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Assessing the Impact of Efalizumab on Nail, Scalp and Palmoplantar Psoriasis and on Quality of Life: Results from a Multicentre, Open-label, Phase IIIb/IV TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This post-approval, open-label trial (n = 1266) assessed the efficacy of efalizumab, administered in accordance with the European label at that time, in patients with concomitant nail, scalp or palmoplantar psoriasis. Patients received subcutaneous efalizumab 1.0 mg/kg weekly for up to 20 weeks. By Week 12, an improvement from baseline of 50% or more was observed in 21.4% (181/844) of patients with nail psoriasis, 62.4% (718/1150) of patients with scalp psoriasis, and 51.4% (127/247) of patients with palmoplantar psoriasis. Quality of life improved throughout the trial, with a 50% median improvement in DLQI score after 12 ...
Source: Archives of Drug Information - November 21, 2009 Category: Drugs & Pharmacology Authors: Andreas Katsambas, Ketty Peris, Gino Vena, Peter Freidmann, Gottfried Wozel, Esteban Daudén, Daiana Licu, Mauro Placchi, Michel De La Brassinne Source Type: journals

Ascorbic Acid Potentiation of Arsenic Trioxide Anticancer Activity Against Acute Promyelocytic LeukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These suggest that AA may enhance the cytotoxicity of As2O3, suggesting a possible future role of AA/As2O3 combination therapy in patients with APL. (Source: Archives of Drug Information)
Source: Archives of Drug Information - November 5, 2009 Category: Drugs & Pharmacology Authors: Clement Yedjou, Laurette Thuisseu, Christine Tchounwou, Maria Gomes, Carolyn Howard, Paul Tchounwou Source Type: journals

Effects of 4-Aminopyridine on Cloned hERG Channels Expressed in Mammalian CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion. We observed concentration-dependent inhibition of hERG current with 4-aminopyridine doses between 0.3 and 30 mM. The concentration of 3.8 mM resulting in 50% inhibition (IC50) is approximately three orders of magnitude higher than expected therapeutic plasma concentrations, suggesting 4-aminopyridine has low potential for prolonging QT interval or inducing TdP. (Source: Archives of Drug Information)
Source: Archives of Drug Information - August 26, 2009 Category: Drugs & Pharmacology Authors: Muthukrishnan Renganathan, Serguei Sidach, Andrew R. Blight Source Type: journals

Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological ResponseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The expression of several genes not previously identified as part of the adrenergic signaling pathway changed in response to a single oral dose of atenolol. Variation in these genes could contribute to unexplained differences in response to [beta]-blockers. (Source: Archives of Drug Information)
Source: Archives of Drug Information - July 20, 2009 Category: Drugs & Pharmacology Authors: Utkarsh Kohli, Britney L. Grayson, Thomas M. Aune, Laxmi V. Ghimire, Daniel Kurnik, C. Michael Stein Source Type: journals

Drugs Used in the Treatment of Rheumatoid Arthritis: Relationship between Current Use and Cardiovascular Risk FactorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In a cross-sectional setting drugs used to treat RA did not have major adverse effects on cardiovascular risk factors and use of antimalarials was associated with beneficial lipid profiles. (Source: Archives of Drug Information)
Source: Archives of Drug Information - May 15, 2009 Category: Drugs & Pharmacology Authors: Young Hee Rho, Annette Oeser, Cecilia P. Chung, Ginger L. Milne, C. Michael Stein Source Type: journals

Improved Glycaemic Control with Biphasic Insulin Aspart 30 in Type 2 Diabetes Patients Failing Oral Antidiabetic Drugs: PRESENT Study ResultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. BIAsp 30 treatment in a clinical setting improved glycaemic control in type 2 diabetes patients failing OADs. (Source: Archives of Drug Information)
Source: Archives of Drug Information - May 13, 2009 Category: Drugs & Pharmacology Authors: Serdar Güler, Surendra Kumar Sharma, Majeed Almustafa, Chong Hwa Kim, Sami Azar, Rucsandra Danciulescu, Marina Shestakova, Duma Khutsoane, Ole Molskov Bech Source Type: journals

Desloratadine for the Relief of Nasal and Non-nasal Allergy Symptoms: An Observational StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In an open-label, uncontrolled, non-randomized, observational study allergy symptoms improved significantly in subjects treated with desloratadine. (Source: Archives of Drug Information)
Source: Archives of Drug Information - March 17, 2009 Category: Drugs & Pharmacology Authors: Werner Aberer Source Type: journals

Potential Hepatotoxicity of Efavirenz and Saquinavir/Ritonavir Coadministration in Healthy VolunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The early termination of this study precluded drawing any definitive conclusions regarding the pharmacokinetics at steady state of coadministered saquinavir/ritonavir and efavirenz. (Source: Archives of Drug Information)
Source: Archives of Drug Information - February 27, 2009 Category: Drugs & Pharmacology Authors: Candice Jamois, Myriam Riek, Christophe Schmitt Source Type: journals

Utility of Pretreatment Bilirubin Level and UGT1A1 Polymorphisms in Multivariate Predictive Models of Neutropenia Associated with Irinotecan Treatment in Previously Untreated Patients with Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Ability of UGT1A1 or baseline bilirubin to predict neutropenia is low and depends on regimen. (Source: Archives of Drug Information)
Source: Archives of Drug Information - October 3, 2008 Category: Drugs & Pharmacology Authors: Luis Parodi, Eve Pickering, Laura A. Cisar, Doug Lee, Raoudha Soufi-Mahjoubi Source Type: journals

A Phase 3, Randomized, Placebo-controlled Trial of Filgrastim in Patients with Haematological Malignancies Undergoing Matched-related Allogeneic Bone Marrow TransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction. Recombinant granulocyte colony-stimulating factor (G-CSF) may aid engraftment post high-dose chemo-/radiotherapy in patients with haematological malignancies undergoing allogeneic bone marrow transplantation (BMT); however, the effects of G-CSF on graft-versus-host disease (GvHD), relapse, and survival are not well defined.Methods. In this double-blind, randomized, placebo-controlled, multicentre, phase 3 study, the effects of the G-CSF Filgrastim on neutrophil and platelet recovery, and on clinical outcomes were evaluated. Patients (12[ndash]55 years) receiving an allogeneic BMT for a haematological malignan...
Source: Archives of Drug Information - September 3, 2008 Category: Drugs & Pharmacology Authors: Peter Ernst, Andrea Bacigalupo, Olle Ringdén, Tapani Ruutu, Hans J. Kolb, Susan Lawrinson, Tomas Skacel Source Type: journals

Exploratory Study of Tegaserod for Dyspepsia in Women Receiving PPIs for HeartburnEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. A significant treatment effect was not demonstrated in this study using a treatment-withdrawal methodology. In future studies of functional dyspepsia patients with heartburn, a more rigorous parallel-group study design should be considered. (Source: Archives of Drug Information)
Source: Archives of Drug Information - August 28, 2008 Category: Drugs & Pharmacology Authors: Nimish Vakil, Farid Kianifard, Ivan Bottoli Source Type: journals

Patients' Perceptions of Physician-Patient Discussions and Adverse Events with Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These findings suggest that discussions alone do not provide patients with sufficient understanding of the events, nor do they appear to adequately equip patients to cope with them. Therefore, efforts to improve cancer care should focus on developing tools to improve patients' understanding of the toxicities of chemotherapy, as well as providing resources to reduce the effects of adverse events. (Source: Archives of Drug Information)
Source: Archives of Drug Information - July 24, 2008 Category: Drugs & Pharmacology Authors: Dawn Hershman, Elizabeth Calhoun, Kinga Zapert, Shawn Wade, Jennifer Malin, Rich Barron Source Type: journals

Dose Proportionality of Fentanyl Buccal Tablet in Healthy Japanese VolunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Systemic exposure to FBT was approximately dose proportional across the range 100 µg to 800 µg in healthy Japanese adults. Adverse events were mild or moderate. (Source: Archives of Drug Information)
Source: Archives of Drug Information - July 11, 2008 Category: Drugs & Pharmacology Authors: Mona Darwish, Kenneth Tempero, John G. Jiang, Jeffrey Thompson, Philip G. Simonson Source Type: journals

Impact of Desloratadine on Symptoms and Quality of Life in Subjects with Chronic Idiopathic Urticaria: A Multicenter, Practice-based StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. In an open-label, observational study, desloratadine 5 mg once daily significantly decreased symptoms of chronic idiopathic urticaria and improved subject QoL. (Source: Archives of Drug Information)
Source: Archives of Drug Information - July 8, 2008 Category: Drugs & Pharmacology Authors: Harold Kim, Charles Lynde Source Type: journals

Relative Bioavailability of Fentanyl Following Various Dosing Regimens of Fentanyl Buccal Tablet in Healthy Japanese VolunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Bioavailability of fentanyl after FBT 400 µg administered as a single tablet was bioequivalent to that after 2 simultaneously administered 200 µg tablets in healthy Japanese volunteers. AEs were mild or moderate. (Source: Archives of Drug Information)
Source: Archives of Drug Information - June 28, 2008 Category: Drugs & Pharmacology Authors: Mona Darwish, Kenneth Tempero, John G. Jiang, Philip G. Simonson Source Type: journals

Extent of Fentanyl Accumulation Following Multiple Doses of Fentanyl Buccal Tablet 400 µg in Healthy Japanese VolunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Following administration of FBT at 6-hour intervals to healthy Japanese volunteers, at steady state, fentanyl exposure was higher by 55% (AUC0[ndash]6) and 23% (Cmax) than after a single dose of FBT. Adverse events were mild or moderate. (Source: Archives of Drug Information)
Source: Archives of Drug Information - June 28, 2008 Category: Drugs & Pharmacology Authors: Mona Darwish, Kenneth Tempero, John G. Jiang, Philip G. Simonson Source Type: journals