not included in the 2016 WHO urothelial carcinoma classification and is a very rare entity identified in recent years [3]. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 16, 2017 Category: Pathology Authors: Pelin Y ıldız, Kemal Behzatoğlu, Ezgi Hacıhasanoğlu, Oğuzhan Okcu, Haydar Durak, Uğur Yücetaş Source Type: research
