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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

More on grid morphometry in hotdogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the study by Prayson et al in which the authors used morphometric methods to assess the meat and fat contents of different hotdog brands and compare their results to the package labels. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Authors: Shilan Hameed, Omar Hameed Tags: Letters to the Editors Source Type: journals

Anaplastic large cell lymphoma: another entity in the differential diagnosis of small round blue cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We saw in consultation a biopsy specimen from a 6-year old girl with anaplastic lymphoma kinase (ALK)–positive anaplastic large cell lymphoma (ALCL). The tumor arose in soft tissue of the neck, and diagnostic tissue was obtained by core needle biopsy. Histologically, the neoplasm was cellular without pattern. Immunohistochemical workup with a large panel of antibodies at another institution showed immunoreactivity for NB84 and neuron specific enolase (dim). Antibodies specific for CD3, CD20, and CD45/LCA were negative; CD30 or ALK were not assessed. Electron microscopy showed cytoplasmic structures thought to b...
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Authors: Steven Gustafson, L. Jeffrey Medeiros, Neda Kalhor, Carlos E. Bueso-Ramos Tags: Review Article Source Type: journals

Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Because thyrolipoma (adenolipoma of thyroid) and thyrolipomatosis (diffuse lipomatosis of thyroid) are distinctively rare conditions with only few cases reported in the literature, we are reporting 5 additional cases. All the 5 patients were adult females, with ages from 38 to 79 years, who presented with thyroid masses. Four of the patients had normal thyroid function tests and one had mild hypothyroidism. All patients received partial or total thyroidectomy. The thyroid specimens showed either circumscribed yellow-tan masses (cases 1, 2, and 3) or diffuse yellow-brown discoloration (cases 4 and 5). Histologic e...
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Authors: Yimin Ge, Mario A. Luna, Daniel F. Cowan, Luan D. Truong, Alberto G. Ayala Tags: Original Contributions Source Type: journals

Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Primary neuroendocrine tumors of the gallbladder (GB) and extrahepatic biliary ducts (EHBDs) include carcinoid tumors and small-cell carcinomas (SCCs). They are uncommon, and therefore, little is known about their demographics and clinical course. From National Cancer Institute's Surveillance, Epidemiology, and End Results program (1973-2005), we analyzed the demographics and 10-year relative survival rates of carcinoids and SCCs of the GB and EHBD according to histologic type and stage. There were 119 cases of carcinoid tumors and 54 cases of SCCs in the GB. There were 31 carcinoid tumors and 17 SCCs in the EHBD...
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Authors: Jorge Albores-Saavedra, Kristen Batich, Sarah Hossain, Donald E. Henson, Arnold M. Schwartz Tags: Original Contributions Source Type: journals

Cyclooxygenase-2 expression, Ki-67 labeling index, and perifocal neovascularization in endometriotic lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There is a suggested pathogenetic role of cyclooxygenase-2 (COX-2) in endometriosis via angiogenesis and proproliferative mechanisms. The aim of the study was to investigate the immunohistochemical COX-2 expression in different anatomical sites of endometriosis and its correlation to proliferative activity and periendometriotic vascularization. Sixty endometrioses from different sites (ovarian, uterine, and peritoneal) were evaluated immunohistochemically for COX-2 expression. Cyclooxygenase-2 staining of 75% or more of the cells was defined as COX-2 overexpression and used as cutoff. Proliferative activity was d...
Source: Annals of Diagnostic Pathology - November 16, 2009 Category: Pathology Authors: Lars-Christian Horn, Bettina Hentschel, Alexandra Meinel, Henry Alexander, Cornelia Leo Tags: Original Contributions Source Type: journals

Epithelial cell adhesion molecule (EpCAM) expression in adamantinomatous craniopharyngiomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I have read with great interest the recent article by Tena-Suck et al in Annals of Diagnostic Pathology concerning EpCAM expression in adamantinomatous craniopharyngioma. More and more EpCAM emerges as a valuable marker for numerous cancer types, and its high expression is, with a few exceptions, associated with a negative prognosis for the afflicted patients . This detrimental phenotype can be explained in great parts upon its newly discovered capacities as an oncogenic signaling receptor . (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 22, 2009 Category: Pathology Authors: Olivier Gires Tags: Letters to the Editors Source Type: journals

Retained capsule endoscope leading to the identification of small bowel adenocarcinoma in a patient with undiagnosed Crohn diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the case of a 70-year-old patient who presented with several years of chronic, intermittent abdominal pain, previously diagnosed as irritable bowel syndrome. Radiographic evaluation, including upper gastrointestinal series with small bowel follow-through and computed tomography, demonstrated dilated small bowel with possible strictures. Colonoscopy and upper endoscopy were unrevealing. Attempted capsule endoscopy resulted in capsule retention. Subsequent laparoscopy led to the identification of severe, active Crohn disease with strictures, ulcers, crypt abscesses, pyloric metaplasia, and transmural inflammation...
Source: Annals of Diagnostic Pathology - September 22, 2009 Category: Pathology Authors: Christopher E. McGowan, Jorge A. Lagares-Garcia, Baishali Bhattacharya Tags: Radiologic-Pathologic Correlations Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 14, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 14, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 14, 2009 Category: Pathology Source Type: journals

Microscopic thrombi in glioblastoma multiforme do not predict the development of deep venous thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Patients with glioblastoma multiforme (GBM) are known to be at risk for hypercoagulable events. Tumoral intravascular thrombi likely contribute to the development of hypoxia and necrosis. The purpose of this study was to assess whether there is a relationship between the number of thrombi identified microscopically at the time of tumor resection and the subsequent development of extremity deep venous thrombosis (DVT). A retrospective review of 96 patients (53 men and 43 women; age range, 21-92 years; mean age, 60.2 years) with GBM (World Health Organization grade IV) was carried out. Thrombi were counted (number ...
Source: Annals of Diagnostic Pathology - September 14, 2009 Category: Pathology Authors: Nicholas F. Prayson, Lilyana Angelov, Richard A. Prayson Tags: Original Contributions Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 14, 2009 Category: Pathology Source Type: journals

Expression of matrix metalloproteinase-9 and significance of a macrophage assay in eosinophilic granulomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, there may be a cooperation between macrophages and MMP-9 in EGs, which correlates well with local recurrence. Their expression may therefore provide some prognostic indication of the possible aggressive and recurrence behavior of this lesion. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 9, 2009 Category: Pathology Authors: Manal Mohamed Zyada Tags: Original Contributions Source Type: journals

Frozen section discrepancy in the evaluation of nonneoplastic central nervous system samplesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Frozen section (FS) for intraoperative evaluation of central nervous system (CNS) lesions provides the neurosurgeon with a rapid preliminary pathologic diagnosis. Diagnosis of nonneoplastic lesions is particularly challenging in this venue. To highlight common diagnostic pitfalls, we sought to identify discrepancies between FS and final diagnoses among nonneoplastic CNS samples via a retrospective review of 303 FS cases encountered from 1997 to 2006. Thirty-nine (12.9%) discrepant diagnoses were identified, of which 27 were clinically suspected tumors. Final diagnoses in the discrepant group included the followin...
Source: Annals of Diagnostic Pathology - September 9, 2009 Category: Pathology Authors: Thomas P. Plesec, Richard A. Prayson Tags: Original Contributions Source Type: journals

Adapting lean to histology laboratoriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Histology laboratories (histolabs) can increase productivity and reduce turnaround time and errors by using any one of several available management tools. After a few years of operation, all histolabs develop workflow problems. Histology laboratories handling more than 20 000 cases per year benefit the most from implementing management tools, as occurred in the 25 facilities summarized in this article. Discontinuous workflow, lack of “pulling” between steps, accepting unavoidable waiting times while working with small batches within work cells, and a workflow with an uneven rate of completion, are some of th...
Source: Annals of Diagnostic Pathology - August 16, 2009 Category: Pathology Authors: René J. Buesa Tags: Technical Note Source Type: journals

Predictive value of cyclooxygenase 2 and Bcl-2 for cervical lymph node metastasis in mucoepidermoid carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to investigate the expression of COX-2 and BCl-2 and to correlate their expressions with the clinicopathologic features in the mucoepidermoid carcinoma (MEC). The expression of COX-2 and BCl-2 proteins was investigated in 16 archival tumor tissues of MEC using the streptavidin-biotin complex technique. Clinical information was obtained through the computerized retrospective database from the tumor registry between 2001 and 2007. It revealed that grading system of MEC did not correlate with the presence or absence of node metastasis. The expression of COX-2 and BCl-2 was variably expressed in all the...
Source: Annals of Diagnostic Pathology - August 16, 2009 Category: Pathology Authors: Manal M. Zyada, Mohammed E. Grawish, Heba M. Elsabaa Tags: Original Contributions Source Type: journals

Nucleoporin 88 expression in normal and neoplastic squamous epithelia of the uterine cervixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the expression of nucleoporin 88 (Nup88) in formalin-fixed, paraffin-embedded archival tissues of cervical specimens consisting of normal ectocervical squamous epithelia (n = 34), low-grade squamous intraepithelial lesions corresponding to cervical intraepithelial neoplasia (CIN) 1 (n = 9), high-grade squamous intraepithelial lesions corresponding to CIN2 and CIN3 (n = 28), and invasive squamous cell carcinoma (ISCC; n = 30) to determine whether expression of this factor is involved in the progression of the morphological spectrum from normal cervical epithelia to CIN and cervical ISCC. A standard i...
Source: Annals of Diagnostic Pathology - August 6, 2009 Category: Pathology Authors: Hermann Brustmann, Martina Hager Tags: Original Contributions Source Type: journals

Asbestosis: demonstration of distinctive interstitial fibroelastosis: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Asbestosis has long been defined as a diffuse interstitial “fibrotic” process, in similarity to other chronic interstitial pulmonary diseases. To address the hypothesis (which was based on morphological nuances) that the interstitial connective tissue response in asbestosis may be fibroelastotic rather than fibrotic, a comparative characterization of the connective response in cases of asbestosis and other forms of interstitial lung disease was performed. Archival open lung biopsies or autopsy specimens of pulmonary diseases featuring interstitial connective tissue abnormalities (15 of asbestosis, 21 of organ...
Source: Annals of Diagnostic Pathology - August 6, 2009 Category: Pathology Authors: Mark R. Wick, Todd J. Kendall, Jon H. Ritter Tags: Original Contributions Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - July 16, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - July 16, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - July 16, 2009 Category: Pathology Source Type: journals

Comparative analysis of the expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Several epidemiologic studies have shown the malignant transformation potential of oral lichen planus; however, this potential is subject of much controversy. To evaluate the expression of proteins related to the cell proliferation and apoptosis processes in oral lichen planus, we compared oral lichen planus with oral squamous cell carcinoma. Twenty-four cases of each lesion were submitted according to streptavidin-biotin technique to evaluate the immunohistochemical expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 proteins. χ2 test showed no statistically significant differences between the...
Source: Annals of Diagnostic Pathology - July 12, 2009 Category: Pathology Authors: Fernando Augusto Cervantes Garcia de Sousa, Thaís Cachuté Paradella, Yasmin Rodarte Carvalho, Luiz Eduardo Blumer Rosa Tags: Original Contributions Source Type: journals

Wegener's granulomatosis of the breast: a rare entity with daily clinical relevanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Wegener's granulomatosis (WG) is frequently diagnosed based on respiratory and renal manifestations. Breast involvement is rare. To date, approximately 27 cases of breast involvement by WG have been published. Most cases present in women between the third and seventh decades are unilateral and are accompanied by systemic manifestations of the disease. Although breast tissue is rarely affected by WG, the clinical presentation of these lesions requires that breast carcinoma be excluded from the clinical differential diagnosis. This publication is the most extensive review of the entity in the English literature in ...
Source: Annals of Diagnostic Pathology - June 21, 2009 Category: Pathology Authors: Daniela S. Allende, Christine N. Booth Tags: Review Article Source Type: journals

Mesonephric remnant hyperplasia: an unusual benign mimicker of prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of prostatic MR hyperplasia with architectural and cytologic atypia in a 56-year-old man. The microscopic appearance strongly suggested malignancy, but immunohistochemistry allowed the diagnosis to be corrected. The presence of MRs in prostate tissues may be more common than appreciated or reported. Once the possibility is considered, the diagnosis is easily confirmed using immunochemistry. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 25, 2009 Category: Pathology Authors: Mokrane Yacoub, Serge Milin, Jacques Irani, Gaëlle Fromont Tags: Case Reports Source Type: journals

Causes of death in older people autopsiedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Studies of causes of death in autopsied older people are not common in Brazil. The aims were to compare demographic data and causes of death in elderly people autopsied in the 1970s, 1980s, and 1990s and to relate causes of death to age, sex, color, and body mass index. Data survey of the autopsy reports came from the Hospital de Clínicas of the Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. The data were obtained from the autopsied individuals 60 years or older. Median age was 69 years (60-120 years) and was higher in the 1990s than in the 1970s (70.5 vs 68.0, P < .05) and higher in ...
Source: Annals of Diagnostic Pathology - May 24, 2009 Category: Pathology Authors: Flávia Aparecida de Oliveira, Vicente de Paula Antunes Teixeira, Ruy de Souza Lino Junior, Janaina Valadares Guimarães, Marlene Antônia dos Reis Tags: Original Contributions Source Type: journals

Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells. Two cases had focal stromal hypercellularity, one of which was with architectural features borderline between a fibroadenoma and a phyllodes tumor, but none was considered diagnostic of phyllodes tumor. One lesion had up to 4 mitotic figures per 10 high-power fields, including rare atypical mitotic figures. The remaining 3 cases lacked mitotic activity. Follow-up for 3 cases at 16 to 59 months revealed no evidence of tumor recurrence. The fourth case was lost to follow-up. It appears that the presence of pleomorphic ...
Source: Annals of Diagnostic Pathology - May 24, 2009 Category: Pathology Authors: Lei Huo, Michael Z. Gilcrease Tags: Original Contributions Source Type: journals

Central granular cell odontogenic tumor: a histopathologic and immunohistochemical studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of CGCOT involving the mandible of a 20-year-old white woman, emphasizing the immunohistochemical characteristics using a large panel of antibodies. The lesion was removed surgically, and after 4 years of follow-up, there are no evidences of recurrences. The odontogenic epithelium (OE) showed positivity for cytokeratins (CKs) AE1/AE3, 34βE12, CK5, CK7, CK8, CK14, CK19, E-cadherin, β-catenin, CD138, and p63. The granular cells were positive for vimentin, CD68, lysozyme, muscle-specific actin, α-smooth muscle actin, calponin, neuron-specific enolase (NSE), CD138, and bcl-2. Dendritic-like cells surroundi...
Source: Annals of Diagnostic Pathology - May 22, 2009 Category: Pathology Authors: Ana Terezinha Marques Mesquita, Cássio Roberto Rocha Santos, Ricardo Santiago Gomez, Jacks Jorge, Jorge Esquiche León, Oslei Paes de Almeida Tags: Case Reports Source Type: journals

High-grade serous carcinoma of the ovaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Most carcinomas of the ovary are diagnosed as serous carcinomas, even when they do not have featured characteristics of serous neoplasms. In this review article, we describe and illustrate the 7 different types of ovarian carcinomas. We believe that it is essential to separate these tumors because it is most probable that they follow different molecular pathways and/or hormonal backgrounds. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 21, 2009 Category: Pathology Authors: Danielle Westfall, Andres A. Roma, Elvio G. Silva Tags: Review Article Source Type: journals

Imprint cytology of primary cardiac sarcomas: a report of 3 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study elucidated the cellular characteristics and immunohistochemistry for cardiac sarcomas using imprint smears as an aid to cytopathologic diagnosis. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 21, 2009 Category: Pathology Authors: Nobuzo Iwa, Kazuyoshi Masuda, Chikao Yutani, Tadao K. Kobayashi Tags: Original Contributions Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 15, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 15, 2009 Category: Pathology Tags: Frontmatter Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 15, 2009 Category: Pathology Source Type: journals

Instructions for AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 15, 2009 Category: Pathology Source Type: journals

Diseases associated with HIV infection: study of biopsies and surgical resection specimens at a large general hospital in Mexico CityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to analyze the type of diseases associated with HIV infection from a survey of the surgical pathology material accessioned at a large general hospital in Mexico City. From the archives of the pathology unit of the General Hospital of Mexico (Ministry of Health), we compiled data on biopsies and surgical specimen from different organs and tissues of HIV-infected patients (HIV/AIDS) received in the period from January 2005 to July 2008. We found a total of 52 cases, 41 men and 11 women. The main affected anatomical organ was the lymphatic nodes in 33 cases (63.4%), 7 corresponded to the digest...
Source: Annals of Diagnostic Pathology - May 15, 2009 Category: Pathology Authors: P. Sánchez-Peña, Monica B. Romero-Guadarrama, J. Aguirre-García Tags: Original Contributions Source Type: journals

Inverted urothelial papilloma of the urinary bladder with focal papillary pattern: a previously undescribed featureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report 2 examples of inverted urothelial papillomas with a focal papillary pattern. Both patients, a 43-year-old man and a 13-year-old adolescent boy, presented with hematuria. In addition to the characteristic trabecular endophytic growth pattern and bland cytologic features, the tumors showed focal papillary architecture in the endophytic component. Because of this feature, both tumors were misinterpreted as papillary urothelial carcinoma with inverted pattern. However, the papillary fronds were similar to those of exophytic urothelial papilloma. They were lined by 3 to 8 layers of normal-appearing urothelial cells of...
Source: Annals of Diagnostic Pathology - May 15, 2009 Category: Pathology Authors: Jorge Albores-Saavedra, Fredy Chable-Montero, Oscar X. Hernández-Rodríguez, Daniel Montante-Montes de Oca, Arturo Angeles-Angeles Tags: Original Contributions Source Type: journals

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(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 15, 2009 Category: Pathology Source Type: journals

Histologic grading of invasive lobular carcinoma: does use of a 2-tiered nuclear grading system improve interobserver variability?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The Nottingham histologic grade (NHG) is a prognostic marker for infiltrating ductal carcinoma. Its usefulness for invasive lobular carcinoma (ILC) has been less clear, given that 2 of the 3 parameters, tubule formation and mitotic activity, show little variation in ILC, placing much of the emphasis on nuclear grade. We have previously reported a trend for improved overall and relapse-free survival in patients with ILC of low nuclear grade, as classified by a 2-tiered nuclear grading system. Given the inherent potential for interobserver variability with any grading system, the goal of this study is to compare in...
Source: Annals of Diagnostic Pathology - May 10, 2009 Category: Pathology Authors: Amy L. Adams, David C. Chhieng, Walter C. Bell, Tom Winokur, Omar Hameed Tags: Original Contributions Source Type: journals

Monotypic epithelioid angiomyolipoma of the adrenal gland: an unusual site for a rare extrarenal tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Epithelioid angiomyolipoma (AML) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis. Extrarenal AMLs are rare, and to the best of our knowledge, this is the first reported case of a primary monotypic epithelioid AML of adrenal gland in a patient without evidence of tuberous sclerosis. The patient is a 42-year old man who presented with retroperitoneal hemorrhage resulting from spontaneous rupture of adrenal mass. Histologically, the tumor showed a prominent component of epithelioid smooth muscle cells with slightly pleomorphic nuclei, sometimes wit...
Source: Annals of Diagnostic Pathology - April 26, 2009 Category: Pathology Authors: Antonio D'Antonio, Alessia Caleo, Oliviero Caleo, Gianfranco De Dominicis, Amedeo Boscaino Tags: Case Reports Source Type: journals

Mantle cell lymphoma as a rare cause of intussusception: a report of 2 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present 2 additional cases of intussusception at the ileocecal valve in patients being treated for mantle cell lymphoma, and a review of the pertinent literature is presented. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 23, 2009 Category: Pathology Authors: Andrea Grin, Runjan Chetty, Denis Bailey Tags: Case Reports Source Type: journals

Ghost cell odontogenic carcinoma arising in calcifying odontogenic cystEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A case of exceptionally rare odontogenic malignant tumor, called ghost cell odontogenic carcinoma, is described. The tumor was considered to be derived from calcifying odontogenic cyst, which had been resected 5 years before. In the present resected specimen, cellular atypia, mitotic activity, Ki-67 labeling index, and p53 positivity were all increased in comparison with the initially resected specimen. This is a valuable case in which malignant transformation from calcifying odontogenic cyst to ghost cell odontogenic carcinoma was proven by the histopathologic and immunohistochemical findings. Pathologists shoul...
Source: Annals of Diagnostic Pathology - April 20, 2009 Category: Pathology Authors: Utaroh Motosugi, Ikuko Ogawa, Tetsuya Yoda, Takahiro Abe, Masashi Sugasawa, Shin-ichi Murata, Masanori Yasuda, Takaki Sakurai, Yoshihiko Shimizu, Michio Shimizu Tags: Case Reports Source Type: journals

Detection of lymphatic invasion in resected cases of primary pancreatic cancer based on immunohistochemistry of D2-40Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We investigated the presence of lymphatic invasion detected by D2-40 immunostaining compared to conventional hematoxylin-eosin (HE) staining in primary pancreatic cancer. We also compared the alkaline phosphatase-fast red detection method with the 3,3′-diaminobenzidine (DAB) detection method. We reviewed 25 cases of pancreatic cancer with lymph node (LN) metastases and 15 cases without LN metastases and evaluated the detection rate of lymphatic invasion by HE stain slide alone and D2-40 immunostains. Regarding the cases with positive LN metastasis, 4 (16%) of the 25 cases showed lymphatic invasion by HE slide a...
Source: Annals of Diagnostic Pathology - April 3, 2009 Category: Pathology Authors: Yoshihiko Shimizu, Ling Jin, Hiroshi Yamaguchi, Utaroh Motosugi, Seiya Sannohe, Koji Nagata, Takaki Sakurai, Shinichi Murata, Masanori Yasuda, Michio Shimizu Tags: Original Contributions Source Type: journals

Barrett's esophagus: diagnostic challenges and recent developmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study are as follows: (1) Discuss the definition of BE and features differentiating BE vs intestinal metaplasia involving cardia. (2) Describe the morphological approach of diagnosing and grading of dysplasia and differentiation of high-grade dysplasia from intramucosal carcinoma. (3) Role of special stains in diagnosis of BE and dysplasia. (4) Brief review the literature on histologic and endoscopic factors associated with progression of BE to adenocarcinoma. (5) Discuss the biomarkers in progression of BE to adenocarcinoma. The following conclusions from this review are important and should be appl...
Source: Annals of Diagnostic Pathology - April 2, 2009 Category: Pathology Authors: Dipen M. Maru Tags: Review Article Source Type: journals

Incidence of pathologic complete response in women treated with preoperative chemotherapy for locally advanced breast cancer: correlation of histology, hormone receptor status, Her2/Neu, and gross pathologic findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Neoadjuvant chemotherapy is the standard of care for patients with locally advanced breast cancer and is used increasingly for large operable breast cancer. The aim of this study was to assess the rate of pathologic complete response (pCR) in our patient population with locally advanced breast cancer and identify predictive factors for pCR after neoadjuvant chemotherapy. We studied a cohort of 205 patients and compared histologic features and biomarkers in the pretreatment biopsy with the corresponding pathologic response in the subsequent resection specimen. A pCR was defined as the absence of any microscopic ev...
Source: Annals of Diagnostic Pathology - April 2, 2009 Category: Pathology Authors: Isabel Alvarado-Cabrero, Georgia Alderete-Vázquez, Marissa Quintal-Ramírez, Marcia Patiño, Erika Ruíz Tags: Original Contributions Source Type: journals

Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, breast angiosarcoma remains a rare disease. Rosen's method for grading breast angiosarcoma is easy to implement and correlates well with clinical outcome. There are no distinct clinical or histologic differences between primary and postradiation breast angiosarcomas. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 2, 2009 Category: Pathology Authors: Xiao Yun Wang, Joseph Jakowski, Ossama W. Tawfik, Patricia A. Thomas, Fang Fan Tags: Original Contributions Source Type: journals

Verrucous carcinoma of the cervix in a case with uterine prolapseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case involving association of verrucous carcinoma of the cervix with uterine prolapse. A 86-year-old woman was admitted with postmenopausal vaginal bleeding. The gynecologic examination revealed the uterine prolapse with a exophytic tumorous mass (3 × 6 × 8 cm) on the cervix. A punch biopsy was taken from the tumor, which revealed coilocytotic and mild dysplastic changes in the squamous epithelium; invasion of the underlying stroma could not be evaluated. A cervical swab was tested for human papillomavirus (HPV) DNA using the polymerase chain reaction, and HPV type 31 was detected. The tumorous mass was tota...
Source: Annals of Diagnostic Pathology - April 1, 2009 Category: Pathology Authors: Banu Dane, Cem Dane, Murat Erginbas, Safak Baran, Ahmet Cetin Tags: Case Reports Source Type: journals

Solitary fibrous tumor of the pancreasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 67-year-old woman was found to have an incidental pancreatic mass on computed tomographic examination of her abdomen in the course of investigation of hematuria. The radiologic features were of a hypervascular mass in the uncinate process of the head of the pancreas, and a preoperative diagnosis of a neuroendocrine tumor was favored. A Whipple procedure was performed. The uncinate process contained a 2.6-cm well-circumscribed mass. Histologic evaluation showed a lesion composed of alternating hypercellular areas made up of spindle-shaped cells and hypocellular areas with hyalinized, keloidal-like fibrous tissue...
Source: Annals of Diagnostic Pathology - April 1, 2009 Category: Pathology Authors: Runjan Chetty, Richa Jain, Stefano Serra Tags: Case Reports Source Type: journals