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Apolipoprotein ε4 allele is associated with psoriasis severityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Many reports provided strong evidence of the influence of genetic factors in the pathogenesis of psoriasis (Ps). A higher prevalence of lipid disorders in psoriatic patients has been reported. Because apolipoprotein E (apoE) is involved in lipid metabolism, APOE gene variants could be candidates to influence Ps-risk. However, data about the potential influence of the APOE genotypes in Ps are inconclusive. Our objective was to investigate the relationship between the common APOE-ε2/ε3/ε4 variation and Ps in a Caucasian population. Our study involved 331 unrelated Ps-patients and 400 healthy controls...
Source: Archives of Dermatological Research - November 12, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

A novel missense mutation of CYLD gene in a Chinese family with multiple familial trichoepitheliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we identified a novel mutation of CYLD gene in a Chinese family with MFT. It is a novel heterozygous nucleotide G→A transition at position 2,317 in exon 17 of the CYLD gene. Our study expands the database on the CYLD gene mutations in MFT. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00403-009-1003-1Authors Fu-Xi Wang, Shenzhen Second People’s Hospital Department of Dermatology 3002 Sungang West Road 518039 Shenzhen Guangdong ChinaLi-Jia Yang, Nanjing Medical University Department of Dermatology, Affiliated Wuxi No.2 Hospital 214002 Wuxi Jiangsu ChinaMing Li, Nanjing Medica...
Source: Archives of Dermatological Research - November 12, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Association between basal, squamous cell carcinomas, dysplastic nevi and myotonic muscular dystrophy indicates an important role of RNA-binding proteins in development of human skin cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Myotonic muscular dystrophy (MMD) is caused by an abnormal function of RNA-binding proteins (RBP) resulting in DNA spliceopathy. A case of a patient, with MMD multiple basal and squamous cell carcinomas and dysplastic nevi, is described. The association between MMD and non-melanoma skin cancer has been reported before; however, this association was described before the genetic defect of myotonic dystrophy has been fully elucidated. The author proposes a genetic mechanism on how abnormal function of RBP can result or contribute to the development of human skin cancer and propose an explanation for th...
Source: Archives of Dermatological Research - November 10, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse or retard the process of these harmful e...
Source: Archives of Dermatological Research - November 6, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Optical coherence tomography imaging of psoriasis vulgaris: correlation with histology and disease severityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Epidermal thickness (ET) has been suggested as a surrogate measure of psoriasis severity. Optical coherence tomography (OCT) is a recent imaging technology that provides real-time skin images to a depth of 1.8 mm with a micrometre resolution. OCT may provide an accurate in vivo measure of ET. It is, therefore, speculated that OCT may be used in the assessment of psoriasis vulgaris. A total of 23 patients with psoriasis vulgaris were systematically evaluated by OCT imaging and skin biopsy during treatment. Biopsies were graded for disease severity, and additional evaluation was done by the physi...
Source: Archives of Dermatological Research - November 6, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Solar radiation is a very important exogenous factor in skin pathogenesis and can lead to the development of a number of skin disorders. UVB irradiation is known to induce oxidative stress, inflammation and especially DNA lesions in exposed cells. It is important, therefore, to identify agents that can offer protection against UVB-caused skin damage. Natural compounds have been studied for their possible ability to control/modulate various lifestyle-related diseases. The application of plant compounds/extracts with screening, antioxidant and anti-inflammatory activities may also successfully protect...
Source: Archives of Dermatological Research - October 28, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Capparis spinosa protects against oxidative stress in systemic sclerosis dermal fibroblastsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, ECS exhibits a notable activity in protecting against oxidative stress and interrupting of ROS-ERK1/2-Ha-Ras signal loop in SSc, suggesting its potential protective effects against skin sclerosis. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00403-009-0998-7Authors Yue-lan Cao, Zhejiang University Department of Dermatology, Second Affiliated Hospital, School of Medicine 88 Jiefang Road 310009 Hangzhou ChinaXin Li, Hangzhou Center for Disease Control and Prevention Department of STD and AIDS Prevention 310006 Hangzhou ChinaMin Zheng, Zhejiang University Department of Dermatology, Sec...
Source: Archives of Dermatological Research - October 22, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis and vascular changes in the skin and internal organs with autoimmune background. It has been suggested that oxidative stress plays an important role in the development of SSc. To determine the prevalence and clinical correlation of autoantibody to methionine sulfoxide reductase A (MSRA), one of the antioxidant repair enzymes, in SSc, serum anti-MSRA autoantibody levels were examined in patients with SSc by enzyme-linked immunosorbent assay using recombinant MSRA. The presence of anti-MSRA antibody was evaluated by immu...
Source: Archives of Dermatological Research - October 21, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Upregulation of chemokine (C–C motif) ligand 20 in adult epidermal keratinocytes in direct current electric fieldsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the early transcriptional response of human epidermal keratinocytes to EFs is examined using microarrays. Increased expression of various chemokines, interleukins, and other inflammatory response genes indicates that EFs stimulate keratinocyte activation and immune stimulatory activity. Gene expression activity further suggests that interleukin 1 is either released or activated in EFs. Expression of the chemokine CCL20 steadily increases at 100 mV/mm over time until around 8 h after exposure. This chemokine is also expressed at field strengths of 300 mV/mm—above the level of endogenous ...
Source: Archives of Dermatological Research - September 28, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Effects of a three-session skin rejuvenation treatment using stabilized hyaluronic acid-based gel of non-animal origin on skin elasticity: a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  The purpose of this study was to evaluate in vivo the effects of micropuncture injections of stabilized hyaluronic acid-based gel of non-animal origin (NASHA™, Restylane Vital™) on skin elasticity, a major aspect of skin ageing. Patients (n = 19) underwent a series of three treatment sessions, spaced 4 weeks apart, with NASHA injected into the lower facial cheeks. Using the suction principle, 12 parameters describing the viscoelastic properties of the skin were assessed, before each treatment session and at follow-up visits 4 and 16 weeks after the last treatment. Treatment wi...
Source: Archives of Dermatological Research - September 17, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Patented natural avocado sugars modulate the HBD-2 expression in human keratinocytes through the involvement of protein kinase C and protein tyrosine kinasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Skin keratinocytes constitute a protective mechanical barrier against invading microorganisms. Stimulated keratinocytes produce endogenous peptides such as the β-defensins that have direct antimicrobial activity against a broad spectrum of pathogens, including most bacteria, certain fungi and enveloped viruses. In particular, human β-defensin 2 (HBD-2) is virtually absent in normal skin and its expression in human keratinocytes requires stimulation by cytokines or bacteria. AV119, a patented avocado sugar, triggers the up-regulation of HBD-2, but the signalling mechanisms involved in this up-regul...
Source: Archives of Dermatological Research - September 17, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Effect of lipopolysaccharide, skin sensitizers and irritants on thioredoxin-1 expression in dendritic cells: relevance of different signalling pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Thioredoxin-1 is a ubiquitous protein involved in phenotypical and functional changes in dendritic cells (DC). We investigated the effect of lipopolysaccharide (LPS), skin sensitizers, and irritants on thioredoxin-1 by Western blot and immunofluorescence and on mRNA by real-time PCR. As DC models, we used a skin DC line and DC derived from human blood monocytes. We observed that all tested chemicals increased thioredoxin-1 expression, which is only transient for irritants, being the strongest effect observed for LPS (63 ± 15%). To address the involvement of thioredoxin-1 in DC maturation,...
Source: Archives of Dermatological Research - September 16, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

The UV response of the skin: a review of the MAPK, NFκB and TNFα signal transduction pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  The sun emits different types of ultraviolet (UV) light. Our skin is a natural target of UV radiation which is involved in vitamin D3 production in our body. UV radiation at high doses is an environmental carcinogen which can elicit skin damage as well as inducing skin cancer. It can mediate inflammatory and immunological reactions through activation of receptors, DNA/RNA damage and production of reactive oxygen species. It is also involved in the release of pro-inflammatory cytokines, of which TNFα has been implicated in tumorigenic activities. In order to mediate its effects, UV radiation is know...
Source: Archives of Dermatological Research - September 16, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Lymphocyte subsets in peripheral blood of patients with psoriasis before and after treatment with leishmania antigensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Peripheral blood mononuclear cells (PBMC) collected from subjects prior to treatment and post-treatment with a vaccine composed of leishmania antigens were analyzed by flow cytometry. Upon analysis, it was noticed that lymphocyte subsets (LS) varied with psoriasis area and severity index (PASI) range (1–10, 11–20 and 21–72). Pre-treatment absolute values of gated LS were as follows. CD4+CD8−, CD3+CD8−, CD8+CD3+, CD8+CD4− and CD8+HLA− decreased in PBMC as PASI increased, suggesting migration from the blood to the skin. Contrary to the previous finding, the following LS, CD8+HLA+ and HLA...
Source: Archives of Dermatological Research - August 25, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Genetic evidence for involvement of the IL23 pathway in Thai psoriaticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  A recent genome-wide association analysis of psoriasis identified IL12B and IL23R as significantly associated with psoriasis. Here we report association test results of a Thai cohort consisting of 206 psoriasis cases and 114 controls. The IL23R SNPs rs7530511 and rs11209026, and IL12B SNPs rs3212227 and rs6887695 were genotyped using Taqman assays. Data were analyzed using a logistic regression model for linear trend of association. One of the IL23R markers, rs7530511, was marginally significant (P = 0.017). The other IL23R marker, rs11209026, was not polymorphic. One of the IL12B markers, r...
Source: Archives of Dermatological Research - August 25, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Rhodiola rosea ability to enrich cellular antioxidant defences of cultured human keratinocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Keratinocytes are cells strongly exposed to oxidative stress, but normally good equipped for antioxidant responses. However, it has long been suggested that exogenous antioxidants could play a useful role in minimizing the adverse skin responses associated with such oxidant species. In this work it was paid attention to the extract of Rhodiola rosea L. roots by using the phytocomplex as a whole because of the important activity of its composition and mutual distribution of its components. We have measured the protection afforded by the extract to reduced glutathione levels, glyceraldehyde-3-phosphate...
Source: Archives of Dermatological Research - August 25, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Expression and function of glycogen synthase kinase-3 in human hair folliclesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  β-Catenin is involved in the hair follicle morphogenesis and stem cell differentiation, and inhibition of glycogen synthase kinase-3 (GSK-3) increases β-catenin concentration in the cytoplasm. To examine the effects of GSK-3 inhibition on the hair follicle epithelium, we first examined the expression of GSK-3 in plucked human hair follicles by RT-PCR and found GSK-3 expression in hair follicles. Western blotting with a GSK-3β-specific antibody, Y174, also demonstrated GSK-3β expression in the follicles. Moreover, GSK-3β immunostaining with Y174 showed that GSK-3β colocalized with hair follicle...
Source: Archives of Dermatological Research - August 24, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Comparison between human fetal and adult skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that, especially, dermal components are important in fetal scarless healing. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00403-009-0989-8Authors Neeltje A. Coolen, Association of Dutch Burn Centres P.O. Box 1015 1940 EA Beverwijk The NetherlandsKelly C. W. M. Schouten, Association of Dutch Burn Centres P.O. Box 1015 1940 EA Beverwijk The NetherlandsEsther Middelkoop, Association of Dutch Burn Centres P.O. Box 1015 1940 EA Beverwijk The NetherlandsMagda M. W. Ulrich, Association of Dutch Burn Centres P.O. Box 1015 1940 EA Beverwijk The Netherlands Journal Archives of Derm...
Source: Archives of Dermatological Research - August 22, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Behçet’s disease: an algorithmic approach to its treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Behçet’s disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology with the clinical features of mucocutaneous lesions, ocular, vascular, articular, gastrointestinal, urogenital, pulmonary, and neurologic involvement. Mucocutaneous lesions figure prominently in the presentation and diagnosis, and may be considered the hallmarks of BD. Therefore, their recognition may permit earlier diagnosis and treatment. Although, the treatment has become much more effective in recent years, BD is still associated with severe morbidity and considerable mortality. The main aim of the treatmen...
Source: Archives of Dermatological Research - August 21, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

PCR analysis for Wolbachia in human and canine Demodex mitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  In many skin diseases such as Demodex folliculitis, rosacea- or steroid-induced rosacea Demodex mites are present in abundance and are at least partially held responsible for causing these disorders. Although it is known that these diseases respond well to tetracyclines, it is unclear if this is due to the antiinflammatory effects of the antibiotics or to an antibacterial effect on so far unknown bacteria within the Demodex mites. As in filariasis, where the response to doxycycline can be explained by the presence of Wolbachia within the filarial nematodes, this study was performed to see whether Wolb...
Source: Archives of Dermatological Research - August 3, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Topical tamoxifen therapy in hypertrophic scars or keloids in burnsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  As acute burn patients have experienced increasing survival rates, the number of patients who need specific care due to aberrant scarring is also increasing. The burned skin often responds with fibrotic tissue proliferation, which can lead to a hypertrophic scar or a keloid. Non-physiologic scars are mostly not acceptable for the burn patient. Intradermal and topical therapy in burns comprise the treatment of the skin injury and its possible texture, elasticity and color alterations with the aid of active substances that result in fibroblastic modulation. An alteration of cytokine levels may mediate...
Source: Archives of Dermatological Research - July 27, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Validity, reliability, and sensitivity-to-change properties of the psoriatic arthritis screening and evaluation questionnaireEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Psoriatic arthritis (PsA) is an inflammatory arthritis associated with irreversible joint damage in a subset of individuals. There is a need to screen early for this condition to prevent damage. To meet this need, we have developed the psoriatic arthritis screening and evaluation (PASE) questionnaire. The 15-item PASE questionnaire was administered to 190 individuals with either psoriasis or PsA. The PASE questionnaire was readministered to a subset of individuals with PsA in order to assess test–retest reliability and sensitivity-to-change. Receiver operator curves were constructed to optimize se...
Source: Archives of Dermatological Research - July 23, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Decrease in Mycobacterium tuberculosis specific immune responses in patients with untreated psoriasis living in a tuberculosis endemic areaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Tuberculosis has emerged as a major concern in patients with immuno-mediated diseases, including psoriasis, undergoing treatment with biologicals. However, it is not known whether the chronically activated immune system of psoriasis patients interferes with their Mycobacterium tuberculosis (Mtb)-specific immunity, especially in tuberculosis-endemic areas like Brazil. We evaluated T-cell responses to a Mtb lysate and to the recombinant Mtb proteins ESAT-6 and Ag85B of tuberculin skin test (TST) positive and TST negative patients with severe or mild/moderate, untreated psoriasis in three different ass...
Source: Archives of Dermatological Research - July 18, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Do guidelines change the way we treat? Studying prescription behaviour among private practitioners before and after the publication of the German Psoriasis GuidelinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Evidence-based psoriasis treatment guidelines may help physicians overcome uncertainties in initiating and monitoring systemic treatment and have thus been suggested as a tool for improving the care provided to psoriasis patients. A prospective cohort study of dermatologists’ prescription behaviour was performed with two consecutive documentation periods (before and after the publication of the guidelines). 49 dermatologists were asked to provide continuous documentation of their treatment choices for patients with psoriasis by filling in a standardised documentation form. In addition, a questionn...
Source: Archives of Dermatological Research - July 18, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Gingko biloba extract reduces VEGF and CXCL-8/IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  In skin inflammation, vascular endothelial growth factor (VEGF) and CXCL-8/IL-8 play an important role and are produced by activated keratinocytes. Extracts from Ginkgo biloba leaves (GBE), widely used in phytotherapy, have been reported to exert antioxidant and anti-inflammatory properties in the skin. We therefore evaluated the effects of GBE on the release of VEGF and CXCL8/IL-8 by normal human keratinocytes (NHKs) activated by tumor necrosis factor α (TNFα). Moreover, as we previously showed that epigallocatechin-3-gallate (EGCG) reduces VEGF and CXCL8/IL-8 secretion in TNFα-activated NHKs, w...
Source: Archives of Dermatological Research - July 14, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Short- and long-term effects of single and repetitive glove occlusion on the epidermal barrierEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study could not verify significant damage to skin barrier after 7 days of repeated occlusion 4 h daily in healthy volunteers. These findings require further discussion regarding the definitions in the current German ordinance on hazardous substances and in the TRGS 401. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00403-009-0980-4Authors Ulrike Wetzky, University of Osnabrueck Department of Dermatology, Environmental Medicine and Health Theory Sedanstrasse 115 49090 Osnabrueck GermanyMeike Bock, University of Osnabrueck Department of Dermatology, Environmental Medicine and Health Th...
Source: Archives of Dermatological Research - July 7, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Effect of erythromycin A and its new derivative EM201 on type I collagen production by cultured dermal fibroblastsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the effects of erythromycin A (EMA) and its new derivative EM201 on type I collagen production by cultured dermal fibroblasts. Dermal fibroblasts were cultured with 10−9 M-10−5 M EMA or EM201, and collagen production was measured by incubation with radioactive proline, SDS-polyacrylamide gel electrophoresis and fluorography. mRNA levels were measured by Northern blots analysis, and to investigate transcriptional levels luciferase assays were also performed. The results showed that both EMA and EM201 increased collagen production and type I collagen mRNA level (to a maximum of 200% wit...
Source: Archives of Dermatological Research - July 6, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Toll like receptor agonists augment HPV 11 E7-specific T cell responses by modulating monocyte-derived dendritic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Impaired local cellular immunity is one of the mechanisms responsible for condyloma acuminatum (CA) recurrence. The activation of dendritic cells (DCs) is important in vaccine development. We investigated the effect of different toll like receptor (TLR) agonists including LPS (TLR4 agonist), polyinosinic acid-polycytidylic acid (PIC, TLR3 agonist), CpG oligonucleotide (TLR9 agonist), and imiquimod (TLR7 agonist) on human monocyte-derived dendritic cells (mdDCs) loading of human papillomavirus (HPV) type 11 E7 epitope. As a result, we found that mdDCs loading HLA-A*0201-restricted HPV 11 E7 CTL epito...
Source: Archives of Dermatological Research - July 6, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Recurrent mutations in functionally-related EDA and EDAR genes underlie X-linked isolated hypodontia and autosomal recessive hypohidrotic ectodermal dysplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Mutations in three functionally related genes EDA, EDAR and EDARDD have been reported to cause hypohidrotic ectodermal dysplasia (HED), which is characterized by sparse hair, reduced ability to sweat, and hypodontia. In few cases mutations in the EDA gene have been found to result in X-linked recessive isolated hypodontia. In the study, presented here, we have ascertained two large Pakistani families (A and B) with autosomal recessive form of hypohidrotic ectodermal dysplasia and X-linked recessive isolated hypodontia. Genetic mapping showed linkage of family A to EDAR gene on chromosome 2q11-q13 and...
Source: Archives of Dermatological Research - June 24, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Time-kinetic study of repigmentation in vitiligo patients by tacrolimus or pimecrolimusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  New topical immunomodulators have been reported to cause repigmentation of vitiligo lesions. However, time-kinetics of such repigmentation in different anatomic locations is not well known. We performed a randomized double-blind placebo control study with tacrolimus versus the vehicle and a nonrandomized control study with pimecrolimus to evaluate the time to reach significant pigmentation, its duration and extent in treated areas. Antioxidant status of serum was also assessed. Twenty patients, in the tacrolimus study, had one pair of lesions on different localizations, and 20 on face and/or upper l...
Source: Archives of Dermatological Research - June 23, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Autoantibodies to sweat glands detected by different methods in serum and in tissue from patients affected by a new variant of endemic pemphigus foliaceusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Examining the patients with a new variant of endemic pemphigus foliaceus (EPF) in El Bagre, Colombia, (El Bagre-EPF), we noted several polymorphic clinical lesions around their axillary areas. Based on our clinical findings and on previous histopathological studies on the skin of these patients that showed abnormalities in their sweat glands, and the presence of mercuric selenides and iodines by autometallography assay, we decided to investigate immunoreactivity to the sweat glands in these patients. We tested for autoreactivity utilizing direct and indirect immunofluorescence (DIF, IIF). To be able...
Source: Archives of Dermatological Research - June 23, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Are cosmetic products which include an SPF appropriate for daily use?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  The goal of this study is to investigate commercially available cosmetics (foundations, skin care creams) which also claim to include a sun protection factor (SPF). Are these products, which are not considered sunscreen products, helpful or could they be harmful? Using an in vitro method, we tested the effectiveness of 35 commercially available products against UVB and UVA radiation. For each product, our testing focused on determining the following four values in terms of current legal recommendations: SPF, UVA protection factor (PF-UVA), UVB/UVA ratio and critical wavelength (λc). We also tested ...
Source: Archives of Dermatological Research - June 20, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Impaired cutaneous wound healing with excess granulation tissue formation in TNFα-null miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, lacking TNFα potentiates Smad-mediated fibrogenic reaction in healing dermis and retards reepithelialization in a healing mouse cutaneous wound. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00403-009-0969-zAuthors Maki Shinozaki, Wakayama Medical University School of Medicine Department of Critical Care Medicine 811-1 Kimiidera Wakayama 641-0012 JapanYuka Okada, Wakayama Medical University School of Medicine Department of Ophthalmology 811-1 Kimiidera Wakayama 641-0012 JapanAi Kitano, Wakayama Medical University School of Medicine Department of Ophthalmology 811-1 Kimiidera Wakayama...
Source: Archives of Dermatological Research - June 20, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

A novel point mutation at donor splice-site in intron 42 of type III collagen gene resulting in the inclusion of 30 nucleotides into the mature mRNA in a case of vascular type of Ehlers–Danlos syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a novel point mutation at donor splice-site in intron 42 of type III collagen gene resulting in the inclusion of 30 nucleotides into the mature mRNA in a case of vascular type of EDS. Since the age of approximately 8 months, the patient had had repeated episodes of purpura and gradually developed thin, translucent skin. She had a past history of pneumothorax. At the initial examination, she was found to have the characteristic facies, i.e., bird-like face, of the vascular type of EDS, thinning of skin over the limbs and trunk, and scattered purpura. The blood vessels under the skin could be clearly visua...
Source: Archives of Dermatological Research - June 20, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Novel mutations in the P2RY5 gene in one Turkish and two Indian patients presenting with hypotrichosis and woolly hairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Hypotrichosis simplex comprises a group of non-syndromic human alopecias. Diffuse loss of hair typically starts in early childhood and progresses throughout adolescence. We and others have previously reported mutations in the P2RY5 gene and the LIPH gene as being causal factors of autosomal recessive hypotrichosis simplex with or without woolly hair. In the present study, we analyzed one Turkish family and two non-related girls of Indian ethnicity affected with hypotrichosis and woolly hair for mutations in these genes. We identified as yet unreported mutations in the P2RY5 gene: a 1-base pair deleti...
Source: Archives of Dermatological Research - June 16, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Localization and quantification of intact, undamaged right-handed double-stranded B-DNA, and denatured single-stranded DNA in normal human epidermis and its effects on apoptosis and terminal differentiation (denucleation)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study characterized, for the first time, the deterioration of right-handed ds-B-DNA and the increase in denatured ss-DNA during epidermal maturation. For the first time, this approach also allowed for the quantitative and qualitative characterization of DNA content and structure in all epidermal strata, using anti-ds-B-DNA and anti-ss-DNA antibodies. In order to improve the retention and quality of DNA, a novel histotechnological processing procedure was used. The results indicate that the largest decline in DNA occurred within the stratum granulosum, followed by the EPTZ, and the stratum spinosum. Not all epiderm...
Source: Archives of Dermatological Research - June 11, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Expression of chemokine receptor CXCR3 by lymphocytes and plasmacytoid dendritic cells in human psoriatic lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  In psoriasis, leukocytes that infiltrate skin lesions have been shown to be involved in the pathogenesis of this disease. Previous investigations reporting the presence of CXCR3+ T lymphocytes in psoriatic lesional skin have suggested a role of this receptor in the recruitment of T cells into the lesion. The purpose of this study was to quantify the mRNA levels of CXCR3 and to perform a systematic analysis of the cell populations that express CXCR3 in human lesional and non-lesional psoriatic biopsies. We showed by real-time reverse transcriptase-polymerase chain reaction that the mRNA levels of CXC...
Source: Archives of Dermatological Research - June 11, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Apolipoprotein E gene polymorphism in psoriasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Polymorphism in the apolipoprotein E gene has been associated with several neurological, cardiological and ophthalmological diseases. Apolipoprotein E is involved in psoriasis by modifying mitogen-activated T lymphocyte proliferation and by assuring protection against some infections. We evaluated the apolipoprotein E gene polymorphism in patients suffering from psoriasis (compared to matched controls) in Thrace, Northern Greece. One hundred and forty patients suffering from psoriasis vulgaris and 155 matched controls were included in this study and genotyped by semi-nested polymerase chain reaction ...
Source: Archives of Dermatological Research - June 5, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Immunochemotherapy for Bcl-2 and MUM-negative aggressive primary cutaneous B-cell non-Hodgkin’s lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  The case of a 44-year-old man with a primary cutaneous large B-cell non-Hodgkin’s lymphoma of the scalp is reported. His mother died of gastric lymphoma and his sib brother is in a 20-year remission of T-cell lymphoma. The patient presented with a 16-year history of occipital and parietal alopecia and a recently worsening scalp rash. The histopathology and immunohistochemistry performed in April 2006 indicated a bcl-6+, MUM− and bcl-2−, primary cutaneous follicle center B-cell non-Hodgkin’s lymphoma, with an aggressive transformation to a diffuse large B-cell lymphoma. Bone marrow biopsy and...
Source: Archives of Dermatological Research - June 4, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

New mutations of Darier disease in Tunisian patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Darier’s disease (DD, MIM 124200) also known as Darier-White disease and keratosis follicularis, is a rare autosomal dominant skin disorder characterized by warty papules and plaques in the seborrheic area (central trunk, flexures, scalp, and forehead). Pathogenic mutations in the ATP2A2 gene encoding the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) 2 gene underlie the disease. In the present study, we performed genetic investigation of three unrelated Tunisian families affected by DD. Mutation screening was performed by direct sequencing of the coding region and exon/intron boundaries o...
Source: Archives of Dermatological Research - June 2, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Circulatory levels of antioxidants and lipid peroxidation in Indian patients with generalized and localized vitiligoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Vitiligo is an acquired skin disease, characterized by white areas on the skin due to loss of functional melanocytes. The pathogenesis of the disease is still unclear. Published data show the involvement of oxidative stress in the pathophysiology of vitiligo. A total of 30 vitiligo patients and 30 healthy controls were included in this study. We estimated serum levels of malondialdehyde (MDA), vitamins E and C, total antioxidant activity and whole blood levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in vitiligo patients and controls. We found significantly higher levels of MDA...
Source: Archives of Dermatological Research - June 2, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  The aim of the study was to investigate the expression of PGP 9.5 in cutaneous keratoacanthomas (KAs) and squamous cell carcinomas (SCCs). Thirty-one cases of KA (10 in the growth stage, 9 in the mature phase and 12 in the involution stage) and 36 SCCs including 13 well differentiated cases, 12 moderately differentiated tumors, 7 poorly differentiated lesions and 4 pseudoadenoid entities were investigated. PGP 9.5 expression was positively correlated with tumor stage (P < 0.001) and potential perineural invasion (P < 0.001). There was no significant difference in the distrib...
Source: Archives of Dermatological Research - June 2, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Humanized anti-CD2 monoclonal antibody treatment of plaque psoriasis: efficacy and pharmacodynamic results of two randomized, double-blind, placebo-controlled studies of intravenous and subcutaneous siplizumabEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  New biologic therapies focused primarily on cytokine pathways, some targeting T cell-mediated immune responses, are being developed for the treatment of psoriasis. Siplizumab is a humanized anti-CD2 monoclonal antibody that interferes with costimulation necessary for T cell activation and proliferation. We assessed the biological activity, serum concentrations, and pharmacodynamic effects of siplizumab in patients with plaque psoriasis. Two multicenter, phase II randomized, double-blind, placebo-controlled studies were conducted: one study randomized 124 patients to one of two intravenous (IV) doses...
Source: Archives of Dermatological Research - May 27, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Activation of peroxisome proliferator-activated receptor-γ inhibits transforming growth factor-β1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands have been recently reported to have beneficial effects on organ fibrosis. However, their effects on extracellular matrix (ECM) turnover in hypertrophic scar fibroblasts (HSFs), and the related molecular mechanisms are unknown. HSFs were cultured and exposed to different concentration PPAR-γ ligands in the presence of transforming growth factor-β1 (TGF-β1). In growth-arrested HSFs, a PPAR-γ natural ligand (15-deoxy-D12,14-prostaglandin J2, 15d-PGJ2) and a synthetic ligand (GW7845) dose-dependently attenuated TGFβ1-induced expression...
Source: Archives of Dermatological Research - May 24, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Moisturizers change the mRNA expression of enzymes synthesizing skin barrier lipidsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  In a previous study, 7-week treatment of normal human skin with two test moisturizers, Complex cream and Hydrocarbon cream, was shown to affect mRNA expression of certain genes involved in keratinocyte differentiation. Moreover, the treatment altered transepidermal water loss (TEWL) in opposite directions. In the present study, the mRNA expression of genes important for formation of barrier lipids, i.e., cholesterol, free fatty acids and ceramides, was examined. Treatment with Hydrocarbon cream, which increased TEWL, also elevated the gene expression of GBA, SPTLC2, SMPD1, ALOX12B, ALOXE3, and HMGCS...
Source: Archives of Dermatological Research - May 24, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Changes in S100A8 expression in UV-irradiated and aged human skin in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the changes in S100A8 mRNA and protein following acute UV irradiation to human buttock skin and by intrinsic aging and photoaging in human sun-protected (upper-inner arm) and sun-exposed (forearm) skin of elderly subjects. Real-time PCR, western blot and immunohistochemical staining analyses of UV-irradiated young buttock skin revealed that S100A8 protein expression was increased at 24 h (3.0-fold) and 48 h (4.4-fold) after UV irradiation. S100A8 mRNA and protein were more highly expressed by 2.3- and 4.0-fold, respectively, in the sun-protected skin of elderly people than in t...
Source: Archives of Dermatological Research - May 24, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

A novel KIT missense mutation in one Chinese family with piebaldismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study contributes to the database on KIT in piebaldism and enriches the knowledge about the genotype/phenotype correlation. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00403-009-0955-5Authors Xian-Yong Yin, Anhui Medical University Institute of Dermatology 81 Meishan Road 230032 Hefei Anhui People’s Republic of ChinaYun-Qing Ren, Anhui Medical University Institute of Dermatology 81 Meishan Road 230032 Hefei Anhui People’s Republic of ChinaSen Yang, Anhui Medical University Institute of Dermatology 81 Meishan Road 230032 Hefei Anhui People’s Republic of ChinaSheng-Xin Xu, Anhui Medi...
Source: Archives of Dermatological Research - May 9, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

The effect of the moisture content of a local heat source on the blood flow response of the skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Numerous studies have examined the effect of local and global heating of the body on skin blood flow. However, the effect of the moisture content of the heat source on the skin blood flow response has not been examined. Thirty-three subjects, without diabetes or cardiovascular disease, between the ages of 22 and 32 were examined to determine the relationship between the effects of dry vs. moist heat applied for the same length of time and with the skin clamped at the same skin temperature on the blood flow response of the skin. The skin, heated with an infrared heat lamp (skin temperature monitored ...
Source: Archives of Dermatological Research - May 5, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Therapeutic effects of heme oxygenase-1 on psoriasiform skin lesions in guinea pigsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Heme oxygenase-1 (HO-1) has been shown to exert immunosuppressive, anti-inflammatory, anti-apoptotic and anti-proliferative effects. Its unique positive effects indicate that this enzyme might be a potential therapeutic target for psoriasis. To determine the effect of pharmacologic up-regulation of HO-1 on psoriasis, we generated a guinea pig model of psoriasiform skin lesions using propranolol induction. In this in vivo model, the 3-week propranolol challenge generated the psoriasiform pathological changes on the ears of guinea pigs. And then, guinea pigs were intraperitoneally injected with 5 ...
Source: Archives of Dermatological Research - May 5, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals

Protective role of adipose-derived stem cells and their soluble factors in photoagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  As individuals age, the skin undergoes changes, such as irregular pigmentation, thinning and loss of elasticity, that are due to both genetic and environmental factors. These changes may worsen, progressing to precancerous and cancerous diseases. Various medical treatments and topical cosmeceuticals have been used to treat some symptoms of photoaging, however, the results have been less than satisfactory. Mesenchymal stem cells within the stromal-vascular fraction of subcutaneous adipose tissue, adipose-derived stem cells (ADSCs), display multi-lineage developmental plasticity and secrete various gr...
Source: Archives of Dermatological Research - April 26, 2009 Category: Dermatology Tags: Archives of Dermatological Research Source Type: journals