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Vascular Factors and Markers of Inflammation in Offspring With a Parental History of Late-Onset Alzheimer Disease [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Hypertension and the expression of an innate pro-inflammatory cytokine profile in middle age are early risk factors of AD in old age. For the offspring of affected families, it provides clues for screening and preventive strategies, of which blood pressure control can be implemented directly. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: van Exel, E., Eikelenboom, P., Comijs, H., Frolich, M., Smit, J. H., Stek, M. L., Scheltens, P., Eefsting, J. E., Westendorp, R. G. J. Tags: Neurology, Alzheimer Disease, Neurogenetics, Psychiatry, Psychiatry, Other, Genetics, Genetic Disorders, Hypertension Original Article Source Type: journals

A Randomized Placebo-Controlled Clinical Trial of 5 Smoking Cessation Pharmacotherapies [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  While the nicotine lozenge, bupropion, and bupropion plus lozenge produced effects that were comparable with those reported in previous research, the nicotine patch plus lozenge produced the greatest benefit relative to placebo for smoking cessation. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Piper, M. E., Smith, S. S., Schlam, T. R., Fiore, M. C., Jorenby, D. E., Fraser, D., Baker, T. B. Tags: Psychiatry, Psychopharmacology, Public Health, Tobacco, Randomized Controlled Trial, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

Orbitofrontal Cortex and Drug Use During Adolescence: Role of Prenatal Exposure to Maternal Smoking and BDNF Genotype [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  We speculate that PEMCS interferes with the development of the OFC and, in turn, increases the likelihood of drug use among adolescents. In contrast, we suggest that, among nonexposed adolescents, drug experimentation influences the OFC thickness via processes akin to experience-induced plasticity. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Lotfipour, S., Ferguson, E., Leonard, G., Perron, M., Pike, B., Richer, L., Seguin, J. R., Toro, R., Veillette, S., Pausova, Z., Paus, T. Tags: Neurology, Neurology, Other, Pediatrics, Adolescent Medicine, Psychiatry, Adolescent Psychiatry, Public Health, Substance Abuse/ Alcoholism, Women's Health, Pregnancy and Breast Feeding Original Article Source Type: journals

Association of the Glutamate Transporter Gene SLC1A1 With Atypical Antipsychotics-Induced Obsessive-compulsive Symptoms [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  These results suggest that sequence variations in SLC1A1 are associated with susceptibility to AAP-induced OC symptoms. This is the first published pharmacogenetic study on this phenomenon and provides preliminary evidence of the involvement of glutamatergic neurotransmission in the pathogenesis of AAP-induced OC symptoms. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Kwon, J. S., Joo, Y. H., Nam, H. J., Lim, M., Cho, E.-Y., Jung, M. H., Choi, J.-S., Kim, B., Kang, D.-H., Oh, S., Park, T., Hong, K. S. Tags: Psychiatry, Obsessive-Compulsive Disorder, Psychopharmacology, Schizophrenia, Drug Therapy, Adverse Effects, Drug Therapy, Other, Genetics, Genetic Disorders Original Article Source Type: journals

Brain Structural Abnormalities and Mental Health Sequelae in South Vietnamese Ex-Political Detainees Who Survived Traumatic Head Injury and Torture [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Structural deficits in prefrontotemporal brain regions are linked to THI exposures. These brain lesions are associated with the symptom severity of depression in Vietnamese ex–political detainees. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Mollica, R. F., Lyoo, I. K., Chernoff, M. C., Bui, H. X., Lavelle, J., Yoon, S. J., Kim, J. E., Renshaw, P. F. Tags: Neurology, Neurology, Other, Psychiatry, Depression, Post Traumatic Stress Disorder, Stress, Violence and Human Rights, War Original Article Source Type: journals

Posttraumatic Stress Disorder and Health-Related Quality of Life in Patients With Coronary Heart Disease: Findings From the Heart and Soul Study [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Among patients with heart disease, PTSD is more strongly associated with patient-reported cardiovascular health status than objective measures of cardiac function. Future studies should explore whether assessing and treating PTSD symptoms can improve function and quality of life in patients with heart disease. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Cohen, B. E., Marmar, C. R., Neylan, T. C., Schiller, N. B., Ali, S., Whooley, M. A. Tags: Psychiatry, Depression, Post Traumatic Stress Disorder, Stress, Cardiovascular System, Quality of Life, Cardiovascular Disease/ Myocardial Infarction Original Article Source Type: journals

Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Participants who had both childhood adversity and adult traumatic events were more likely to develop lifetime PTSD compared with those who experienced either type of adverse event. The risk was increased in individuals with 1 or 2 copies of the S’ (S) allele compared with the L’ (L) homozygotes. Our study provides additional direct evidence that PTSD is influenced by the interactive effect of environmental and genetic factors. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Xie, P., Kranzler, H. R., Poling, J., Stein, M. B., Anton, R. F., Brady, K., Weiss, R. D., Farrer, L., Gelernter, J. Tags: Psychiatry, Child Psychiatry, Post Traumatic Stress Disorder, Stress, Genetics, Genetic Disorders Original Article Source Type: journals

Altered Corticostriatal Functional Connectivity in Obsessive-compulsive Disorder [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  This study directly supports the hypothesis that OCD is associated with functional alterations of brain corticostriatal networks. Specifically, our findings emphasize abnormal and heightened functional connectivity of ventrolimbic corticostriatal regions in patients with OCD. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Harrison, B. J., Soriano-Mas, C., Pujol, J., Ortiz, H., Lopez-Sola, M., Hernandez-Ribas, R., Deus, J., Alonso, P., Yucel, M., Pantelis, C., Menchon, J. M., Cardoner, N. Tags: Neurology, Functional Imaging, Psychiatry, Obsessive-Compulsive Disorder, Radiologic Imaging, Magnetic Resonance Imaging Original Article Source Type: journals

Cognitive Behavioral Analysis System of Psychotherapy and Brief Supportive Psychotherapy for Augmentation of Antidepressant Nonresponse in Chronic Depression: The REVAMP Trial [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Although 37.5% of the participants experienced partial response or remitted in phase 2, neither form of adjunctive psychotherapy significantly improved outcomes over that of a flexible, individualized pharmacotherapy regimen alone. A longitudinal assessment of later-emerging benefits is ongoing. Trial Registration  clinicaltrials.gov Identifier: NCT00057551 (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Kocsis, J. H., Gelenberg, A. J., Rothbaum, B. O., Klein, D. N., Trivedi, M. H., Manber, R., Keller, M. B., Leon, A. C., Wisniewski, S. R., Arnow, B. A., Markowitz, J. C., Thase, M. E., for the REVAMP Investigators Tags: Patient-Physician Relationship/ Care, Psychosocial Issues, Psychiatry, Cognitive Therapy, Depression, Psychopharmacology, Psychotherapy, Prognosis/ Outcomes, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

The Catatonia Syndrome: Forgotten but Not Gone [Review]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Fink, M., Taylor, M. A. Tags: Neurology, Movement Disorders, Neurology, Other, Psychiatry, Delirium, Psychopharmacology, Schizophrenia, Review, Drug Therapy, Drug Therapy, Other Source Type: journals

Altered Effect of Dopamine Transporter 3'UTR VNTR Genotype on Prefrontal and Striatal Function in Schizophrenia [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Insular, cingulate, and striatal function during an executive task is normally modulated by variation in the dopamine transporter gene. Its effect on activation in the dorsolateral prefrontal cortex and ventral striatum is altered in patients with schizophrenia. This may reflect altered dopamine function in these regions in schizophrenia. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Prata, D. P., Mechelli, A., Picchioni, M. M., Fu, C. H. Y., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R. M., Collier, D. A., McGuire, P. Tags: Neurology, Functional Imaging, Psychiatry, Schizophrenia, Genetics, Genetic Disorders Original Article Source Type: journals

Cattleya Orchid and Three Brazilian Hummingbirds [Art and Images in Psychiatry]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Harris, J. C. Tags: Psychiatry, Psychiatry, Other, Humanities Art and Images in Psychiatry Source Type: journals

This Month in Archives of General Psychiatry [This Month in Archives of General Psychiatry]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Tags: This Month in Archives of General Psychiatry Source Type: journals

About This Journal [About This Journal]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Tags: About This Journal Source Type: journals

ORIGINAL ARTICLE: Vascular Factors and Markers of Inflammation in Offspring With a Parental History of Late-Onset Alzheimer DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Hypertension and the expression of an innate pro-inflammatory cytokine profile in middle age are early risk factors of AD in old age. For the offspring of affected families, it provides clues for screening and preventive strategies, of which blood pressure control can be implemented directly. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: van Exel, E., Eikelenboom, P., Comijs, H., Frolich, M., Smit, J. H., Stek, M. L., Scheltens, P., Eefsting, J. E., Westendorp, R. G. J. Tags: Neurology, Alzheimer Disease, Neurogenetics, Psychiatry, Psychiatry, Other, Genetics, Genetic Disorders, Hypertension Original Article Source Type: journals

ORIGINAL ARTICLE: A Randomized Placebo-Controlled Clinical Trial of 5 Smoking Cessation PharmacotherapiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  While the nicotine lozenge, bupropion, and bupropion plus lozenge produced effects that were comparable with those reported in previous research, the nicotine patch plus lozenge produced the greatest benefit relative to placebo for smoking cessation. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Piper, M. E., Smith, S. S., Schlam, T. R., Fiore, M. C., Jorenby, D. E., Fraser, D., Baker, T. B. Tags: Psychiatry, Psychopharmacology, Public Health, Tobacco, Randomized Controlled Trial, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

ORIGINAL ARTICLE: Orbitofrontal Cortex and Drug Use During Adolescence: Role of Prenatal Exposure to Maternal Smoking and BDNF GenotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  We speculate that PEMCS interferes with the development of the OFC and, in turn, increases the likelihood of drug use among adolescents. In contrast, we suggest that, among nonexposed adolescents, drug experimentation influences the OFC thickness via processes akin to experience-induced plasticity. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Lotfipour, S., Ferguson, E., Leonard, G., Perron, M., Pike, B., Richer, L., Seguin, J. R., Toro, R., Veillette, S., Pausova, Z., Paus, T. Tags: Neurology, Neurology, Other, Pediatrics, Adolescent Medicine, Psychiatry, Adolescent Psychiatry, Public Health, Substance Abuse/ Alcoholism, Women's Health, Pregnancy and Breast Feeding Original Article Source Type: journals

ORIGINAL ARTICLE: Association of the Glutamate Transporter Gene SLC1A1 With Atypical Antipsychotics-Induced Obsessive-compulsive SymptomsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  These results suggest that sequence variations in SLC1A1 are associated with susceptibility to AAP-induced OC symptoms. This is the first published pharmacogenetic study on this phenomenon and provides preliminary evidence of the involvement of glutamatergic neurotransmission in the pathogenesis of AAP-induced OC symptoms. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Kwon, J. S., Joo, Y. H., Nam, H. J., Lim, M., Cho, E.-Y., Jung, M. H., Choi, J.-S., Kim, B., Kang, D.-H., Oh, S., Park, T., Hong, K. S. Tags: Psychiatry, Obsessive-Compulsive Disorder, Psychopharmacology, Schizophrenia, Drug Therapy, Adverse Effects, Drug Therapy, Other, Genetics, Genetic Disorders Original Article Source Type: journals

ORIGINAL ARTICLE: Brain Structural Abnormalities and Mental Health Sequelae in South Vietnamese Ex-Political Detainees Who Survived Traumatic Head Injury and TortureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Structural deficits in prefrontotemporal brain regions are linked to THI exposures. These brain lesions are associated with the symptom severity of depression in Vietnamese ex–political detainees. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Mollica, R. F., Lyoo, I. K., Chernoff, M. C., Bui, H. X., Lavelle, J., Yoon, S. J., Kim, J. E., Renshaw, P. F. Tags: Neurology, Neurology, Other, Psychiatry, Depression, Post Traumatic Stress Disorder, Stress, Violence and Human Rights, War Original Article Source Type: journals

ORIGINAL ARTICLE: Posttraumatic Stress Disorder and Health-Related Quality of Life in Patients With Coronary Heart Disease: Findings From the Heart and Soul StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Among patients with heart disease, PTSD is more strongly associated with patient-reported cardiovascular health status than objective measures of cardiac function. Future studies should explore whether assessing and treating PTSD symptoms can improve function and quality of life in patients with heart disease. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Cohen, B. E., Marmar, C. R., Neylan, T. C., Schiller, N. B., Ali, S., Whooley, M. A. Tags: Psychiatry, Depression, Post Traumatic Stress Disorder, Stress, Cardiovascular System, Quality of Life, Cardiovascular Disease/ Myocardial Infarction Original Article Source Type: journals

ORIGINAL ARTICLE: Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent PopulationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Participants who had both childhood adversity and adult traumatic events were more likely to develop lifetime PTSD compared with those who experienced either type of adverse event. The risk was increased in individuals with 1 or 2 copies of the S’ (S) allele compared with the L’ (L) homozygotes. Our study provides additional direct evidence that PTSD is influenced by the interactive effect of environmental and genetic factors. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Xie, P., Kranzler, H. R., Poling, J., Stein, M. B., Anton, R. F., Brady, K., Weiss, R. D., Farrer, L., Gelernter, J. Tags: Psychiatry, Child Psychiatry, Post Traumatic Stress Disorder, Stress, Genetics, Genetic Disorders Original Article Source Type: journals

ORIGINAL ARTICLE: Altered Corticostriatal Functional Connectivity in Obsessive-compulsive DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  This study directly supports the hypothesis that OCD is associated with functional alterations of brain corticostriatal networks. Specifically, our findings emphasize abnormal and heightened functional connectivity of ventrolimbic corticostriatal regions in patients with OCD. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Harrison, B. J., Soriano-Mas, C., Pujol, J., Ortiz, H., Lopez-Sola, M., Hernandez-Ribas, R., Deus, J., Alonso, P., Yucel, M., Pantelis, C., Menchon, J. M., Cardoner, N. Tags: Neurology, Functional Imaging, Psychiatry, Obsessive-Compulsive Disorder, Radiologic Imaging, Magnetic Resonance Imaging Original Article Source Type: journals

ORIGINAL ARTICLE: Cognitive Behavioral Analysis System of Psychotherapy and Brief Supportive Psychotherapy for Augmentation of Antidepressant Nonresponse in Chronic Depression: The REVAMP TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Although 37.5% of the participants experienced partial response or remitted in phase 2, neither form of adjunctive psychotherapy significantly improved outcomes over that of a flexible, individualized pharmacotherapy regimen alone. A longitudinal assessment of later-emerging benefits is ongoing. Trial Registration  clinicaltrials.gov Identifier: NCT00057551 (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Kocsis, J. H., Gelenberg, A. J., Rothbaum, B. O., Klein, D. N., Trivedi, M. H., Manber, R., Keller, M. B., Leon, A. C., Wisniewski, S. R., Arnow, B. A., Markowitz, J. C., Thase, M. E., for the REVAMP Investigators Tags: Patient-Physician Relationship/ Care, Psychosocial Issues, Psychiatry, Cognitive Therapy, Depression, Psychopharmacology, Psychotherapy, Prognosis/ Outcomes, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

REVIEW: The Catatonia Syndrome: Forgotten but Not GoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Fink, M., Taylor, M. A. Tags: Neurology, Movement Disorders, Neurology, Other, Psychiatry, Delirium, Psychopharmacology, Schizophrenia, Review, Drug Therapy, Drug Therapy, Other Source Type: journals

ORIGINAL ARTICLE: Altered Effect of Dopamine Transporter 3'UTR VNTR Genotype on Prefrontal and Striatal Function in SchizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Insular, cingulate, and striatal function during an executive task is normally modulated by variation in the dopamine transporter gene. Its effect on activation in the dorsolateral prefrontal cortex and ventral striatum is altered in patients with schizophrenia. This may reflect altered dopamine function in these regions in schizophrenia. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Prata, D. P., Mechelli, A., Picchioni, M. M., Fu, C. H. Y., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R. M., Collier, D. A., McGuire, P. Tags: Neurology, Functional Imaging, Psychiatry, Schizophrenia, Genetics, Genetic Disorders Original Article Source Type: journals

ART AND IMAGES IN PSYCHIATRY: Cattleya Orchid and Three Brazilian HummingbirdsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Authors: Harris, J. C. Tags: Psychiatry, Psychiatry, Other, Humanities Art and Images in Psychiatry Source Type: journals

THIS MONTH IN ARCHIVES OF GENERAL PSYCHIATRY: This Month in Archives of General PsychiatryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Tags: This Month in Archives of General Psychiatry Source Type: journals

ABOUT THIS JOURNAL: About This JournalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - November 2, 2009 Category: Psychiatry Tags: About This Journal Source Type: journals

ORIGINAL ARTICLE: Dopaminergic Haplotype as a Predictor of Spatial Inattention in Children With Attention-Deficit/Hyperactivity DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Heterogeneity in selective attention in ADHD can be explained by a replicated genetic risk factor for ADHD, the 10/3 DAT1 haplotype. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Bellgrove, M. A., Johnson, K. A., Barry, E., Mulligan, A., Hawi, Z., Gill, M., Robertson, I., Chambers, C. D. Tags: Psychiatry, Attention Deficit Hyperactivity Disorder, Child Psychiatry, Genetics, Genetic Disorders Original Article Source Type: journals

ORIGINAL ARTICLE: Positron Emission Tomography Measures of Endogenous Opioid Neurotransmission and Impulsiveness Traits in HumansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Individual differences in the function of the endogenous µ-receptor system predict personality traits that confer vulnerability to or resiliency against risky behaviors such as the predisposition to develop substance use disorders. These personality traits are also implicated in psychopathological states (eg, personality disorders) in which variations in the function of this neurotransmitter system also may play a role. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Love, T. M., Stohler, C. S., Zubieta, J.-K. Tags: Neurology, Neurology, Other, Psychiatry, Stress, Psychiatry, Other, Public Health, Substance Abuse/ Alcoholism Original Article Source Type: journals

ORIGINAL ARTICLE: Cocaine Vaccine for the Treatment of Cocaine Dependence in Methadone-Maintained Patients: A Randomized, Double-blind, Placebo-Controlled Efficacy TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Attaining high (≥43 µg/mL) IgG anticocaine antibody levels was associated with significantly reduced cocaine use, but only 38% of the vaccinated subjects attained these IgG levels and they had only 2 months of adequate cocaine blockade. Thus, we need improved vaccines and boosters. Trial Registration  clinicaltrials.gov Identifier: NCT00142857 (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Martell, B. A., Orson, F. M., Poling, J., Mitchell, E., Rossen, R. D., Gardner, T., Kosten, T. R. Tags: Psychiatry, Psychopharmacology, Psychiatry, Other, Public Health, Immunization, Substance Abuse/ Alcoholism, Randomized Controlled Trial, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

ORIGINAL ARTICLE: Improving Clinical Outcomes in Treating Heroin Dependence: Randomized, Controlled Trial of Oral or Implant NaltrexoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  The naltrexone implant effectively reduced relapse to regular heroin use compared with oral naltrexone and was not associated with major adverse events. Clinical Trial Registration  anzctr.org.au Identifier: ACTRN12606000308594 (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Hulse, G. K., Morris, N., Arnold-Reed, D., Tait, R. J. Tags: Patient-Physician Relationship/ Care, Treatment Adherence, Psychiatry, Psychopharmacology, Psychiatry, Other, Public Health, Substance Abuse/ Alcoholism, Randomized Controlled Trial, Prognosis/ Outcomes, Drug Therapy, Adherence, Drug Therapy, Other Orig Source Type: journals

ORIGINAL ARTICLE: Resting Metabolic Activity in the Cingulate Cortex and Vulnerability to Posttraumatic Stress DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Enhanced resting metabolic activity in the dACC/MCC appears to represent a familial risk factor for developing PTSD after exposure to psychological trauma. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Shin, L. M., Lasko, N. B., Macklin, M. L., Karpf, R. D., Milad, M. R., Orr, S. P., Goetz, J. M., Fischman, A. J., Rauch, S. L., Pitman, R. K. Tags: Neurology, Neuropathology, Neurology, Other, Nutritional and Metabolic Disorders, Metabolism, Psychiatry, Post Traumatic Stress Disorder, Stress Original Article Source Type: journals

ORIGINAL ARTICLE: Association of the Mediterranean Dietary Pattern With the Incidence of Depression: The Seguimiento Universidad de Navarra/University of Navarra Follow-up (SUN) CohortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Our results suggest a potential protective role of the MDP with regard to the prevention of depressive disorders; additional longitudinal studies and trials are needed to confirm these findings. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Sanchez-Villegas, A., Delgado-Rodriguez, M., Alonso, A., Schlatter, J., Lahortiga, F., Majem, L. S., Martinez-Gonzalez, M. A. Tags: Psychiatry, Depression, Public Health, Diet Original Article Source Type: journals

ORIGINAL ARTICLE: Incremental Benefit and Cost of Telephone Care Management and Telephone Psychotherapy for Depression in Primary CareEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Compared with current primary care practice, a structured telephone program including care management and cognitive behavioral psychotherapy has significant clinical benefit with only a modest increase in health services cost. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Simon, G. E., Ludman, E. J., Rutter, C. M. Tags: Patient-Physician Relationship/ Care, Psychosocial Issues, Primary Care/ Family Medicine, Psychiatry, Cognitive Therapy, Depression, Psychotherapy, Randomized Controlled Trial, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

ORIGINAL ARTICLE: A Reverse-Translational Study of Dysfunctional Exploration in Psychiatric Disorders: From Mice to MenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  These findings validate the human open field paradigm and identify defining characteristics of bipolar mania that are distinct from those of schizophrenia. This cross-species study of exploration calls into question an accepted animal model of mania and should help to develop more accurate human and animal models, which are essential to the identification of the neurobiological underpinnings of neuropsychiatric disorders. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Perry, W., Minassian, A., Paulus, M. P., Young, J. W., Kincaid, M. J., Ferguson, E. J., Henry, B. L., Zhuang, X., Masten, V. L., Sharp, R. F., Geyer, M. A. Tags: Psychiatry, Bipolar Disorder, Schizophrenia Original Article Source Type: journals

ORIGINAL ARTICLE: Susceptibility Locus on Chromosome 1q23-25 for a Schizophrenia Subtype Resembling Deficit Schizophrenia Identified by Latent Class AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Genetic analyses of heritable, homogeneous phenotypes may improve the power of linkage and association studies of schizophrenia and thus have relevance to the design and analysis of genome-wide association studies. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Holliday, E. G., McLean, D. E., Nyholt, D. R., Mowry, B. J. Tags: Psychiatry, Schizophrenia, Genetics, Genetic Disorders Original Article Source Type: journals

ORIGINAL ARTICLE: Influence of NOS1 on Verbal Intelligence and Working Memory in Both Patients With Schizophrenia and Healthy Control SubjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  NOS1 is associated with clinically significant variation in cognition. Whether this is a mechanism by which schizophrenia risk is increased (eg, via an influence on cognitive reserve) is yet to be confirmed. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Donohoe, G., Walters, J., Morris, D. W., Quinn, E. M., Judge, R., Norton, N., Giegling, I., Hartmann, A. M., Moller, H.-J., Muglia, P., Williams, H., Moskvina, V., Peel, R., O'Donoghue, T., Owen, M. J., O'Donovan, M. C., Gill, M., Rujescu, D., Corvin, A. Tags: Neurology, Cognitive Disorders, Psychiatry, Schizophrenia, Genetics, Genetic Disorders Original Article Source Type: journals

ART AND IMAGES IN PSYCHIATRY: Mother and ChildEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Authors: Harris, J. C. Tags: Psychiatry, Psychiatry, Other, Humanities Art and Images in Psychiatry Source Type: journals

THIS MONTH IN ARCHIVES OF GENERAL PSYCHIATRY: This Month in Archives of General PsychiatryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Tags: This Month in Archives of General Psychiatry Source Type: journals

ABOUT THIS JOURNAL: About This JournalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - October 5, 2009 Category: Psychiatry Tags: About This Journal Source Type: journals

ORIGINAL ARTICLE: Psychiatric Characteristics Associated With Long-term Mortality Among 361 Patients Having an Acute Coronary Syndrome and Major Depression: Seven-Year Follow-up of SADHART ParticipantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Severity of MDD measured within a few weeks of hospitalization for ACS or failure of MDD to improve during the 6 months following ACS predicted more than a doubling of mortality over 6.7 years of follow-up. Because persistent depression increases mortality and decreases medication adherence, physicians need to aggressively treat depression and be diligent in promoting adherence to guideline cardiovascular drug therapy. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Glassman, A. H., Bigger, J. T., Gaffney, M. Tags: Psychiatry, Depression, Psychopharmacology, Cardiovascular System, Randomized Controlled Trial, Cardiovascular Disease/ Myocardial Infarction, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

ORIGINAL ARTICLE: Impact of Multifamily Psychoeducational Psychotherapy in Treating Children Aged 8 to 12 Years With Mood DisordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Brief, adjunctive psychoeducational group psychotherapy is associated with improved outcome for children aged 8 to 12 years with major mood disorders. Trial Registration  clinicaltrials.gov Identifier: NCT00050557 (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Fristad, M. A., Verducci, J. S., Walters, K., Young, M. E. Tags: Patient-Physician Relationship/ Care, Psychosocial Issues, Psychiatry, Bipolar Disorder, Child Psychiatry, Depression, Mood Disorders, Randomized Controlled Trial Original Article Source Type: journals

ORIGINAL ARTICLE: Childhood Bullying Behavior and Later Psychiatric Hospital and Psychopharmacologic Treatment: Findings From the Finnish 1981 Birth Cohort StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Boys and girls who display frequent bullying behavior should be evaluated for possible psychiatric problems, as bullying behaviors in concert with psychiatric symptoms are early markers of risk of psychiatric outcome. Among females, frequent childhood victimization predicts later psychiatric problems irrespective of psychiatric problems at baseline. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Sourander, A., Ronning, J., Brunstein-Klomek, A., Gyllenberg, D., Kumpulainen, K., Niemela, S., Helenius, H., Sillanmaki, L., Ristkari, T., Tamminen, T., Moilanen, I., Piha, J., Almqvist, F. Tags: Psychiatry, Child Psychiatry, Psychopharmacology, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

ORIGINAL ARTICLE: Association of Time Since Deployment, Combat Intensity, and Posttraumatic Stress Symptoms With Neuropsychological Outcomes Following Iraq War DeploymentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  In this study of army soldiers deployed to the Iraq war, only PTSD symptoms (among soldiers back from deployment for 1 year) were associated with a neuropsychological deficit (reduced attention). Greater combat intensity was associated with enhanced reaction time, irrespective of time since return. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Marx, B. P., Brailey, K., Proctor, S. P., MacDonald, H. Z., Graefe, A. C., Amoroso, P., Heeren, T., Vasterling, J. J. Tags: Psychiatry, Post Traumatic Stress Disorder, Stress, Violence and Human Rights, War Original Article Source Type: journals

ORIGINAL ARTICLE: Localization of Deformations Within the Amygdala in Individuals With PsychopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Results provide the first evidence, to our knowledge, of focal amygdala abnormalities in psychopathic individuals and corroborate findings from previous lesion studies. Findings support prior hypotheses of amygdala deficits in individuals with psychopathy and indicate that amygdala abnormalities contribute to emotional and behavioral symptoms of psychopathy. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Yang, Y., Raine, A., Narr, K. L., Colletti, P., Toga, A. W. Tags: Neurology, Neuroimaging, Neurology, Other, Psychiatry, Antisocial Personality Disorder Original Article Source Type: journals

ORIGINAL ARTICLE: Protective Effect of CRHR1 Gene Variants on the Development of Adult Depression Following Childhood Maltreatment: Replication and ExtensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. This suggests the hypothesis that CRHR1's protective effect may relate to its function in the consolidation of memories of emotionally arousing experiences. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Polanczyk, G., Caspi, A., Williams, B., Price, T. S., Danese, A., Sugden, K., Uher, R., Poulton, R., Moffitt, T. E. Tags: Pediatrics, Child Abuse, Psychiatry, Child Psychiatry, Depression, Violence and Human Rights, Violence and Human Rights, Other, Women's Health, Women's Health, Other, Genetics, Genetics, Other Original Article Source Type: journals

ORIGINAL ARTICLE: A Genomewide Association Study Points to Multiple Loci That Predict Antidepressant Drug Treatment Outcome in DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  These results demonstrate the importance of multiple genetic factors combined with clinical features in the prediction of antidepressant drug treatment outcome, which underscores the multifactorial nature of this trait. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Ising, M., Lucae, S., Binder, E. B., Bettecken, T., Uhr, M., Ripke, S., Kohli, M. A., Hennings, J. M., Horstmann, S., Kloiber, S., Menke, A., Bondy, B., Rupprecht, R., Domschke, K., Baune, B. T., Arolt, V., Rush, A. J., Holsboer, F., Muller-Myhsok, B. Tags: Psychiatry, Depression, Psychopharmacology, Prognosis/ Outcomes, Genetics, Genetic Disorders Original Article Source Type: journals

ORIGINAL ARTICLE: Genetic and Environmental Influences on Pro-Inflammatory Monocytes in Bipolar Disorder: A Twin StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  The association of the monocyte pro-inflammatory state with BD is primarily the result of a common shared environmental factor. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Padmos, R. C., Van Baal, G. C. M., Vonk, R., Wijkhuijs, A. J. M., Kahn, R. S., Nolen, W. A., Drexhage, H. A. Tags: Occupational and Environmental Medicine, Psychiatry, Bipolar Disorder, Genetics, Genetic Disorders Original Article Source Type: journals

ORIGINAL ARTICLE: Recurrent Rearrangements in Synaptic and Neurodevelopmental Genes and Shared Biologic Pathways in Schizophrenia, Autism, and Mental RetardationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Weakly to moderately recurrent CNVs (transmitted or occurring de novo) seem to be causative or contributory factors for these diseases. Most of these CNVs (which contain genes involved in neurotransmission or in synapse formation and maintenance) are present in the 3 pathologic conditions (schizophrenia, autism, and mental retardation), supporting the existence of shared biologic pathways in these neurodevelopmental disorders. (Source: Archives of General Psychiatry)
Source: Archives of General Psychiatry - September 6, 2009 Category: Psychiatry Authors: Guilmatre, A., Dubourg, C., Mosca, A.-L., Legallic, S., Goldenberg, A., Drouin-Garraud, V., Layet, V., Rosier, A., Briault, S., Bonnet-Brilhault, F., Laumonnier, F., Odent, S., Le Vacon, G., Joly-Helas, G., David, V., Bendavid, C., Pinoit, J.-M., Henry, C Tags: Neurology, Neurogenetics, Psychiatry, Autism, Schizophrenia, Genetics, Genetic Disorders Original Article Source Type: journals