Uncertainty and innovation: Understanding the role of cell-based manufacturing facilities in shaping regulatory and commercialization environments
This study aims to fill an empirical gap in the literature that explores how CPT manufacturing facilities navigate current regulatory and commercialization environments in Canada, which together drive the translation of novel CPTs from bench to bedside. Using the multi-level model of practice-driven institutional change proposed by Smets et al., we demonstrate how CPT manufacturing practices are governed by established standards, yet meaningfully shape higher-order regulatory and commercial norms in CPT research and development. (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - November 11, 2016 Category: Genetics & Stem Cells Source Type: research
Genomic advancement: Aiming to affirm and improve human life
Publication date: Available online 9 November 2016 Source:Applied & Translational Genomics Author(s): Carol Isaacson Barash, Nigel G. Halford (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - November 9, 2016 Category: Genetics & Stem Cells Source Type: research
Developing integrated crop knowledge networks to advance candidate gene discovery
We describe the datasets and outline the methods, workflows and tools that we have developed for creating and visualizing these networks for the major crop species, wheat and barley. We present the global characteristics of such knowledge networks and with an example linking a seed size phenotype to a barley WRKY transcription factor orthologous to TTG2 from Arabidopsis, we illustrate the value of integrated data in biological knowledge discovery. The software we have developed (www.ondex.org) and the knowledge resources http://knetminer.rothamsted.ac.uk we have created are all open-source and provide a first step towards ...
Source: Applied and Translational Genomics - November 2, 2016 Category: Genetics & Stem Cells Source Type: research
Maximizing the potential of multi-parental crop populations
We present and apply two open software resources to simulate alternate strategies for the development of multi-parent populations. (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - October 29, 2016 Category: Genetics & Stem Cells Source Type: research
Wheat quality improvement at CIMMYT and the use of genomic selection on it
Publication date: Available online 29 October 2016 Source:Applied & Translational Genomics Author(s): Carlos Guzman, Roberto Javier Peña, Ravi Singh, Enrique Autrique, Susanne Dreisigacker, Jose Crossa, Jessica Rutkoski, Jesse Poland, Sarah Battenfield The International Center for Maize and Wheat Improvement (CIMMYT) leads the Global Wheat Program, whose main objective is to increase the productivity of wheat cropping systems to reduce poverty in developing countries. The priorities of the program are high grain yield, disease resistance, tolerance to abiotic stresses (drought and heat), and desirable q...
Source: Applied and Translational Genomics - October 29, 2016 Category: Genetics & Stem Cells Source Type: research
Mitochondrial transfer: Implications for assisted reproductive technologies
Publication date: Available online 15 October 2016 Source:Applied & Translational Genomics Author(s): A S Reznichenko, C Huyser, M S Pepper The use of mitochondrial transfer as a clinic procedure is drawing closer to reality. Here we provide a detailed overview of mitochondrial transfer techniques – both established and recent – including pronuclear, spindle, ooplasmic and blastomere transfer. Reasons as to why some techniques are more suitable for the prevention of mitochondrial DNA disease than others, as well as the advantages and disadvantages of each methodology, are discussed. The possible clinical i...
Source: Applied and Translational Genomics - October 14, 2016 Category: Genetics & Stem Cells Source Type: research
Translating Genetics Beyond Bench and Bedside: A Comparative Perspective on Health Care Infrastructures for ‘Familial’ Breast Cancer
Publication date: Available online 29 September 2016 Source:Applied & Translational Genomics Author(s): Erik Aarden Developments in genomics research are considered to have great potential for improving health care – making genomics an urgent site for translational efforts. Yet while much emphasis is put on the technical challenges of translation, there is less scholarly attention for the social infrastructures through which novel medical interventions may be delivered to patient populations. Reflecting the idea that cancer is at the frontier of genomic applications in health care, this paper explores how the ...
Source: Applied and Translational Genomics - September 28, 2016 Category: Genetics & Stem Cells Source Type: research
Omics challenges and unmet translational needs
Publication date: Available online 18 August 2016 Source:Applied & Translational Genomics Author(s): Carol Isaacson Barash (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - August 18, 2016 Category: Genetics & Stem Cells Source Type: research
A Systems Approach to Personalised Nutrition: Report on the Keystone Symposium “Human Nutrition, Environment and Health”
Publication date: Available online 4 August 2016 Source:Applied & Translational Genomics Author(s): Michael Maher, Amy Pooler, James Kaput, Martin Kussmann (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - August 4, 2016 Category: Genetics & Stem Cells Source Type: research
Empowered genome community: leveraging a bioinformatics platform as a citizen –scientist collaboration tool
Publication date: September 2015 Source:Applied & Translational Genomics, Volume 6 Author(s): Katherine Wendelsdorf, Sohela Shah There is on-going effort in the biomedical research community to leverage Next Generation Sequencing (NGS) technology to identify genetic variants that affect our health. The main challenge facing researchers is getting enough samples from individuals either sick or healthy – to be able to reliably identify the few variants that are causal for a phenotype among all other variants typically seen among individuals. At the same time, more and more individuals are having their genom...
Source: Applied and Translational Genomics - July 20, 2016 Category: Genetics & Stem Cells Source Type: research
Standardization and quality management in next-generation sequencing
Publication date: Available online 1 July 2016 Source:Applied & Translational Genomics Author(s): Christoph Endrullat, Jörn Glökler, Philipp Franke, Marcus Frohme DNA sequencing continues to evolve quickly even after >30years. Many new platforms suddenly appeared and former established systems have vanished in almost the same manner. Since establishment of next-generation sequencing devices, this progress gains momentum due to the continually growing demand for higher throughput, lower costs and better quality of data. In consequence of this rapid development, standardized procedures and data f...
Source: Applied and Translational Genomics - July 15, 2016 Category: Genetics & Stem Cells Source Type: research
Barriers to Clinical Adoption of Next Generation Sequencing: Perspectives of a Policy Delphi Panel
Publication date: Available online 25 May 2016 Source:Applied & Translational Genomics Author(s): Donna A. Messner, Jennifer Al Naber, Pei Koay, Robert Cook-Deegan, Mary Majumder, Gail Javitt, Patricia Deverka, Rachel Dvoskin, Juli Bollinger, Margaret Curnutte, Amy Maguire This research aims to inform policymakers by engaging expert stakeholders to identify, prioritize, and deliberate the most important and tractable policy barriers to the clinical adoption of next generation sequencing (NGS). A 4-round Delphi policy study was done with a multi-stakeholder panel of 48 experts. The first 2 ...
Source: Applied and Translational Genomics - May 24, 2016 Category: Genetics & Stem Cells Source Type: research
Unsung Heroes: Genomic Successes in the Developing World
Publication date: Available online 17 May 2016 Source:Applied & Translational Genomics Author(s): Vajira Dissanayake, Carol Isaacson Barash (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - May 16, 2016 Category: Genetics & Stem Cells Source Type: research
Implementation of genomic medicine in Sri Lanka: Initial experience and challenges
Publication date: Available online 17 May 2016 Source:Applied & Translational Genomics Author(s): Nirmala D. Sirisena, Nilaksha Neththikumara, Kalum Wetthasinghe, Vajira H.W. Dissanayake The recent advances in next generation sequencing technologies have made it possible to implement genomic medicine in developing countries such as Sri Lanka where capacity for utilization is limited. This paper aims to describe our initial experience and challenges faced in integrating genomic medicine into routine clinical practice. Using the Illumina MiSeq Next generation sequencing (NGS) platform and an in-house deve...
Source: Applied and Translational Genomics - May 16, 2016 Category: Genetics & Stem Cells Source Type: research
Addressing ethical challenges in the Genetics Substudy of the National Eye Survey of Trinidad and Tobago (GSNESTT)
Conclusion This paper outlines an ethical framework for the conduct of population-based genetics and genomics research in Trinidad and Tobago; highlights common issues arising in the field and strategies to address these. (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - May 12, 2016 Category: Genetics & Stem Cells Source Type: research
