No prognostic impact of staging bone scan in patients with stage IA non-small cell lung cancer
ConclusionThere were no significant differences in overall survival, bone metastasis-free survival, and recurrence-free survival between asymptomatic patients with clinical stage IA NSCLC with or without preoperative bone scan. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 11, 2024 Category: Nuclear Medicine Source Type: research
Diagnostic performance of a deep-learning model using 18F-FDG PET/CT for evaluating recurrence after radiation therapy in patients with lung cancer
ConclusionThe 2D slice-based CNN model using18F-FDG PET imaging was able to distinguish well between RT-related changes and tumour recurrence in patients with lung cancer. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 8, 2024 Category: Nuclear Medicine Source Type: research
Parametric net influx rate imaging of 68Ga-DOTATATE in patients with neuroendocrine tumors: assessment of lesion detectability
ConclusionsPatlakKi imaging provides nuclear physicians with a PET image with higher tumor contrast which may enhance confidence in diagnosis with possibly reduced false positive results, albeit an equivalent detectability, compared to static SUV image. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 4, 2024 Category: Nuclear Medicine Source Type: research
The effect of harmonization on the variability of PET radiomic features extracted using various segmentation methods
ConclusionRadiomic features are vulnerable to different segmentation methods. ComBat harmonization might be considered a solution to overcome the poor reliability of radiomic features. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 4, 2024 Category: Nuclear Medicine Source Type: research
Examination of iatrogenic FDG accumulation after COVID-19 vaccination
ConclusionOur study found that FDG accumulation in the axillary lymph nodes and deltoid muscle was higher within a shorter time after vaccination, and axillary lymph node accumulation was higher in young patients, females, and those with adverse reactions of fever and myalgia. No significant relationship was observed between blood type and the frequency of FDG accumulation. Confirming the vaccination status, time since vaccination, and the presence of adverse reactions before PET may reduce false positives. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 2, 2024 Category: Nuclear Medicine Source Type: research
Manual on the proper use of the 211At-labeled PSMA ligand ([211At]PSMA-5) for clinical trials of targeted alpha therapy (1st edition)
AbstractRecently, an astatine-labeled prostate-specific membrane antigen (PSMA) ligand ([211At]PSMA-5) has been developed for the targeted alpha therapy of patients with prostate cancer. This manual delineates its physicochemical characteristics to assist healthcare professionals in understanding the α-ray-emitting drug of [211At]PSMA-5 when administered to patients. The safety considerations regarding the handling and use of this drug in clinical trials are outlined, based on the proper usage manual of previous studies. The dose limits, as defined by the guidelines of the International Commission on Radiological Protecti...
Source: Annals of Nuclear Medicine - March 28, 2024 Category: Nuclear Medicine Source Type: research
18F-FDG PET/CT metabolism multi-parameter prediction of chemotherapy efficacy in locally progressive gastric cancer
ConclusionsUsing18F-FDG PET/CT multiparametric quantitative analysis, Lauren bowel type and change in total lesion glycolysis>45.2% were independent predictors of the efficacy of neoadjuvant chemotherapy in patients with gastric adenocarcinoma. Additionally, the dual-module assessment demonstrated high predictive efficacy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 27, 2024 Category: Nuclear Medicine Source Type: research
Evaluation of two-dimensional total bone uptake (2D-TBU) and bone scan index (BSI) extracted from active bone metastatic burden on the bone scintigraphy in patients with radium-223 treatment
ConclusionsThe 2D-TBU may offer advantages over BSI in classifying patients towards radium-223 treatment based on the degree of progression of bone metastases. This study supports the importance of preliminary assessment of bone metastasis status using BSI and 2D-TBU extracted from VSBONE BSI for radium-223 treatment decisions. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 22, 2024 Category: Nuclear Medicine Source Type: research
Comparison of consistency in centiloid scale among different analytical methods in amyloid PET: the CapAIBL, VIZCalc, and Amyquant methods
ConclusionsThe study demonstrated strong agreement among the three methods for calculating CL values. Despite minor variations in the absolute values of the Centiloid scores obtained using these methods, the overall agreement suggests that they are interchangeable. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 21, 2024 Category: Nuclear Medicine Source Type: research
Novel indices representing heterogeneous distributions of myocardial perfusion imaging
ConclusionsHeterogeneity in MPI can be evaluated using SD, BW95%, and entropy through histogram analysis. These novel indices may help identify patients with subtle myocardial changes, even in images that show preserved perfusion (345/350). (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 19, 2024 Category: Nuclear Medicine Source Type: research
Prognostic value of left ventricular mechanical dyssynchrony indices derived from gated myocardial perfusion SPECT in coronary artery disease: a systematic review and meta-analysis
ConclusionLVMD from gated myocardial SPECT is a significant prognostic factor for coronary artery disease. Phase analysis of gated SPECT may be useful for accurate risk stratification and could be applied for clinical decision-making in such patients. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 18, 2024 Category: Nuclear Medicine Source Type: research
Improvement in the estimation of perfusable tissue fraction and myocardial flow reserve in the ischemic myocardial lesions using ECG-gated dynamic myocardial PET with 15O-water
ConclusionsThe ECG-gated dynamic15O-water PET suppressed the myocardial motion effect and resulted in a lower PTF and MFR in ischemic myocardial lesions than the non-gated PET. The ECG-gated PET seemed to be better than the conventional non-gated dynamic PET for the detection of ischemic myocardial lesion. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 13, 2024 Category: Nuclear Medicine Source Type: research
Flare phenomenon visualized by 99mTc-bone scintigraphy has prognostic value for patients with metastatic castration-resistant prostate cancer
ConclusionFavorable prognosis, with fewer disturbances from other factors such as the use of abiraterone or/and enzalutamide, PSA changes, and BSI, was attainable in cases when the mCRPC patient demonstrated flare phenomenon. Follow-up bone scintigraphy at least every 3 months could help to determine the prognosis of patients with bone metastasis of mCRPC. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 13, 2024 Category: Nuclear Medicine Source Type: research
Quantitative analysis of abdominal aortic blood flow by 99mTc-DTPA renal scintigraphy in patients with heart failure
ConclusionsBased on99mTc-DTPA renal scintigraphy, TTPa may be used as a straightforward and non-invasive tool that can effectively distinguish patients with and without HF. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 11, 2024 Category: Nuclear Medicine Source Type: research
Impact of [11C]methionine PET with Bayesian penalized likelihood reconstruction on glioma grades based on new WHO 2021 classification
ConclusionsThe BPL increased mean SUVmax and mean T/Nmax in lesions with higher contrast such as grade 4 glioma. The discrimination power between grades 2/3 and 4 in SUVmax was also increased using [11C]methionine PET images reconstructed with BPL. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 11, 2024 Category: Nuclear Medicine Source Type: research
