Annals of Hematology
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Clinical efficacy of a bortezomib, cyclophosphamide, thalidomide, and dexamethasone (Vel-CTD) regimen in patients with relapsed or refractory multiple myeloma: a phase II study
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Abstract The clinical efficacy and safety of a four-drug combination of bortezomib, cyclophosphamide, thalidomide, and dexamethasone
was assessed for patients with relapsed or refractory multiple myeloma. Seventy patients received at least two cycles of treatment
with bortezomib 1.3 mg/m2 intravenously on days 1, 4, 8, and 11; cyclophosphamide 150 mg/m2 orally on days 1–4; thalidomide 50 mg/day orally every day; and dexamethasone 20 mg/m2 intravenously on days 1, 4, 8, and 11. The overall best response rate was 88%, with 46% complete response, 9% very good partial
response, and 33% parti...
Source: Annals of Hematology - November 18, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Erratum to: Results of FLT3 mutation screening and correlations with immunophenotyping in 169 Brazilian patients with acute myeloid leukemiaEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s00277-009-0860-1Authors
Antonio R. Lucena-Araujo, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilDanielle L. Souza, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilFabio Morato de Oliveira, University of São Paulo Hematology Division, Department of Internal...
Source: Annals of Hematology - November 18, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Cytogenetic features and prognosis analysis in Chinese patients with myelodysplastic syndrome: a multicenter studyEmail this article to a colleague.
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In this study, we retrospectively analyzed clinical and cytogenetic data from 435 Chinese adult primary MDS patients.
In addition, we evaluated the prognostic value of the World Health Organization classification as well as six prognostic scoring
systems in these patients. The median follow-up time was 25.1 months (5.5–53.2). Of the 435 patients, 186 (42.8%) had died
and 40 (9.2%) had progressed to acute myeloid leukemia. Multivariate analysis identified older age, higher percent of marrow
blasts, and poor-risk IPSS cytogenetics as characteristics associated with worse survival and higher risk of leukemia transf...
Source: Annals of Hematology - November 18, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Hyperlipidemic myeloma: review of 53 casesEmail this article to a colleague.
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In conclusion, the clinical characteristics, the therapeutic options,
and the pathophysiologic mechanisms of hyperlipidemic myeloma are comprehensively reported using the available data from all
53 published cases in the literature.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0849-9Authors
Benjamin Misselwitz, University Hospital Zürich Department of Internal Medicine Rämistr. 100 8091 Zürich SwitzerlandJeroen S. Goede, University Hospital Zürich Clinic of Haematology Rämistr. 100 8091 Zürich SwitzerlandBernhard C. Pestalozzi, University Hospital Zürich Clinic of Oncology Rämi...
Source: Annals of Hematology - November 18, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Jumping translocation involving 1q21 during long-term complete remission of acute myeloid leukemiaEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0855-yAuthors
Sumimasa Nagai, University of Tokyo Department of Hematology and Oncology, Graduate School of Medicine 7-3-1, Hongo, Bunkyo-ku Tokyo 1138655 JapanYasuhito Nannya, University of Tokyo Department of Hematology and Oncology, Graduate School of Medicine 7-3-1, Hongo, Bunkyo-ku Tokyo 1138655 JapanTsuyoshi Takahashi, University of Tokyo Department of Hematology and Oncology, Graduate School of Medicine 7-3-1, Hongo, Bunkyo-ku Tokyo 1138655 JapanMineo Kurokawa, University of Tokyo Department of Hematology and Oncology, Graduate Schoo...
Source: Annals of Hematology - November 10, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
ABO discrepancy in an elderly patient with IgA kappa-type multiple myelomaEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0858-8Authors
So Young Kim, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi-dong, Dongdaemun-gu Seoul 130-702 Republic of KoreaSeung Hwan Oh, Inje University College of Medicine Department of Laboratory Medicine Gaegeum-dong, Busanjin-gu Busan 614-735 Republic of KoreaKyung Sun Park, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi-dong, Dongdaemun-gu Seoul 130-702 Republic of KoreaMin Jin Kim, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi...
Source: Annals of Hematology - November 10, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Acquired erythropoietic protoporphyriaEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0859-7Authors
Daniel Blagojevic, Landesklinikum St. Poelten Karl Landsteiner Institute for Dermatological Research St. Poelten AustriaThomas Schenk, Landesklinikum St. Poelten Department of Internal Medicine I St. Poelten AustriaOskar Haas, Ambulatorium Medgen Vienna AustriaBrigitte Zierhofer, Landesklinikum St. Poelten Karl Landsteiner Institute for Dermatological Research St. Poelten AustriaChristophoros Konnaris, Medical University of Vienna Department of Gynecology and Obstetrics Vienna AustriaFranz Trautinger, Landesklinikum St. Poelte...
Source: Annals of Hematology - November 9, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Resolution of invasive fungal sinusitis in immunocompromised patients: neutrophil count is crucial beside a combined medical and surgical approachEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0854-zAuthors
Patrizia Zappasodi, Foundation IRCCS Policlinico San Matteo, University of Pavia Division of Haematology 27100 Pavia ItalyMarianna Rossi, Foundation IRCCS Policlinico San Matteo, University of Pavia Division of Haematology 27100 Pavia ItalyCarlo Castagnola, Foundation IRCCS Policlinico San Matteo, University of Pavia Division of Haematology 27100 Pavia ItalyFabio Pagella, Foundation IRCCS Policlinico San Matteo, University of Pavia Department of Otorhinolaryngology Pavia ItalyElina Matti, Foundation IRCCS Policlinico San Matte...
Source: Annals of Hematology - November 6, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Amyloid in bone marrow smears of patients affected by multiple myelomaEmail this article to a colleague.
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Abstract Systemic AL amyloidosis is associated with nearly 15% of cases of multiple myeloma, but data on the frequency and significance
of amyloid deposits in the bone marrow of patients affected by multiple myeloma without clinical signs of systemic amyloidosis
are scanty. Bone marrow smears of 166 unselected patients affected by multiple myeloma (126 at diagnosis and 40 after treatment)
were stained with Congo red and studied by transmission and birefringence microscopy. Both focal and diffuse storages were
considered positive. Overall, 67 patients were positive and 99 were negative to Congo red and apple-...
Source: Annals of Hematology - November 5, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Splenic artery pseudoaneurysm with rupture by transformed splenic marginal zone B cell lymphomaEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0851-2Authors
Yu-Chung Huang, Taipei Veterans General Hospital Division of Hematology & Oncology, Department of Medicine No. 201, Sec. 2, Shipai Rd Taipei 112 TaiwanZhi-Yi Xie, Taipei Veterans General Hospital Division of Hematology & Oncology, Department of Medicine No. 201, Sec. 2, Shipai Rd Taipei 112 TaiwanHsiou-Shan Tseng, Taipei Veterans General Hospital Department of Radiology No. 201, Sec. 2, Shipai Rd Taipei 112 TaiwanChing-Feng Yang, Taipei Veterans General Hospital Department of Pathology No. 201, Sec. 2, Shipai Rd Taipei 112...
Source: Annals of Hematology - November 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Impact of critical care reconfiguration and track-and-trigger outreach team intervention on outcomes of haematology patients requiring intensive care admissionEmail this article to a colleague.
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This study was done to assess outcomes and the impact of an early warning scoring system (EWS) and early involvement
of ICU outreach teams. One hundred five haematology patients (haematopoietic stem cell transplant (HSCT) or non-HSCT) had
114 admissions to ICU between April 2006 and August 2008 which coincided with hospital-wide implementation of EWS. The survival
to ICU discharge was 56 (53%). Thirty-three (33%) patients were alive at 6 months giving a 1-year survival of 31%. Of the
39 HSCT patients, nine were post-autologous and 30 post-allogeneic transplant. The survival to ICU discharge was 22 (56%)
with 14 (...
Source: Annals of Hematology - October 29, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progressionEmail this article to a colleague.
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Abstract Lenalidomide consistently induces transfusion independence and complete cytogenetic response in patients with myelodysplastic
syndromes with 5q deletion. Only limited information on long-term outcome is currently available. We performed a long-term
follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide.
At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six
percent of patients progressed into acute myeloid leukaemia. Most of them (87%) acquired ...
Source: Annals of Hematology - October 23, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Serum albumin level is a significant prognostic factor reflecting disease severity in symptomatic multiple myelomaEmail this article to a colleague.
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Abstract Serum albumin level, in association with serum interleukin-6 level, is a significant prognostic factor in multiple myeloma
patients. The aim of this study was to determine any clinical factors associated with decreased serum albumin level. We retrospectively
reviewed the records of 373 patients diagnosed with multiple myeloma at the Asan Medical Center, Seoul, Korea, between January
1996 and March 2008. Patients were divided into two groups according to serum albumin level (above or below 3.5 g/dL, the
prognostic cutoff value), and clinical parameters were compared between groups. We aimed to i...
Source: Annals of Hematology - October 21, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
ABO discrepancy in a young Korean serviceman with common variable immunodeficiencyEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0840-5Authors
Seung Hwan Oh, Inje University Department of Laboratory Medicine, College of Medicine GaeGeum-dong, Busanjin-gu Busan 614-735 South KoreaCheol-In Kang, Sungkyunkwan University School of Medicine Division of Infectious Diseases, Samsung Medical Center 50 Ilwon-dong, Gangnam-gu Seoul 135-710 South KoreaJuwon Kim, Yonsei University College of Medicine Department of Laboratory Medicine 250 Seongsanno, Seodaemun-gu Seoul 120-752 South KoreaTae Sung Park, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Ho...
Source: Annals of Hematology - October 21, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Plasmablastic crisis of Philadelphia chromosome-positive chronic myeloid leukemiaEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0852-1Authors
Kalliopi N. Manola, National Center for Scientific Research (NCSR) “Demokritos” Laboratory of Cytogenetics 15310 Aghia Paraskevi Athens GreeceDespina Pantelidou, Medical School AUTH First Department of Internal Medicine, Hematology department Thessaloniki GreeceMaria Papaioannou, Medical School AUTH First Department of Internal Medicine, Hematology department Thessaloniki Greece
Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology)
Source: Annals of Hematology - October 21, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
18F-FDG PET/CT in primary non-Hodgkin's lymphoma of the sinonasal tractEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0842-3Authors
Adrian Tempescul, CHU Brest Department of Clinical Hematology, Institute of Cancerology and Hematology Avenue Foch 29609 Brest FranceSolene Querellou, CHU Brest Department of Nuclear Medicine Avenue Foch 29609 Brest FranceJean-Christophe Ianotto, CHU Brest Department of Clinical Hematology, Institute of Cancerology and Hematology Avenue Foch 29609 Brest FranceSylvie Boisramé, CHU Brest Department of Odontology Avenue Foch 29609 Brest FranceGerald Valette, CHU Brest Department of ORL Avenue Foch 29609 Brest FranceChristian Ber...
Source: Annals of Hematology - October 21, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Vitamin D deficiency and anemia: a cross-sectional studyEmail this article to a colleague.
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This study demonstrates an association of vitamin D deficiency and a greater risk of anemia, lower mean hemoglobin,
and higher usage of erythrocyte-stimulating agents. Future randomized studies are warranted to examine whether vitamin D directly
affects erythropoiesis.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0850-3Authors
John J. Sim, Kaiser Permanente Los Angeles Medical Center Division of Nephrology and Hypertension 4700 Sunset Blvd., 2nd Floor Nephrology Los Angeles CA 90027 USAPeter T. Lac, Kaiser Permanente Los Angeles Medical Center Division of Nephrology and Hypertension 47...
Source: Annals of Hematology - October 20, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Glutathione S-transferase gene deletions and their effect on iron status in HbE/β thalassemia patientsEmail this article to a colleague.
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This study was aimed to compare the prevalence of GST deletions in 240 HbE/β thalassemia patients with 100 controls and to
determine role of deletions on iron overload. We observed significantly higher frequency of GSTT1 (P = 0.001) and GSTT1/GSTM1 (P = 0.03) in comparison to controls. Patients who had null genotype for both the alleles, i.e., GSTT1/GSTM1 had significantly
higher levels of serum iron (P = 0.007) and serum ferritin (P = 0.001) than patients with normal genotype for GST deletions. This is the first study to prove the role of GST gene deletions
with iron overload in HbE/β thalassemia...
Source: Annals of Hematology - October 16, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Relevance of target cell-induced apoptosis as mechanism of resistance against natural killer cellsEmail this article to a colleague.
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Abstract Natural killer (NK) cells contribute to the graft-versus-leukemia effect after allogeneic stem cell transplantation. However,
the efficacy of NK cell-mediated tumor cell lysis is limited due to target cell resistance, and target cell-induced apoptosis
(TiA) was proposed to contribute to differences in susceptibility to NK cells. Here we analyzed the effects of target cells
on the apoptosis of cytokine-activated NK cells in vitro. We found no association of target cell susceptibility and TiA of
NK cells in an array of human and murine target-effector cell combinations. Incubation of NK cells with cas...
Source: Annals of Hematology - October 13, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Idiopathic neutropenia with fewer than 5% dysplasia may be a distinct entity of idiopathic cytopenia of undetermined significanceEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0845-0Authors
Keiko Ando, Tokyo Medical University The First Department of Internal Medicine (Hematology Division) 6-7-1 Nishishinjuku, Shinjuku-ku Tokyo 160-0023 JapanAtsushi Kodama, Tokyo Medical University Division of Cytogenetics, Central Laboratory Tokyo JapanTamiko Iwabuchi, Tokyo Medical University The First Department of Internal Medicine (Hematology Division) 6-7-1 Nishishinjuku, Shinjuku-ku Tokyo 160-0023 JapanJunko H. Ohyashiki, Tokyo Medical University Intractable Disease Research Center Tokyo JapanKazuma Ohyashiki, Tokyo Medica...
Source: Annals of Hematology - October 13, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Subcutaneous anti-d globulin application is a safe treatment option of immune thrombocytopenia in childrenEmail this article to a colleague.
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Abstract Subcutaneous (sc) administration of anti-d seems to offer the same efficacy as intravenous administration but with less side effects. Here we report our experience
with sc anti-d for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc
anti-d. They received a median of 2 sc anti-d applications (range 1–31) with a dosage of 250–375 IE/kg body weight. Only in one out of a total of 102 single applications,
a minimal and self-limited side effect (chills) had been observed. The mean platelet count was almost doubled after sc a...
Source: Annals of Hematology - October 13, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Postallogeneic hematopoietic stem cell transplantation relapse of acute myeloid leukemia presenting with salivary gland myelosarcomaEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0843-2Authors
Yu-Hsuan Lai, Kaohsiung Medical University Hospital Division of Hematology-Oncology, Department of Internal Medicine Kaohsiung TaiwanChao-Sung Chang, Kaohsiung Medical University Hospital Division of Hematology-Oncology, Department of Internal Medicine Kaohsiung TaiwanYi-Chang Liu, Kaohsiung Medical University Hospital Division of Hematology-Oncology, Department of Internal Medicine Kaohsiung TaiwanTa-Chih Liu, Kaohsiung Medical University Hospital Division of Hematology-Oncology, Department of Internal Medicine Kaohsiung Taiw...
Source: Annals of Hematology - October 9, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Cell cycle and apoptosis regulatory gene expression in the bone marrow of patients with de novo myelodysplastic syndromes (MDS)Email this article to a colleague.
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In conclusion, our study showed altered expression of genes involved in apoptosis and cell cycle in MDS
and increased expression of cyclin D1 in patients with CMML.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0835-2Authors
Christina Economopoulou, Attikon University Hospital, 2nd Propedeutic Clinic of Internal Medicine 1 Rimini Str., Haidari Athens GreeceVassiliki Pappa, Attikon University Hospital, 2nd Propedeutic Clinic of Internal Medicine 1 Rimini Str., Haidari Athens GreeceSotiris Papageorgiou, Attikon University Hospital, 2nd Propedeutic Clinic of Internal Medicine 1 Rimini Str.,...
Source: Annals of Hematology - October 8, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes: associations with childhood leukemiaEmail this article to a colleague.
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Abstract The most common mutation of the HFE gene C282Y has shown a risk association with childhood acute lymphoblastic leukemia (ALL) in Welsh and Scottish case–control
studies. This finding has not been replicated outside Britain. Here, we present a thorough analysis of the HFE gene in a panel of HLA homozygous reference cell lines and in the original population sample from South Wales (117 childhood
ALL cases and 414 newborn controls). The 21 of 24 variants analyzed were from the HFE gene region extending 52 kb from the histone gene HIST1H1C to HIST1H1T. We identified the single-nucleotide polymorphi...
Source: Annals of Hematology - October 6, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Deferasirox (Exjade®) significantly improves cardiac T2* in heavily iron-overloaded patients with β-thalassemia majorEmail this article to a colleague.
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This study monitored cardiac siderosis using T2* MRI in a cohort of 19 heavily iron-overloaded
patients with β-thalassemia major receiving iron chelation therapy with deferasirox over an 18-month period. Overall, deferasirox
therapy significantly improved mean ± standard deviation cardiac T2* from a baseline of 17.2 ± 10.8 to 21.5 ± 12.8 ms (+25.0%;
P = 0.02). A concomitant reduction in median serum ferritin from a baseline of 5,497 to 4,235 ng/mL (−23.0%; P = 0.001), and mean liver iron concentration from 24.2 ± 9.0 to 17.6 ± 12.9 mg Fe/g dry weight (−27.1%; P =...
Source: Annals of Hematology - October 1, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Hemophagocytosis associated with leukemia: a striking association with juvenile myelomonocytic leukemiaEmail this article to a colleague.
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Abstract The aim of this study was to describe the characteristics and outcome in a group of pediatric patients with hematological
malignancies who developed hemophagocytosis at diagnosis or during the disease course. Eight patients with hematological malignancy
and associated hemophagocytosis were included. The initial diagnosis was juvenile myelomonocytic leukemia (JMML) in five,
nonlymphoblastic leukemia (ANLL) in two, and T-cell lymphoma associated with myeloproliferative syndrome in one patient. Hemophagocytosis
was concomitantly present at the time of diagnosis of the primary disease in four of the fiv...
Source: Annals of Hematology - October 1, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrateEmail this article to a colleague.
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This study provides the first direct evidence that Beriplex®
P/N can be rapidly infused for emergency coumarin therapy reversal without altering safety or effectiveness.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0830-7Authors
Ingrid Pabinger, Medical University Vienna Department of Internal Medicine, Division of Haematology and Haemostaseology Vienna AustriaAndreas Tiede, Hannover Medical School Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation Hannover GermanyUwe Kalina, Hemophilia/Critical Care, CSL Behring GmbH Clinical Research & Development Marburg ...
Source: Annals of Hematology - September 29, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Reduction of serum free light chains predict renal recoveryEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0836-1Authors
Colin A. Hutchison, University Hospital Birmingham Renal Institute of Birmingham, Department of Nephrology Birmingham B152TH UK
Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology)
Source: Annals of Hematology - September 28, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Levels of angiogenic factors in patients with multiple myeloma correlate with treatment responseEmail this article to a colleague.
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Abstract Angiogenesis plays a significant role in the pathogenesis of multiple myeloma (MM). We have measured concentrations of angiogenesis
activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and hepatocyte growth factor
(HGF), and inhibitors, including endostatin, thrombospondin-1 (TSP-1), and angiostatin in the peripheral and bone marrow blood
of MM patients at diagnosis and after high-dose chemotherapy. We have analyzed 96 patients with secretory MM. Serial measurements
of angiogenesis factors/inhibitors were analyzed in the plasma by subgroups based on the be...
Source: Annals of Hematology - September 28, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Stomatocytosis heralding a case of acute Wilsonian crisisEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0832-5Authors
Amit R. Mehta, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School Department of Medicine New Brunswick NJ USAGratian Salaru, The Cancer Institute of New Jersey New Brunswick NJ USAJonathan S. Harrison, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School Department of Medicine New Brunswick NJ USA
Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology)
Source: Annals of Hematology - September 24, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Fatal pneumocystis jiroveci pneumonia in ABVD-treated Hodgkin lymphoma patientsEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0833-4Authors
Mats Kalin, Karolinska University Hospital Solna and Institutet Department of Medicine, Division of Infectious Diseases Stockholm SwedenSigurdur Yngvi Kristinsson, Karolinska University Hospital Solna Department of Medicine, Division of Hematology SE-171 76 Stockholm SwedenHonar Cherif, Karolinska University Hospital Solna Department of Medicine, Division of Hematology SE-171 76 Stockholm SwedenMarianne Lebbad, Swedish Institute for Infectious Disease Control Stockholm SwedenMagnus Björkholm, Karolinska University Hospital So...
Source: Annals of Hematology - September 18, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myelomaEmail this article to a colleague.
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Abstract Multiple myeloma is a malignant B-cell neoplasm that involves the skeleton in approximately 80% of the patients. With an average
age of 60 years and a 5-years survival of nearly 45% Brenner et al. (Blood 111:2516–2520, 35) the onset is to be classified as occurring still early in life while the disease can be very aggressive and debilitating.
In the last decades, several new imaging techniques were introduced. The aim of this review is to compare the different techniques
such as radiographic survey, multidetector computed tomography (MDCT), whole-body magnetic resonance imaging (WB-MRI), fluor...
Source: Annals of Hematology - September 17, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Decreased hemolysis following administration of antioxidant—fermented papaya preparation (FPP) to a patient with PNHEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0821-8Authors
Hussam Ghoti, Edit Wolfson Medical Center Department of Hematology Holon IsraelHanna Rosenbaum, Rambam Medical Center Department of Hematology and Bone Marrow Transplantation Haifa IsraelEitan Fibach, Hadassah–Hebrew University Medical Center Department of Hematology Jerusalem IsraelEliezer A. Rachmilewitz, Edit Wolfson Medical Center Department of Hematology Holon Israel
Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology)
Source: Annals of Hematology - September 16, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/REmail this article to a colleague.
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In conclusion, curcumin reversed multidrug
resistance of MOLP-2/R through inhibition of FA/BRCA pathway. The possible mechanisms include (1) reduction of DNA damage
repair and stimulation of apoptosis of tumor cells through inhibition of FA/BRCA pathway, which is important for DNA repair,
and (2) achievement of high concentration in target cells. Curcumin may be a safe reversal agent of multidrug resistance with
low-dose DNA cross-linking agents.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0831-6Authors
Hui Xiao, Zhongnan Hospital of Wuhan University Department of Hematology No.169 ...
Source: Annals of Hematology - September 16, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Results of FLT3 mutation screening and correlations with immunophenotyping in 169 Brazilian patients with acute myeloid leukemiaEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0817-4Authors
Antonio R. Lucena-Araujo, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilDanielle L. Souza, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilFabio Morato de Oliveira, University of São Paulo Hematology Division, Departmen...
Source: Annals of Hematology - September 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Long-term response to deferiprone therapy in Asian IndiansEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s00277-009-0825-4Authors
Inusha Panigrahi, Post-Graduate Institute of Medical Education & Research (PGIMER) Hemato-Oncology & Genetics Units, Department of Pediatrics, Advanced Pediatrics Centre (APC) Chandigarh IndiaRam K. Marwaha, Post-Graduate Institute of Medical Education & Research (PGIMER) Hemato-Oncology & Genetics Units, Department of Pediatrics, Advanced Pediatrics Centre (APC) Chandigarh IndiaRashmi R. Das, Post-Graduate Institute of Medical Education & Research (PGIMER) Hemato-Oncology & Genetics Units, Department of Pediatrics, Advanced Pediatrics Cen...
Source: Annals of Hematology - September 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Compound heterozygosity of Hb Hamilton and de novo mutated HbM SaskatoonEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0828-1Authors
Saskia Brunner-Agten, Kantonsspital Aarau Zentrum für Labormedizin 5001 Aarau SwitzerlandMartin Hergersberg, Kantonsspital Aarau Zentrum für Labormedizin 5001 Aarau SwitzerlandRoberto Herklotz, Kantonsspital Aarau Zentrum für Labormedizin 5001 Aarau SwitzerlandAndreas Hirt, Inselspital Bern Kinderpoliklinik 3010 Bern SwitzerlandAndreas R. Huber, Kantonsspital Aarau Zentrum für Labormedizin 5001 Aarau Switzerland
Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology)
Source: Annals of Hematology - September 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Compound heterozygosity for HbD Punjab and polyadenylation signal mutation causes clinically asymptomatic mild hypochromia and microcytosisEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0827-2Authors
Katta Mohan Girisha, Kasturba Medical College Genetics Clinic, Department of Pediatrics Manipal 576104 IndiaSaadi Abdul Vahab, Manipal University Manipal Life Sciences Center Manipal 576104 IndiaAshwin B. Dalal, Center for DNA Fingerprinting and Diagnostics Hyderabad IndiaP. M. Gopinath, Manipal University Manipal Life Sciences Center Manipal 576104 IndiaK. Satyamoorthy, Manipal University Manipal Life Sciences Center Manipal 576104 India
Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology)
Source: Annals of Hematology - September 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Expression analysis of proteins involved in the non homologous end joining DNA repair mechanism, in the bone marrow of adult de novo myelodysplastic syndromesEmail this article to a colleague.
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Abstract Myelodysplastic syndromes (MDS) are characterized by genetic instability which is associated with abnormal DNA repair mechanisms.
The most lethal type of DNA damage are double strand DNA breaks (DSBs), which are mainly repaired by Non Homologous End Joining
Mechanism (NHEJ), whose core enzyme components include the Ku70/Ku80 heterodimer, DNA–PKcs, XRCC4 and DNA Ligase IV. The aim
of the present study was the analysis of expression of proteins required for NHEJ in bone marrow cells of adult de novo MDS
and their association with clinical characteristics and prognosis. Our analysis included 48 cases...
Source: Annals of Hematology - September 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significanceEmail this article to a colleague.
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Abstract Aberrant DNA methylation is considered an important epigenetic mechanism for gene inactivation. Monoclonal gammopathy of undetermined
significance (MGUS) is believed to be a precursor of multiple myeloma (MM). We have analyzed methylation status of p15
INK4B
, p16
INK4A
, ARF, SOCS-1, p27
KIP1
, RASSF1A, and TP73 genes in bone marrow DNA samples from 21 MGUS and 44 MM patients, in order to determine the role of aberrant promoter methylation
as one of the steps involved in the progression of MGUS to MM. Methylation specific polymerase chain reaction assay followed
by DNA sequencing of the ...
Source: Annals of Hematology - September 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survivalEmail this article to a colleague.
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This study was designed to identify ALL patients with initial diagnosis of JRA, compare their
clinicolaboratory characteristics and outcome with other ALL patients treated at our center. Case records of 762 patients
with ALL were analyzed. Information regarding the clinical-demographic profile, therapy and outcome were recorded. Of the
children, 49 (6.4%) had initial presentation mimicking JRA. Asymmetric oligoarthritis was the most common pattern of joint
involvement. Majority presented with fever, pallor, arthritis, night pain, and bone pain. None of the routine prognostic factors
including age, gender, lymphadenopa...
Source: Annals of Hematology - September 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Progressive multifocal leukoencephalopathy: a report of three cases in HIV-negative patients with non-Hodgkin's lymphomas treated with rituximabEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0819-2Authors
Marco Tuccori, University of Pisa Division of Pharmacology and Chemotherapy, Department of Internal Medicine Via Roma 55 56126 Pisa ItalyDaniele Focosi, University of Pisa Division of Haematology, Department of Oncology, Transplantations and New Technologies in Medicine Pisa ItalyFabrizio Maggi, University of Pisa Virology Section and Retrovirus Centre, Department of Experimental Pathology Pisa ItalyMirco Cosottini, University of Pisa Department of Neuroscience Pisa ItalyBarbara Meini, Tuscan Regional Centre for Pharmacovigila...
Source: Annals of Hematology - September 3, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Rituximab retherapy in patients with relapsed aggressive B cell and mantle cell lymphomaEmail this article to a colleague.
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We report here a single-centre retrospective
outcome analysis of second-line immunochemotherapy with rituximab. In 28 patients with relapsed or refractory diffuse large
B cell lymphomas, first-line immunochemotherapy had induced objective responses in 18 patients. Nine of 28 patients responded
to rituximab containing salvage therapy, leading to a median overall survival of 243 days after start of second immunochemotherapy.
Long-term disease free survivors (1,260 and 949 days) were restricted to the group of twelve patients that had received allogeneic
stem cell transplantation as consolidation therapy. In 21...
Source: Annals of Hematology - September 1, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oilEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0824-5Authors
Uwe Platzbecker, Universitätsklinikum “Carl Gustav Carus” Dresden Medizinische Klinik und Poliklinik I 01307 Dresden GermanyCarlo Aul, St. Johannes Hospital Duisburg Duisburg GermanyGerhard Ehninger, Universitätsklinikum “Carl Gustav Carus” Dresden Medizinische Klinik und Poliklinik I 01307 Dresden GermanyAristoteles Giagounidis, St. Johannes Hospital Duisburg Duisburg Germany
Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology)
Source: Annals of Hematology - August 28, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Response to Imatinib mesylate in chronic myeloid leukemia patients with variant BCR-ABL fusion transcriptsEmail this article to a colleague.
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Abstract Chronic myeloid leukemia patients with different BCR-ABL transcripts might respond differently to Imatinib mesylate. This
prompted us to study BCR-ABL transcripts in chronic myeloid leukemia (CML) patients and their correlation with response to
Imatinib. Eighty-seven chronic phase CML patients (median age, 35 years; range, 13–62 years; M/F, 59:28) were included in
this study; 57 patients had received interferon-α and/or hydroxyurea, and 30 were previously untreated. All patients received
Imatinib mesylate (Gleevec) 400 mg daily. Complete hematological remission rate and major cytog...
Source: Annals of Hematology - August 28, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Frequencies of non-Hodgkin’s lymphoma subtypes in Kuwait: comparisons between different ethnic groupsEmail this article to a colleague.
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Abstract There is a wide variation in the prevalence of various subtypes of non-Hodgkin’s lymphoma worldwide. The aim of this study
was to determine the relative frequency of different subtypes of non-Hodgkin’s lymphoma in Kuwait based on the Revised European–American
Lymphoma (REAL) classification. From 1998 to 2006, 738 subjects were included that were registered with non-Hodgkin’s lymphoma
in the population-based cancer registry at the Kuwait Cancer Control Center. Expert pathologists reviewed histological slides
from all subjects. We performed detailed immunohistochemical studies and classified s...
Source: Annals of Hematology - August 27, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Low incidence of clinically apparent thromboembolism in Korean patients with multiple myeloma treated with thalidomideEmail this article to a colleague.
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Abstract The frequency of thromboembolic events (TE) in Caucasian patients with multiple myeloma (MM) receiving thalidomide as the
initial treatment has been reported to be 10~58% without prophylactic anticoagulation. Korean MM patients treated with thalidomide
were studied to determine the frequency of TE and associated risk factors. A retrospective medical record review of the Korean
MM registry from 25 centers in Korea between 2003 and 2007 was performed. We assessed the incidence of arterial and venous
TE and the associated clinical parameters. Three hundred and sixty MM patients (median age 61 year...
Source: Annals of Hematology - August 24, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Subcutaneous alemtuzumab plus cyclosporine for the treatment of aplastic anemiaEmail this article to a colleague.
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Abstract Aplastic anemia (AA) is most frequently due to autoimmune attack on its own stem cells. Alemtuzumab is a monoclonal antibody
which recognizes the CD52 antigen on the surface of T and B cells. It has proved useful in autoimmune diseases, lymphoproliferative
conditions, and graft versus host disease. Based on its immunosuppressive properties, we treated 14 AA patients with alemtuzumab.
Median age was 23 years. Ten milligrams of alemtuzumab were injected subcutaneously each day for five consecutive days. Cyclosporine
A was also administered orally at a dose of 2 mg/kg every 12 h for 3&nb...
Source: Annals of Hematology - August 24, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Treatment of 5q-syndrome with lenalidomide in an HIV-positive patient under cARTEmail this article to a colleague.
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0815-6Authors
Sabine Blum, Centre Hospitalier Universitaire Vaudois Service of Haematology Rue du Bugnon 46 1011 Lausanne SwitzerlandMatthias Cavassini, Centre Hospitalier Universitaire Vaudois Department of Infectious Diseases Rue du Bugnon 46 1011 Lausanne SwitzerlandJean-François Lambert, Centre Hospitalier Universitaire Vaudois Service of Haematology Rue du Bugnon 46 1011 Lausanne SwitzerlandAurélie Fayet, Centre Hospitalier Universitaire Vaudois Division of Clinical Pharmacology Rue du Bugnon 46 1011 Lausanne SwitzerlandMarc Schapira...
Source: Annals of Hematology - August 24, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
Reactivation of hepatitis B virus following rituximab-based regimens: a serious complication in both HBsAg-positive and HBsAg-negative patientsEmail this article to a colleague.
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In conclusion, rituximab-based therapy may cause serious HBV-related complications and even death
in both HBsAg-positive and HBsAg-negative patients.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0806-7Authors
Sung-Nan Pei, Chang Gung University College of Medicine Division of Hema-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital–Kaohsiung Medical Center Kaohsiung TaiwanChien-Hung Chen, Chang Gung University College of Medicine Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital–Kaohsiung Medical Center Kaohsiung Ta...
Source: Annals of Hematology - August 21, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals
