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Elsevier Journal Vaccine Features Milestone Biodefense PublicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Last week during the 'Vaccines for Biothreats and Emerging and Neglected Diseases Symposium' in Galveston TX, USA, the Elsevier journal Vaccine released a supplement dedicated to vaccines for biodefense. This publication provides a comprehensive, state-of-the-art overview on vaccines that have been developed against a diverse group of human and veterinary pathogens, including Bacillus anthracis, smallpox, and blue tongue. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 21, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news

Identification of Novel Non-Hydroxamate Anthrax Toxin Lethal Factor Inhibitors by Topomeric Searching, Docking and Scoring, and in Vitro ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Chemical Information and Modeling, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Chemical Information and Modeling)
Source: Journal of Chemical Information and Modeling - November 20, 2009 Category: Chemistry Tags: article Source Type: journals

Milestone biodefense publication by Elsevier journal VaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Elsevier) Last week during the Vaccines for Biothreats and Emerging and Neglected Diseases Symposium in Galveston Texas, the Elsevier journal Vaccine released a supplement dedicated to vaccines for biodefense. This publication provides a comprehensive, state-of-the-art overview on vaccines that have been developed against a diverse group of human and veterinary pathogens, including Bacillus anthracis, smallpox and blue tongue. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2009 Category: Global & Universal Source Type: news

An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anthrax lethal toxin triggers death in some cell types, such as macrophages, and causes a variety of cellular dysfunctions in others. Collectively, these effects dampen the innate and adaptive immune systems to allow Bacillus anthracis to survive and proliferate in the mammalian host. The diverse effects caused by the toxin have in part been attributed to its interference with signaling pathways in target cells. Lethal factor (LF) is the proteolytic component of the toxin, and cleaves six members of the mitogen-activated protein kinase kinase family after being delivered to the cytosol by the cell-binding component of the ...
Source: FEBS Journal - November 18, 2009 Category: Research Authors: Stephanie Ngai, Sarah Batty, Kuo-Chieh Liao, Jeremy Mogridge Source Type: journals

FDA requests more details on HGSI anthrax drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human Genome Sciences Inc. said federal regulators still need more information before they can approve the Rockville company’s anthrax treatment, delivering a blow in what’s otherwise been a good month for the company. (HGSI) (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - November 16, 2009 Category: American Health Source Type: journals

FDA requests more details on HGSI anthrax drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human Genome Sciences Inc. said federal regulators still need more information before they can approve the Rockville company’s anthrax treatment, delivering a blow in what’s otherwise been a good month for the company. (HGSI) (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 16, 2009 Category: Biotechnology Source Type: journals

New Explanation For Nature's Hardiest Life FormEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Got food poisoning? The cause might be bacterial spores, en extremely hardy survival form of bacteria, a nightmare for health care and the food industry and an enigma for scientists. Spore-forming bacteria, present almost everywhere in our environment, can also cause serious infectious diseases, such as tetanus, anthrax, and botulism. Now researchers from Lund University and the U.S. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 14, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

New Explanation For Nature's Hardiest Life FormEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Got food poisoning? The cause might be bacterial spores, en extremely hardy survival form of bacteria, a nightmare for health care and the food industry and an enigma for scientists. Spore-forming bacteria, present almost everywhere in our environment, can also cause serious infectious diseases, such as tetanus, anthrax, and botulism. Now researchers from Lund University and the U.S. (Source: GastroIntestinal News From Medical News Today)
Source: GastroIntestinal News From Medical News Today - November 14, 2009 Category: Gastroenterology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Liver abscess and sepsis with Bacillus pantothenticus in an immunocompetent patient: A first case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bacillus species are aerobic, gram-positive, spore forming rods that are usually found in the soil, dust, streams, and other environmental sources. Except for Bacillus. anthracis (B. anthracis), most species display low virulence, and only rarely cause infections in hosts with weak or damaged immune systems. There are two case reports of B. cereus as a potentially serious bacterial pathogen causing a liver abscess in an immunologically competent patient. We herein report a case of liver abscess and sepsis caused by B. pantothenticus in an immunocompetent patient. Until now, no case of liver abscess due to B. pantothent...
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Na JS, Kim TH, Kim HS, Park SH, Song HS, Cha SW, Yoon HJ Tags: World J Gastroenterol Source Type: journals

New Explanation For Nature's Hardiest Life FormEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Got food poisoning? The cause might be bacterial spores, en extremely hardy survival form of bacteria, a nightmare for health care and the food industry and an enigma for scientists. Spore-forming bacteria, present almost everywhere in our environment, can also cause serious infectious diseases, such as tetanus, anthrax, and botulism. Now researchers have made a breakthrough in our understanding of the molecular characteristics of spores that in the long term may lead to new methods for sterilizing food and medical equipment. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 12, 2009 Category: Science Source Type: news

Research into "biowarfare" diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A $4m federal grant has been given to researchers in US for development of antibiotics to tackle plague, anthrax and tularemia (Source: Pharmacy Europe)
Source: Pharmacy Europe - November 12, 2009 Category: Drugs & Pharmacology Source Type: news

New explanation for nature's hardiest life formEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Swedish Research Council) Got food poisoning? The cause might be bacterial spores, en extremely hardy survival form of bacteria, a nightmare for health care and the food industry and an enigma for scientists. Spore-forming bacteria, present almost everywhere in our environment, can also cause serious infectious diseases, such as tetanus, anthrax, and botulism. Now researchers from Lund University and the US have made a breakthrough in our understanding of the molecular characteristics of spores that in the long term may lead to new methods for sterilizing food and medical equipment. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 12, 2009 Category: Biology Source Type: news

Universal Detection Technology Presents Live Training Demos Of Anthrax Detection Kits At Milipol Paris 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Universal Detection Technology (OTCBB: UNDT), a developer of early-warning monitoring technologies and counter-terrorism training programs to protect people from bioterrorism and other infectious health threats, announced today that it will showcase the latest developments in bio-weapons detection t (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2009 Category: Consumer Health News Tags: Bio-terrorism / Terrorism Source Type: news

Universal Detection Technology Presents Live Training Demos Of Anthrax Detection Kits At Milipol Paris 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Universal Detection Technology (OTCBB: UNDT), a developer of early-warning monitoring technologies and counter-terrorism training programs to protect people from bioterrorism and other infectious health threats, announced today that it will showcase the latest developments in bio-weapons detection technology, including the TS-10-5-agent biodetection kit, with live training kit demos at Milipol Paris 2009. Universal Detection Technology's kits, certified earlier this year by the U. (Source: Bio-terrorism / Terrorism News From Medical News Today)
Source: Bio-terrorism / Terrorism News From Medical News Today - November 11, 2009 Category: Global & Universal Tags: Bio-terrorism / Terrorism Source Type: news

UIC To Develop Antibiotics Against Potential Bioterrorism AgentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers at the University of Illinois at Chicago have received a $4 million federal grant to develop new antibiotics to treat anthrax, tularemia and plague. Anthrax, tularemia and plague are caused by naturally occurring bacteria classified as "category-A" agents that could be used in bioterrorism and biowarfare. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today - November 11, 2009 Category: Infectious Diseases Tags: Bio-terrorism / Terrorism Source Type: news

UIC To Develop Antibiotics Against Potential Bioterrorism AgentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers at the University of Illinois at Chicago have received a $4 million federal grant to develop new antibiotics to treat anthrax, tularemia and plague. Anthrax, tularemia and plague are caused by naturally occurring bacteria classified as "category-A" agents that could be used in bioterrorism and biowarfare. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2009 Category: Consumer Health News Tags: Bio-terrorism / Terrorism Source Type: news

Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide LicensingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Human Anthrax Vaccine Program must be stopped. Scott Miller and Company has completed the feature film "A Call to Arms:2009 Edition" and the one-hour television documentary "Fatal Immunity: The Human Anthrax Vaccine Story" to inform the public about the clear and present danger of top secret government science turned into for-profit human anthrax vaccines with no accountability to its victims. It is available for world-wide licensing by motion picture and television distributors and exhibitors. (PRWeb Nov 4, 2009) Read the full story at http://www.prweb.com/releases/scottmillerandco/documentaryp...
Source: PRWeb: Medical Pharmaceuticals - November 6, 2009 Category: Pharmaceuticals Source Type: news

Heme Transfer to the Bacterial Cell Envelope Occurs via a Secreted Hemophore in the Gram-positive Pathogen Bacillus anthracis [Biomolecular Networks]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present evidence that the heme-bound form of IsdX1 rapidly and directionally transfers heme to IsdC, a NEAT protein covalently attached to the cell wall, as well as to IsdX2. In both cases, the transfer of heme is mediated by a physical association between the donor and recipient. Unlike Staphylococcus aureus, whose NEAT proteins acquire heme from hemoglobin directly at the bacterial surface, B. anthracis secretes IsdX1 to capture heme in the extracellular milieu and relies on NEAT-NEAT interactions to deliver the bound heme to the envelope via IsdC. Understanding the mechanism of NEAT-mediated iron transport into patho...
Source: Journal of Biological Chemistry - November 6, 2009 Category: Chemistry Authors: Fabian, M., Solomaha, E., Olson, J. S., Maresso, A. W. Tags: Biomolecular Networks Source Type: journals

Human Anthrax Vaccines - A Call To ArmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Human Anthrax Vaccine Program must be stopped. Scott Miller and Company has completed the feature film "A Call to Arms:2009 Edition" and the one-hour television documentary "Fatal Immunity: The Human Anthrax Vaccine Story" to inform the public about the clear and present danger of top secret government science turned into for-profit human anthrax vaccines with no accountability to its victims. It is available for world-wide licensing by motion picture and television distributors and exhibitors. (Source: Disabled World)
Source: Disabled World - November 5, 2009 Category: Disability Tags: Books and Publications Source Type: info

Risk of importing zoonotic diseases through wildlife trade, United States.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The United States is the world's largest wildlife importer, and imported wild animals represent a potential source of zoonotic pathogens. Using data on mammals imported during 2000-2005, we assessed their potential to host 27 selected risk zoonoses and created a risk assessment that could inform policy making for wildlife importation and zoonotic disease surveillance. A total of 246,772 mammals in 190 genera (68 families) were imported. The most widespread agents of risk zoonoses were rabies virus (in 78 genera of mammals), Bacillus anthracis (57), Mycobacterium tuberculosis complex (48), Echinococcus spp. (41), and Le...
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Pavlin BI, Schloegel LM, Daszak P Tags: Emerg Infect Dis Source Type: journals

Universal Detection Technology Brings Anthrax Detection Kits And Bioterrorism Prevention Training To Milipol Paris 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Universal Detection Technology (OTCBB: UNDT), a developer of early-warning monitoring technologies and counter-terrorism training programs to protect people from bioterrorism and other infectious health threats, announced that it will showcase the latest developments in bio-weapons detection technology, including the TS-10-5-agent biodetection kit, at Milipol Paris 2009. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 30, 2009 Category: Consumer Health News Tags: Bio-terrorism / Terrorism Source Type: news

[Perspectives] Book In Brief: Parents' guide to H1N1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Outbreaks of infectious diseases have a way of grabbing the public imagination that outstrips any other medical event. The first decade of the 21st century has seen anthrax spores in the US mail, severe acute respiratory syndrome, avian influenza A H5N1, and now a pandemic of influenza A H1N1 (so called swine flu), which have generated a level of media and public attention that has at times bordered on the hysterical. (Source: LANCET)
Source: LANCET - October 30, 2009 Category: Journals (General) Authors: John McConnell Tags: Perspectives Source Type: journals

Anthrax drug approval put on holdEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
More information is needed on an anthrax treatment before the effectiveness of the drug against its anti-bacterial rivals can be assessed (Source: Pharmacy Europe)
Source: Pharmacy Europe - October 29, 2009 Category: Drugs & Pharmacology Source Type: news

DHS Proposes Guidance for Anthrax Responders - JEMS.comEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON - In conjunction with an interagency task force, Department of Homeland Security (DHS) Secretary Janet Napolitano today announced new proposed guidance for protecting the health of emergency... (Source: JEMS Latest News)
Source: JEMS Latest News - October 28, 2009 Category: Emergency Medicine Source Type: news

BioThrax (Anthrax Vaccine Adsorbed Emergent BioSolutions) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BioThrax (Anthrax Vaccine Adsorbed Emergent BioSolutions) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 28, 2009 Category: Drugs & Pharmacology Source Type: consumer

U.S. panel: More study on Human Genome anthrax drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SILVER SPRING, Maryland (Reuters) - Animal data suggests a proposed Human Genome Sciences Inc drug may help people exposed to anthrax but more study is needed to show the treatment adds benefit beyond antibiotics alone, a U.S. advisory panel said on Tuesday. (Source: Reuters: Health)
Source: Reuters: Health - October 27, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

FDA panel want more study of Human Genome Sciences anthrax drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Food and Drug Administration advisory panel says an experimental anthrax drug made by Human Genome Sciences Inc. needs further tests. (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - October 27, 2009 Category: American Health Source Type: journals

FDA panel want more study of Human Genome Sciences anthrax drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Food and Drug Administration advisory panel says an experimental anthrax drug made by Human Genome Sciences Inc. needs further tests. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 27, 2009 Category: Biotechnology Source Type: journals

Anthrax Drug Stirs ConcernEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FDA said it has concerns about the reliability of human data involving an experimental anthrax treatment from Human Genome Sciences. (Source: WSJ.com: Health)
Source: WSJ.com: Health - October 26, 2009 Category: Pharmaceuticals Tags: FREE Source Type: news

Staphylococcus aureus synthesizes adenosine to escape host immune responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the ability of S. aureus to escape phagocytic clearance in blood and identified adenosine synthase A (AdsA), a cell wall–anchored enzyme that converts adenosine monophosphate to adenosine, as a critical virulence factor. Staphylococcal synthesis of adenosine in blood, escape from phagocytic clearance, and subsequent formation of organ abscesses were all dependent on adsA and could be rescued by an exogenous supply of adenosine. An AdsA homologue was identified in the anthrax pathogen, and adenosine synthesis also enabled escape of Bacillus anthracis from phagocytic clearance. Collectively, these results s...
Source: The Journal of Experimental Medicine - October 26, 2009 Category: Internal Medicine Authors: Thammavongsa, V., Kern, J. W., Missiakas, D. M., Schneewind, O. Tags: Articles Source Type: journals

Pharmacometrics-Based Dose Selection of Levofloxacin as a Treatment for Post-Exposure Inhalational Anthrax in Children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this paper is to describe the basis of the chosen pediatric dose recommended for the label. Pharmacokinetic (PK) data from 90 pediatric patients receiving 7 mg/kg levofloxacin and two studies in 47 healthy adults receiving 500 and 750 mg levofloxacin were used for the pharmacometric analyses. Body weight was found to be a significant covariate for levofloxacin clearance and volume of distribution. Consistent with developmental physiology, clearance was also found to be reduced in pediatric patients below 2 years of age due to immature renal function. Different dosing regimens were simulated to match adult ...
Source: Antimicrobial Agents and Chemotherapy - October 26, 2009 Category: Microbiology Authors: Li F, Nandy P, Chien S, Noel GJ, Tornoe CW Tags: Antimicrob Agents Chemother Source Type: journals

Pretreatment of Epithelial Cells with Rifaximin Alters Bacterial Attachment and Internalization Profiles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rifaximin is a poorly absorbed semi-synthetic antibiotic derivative of rifampin licensed for use in the treatment of traveler's diarrhea. Rifaximin reduces symptoms of enteric infection, often without pathogen eradication and with limited effects on intestinal flora. Epithelia cells (HEp-2, larynx; HCT-8, ileocecal; A549, lung and HeLa, cervical) were pretreated with rifaximin (or control antibiotics) prior to the addition of enteroaggregative Echerichia coli (EAEC). EAEC adherence was significantly reduced following rifaximin pretreatment compared to pretreatment with rifampin or doxycycline for 3 of 4 cell lines test...
Source: Antimicrobial Agents and Chemotherapy - October 26, 2009 Category: Microbiology Authors: Brown EL, Xue Q, Jiang ZD, Xu Y, Dupont HL Tags: Antimicrob Agents Chemother Source Type: journals

Questions raised about Human Genome Science's anthrax vaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A report prepared for a Food and Drug Administration panel scheduled to consider approval of Human Genome Sciences Inc.’s experimental anthrax drug questions whether it works better in humans than existing treatments. (HGSI) (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - October 23, 2009 Category: American Health Source Type: journals

Questions raised about Human Genome Science's anthrax vaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A report prepared for a Food and Drug Administration panel scheduled to consider approval of Human Genome Sciences Inc.’s experimental anthrax drug questions whether it works better in humans than existing treatments. (HGSI) (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 23, 2009 Category: Biotechnology Source Type: journals

High-Speed Test To Improve Pathogen Decontamination DevelopedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A NASA chemist has developed a technology intended to rapidly assess any presence of microbial life on spacecraft. This new method may also help the military test for disease-causing bacteria, such as a causative agent for anthrax, and may also be useful in the medical, pharmaceutical and other fields. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 23, 2009 Category: Science Source Type: news

Sensitive and specific enzyme immunoassays for antigenic trisaccharide from Bacillus anthracis sporesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sandrine G. Y. Dhenin, Vincent Moreau, Marie-Claire Nevers, Christophe Creminon, Florence Djedaini-Pilard (Paper from Org. Biomol. Chem.) Sandrine G. Y. Dhenin, Org. Biomol. Chem., 2009, DOI: 10.1039/b914534f To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - October 18, 2009 Category: Molecular Biology Authors: Sandrine G. Y. DheninVincent Moreau Marie-Claire Nevers Christophe Creminon Florence Djedaini-Pilard Source Type: journals

Direct Interaction between Anthrax Toxin Receptor 1 and the Actin CytoskeletonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - October 17, 2009 Category: Biochemistry Tags: article Source Type: journals

Processing, Assembly, and Localization of a Bacillus anthracis Spore Protein.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All Bacillus spores are encased in macromolecular shells. One of these is a proteinacious shell called the coat that, in Bacillus subtilis, provides critical protective functions. The Bacillus anthracis spore is the infectious particle for the disease anthrax. Therefore, the coat is of particular interest because it may provide essential protective functions required for the appearance of anthrax. Here, we analyze a protein component of the spore outer layers that was previously designated as BxpA. Our data indicate that a significant amount of BxpA is located below the spore coat and associated with the cortex. By SDS...
Source: Microbiology - October 14, 2009 Category: Microbiology Authors: Moody KL, Driks A, Rother GL, Cote CK, Brueggemann EE, Hines HB, Friedlander AM, Bozue JA Tags: Microbiology Source Type: journals

Book Review: Beyond Anthrax: The Weaponization of Infectious DiseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 49, Issue 9, Page 1462, 1 November 2009. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 13, 2009 Category: Infectious Diseases Tags: book review Source Type: journals

Proteomic studies of Bacillus anthracisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Future Microbiology , October 2009, Vol. 4, No. 8, Pages 983-998. (Source: Future Microbiology)
Source: Future Microbiology - October 13, 2009 Category: Cardiology Tags: article Source Type: journals

Procurement of spore-free Bacillus anthracis for molecular typing outside of BSL3 environmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This method eliminated viable spores in cell preparations of B. anthracis, yet still allowed the growth of vegetative cells to provide sufficient DNA suitable for analysis by Riboprinter® and PFGE.Significance and Impact of the Study: This method will provide safe cell preparations, prevent instrument contamination, and may be useful for other aerobic and anaerobic spore-formers. (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - October 12, 2009 Category: Microbiology Authors: D.S. King, V.A. Luna, A.C. Cannons, P.T. Amuso Source Type: journals

Humans and evolutionary and ecological forces shaped the phylogeography of recently emerged diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wagner The development of human civilizations and global commerce has led to the emergence and worldwide circulation of many infectious diseases. Anthrax, plague and tularaemia are three zoonotic diseases that have been intensely studied through genome characterization of the causative species and phylogeographical analyses. A few (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - October 11, 2009 Category: Microbiology Authors: Paul S. KeimDavid M. Wagner Tags: Review Source Type: journals

Through the Looking Glass, Mechanistic Insights from Enantiomeric Human Defensins [Protein Structure and Folding]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the small size and conserved tertiary structure of defensins, little is known at a molecular level about the basis of their functional versatility. For insight into the mechanism(s) of defensin function, we prepared enantiomeric pairs of four human defensins, HNP1, HNP4, HD5, and HBD2, and studied their killing of bacteria, inhibition of anthrax lethal factor, and binding to HIV-1 gp120. Unstructured HNP1, HD5, and HBD3 and several other human - and β-defensins were also examined. Crystallographic analysis showed a plane of symmetry that related LHNP1 and DHNP1 to each other. Either d-enantiomerization or line...
Source: Journal of Biological Chemistry - October 9, 2009 Category: Chemistry Authors: Wei, G., de Leeuw, E., Pazgier, M., Yuan, W., Zou, G., Wang, J., Ericksen, B., Lu, W.-Y., Lehrer, R. I., Lu, W. Tags: Protein Structure and Folding Source Type: journals

Temporal production of the two Bacillus anthracis siderophores, petrobactin and bacillibactin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bacillus anthracis secretes two siderophores, petrobactin (PB) and bacillibactin (BB). These siderophores were temporally produced during germination and outgrowth of spores (the usual infectious form of B. anthracis) in low-iron medium. The siderophore PB was made first while BB secretion began several hours later. Spore outgrowth early in an infection may require PB, whereas delayed BB production suggests a role for BB in the later stages of the infection. Incubation of cultures (inoculated as vegetative cells) at 37 degrees C, as compared to 2 degrees C, increased PB production and decreased secretion of BB, suggest...
Source: Biometals - October 8, 2009 Category: Biochemistry Authors: Wilson MK, Abergel RJ, Arceneaux JE, Raymond KN, Byers BR Tags: Biometals Source Type: journals

Universal Detection Technology Inks Deal With U.S. Department Of Commerce To Become Featured Exporter Of Anthrax Detection Equipment In FranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Universal Detection Technology (OTCBB:UNDT), a developer of early-warning monitoring technologies to protect people from bioterrorism and other infectious health threats and provider of counter-terrorism consulting and training services, announced today that the company has entered an agreement with U.S. Department of Commerce's Commercial Service to become a Featured U.S. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 6, 2009 Category: Consumer Health News Tags: Bio-terrorism / Terrorism Source Type: news

Behind the scenes, system sniffs for biological attacksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eight years after the anthrax attacks, a system known as BioWatch is quietly operating in more than 30 cities. A federally funded, ... (Source: USATODAY.com Health)
Source: USATODAY.com Health - October 6, 2009 Category: Consumer Health News Source Type: news

What is the Appropriate Treatment for a Pedal Puncture Wound?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Ciprofloxacin and other fluoroquinolones have demonstrated cartilage and joint toxicity when administered to immature laboratory animals. Therefore health care providers have been reluctant to use fluoroquinolones in young children and voluntarily have avoided them. However in 2002, more than 182,000 courses of fluoroquinolones were administered to children. Research data is limited but the pediatric safety profile appears to be similar to the adult safety profile. Current indications for fluoroquinolones include complicated urinary tract infections, treatment of opportunistic infections in immunocompromised pat...
Source: PediatricEducation.org - October 5, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

[News of the Week] Biosecurity: Lawmakers Signal Tougher Controls on Pathogen ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Concerns over the security of new biocontainment labs that have sprung up around the United States since the 2001 anthrax letter attacks threaten to slow the booming biodefense industry.Author: Yudhijit Bhattacharjee (Source: Science: Current Issue)
Source: Science: Current Issue - October 2, 2009 Category: Science Authors: Yudhijit Bhattacharjee Source Type: journals

NIAID To Fund Development Of Emergent BioSolutions' Advanced Anthrax Vaccine CandidateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Emergent BioSolutions Inc. (NYSE:EBS) announced that it was awarded a cooperative agreement from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, to further the development of one of Emergent's advanced anthrax vaccine candidates known as dmPA7909. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 2, 2009 Category: Consumer Health News Tags: Bio-terrorism / Terrorism Source Type: news