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Guidelines for the reporting of nongynecologic cytopathology specimens.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We describe the major elements of quality nongynecologic cytology reporting and discuss areas of controversy in cytology reporting. Standardized nongynecologic specimen reporting will expand the concept of common report elements already widely implemented in gynecologic cytology reporting. The intent is to improve communication with the health care team while remaining in compliance with federal mandates and accreditation guidelines. PMID: 19886707 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Crothers BA, Tench WD, Schwartz MR, Bentz JS, Moriarty AT, Clayton AC, Fatheree LA, Chmara BA, Wilbur DC Tags: Arch Pathol Lab Med Source Type: journals

Automatic failure in gynecologic cytology proficiency testing. Results from the College of American Pathologists proficiency testing program.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS:The automatic failure rate in PAP PT is lower than expected based on 2004 data from the College of American Pathologists Interlaboratory Comparison Program. Automatic failures are a relatively small component (1% or less) of proficiency testing failures. The rate of automatic failure decreased from 2006 to 2007 and may be due to loss of poor performers in the testing pool, the test-taking environment, or removal of less robust slides from the program. PMID: 19886708 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Moriarty AT, Crothers BA, Bentz JS, Souers RJ, Fatheree LA, Wilbur DC Tags: Arch Pathol Lab Med Source Type: journals

New frontiers in pathology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19886709 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Visscher DW, Myers JL Tags: Arch Pathol Lab Med Source Type: journals

Update on selected salivary gland neoplasms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: When diagnosing carcinoma ex pleomorphic adenoma, pathologists must report several important pieces of information to allow for optimal clinical management. In addition to histologic subtype, the degree of differentiation as well as the degree of invasion, if any, must be reported because all have prognostic relevance. Polymorphous low-grade adenocarcinoma can be a challenging diagnosis on biopsy specimens. Evaluation of the tumor periphery and nuclear features should lead to the correct diagnosis in most cases. Salivary duct carcinoma is an aggressive malignancy characterized by histologic resemblance to brea...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: McHugh JB, Visscher DW, Barnes EL Tags: Arch Pathol Lab Med Source Type: journals

Ovarian cancer update: lessons from morphology, molecules, and mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian carcinomas are a heterogeneous group of neoplasms. Pathologists currently employ a morphology-based classification system to divide ovarian carcinomas into major subgroups based on degree (tumor grade) and type of differentiation (eg, serous, endometrioid, clear cell, or mucinous). Molecular studies have shown that specific genetic defects are likely to be present in certain histologic types of ovarian carcinomas and unlikely to be present in others. Within the serous and endometrioid carcinomas, the molecular defects in low-grade versus high-grade tumors also appear to be largely distinct. Recently, mouse mode...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Cho KR Tags: Arch Pathol Lab Med Source Type: journals

Common diagnostic challenges in the pathology of nonneoplastic lung diseases: a case-based review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We use a case-based format to review 4 relatively common, diagnostic challenges in surgical pathology of nonneoplastic lung diseases. All cases are linked to virtual slides so that the reader can participate in a manner that simulates the breakout session held at the 2008 New Frontiers in Pathology course at the University of Michigan, from which, this material was excerpted. Brief clinical histories and a summary of radiologic findings are followed by a description of the pertinent histologic findings and a concise topic review, intended to focus on practical diagnostic considerations. Our goal is that readers gain a ...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Lagstein A, Myers JL Tags: Arch Pathol Lab Med Source Type: journals

Adenocarcinoma in Barrett mucosa treated by endoscopic mucosal resection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adenocarcinoma and dysplasias are recognized complications of Barrett mucosa. In the past, the treatment for this carcinoma was esophagectomy. However, new techniques, including endoscopic mucosal resection, sometimes replace esophagectomy and are becoming standard procedures in clinical practice, not just in major medical centers. Pathologists must learn to handle these specimens, which have extensive artifacts. Also, Barrett mucosa has duplicated stromal layers beneath the mucosa that include a new lamina propria and a new muscularis mucosae. We must be aware of these peculiarities because of staging implications. Re...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Appelman HD Tags: Arch Pathol Lab Med Source Type: journals

Association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. Similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. Human papillomavirus-associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. The histopathology of this subset of head and neck squamous cell carcinoma is unique and typically characterized by poorly differentiated, nonkeratinizing morphology with a basaloid appearance. These tumor...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: McHugh JB Tags: Arch Pathol Lab Med Source Type: journals

Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer. Most are sporadic, presenting as cutaneous tumors in the scalp/face of elderly patients. However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations. Predisposing conditions include environmental exposures to chemical or radioactive sources. Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy. The latency for radiation-associated mammary angiosarcoma is rel...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Lucas DR Tags: Arch Pathol Lab Med Source Type: journals

Current perspectives on the Gleason grading of prostate cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This review addresses the trend in contemporary practice toward a grading shift, with rare utilization of Gleason patterns 1 and 2, and discusses the refinement of histologic criteria for Gleason patterns 3 and 4; approaches to Gleason grading in the setting of unusual variant morphologies of prostate cancer; significance of higher tertiary pattern 5; and practice recommendations for reporting in the setting of extended multiple core biopsies and multifocal prostate cancers in radical prostatectomy. Finally, the impact of consensus recommendations in current practice, its limitations and pitfalls, are also add...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Shah RB Tags: Arch Pathol Lab Med Source Type: journals

Apocrine ductal carcinoma in situ involving a sclerosing lesion with adenosis: report of a case.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Apocrine metaplasia is a ubiquitous component of the mammary fibrocystic change spectrum. Although mostly associated with cysts, apocrine metaplasia can also present as a proliferative lesion, rarely with cytologic atypism. Apocrine atypia is characterized by 3-fold nuclear enlargement, multiple nucleoli, and hyperchromatism and generally arises in florid adenosis or radial sclerosing lesions. Dramatic apocrine atypia may be very difficult to distinguish from apocrine ductal carcinoma in situ. The latter is distinguished from apocrine atypia by greater extent of the lesion (>0.4 cm) and the presence of greater nucle...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Visscher DW Tags: Arch Pathol Lab Med Source Type: journals

Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This case presentation reviews the histologic distinction between pure medullary carcinoma and breast carcinomas with medullary-like features. This particular case prompts us to analyze the relationship among medullary carcinoma, basal-like breast carcinomas and carcinomas associated with germline BRCA1 mutations. In addition to now well-defined features, such as expression of high-molecular-weight cytokeratins and EGFR (epidermal growth factor receptor), basal-like tumors have a deficiency or dysfunction of BRCA1. This association in part explains the histologic features of BRCA1-associated breast cancers. Recent stud...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Kleer CG Tags: Arch Pathol Lab Med Source Type: journals

Mitotic index of invasive breast carcinoma. Achieving clinically meaningful precision and evaluating tertial cutoffs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Standard errors for MI based on a single count of 10 HPFs are too broad and coefficients of variation too large to be acceptable for clinical use. This is explained as a binomial probability effect, possibly with a contribution from tumor heterogeneity. Errors can be reduced in proportion to the square root of the number of sets of 10 HPFs counted. Tertial cutoffs of MI of the Nottingham system currently used in breast carcinoma grading are too high to be applicable to the population we studied. We recommend validation of cutoffs before they are applied to a particular population of breast carcinomas. Counting...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Meyer JS, Cosatto E, Graf HP Tags: Arch Pathol Lab Med Source Type: journals

Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prognostic factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Primary intraosseous squamous cell carcinoma is a high-grade malignancy with frequent, regional lymph node metastasis and high rates of recurrence and mortality. The tumor grading and regional lymph node metastasis may serve as useful indicators for prognosis. PMID: 19886720 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Huang JW, Luo HY, Li Q, Li TJ Tags: Arch Pathol Lab Med Source Type: journals

Standards to support information systems integration in anatomic pathology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The IHE anatomic pathology working group has defined standard-based informatics transactions to support the basic diagnostic workflow in anatomic pathology laboratories. In further stages, the technical framework will be completed to manage whole-slide images and semantically rich structured reports in the diagnostic workflow and to integrate systems used for patient care and those used for research activities (such as tissue bank databases or tissue microarrayers). PMID: 19886721 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Daniel C, García Rojo M, Bourquard K, Henin D, Schrader T, Mea VD, Gilbertson J, Beckwith BA Tags: Arch Pathol Lab Med Source Type: journals

p38 Mitogen-activated protein kinase and hematologic malignancies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In some hematologic malignancies, activation of p38 plays a key role in promoting or inhibiting proliferation and also in increasing resistance to chemotherapeutic agents. The importance of different p38 isoforms in various cellular functions has been acknowledged recently. Further understanding of these isoforms will allow the design of more specific inhibitors to target particular isoforms to maximize the treatment effect and minimize the side effects for treating hematopoietic malignancies. PMID: 19886722 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Feng Y, Wen J, Chang CC Tags: Arch Pathol Lab Med Source Type: journals

Sarcomatoid chromophobe renal cell carcinoma with heterologous sarcomatoid elements. A case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chromophobe renal cell carcinoma (CRCC) is a distinct subtype of renal cell carcinoma (RCC) that is well known for its relatively good prognosis. Sarcomatoid transformation in this tumor, although rare, has been well documented in the literature and, as in other types of RCC, carries an ominous prognosis for the patient. The finding of heterologous elements in the sarcomatoid component of CRCC is an extraordinary event, which has been reported in only 2 previous cases. Here, we present the third such case, occurring in the left kidney of a previously healthy 63-year-old woman. The nephrectomy specimen showed CRCC with ...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Quiroga-Garza G, Khurana H, Shen S, Ayala AG, Ro JY Tags: Arch Pathol Lab Med Source Type: journals

Crystal-storing histiocytosis as a cause of symptomatic cardiac mass.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a 64-year-old man with a prior history of weakness and weight loss and hematologic evaluation that had revealed immunoglobulin G kappa monoclonal light chains in the serum and negative bone marrow biopsy. He presented with supraventricular tachyarrhythmia and a right atrial mass seen on echocardiogram and excised surgically. Histologically, the tumor was composed of sheets of macrophages infiltrating the atrial myocardium. The histiocytes were filled with multiple needle-shaped, periodic acid-Schiff-negative crystals. These cells and associated plasma cells failed to show clonal light chain restriction by in sit...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Sailey CJ, Alexiev BA, Gammie JS, Pinell-Salles P, Stafford JL, Burke A Tags: Arch Pathol Lab Med Source Type: journals

Dieulafoy disease of the colon.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dieulafoy disease is a rare cause of upper gastrointestinal hemorrhage (usually gastric) and an even rarer cause of colonic bleeding. There is a sudden onset of catastrophic bleeding in a previously healthy individual, which cannot be managed conservatively. Although this entity can be diagnosed and treated by endoscopy and angiography, the knowledge of its existence in colon is critical to making the diagnosis because of its small size. In an era of widespread use of endoscopy, the pathologists uncommonly receive resection specimens for Dieulafoy lesions. However, the diagnosis can be missed because of the small size ...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Jain R, Chetty R Tags: Arch Pathol Lab Med Source Type: journals

Primary bone lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary bone lymphomas are rare, even though secondary involvement of the bone marrow is a common event in systemic lymphomas. Most primary bone lymphomas are primary bone diffuse large B-cell lymphomas (PBDLBCLs) with a rare occurrence of follicular, marginal zone, anaplastic large cell, Hodgkin, and T-cell lymphomas. The PBDLBCL affects the middle-aged to elderly population, with a slight predominance in men. The patients present with bone pain, palpable mass, fractures, or neurologic symptoms. The metaphysis of bones is a common location of PBDLBCL. Morphologically, the lymphoma consists of a polymorphous mixture of...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Bhagavathi S, Fu K Tags: Arch Pathol Lab Med Source Type: journals

Benign fibroblastic polyps of the colon.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Benign fibroblastic polyps of the colon are a recently described entity among mucosal polyps found in the colorectum. These polyps are typically discovered on routine screening colonoscopy within the distal colon. Benign fibroblastic polyps occur most commonly in adult women in the sixth decade of life. Histologically, benign fibroblastic polyps are bland spindle cell lesions that fill the lamina propria and displace the surrounding crypts. The spindle cell proliferation lacks atypia and significant mitotic activity. Hyperplastic changes are frequently present both in the adjacent epithelium and within the lesions. Imm...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Huber AR, Shikle JF Tags: Arch Pathol Lab Med Source Type: journals

Protocol for the examination of specimens from patients with invasive carcinoma of the breast.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19792042 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Lester SC, Bose S, Chen YY, Connolly JL, de Baca ME, Fitzgibbons PL, Hayes DF, Kleer C, O'Malley FP, Page DL, Smith BL, Tan LK, Weaver DL, Winer E, Tags: Arch Pathol Lab Med Source Type: journals

Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19792043 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Washington MK, Berlin J, Branton P, Burgart LJ, Carter DK, Fitzgibbons PL, Halling K, Frankel W, Jessup J, Kakar S, Minsky B, Nakhleh R, Compton CC, Tags: Arch Pathol Lab Med Source Type: journals

Protocol for the examination of specimens from patients with primary non-small cell carcinoma, small cell carcinoma, or carcinoid tumor of the lung.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19792044 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Butnor KJ, Beasley MB, Cagle PT, Grunberg SM, Kong FM, Marchevsky A, Okby NT, Roggli VL, Suster S, Tazelaar HD, Travis WD, Tags: Arch Pathol Lab Med Source Type: journals

Protocol for the examination of specimens from patients with melanoma of the skin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19792045 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Frishberg DP, Balch C, Balzer BL, Crowson AN, Didolkar M, McNiff JM, Perry RR, Prieto VG, Rao P, Smith MT, Smoller BR, Wick MR, Tags: Arch Pathol Lab Med Source Type: journals

Protocol for the examination of specimens from patients with carcinoma of the prostate gland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19792046 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Srigley JR, Humphrey PA, Amin MB, Chang SS, Egevad L, Epstein JI, Grignon DJ, McKiernan JM, Montironi R, Renshaw AA, Reuter VE, Wheeler TM, Tags: Arch Pathol Lab Med Source Type: journals

Human papillomavirus typing and viral gene expression analysis for the triage of women with abnormal results from papanicolaou test smears to colposcopy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The RQ of HPV E6 mRNA and HPV genotype could be useful in a cascade of diagnostic testing designed to refer women with findings of cervical abnormalities for colposcopy or treatment while reducing triage numbers. PMID: 19792047 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Antonishyn NA, Horsman GB, Kelln RA, Severini A Tags: Arch Pathol Lab Med Source Type: journals

Sino-orbital osteoma: a clinicopathologic study of 45 surgically treated cases with emphasis on tumors with osteoblastoma-like features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Osteoblastoma-like features are common in sino-orbital osteomas, but it does not correlate with more adverse clinical features or worse outcome. Osteoblastoma-like areas appear to represent active remodeling within an osteoma rather than defining a distinct clinicopathologic entity. Distinguishing it from osteoblastoma may require careful histologic evaluation and radiographic correlation. PMID: 19792048 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: McHugh JB, Mukherji SK, Lucas DR Tags: Arch Pathol Lab Med Source Type: journals

Phenotyping studies of clonotypic B lymphocytes from patients with multiple myeloma by flow cytometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Clonotypic B lymphocytes expressing CD34, but not CD19, were identified in stem cell harvests from patients with myeloma and could represent progenitor cells of neoplastic plasma cells. However, the same or similar immunophenotyping can be detected in both clonotypic B lymphocytes and benign progenitor B cells, suggesting clonality analysis might be needed to determine clonotypic B lymphocytes in patients with myeloma. Further studies are warranted to study the role of clonotypic B lymphocytes in the pathogenesis of myeloma. PMID: 19792049 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Conway EJ, Wen J, Feng Y, Mo A, Huang WT, Keever-Taylor CA, Hari P, Vesole DH, Chang CC Tags: Arch Pathol Lab Med Source Type: journals

The role of KRAS mutation testing in the management of patients with metastatic colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Multiple methods for detecting KRAS mutations in colorectal tumors are available, and all methods in current clinical use appear to have adequate clinical sensitivity for predicting a lack of response to cetuximab and panitumumab. Pathologist expertise is essential to quality KRAS testing and to determining effective treatment for patients with metastatic colorectal cancer. PMID: 19792050 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Monzon FA, Ogino S, Hammond ME, Halling KC, Bloom KJ, Nikiforova MN Tags: Arch Pathol Lab Med Source Type: journals

Protocol for the examination of specimens from patients with primary carcinomas of the colon and rectum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19722730 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Stewart CJ, Hillery S, Plattell C Tags: Arch Pathol Lab Med Source Type: journals

Examination of specimens from patients with ductal carcinoma in situ of the breast using large-format histology sections.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19722732 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Tot T, Ibarra JA Tags: Arch Pathol Lab Med Source Type: journals

Coronal serial sequential sampling of breast specimen in the assessment of the extent of ductal carcinoma in situ.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19722734 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Mai KT, Stinson WA, Burns BF Tags: Arch Pathol Lab Med Source Type: journals

Erroneous detection of hypercalcemia in specimens stored in Greiner Bio-One Vacuette Plasma Separator Tubes and analyzed by the Arsenazo III methodology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19722736 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Ritter D, Mayo MM Tags: Arch Pathol Lab Med Source Type: journals

The value of transcapsular invasion in patients with thymoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19722737 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Venuta F, Anile M, Rendina EA, Vitolo D, De Giacomo T, Coloni GF Tags: Arch Pathol Lab Med Source Type: journals

Dr Richard Bright--father of medical renal disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19722738 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Young RH Tags: Arch Pathol Lab Med Source Type: journals

Significant and unexpected versus critical results in surgical pathology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19722739 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Sarewitz SJ, Williams RB Tags: Arch Pathol Lab Med Source Type: journals

Circulating tumor cells: seeing is believing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19722740 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Fischer AH Tags: Arch Pathol Lab Med Source Type: journals

Best practices in diagnostic immunohistochemistry: spindle cell neoplasms of the gastrointestinal tract.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The most common spindle cell neoplasm of the gastrointestinal tract is gastrointestinal stromal tumor; this lesion is readily diagnosed with c-kit immunohistochemistry in most cases. Other stains, such as smooth muscle actin, desmin, S100 protein, and beta-catenin, are also useful in the diagnosis of smooth muscle tumors, schwannomas, desmoid-type fibromatoses, and metastatic melanoma. PMID: 19722741 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Turner MS, Goldsmith JD Tags: Arch Pathol Lab Med Source Type: journals

Significant and unexpected, and critical diagnoses in surgical pathology: a College of American Pathologists' survey of 1130 laboratories.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This survey illustrates current anatomic pathology policies and practices with respect to critical and significant and unexpected results. PMID: 19722742 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Nakhleh RE, Souers R, Brown RW Tags: Arch Pathol Lab Med Source Type: journals

Performance of herpes simplex challenges in proficiency testing: observations from the College of American Pathologists proficiency testing program.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is a change in the performance of slide challenges demonstrating the cellular features of HSV in PT, most likely due to testing strategies of participants, rather than lack of recognition of HSV secondary to decreased prevalence. PMID: 19722743 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Moriarty AT, Darragh TM, Souers R, Fatheree LA, Wilbur DC Tags: Arch Pathol Lab Med Source Type: journals

Anaplastic large cell lymphoma involving the breast: a clinicopathologic study of 6 cases and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Including the 6 cases we describe, a total of 21 cases of ALCL involving the breast are reported. Fifteen cases, all ALK(-), were associated with breast implants, suggesting a possible pathogenetic relationship, and associated with an excellent prognosis. Patients with cutaneous ALCL can subsequently develop ALK(-) ALCL involving the breast, and these tumors can be associated with breast implants. PMID: 19722744 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Miranda RN, Lin L, Talwalkar SS, Manning JT, Medeiros LJ Tags: Arch Pathol Lab Med Source Type: journals

Rare nerve lesions of non-nerve sheath origin: a 17-year retrospective series.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Diverse benign and malignant conditions can affect peripheral nerve. PMID: 19722745 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Strom T, Kleinschmidt-Demasters BK, Donson A, Foreman NK, Lillehei KO Tags: Arch Pathol Lab Med Source Type: journals

The RAV12 monoclonal antibody recognizes the N-linked glycotope RAAG12: expression in human normal and tumor tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: High expression of RAAG12 on tumors of gastrointestinal origin suggests these cancers are appropriate targets for RAV12 therapy. Differential subcellular location of RAAG12 on normal epithelia may limit accessibility of RAV12 to the subset of normal tissues that exhibit antigen expression. PMID: 19722746 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Coberly SK, Chen FZ, Armanini MP, Chen Y, Young PF, Mather JP, Loo DT Tags: Arch Pathol Lab Med Source Type: journals

Standardization of HER2 immunohistochemistry in breast cancer by automated quantitative analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data demonstrate that AQUA analysis can provide a standardized HER2 immunohistochemistry test that can meet current guidelines by the American Society of Clinical Oncology/College of American Pathologists. The use of AQUA analysis could allow for standardized and objective HER2 testing in clinical laboratories. PMID: 19722747 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Gustavson MD, Bourke-Martin B, Reilly D, Cregger M, Williams C, Mayotte J, Zerkowski M, Tedeschi G, Pinard R, Christiansen J Tags: Arch Pathol Lab Med Source Type: journals

Presence of c-KIT-positive mast cells in obliterative bronchiolitis from diverse causes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Mast cells appear to be concentrated in the lesional small-airway subepithelium in obliterative bronchiolitis. The possible role of c-KIT inhibitors such as imatinib (Gleevec) in the progression of fibrosis preceding the development of obliterative bronchiolitis is discussed. PMID: 19722748 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Fuehrer NE, Marchevsky AM, Jagirdar J Tags: Arch Pathol Lab Med Source Type: journals

Follow-up findings for women with human papillomavirus-positive and atypical squamous cells of undetermined significance screening test results in a large women's hospital practice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The risk of CIN 2/3 in the study population was significantly lower than reported in widely cited trial data. Neither presence nor absence of an EC/TZS, nor the age of the patient, had a statistically significant impact on the likelihood of biopsy diagnoses of CIN 2/3 and CIN 1 for patients with HPV-positive ASC-US test results. PMID: 19722749 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Armah H, Austin RM, Dabbs D, Zhao C Tags: Arch Pathol Lab Med Source Type: journals

Fellowship trends of pathology residents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Fellowship programs will benefit from an optimally designed Web site because residents seek information predominantly from the Internet. Residents seeking fellowships are particularly concerned with selecting programs that provide job connections, an increase in their marketability, and the opportunity to develop diagnostic expertise. PMID: 19722750 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Lagwinski N, Hunt JL Tags: Arch Pathol Lab Med Source Type: journals

Comparability of different pathologic protocols in sentinel lymph node evaluation: an analysis of two step-sectioning methods for the same patients with breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The 20-microm and 150-microm interval step-sectioning methods produce comparable results for detection of metastatic deposits in sentinel lymph nodes. PMID: 19722751 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Kanngurn S, Chewatanakornkul S, Premprapha T, Thongsuksai P Tags: Arch Pathol Lab Med Source Type: journals

Increased mean platelet volume in patients with acute coronary syndromes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Because MPV is a simple and inexpensive laboratory measurement, it might be considered a useful rule-out test along with other conventional cardiac biomarkers for the risk stratification of ACS patients admitted to the emergency departments. PMID: 19722752 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Lippi G, Filippozzi L, Salvagno GL, Montagnana M, Franchini M, Guidi GC, Targher G Tags: Arch Pathol Lab Med Source Type: journals