Archivum Immunologiae et Therapiae Experimentalis
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Cellular glucose transport and glucotransporter 4 expression as a therapeutic target: clinical and experimental studies
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Conclusions The three-month therapy with sulfonylurea resulted in a significant increase in CGT in all types of culture tests. This sulfonylurea-related
improvement in CGT was associated with a near normalization of GLUT4 expression in the cells.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0052-7Authors
Anna Czech, Warsaw Medical University (Brodnowski Hospital) Chair and Department of Internal Medicine, and Diabetology, Second Medical Faculty Warsaw PolandPaweł Piątkiewicz, Warsaw Medical University (Brodnowski Hospital) Chair and Department of Internal Medicine, and ...
Source: Archivum Immunologiae et Therapiae Experimentalis - November 3, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammationEmail this article to a colleague.
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Conclusions This study documents that both COX isoforms participate in all stages of acute inflammation and that tissue-resident leukocytes,
especially macrophages, are important sites of COX-1/COX-2 expression and prostaglandin synthesis.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0053-6Authors
Elzbieta Kolaczkowska, Jagiellonian University Department of Evolutionary Immunobiology, Institute of Zoology Kraków PolandAnna Goldys, Jagiellonian University Department of Evolutionary Immunobiology, Institute of Zoology Kraków PolandElzbieta Kozakiewicz, Jagiellonian Univer...
Source: Archivum Immunologiae et Therapiae Experimentalis - November 3, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Exploring the immune response against Mycobacterium tuberculosis for a better diagnosis of the infectionEmail this article to a colleague.
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We present here a summary of the current approaches to validate new diagnostics
based on the detection of immunological biomarkers of TB infection.
Content Type Journal ArticleCategory ReviewDOI 10.1007/s00005-009-0050-9Authors
Giovanni Ferrara, University of Perugia Section of Respiratory Disease, Department of Internal Medicine, St. Maria Hospital Via T. Di Joannuccio 1 05100 Terni ItalyMonica Losi, University of Modena and Reggio Emilia Center for Rare Lung Diseases Modena ItalyLeonardo M. Fabbri, University of Modena and Reggio Emilia Sections of Respiratory Diseases, Department of Oncology and Hematology Modena ...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 28, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Cardiomyocyte death in doxorubicin-induced cardiotoxicityEmail this article to a colleague.
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Abstract Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its cumulative and dose-dependent cardiac
toxicity has been a major concern of oncologists in cancer therapeutic practice for decades. With the increasing population
of cancer survivors, there is a growing need to develop preventive strategies and effective therapies against DOX-induced
cardiotoxicity, in particular late-onset cardiomyopathy. Although intensive investigations on DOX-induced cardiotoxicity have
continued for decades, the underlying mechanisms responsible for DOX-induced cardiotoxicity have not been c...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 28, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Complement: coming full circleEmail this article to a colleague.
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Abstract The complement system has long been known to be a major element of innate immunity. Traditionally, it was regarded as the
first line of defense against invading pathogens, leading to opsonization and phagocytosis or the direct lysis of microbes.
However, from the second half of the twentieth century on, it became clear that complement is also intimately involved in
the induction and “fine tuning” of adaptive B- and T-cell responses as well as lineage commitment. This growing recognition
of the complement system’s multifunctional role in immunity is consistent with the recent paradigm that comp...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 28, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
CD40-activated B cells from patients with systemic lupus erythematosus can be modulated by therapeutic immunoglobulins in vitroEmail this article to a colleague.
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Conclusions Taken as a whole, such accelerated differentiation of CD40-activated B cells suggests that IVIg may participate in re-equilibration
of the antibody repertoire by replacing pathological antibodies by de novo harmless antibodies.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0048-3Authors
Sonia Néron, Recherche et développement, Héma-Québec, Ingénierie cellulaire 1070, avenue des Sciences-de-la-vie Québec Qc G1V 5C3 CanadaGilles Boire, Université de Sherbrookeet Centre hospitalier universitaire de Sherbrooke Service de rhumatologie, Faculté de médecine e...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 28, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Recent advances in multivalent self adjuvanting glycolipopeptide vaccine strategies against breast cancerEmail this article to a colleague.
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Abstract Breast cancer (BrCa) is the second leading cause of cancer-related deaths for women worldwide. Evidence from both patients
and mouse cancer models suggests that the simultaneous induction of BrCa-specific CD4+ T cells, CD8+ cytotoxic T cells, and antibodies is crucial for providing immune resistance. However, almost all current vaccines address
only a single arm of the immune system, which may explain their lack of efficacy. We believe that the correct response to
monovalent vaccines’ “failure” is to increase our knowledge about antitumor protective immunity and to develop a multivalent
vaccin...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 28, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
IntroductionEmail this article to a colleague.
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Content Type Journal ArticleCategory Varia – ScientometricsDOI 10.1007/s00005-008-0048-8Authors
Eugene Garfield, Thomson Scientific ISI Philadelphia PA USA
Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X
Journal Volume Volume 56
Journal Issue Volume 56, Number 6 / December, 2008 (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - October 8, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
IRF4 selectively controls cytokine gene expression in chronic intestinal inflammationEmail this article to a colleague.
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Abstract The authors previously showed that interferon regulatory factor (IRF)4 knockout mice are protected from experimental oxazolone
and TNBS colitis. Here the effect of IRF4 on the expression of pro- and anti-inflammatory cytokines in TNBS colitis and long-term
CD45RBhigh transfer colitis is examined. In TNBS colitis, no differences were found in interleukin (IL)-18 and tumor necrosis factor
(TNF)-α expression between IRF4 knockout and wild-type mice. However, significant differences were detected in IL-6 and IL-17 production.
Upon treatment with hyper-IL-6, IRF4–/– mice lost their protective proper...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 19, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Growth inhibition of Staphylococcus aureus by chicken egg yolk antibodiesEmail this article to a colleague.
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Conclusion These findings indicate that eggs from hens immunized with appropriate antigens are a potentially useful source of passive
immunity.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0041-xAuthors
Marco Cesar Cunegundes Guimarães, UFES Laboratory of Cellular and Molecular Biology of Human Cancer Vitória ES BrazilLívia Gomes Amaral, UFES Laboratory of Cellular and Molecular Biology of Human Cancer Vitória ES BrazilLetícia Batista Azevedo Rangel, UFES Laboratory of Cellular and Molecular Biology of Human Cancer Vitória ES BrazilIan Victor Silva, UFES Laboratory ...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 19, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Fetal-cell microchimerism, lymphopoiesis, and autoimmunityEmail this article to a colleague.
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Abstract During all human and murine pregnancies, fetal cells enter the maternal circulation and tissues and may persist there for
decades. The immune consequences of this phenomenon have been explored for many years as a potential origin of autoimmunity
or protection from cancer in women after pregnancy. The leading hypothesis, suggesting that semi-allogenic fetal T cells may
trigger a graft-versus-host type of disease, has been supported by several studies showing an increased frequency of fetal-cell
microchimerism (FMc) in women affected with systemic sclerosis. However, a large proportion of healthy wome...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 18, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Human complement activation by smooth and rough Proteus mirabilis lipopolysaccharidesEmail this article to a colleague.
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Conclusion Regardless of the complement resistance of the P. mirabilis strains, the S1959, R110, and R45 LPSs fragmented C3 and induced C3c neo-antigen exposure. The use of complement-deficient
human serum allows the conclusion that the Re-type P. mirabilis R45 LPS fragmented C3 by the antibody-independent classical pathway.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0043-8Authors
Wiesław Kaca, Huddinge University Hospital, Karolinska Institute Division of Clinical Bacteriology Huddinge SwedenMichał Arabski, Jan Kochanowski University Department of Microbiology, Insti...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 18, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Factors that deregulate the protective immune response in tuberculosisEmail this article to a colleague.
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Abstract Tuberculosis (TB) is a chronic infectious disease which essentially affects the lungs and produces profound abnormalities
on the immune system. Although most people infected by the tubercle bacillus (90%) do not develop the disease during their
lifetime, when there are alterations in the immune system, such as co-infection with HIV, malnutrition, or diabetes, the risk
of developing active disease increases considerably. Interestingly, during the course of active disease, even in the absence
of immunosuppressive conditions, there is a profound and prolonged suppression of Mycobacterium tuberculosis-s...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 18, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseasesEmail this article to a colleague.
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Abstract The skin protects us from water loss and mechanical damage. The surface-exposed epidermis, a self-renewing stratified squamous
epithelium composed of several layers of keratinocytes, is most important in the barrier defense against these challenges.
Endogenous and exogenous proteases such as kallikreins, matriptase, caspases, cathepsins, and proteases derived from microorganisms
are important in the desquamation process of the stratum corneum and are able to activate and inactivate defense molecules
in human epidermis. Protease inhibitors such as like LEKTI, elafin, SLPI, SERPINs, and cystatins regu...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 17, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Immunopathogenesis of bronchial asthmaEmail this article to a colleague.
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Abstract Bronchial asthma is a common immune-mediated disorder characterized by reversible airway inflammation, mucus production, and
variable airflow obstruction with airway hyperresponsiveness. Allergen exposure results in the activation of numerous cells
of the immune system, of which dendritic cells (DCs) and Th2 lymphocytes are of paramount importance. Although the epithelium
was initially considered to function solely as a physical barrier, it is now evident that it plays a central role in the Th2-cell
sensitization process due to its ability to activate DCs. Cytokines are inevitable factors in driving...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 17, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogensEmail this article to a colleague.
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Abstract Numerous studies have demonstrated that targeting immunogens to Fcγ receptors (FcγR) on antigen (Ag)-presenting cells (APC)
can enhance humoral and cellular immunity in vitro and in vivo. FcγR are classified based on their molecular weight, IgG-Fc binding affinities, IgG subclass binding specificity, and cellular
distribution and they consist of activating and inhibitory receptors. However, despite the potential advantages of targeting
Ag to FcR at mucosal sites, very little is known regarding the role of FcR in mucosal immunity or the efficacy of FcR-targeted
mucosal vaccines. In addition, recen...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 17, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Interleukin 7 receptor α as a potential therapeutic target in transplantationEmail this article to a colleague.
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Abstract Drugs targeting memory lymphocytes may allow for a better control of rejection in transplantation, particularly in immunized
patients. In this article the rationale of targeting interleukin 7 receptor a (IL-7Rα), a molecule expressed by both memory
and naive T cells, is reviewed in the context of transplantation. Whereas naive T cells are partly responsible for acute rejection
and are targeted by current immunosuppressive drugs that block costimulatory signals (cyclosporine A, anti-CD3 antibody, anti-CD52
antibody, anti-thymocyte globulin, etc.), memory T cells are resistant to costimulation blocka...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 9, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Immunohistochemical localization of metallothionein and p53 protein in pancreatic serous cystadenomasEmail this article to a colleague.
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Conclusion The weak MT expression and lack of p53 protein expression in pancreatic SCAs confirms the lack of local invasive potential
of the neoplastic lesion. Increased expressions of MT and p53 were observed in the less differentiated tumors. Thus the expression
of MT may be a potential prognostic marker for tumors.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0033-xAuthors
Mariola Śliwińska-Mossoń, Wrocław Medical University Department of Biomedical and Environmental Analyses Grunwaldzka 2 50-355 Wrocław PolandHalina Milnerowicz, Wrocław Medical University Depar...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 6, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Serological characterization of the core region of lipopolysaccharides of rough Proteus sp. strainsEmail this article to a colleague.
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Conclusions Comparing the results of the serological studies with the known chemical structures of the core regions of the LPSs used enabled
the identification of a few core oligosaccharide fragments probably involved in the observed cross-reactions. All were located
in the most distal part of LPS core region, which made them more easily recognized by specific antibodies.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0034-9Authors
Agata Palusiak, University of Łódź Department of General Microbiology, Institute of Microbiology, Biotechnology and Immunology Banacha 12/16...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 6, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patientsEmail this article to a colleague.
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Conclusions Thus our results demonstrate that both IBD and CRC are linked with an intensified production of a wide array of monocyte/macrophage
pro-inflammatory cytokines which is not accompanied by elevated levels of circulating IL-10, except for its insufficiently
inhibitory elevation in UC patients.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0031-zAuthors
Andrzej Szkaradkiewicz, University of Medical Sciences Department of Medical Microbiology Wieniawskiego 3 61-712 Poznań PolandRyszard Marciniak, University of Medical Sciences Department of General, Gastroenterolo...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 6, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Immunomodulation by statins: mechanisms and potential impact on autoimmune diseasesEmail this article to a colleague.
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Abstract Statins are inhibitors of the enzyme 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) and they are the most effective agents
for lowering cholesterol in clinical practice for the treatment of cardiovascular diseases. However, it has become clear that
statins also have pleiotropic immunomodulatory effects in addition to their lipid-lowering properties. As a result, much attention
has been focused on their potential as therapeutic agents for the treatment of inflammatory autoimmune diseases. In this review
the effect of statins on the expression and function of a variety of immune-relevant molecules wil...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 6, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Platelet influence on T- and B-cell responsesEmail this article to a colleague.
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Abstract Understanding the adaptive immune response is an area of research critically important in medicine. Several positive regulators
of B- and T-cell activation exist to eliminate pathogens, in which CD40 ligand (CD154) plays a fundamental role. It is well
documented that CD154 expressed by CD4 T helper cells can be critical in the proper activation of dendritic cells for the
productive stimulation of CD8 T cells and is required for proper T-dependent B-cell immunity. However, platelets are an abundant
and systemic source of CD154. While classically known to be important for hemostasis and inflammation, ...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 6, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Innate immunity: a key player in the mobilization of hematopoietic stem/progenitor cellsEmail this article to a colleague.
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Abstract The mobilization of hematopoietic stem/progenitor cells (HSPCs) from bone marrow into peripheral blood (PB) is still not fully
understood. Different chemokines, cytokines, growth factors, and neurotransmitters have been described that facilitate this
process. However, mounting evidence suggests that mobilization of HSPCs is a part of the immune response and is mediated by
innate immunity. We discuss evidence showing that complement system cleavage fragments play a crucial role in both the retention
and mobilization of HSPCs by modulating their responsiveness to stromal-derived growth factor-1 (SDF-1...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 6, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Pathogenicity of the family LegionellaceaeEmail this article to a colleague.
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Abstract The Legionellae are Gram-negative bacteria able to survive and replicate in a wide range of protozoan hosts in natural environments, but
they also occur in man-made aquatic systems, which are the major source of infection. After transmission to humans via aerosols,
Legionella spp. can cause pneumonia (Legionnaires’ disease) or influenza-like respiratory infections (Pontiac fever). In children, Legionnaires’
disease is uncommon and is mainly diagnosed in children with immunosuppression. The clinical picture of Legionella pneumonia does not allow differentiation from pneumonia caused by others path...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 6, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Role of ocular pigment epithelial cells in immune privilegeEmail this article to a colleague.
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Abstract The ocular microenvironment is both immunosuppressive and anti-inflammatory in nature. Pigment epithelial (PE) cells isolated
from the eye possess the ability to suppress the T cell receptor-dependent activation of T cells and the induction of regulatory
T cells in vitro. This property is dependent on the cells’ capacity to produce cell-surface and soluble inhibitory molecules, for example
CD86 (B7-2), transforming growth factor (TGF)-β, thrombospondin-1, programmed cell death 1 ligand 1 (PD-L1/B7-H1), and cytotoxic
T lymphocyte-associated antigen 2α. Cultured ocular PE cells from the iris, cili...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 1, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Evaluation of lectin pathway activity and mannan-binding lectin levels in the course of pregnancy complicated by diabetes type 1, based on the genetic backgroundEmail this article to a colleague.
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Conclusions Diabetes, an autoimmune disease, is a serious complication of pregnancy. Therefore, determination of MBL status might be beneficial
in identifying type 1 diabetic patients who are at increased risk of developing both vascular complications and poor pregnancy
outcomes.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0029-6Authors
Magdalena Pertyńska−Marczewska, Research Institute Polish Mother’s Memorial Hospital Department of Fetal-Maternal Medicine and Gynecology Łódź PolandMaciej Cedzyński, Polish Academy of Sciences Laboratory of Immunobiology of Inf...
Source: Archivum Immunologiae et Therapiae Experimentalis - June 11, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Dual use of biological research and the role of the scientific unionsEmail this article to a colleague.
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Content Type Journal ArticleCategory VariaDOI 10.1007/s00005-009-0028-7Authors
Angelo Azzi, JM USDA-HNRCA at Tufts University Vascular Biology Laboratory Office 622, 711 Washington St. Boston MA 02111 USA
Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - June 4, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Detection of a CD4+CD8−CD3− cell subpopulation during the differentiation of cord blood CD34+ cells into T cells in vitroEmail this article to a colleague.
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Conclusions: We showed that CD4+CD8−CD3− cells can be derived from highly purified CD34+ cells on TSCs during T-cell lymphopoiesis in vitro.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0022-0Authors
Jian Gang Jin, Bei Tai Ping Lu Hospital Hematopoietic Stem Cell Transplant Center Bei Jing P.R.China 100039Bao Jun Bai, Bei Tai Ping Lu Hospital Hematopoietic Stem Cell Transplant Center Bei Jing P.R.China 100039Zhi Juan Yao, Bei Tai Ping Lu Hospital Hematopoietic Stem Cell Transplant Center Bei Jing P.R.China 100039Ren Na Wu, Bei Tai Ping Lu Hospital Hematopoietic Stem Ce...
Source: Archivum Immunologiae et Therapiae Experimentalis - May 29, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Clinical and research ethics as moral strangersEmail this article to a colleague.
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This article takes issue with those who defend a brand of clinical research ethics that tends to substitute the ethics of
clinical care of patients being recruited as trial subjects. The distinction between therapeutic and non-therapeutic studies
is being disregarded by arguing that research is concerned with the pursuit of knowledge rather than with the medical benefits
for patients. Non-competent patients may therefore be recruited for studies that will offer them no medical benefits in spite
of involving them in the inherent risks of any biomedical trial. Supported by the World Medical Association, clinicians tend
...
Source: Archivum Immunologiae et Therapiae Experimentalis - May 29, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
The expressions of intrinsic and extrinsic apoptotic pathway proteins in neutrophils of oral cavity cancer patients: a preliminary studyEmail this article to a colleague.
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Conclusion: The acceleration of the apoptosis of PMNs of oral cavity cancer patients before treatment is dependent on both the intrinsic
and extrinsic pathways.
Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00005-009-0023-zAuthors
Ewa Jabłońska, Medical University of Białystok Department of Immunology Waszyngtona 15 A 15-274 Białystok PolandMarzena Garley, Medical University of Białystok Department of Immunology Waszyngtona 15 A 15-274 Białystok PolandJakub Jabłoński, Medical University of Białystok Department of Toxicology Białystok Poland
Journal Archivum Immun...
Source: Archivum Immunologiae et Therapiae Experimentalis - May 29, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitisEmail this article to a colleague.
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Conclusion: Increased oxidative stress may lead to premature oxidative DNA damage in the gingival tissue of periodontitis patients and
the salivary 8-OHdG level may signify premature oxidative mtDNA damage in diseased gingival tissue.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0026-9Authors
Cenk Fatih Çanakçi, Ataturk University Department of Periodontology, Faculty of Dentistry Erzurum TurkeyVarol Çanakçi, Ataturk University Department of Periodontology, Faculty of Dentistry Erzurum TurkeyAbdulgani Tatar, Ataturk University Department of Genetics, Faculty of Medici...
Source: Archivum Immunologiae et Therapiae Experimentalis - May 29, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Expanding and converting regulatory T cells: a horizon for immunotherapyEmail this article to a colleague.
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Abstract The human immune system is a myriad of diverse cellular populations, each contributing to maintaining an effective and optimal
immune response against infectious agents. It is important to maintain a “self-check” in the immune system so that responses
do not go haywire, leading to the development of autoimmune diseases. Regulatory/suppressor T (Treg) cells are a specialized
subpopulation of T cells that suppress the activation, expansion, and function of other T cells, thereby maintaining homeostasis
through a fine balance between reactivity to foreign and self antigens. Tregs are characterized ...
Source: Archivum Immunologiae et Therapiae Experimentalis - May 29, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Dendritic cell-based cancer immunotherapiesEmail this article to a colleague.
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Abstract Because of their unique role in linking the innate and adaptive immune systems, dendritic cells (DCs) have been a logical
focus for novel immunotherapies. However, strategies employing active immunization with ex vivo generated and antigen–pulsed DCs have shown limited efficacy in clinical trials. These past approaches did not take into
account the complex interactions between cells of the innate immune system and DCs during DC maturation, antigen processing,
and presentation to naïve T cells. By better understanding the natural sequence of events occurring in vivo during an effective immune respo...
Source: Archivum Immunologiae et Therapiae Experimentalis - May 29, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
The role of IL-1 in the pathogenesis of heart diseaseEmail this article to a colleague.
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Abstract Interleukin (IL)-1 consists of two distinct ligands, IL-1α and IL-1β, with indistinguishable biological activities that signal
through the IL-1 type I receptor (IL-1RI). A naturally occurring IL-1 receptor antagonist (IL-1Ra) binds to IL-1RI without
initiating signal transduction and prevents IL-1 signaling, competitively inhibiting IL-1-mediated responses. Emerging evidence
suggests that the balance between IL-1 agonists and antagonists plays an essential role in a variety of cardiovascular conditions.
IL-1 may play a role in atherothrombotic disease by promoting the formation of atheromatous les...
Source: Archivum Immunologiae et Therapiae Experimentalis - May 29, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Role of ubiquitin ligases in neural stem and progenitor cellsEmail this article to a colleague.
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Abstract Ubiquitin ligases are central components of the ubiquitin-proteasome system (UPS), the major machinery for regulated proteolysis
in eukaryotic cells. Proteins essential for regulating development, differentiation, proliferation, cell cycling, apoptosis,
gene transcription, and signal transduction undergo posttranslational processing via selection by ubiquitin ligases and subsequent
controlled proteolysis by the 26S proteasome, the proteolytic unit of the UPS. Neural stem cells (NSCs) are self-renewing
multipotent cells of the embryonic and adult mammalian central nervous system. In the last few year...
Source: Archivum Immunologiae et Therapiae Experimentalis - May 29, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
TNF-α and sICAM-1 in intracranial aneurismal ruptureEmail this article to a colleague.
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Conclusions This study demonstrated the absence of a systemic TNF-α-mediated inflammatory response at the onset of subarachnoid hemorrhage.
Early measurement of serum sICAM-1 levels offers a potential prognostic value in the assessment of patients’ outcome after
brain aneurismal rupture.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0010-4Authors
Anna Maria Witkowska, Medical University Department of Food Commodities Science and Technology Mieszka I4b 15-054 Białystok PolandMaria Halina Borawska, Medical University Department of Bromatology Białystok PolandKatarzyna ...
Source: Archivum Immunologiae et Therapiae Experimentalis - April 2, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Antigen-restricted γδ T-cell receptors?Email this article to a colleague.
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Abstract After more than two decades of investigation, the biological role of the γδ T-cell receptors (TCRs) remains elusive. In fact,
a theory of ligand recognition is still lacking that accounts for their adaptable structure, their peripheral selection, and
the observed responses of γδ T cells, which do not require immunization but only include cells sharing germline-encoded components
of the TCR. Assuming that all γδ T cells recognize ligands by a common mechanism, we now propose that germline-encoded components
of the γδ TCRs provide for the specific recognition of a select set of antigenic deter...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
A reflection on open-access, citation counts, and the future of scientific publishingEmail this article to a colleague.
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Content Type Journal ArticleCategory VariaDOI 10.1007/s00005-009-0016-yAuthors
Xavier Bosch, University of Barcelona Department of Internal Medicine, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Villarroel 170 08036 Barcelona Spain
Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
On the fairness of using relative indicators for comparing citation performance in different disciplinesEmail this article to a colleague.
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Abstract Relative indicators are commonly used to remove biases due to different citation practices in various scientific fields. Here
we extend our recent investigation on the viability of the use of relative indicators for comparing article impact in different
disciplines. We consider citation distributions for papers published in 14 of the 172 disciplines categorized by the Journal
Citation Reports. The distribution of the number of citations received by publications in a certain discipline divided by
the average number for the discipline is a universal function. Based on it, we compute the relative numbe...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
NKT cells: from totipotency to regenerative medicineEmail this article to a colleague.
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Abstract The recent discovery that natural killer T (NKT) cell nuclei are totipotent opens a novel avenue for further understanding
NKT cell function in normal and diseased states. The progeny of a cloned mouse harboring the in-frame rearranged Vα14-Jα18
T cell receptor in one allele showed a significant increase in NKT cell number compared with wild-type or littermate control
mice that possessed a different TCR. Importantly, NKT cells from such progeny produced both interferon-γ and interleukin-4,
a hallmark of NKT cells. In these progeny, NKT cell development appeared to be instructively, rather than pe...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
ECA-immunogenicity of Proteus mirabilis strainsEmail this article to a colleague.
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Conclusions These results therefore suggest that, similar to E. coli, LPS with a full core is also required as the acceptor of ECA for P. mirabilis strains to produce ECA
LPS
. Since ECA
PG
is not immunogenic unless combined with some proteins, it is likely that ECA
PG
-protein complexes formed during the intravenous immunization with the Rc mutant strain R4/O28.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0018-9Authors
Katarzyna Anna Duda, University of Silesia Department of Microbiology, Faculty of Biology and Environment Protection Katowice PolandKatarzyna Teresa...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Revealing the faults in medical journalsEmail this article to a colleague.
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Abstract Medical journals hold an exalted position in medicine, but have many shortcomings. This perspective reviews some of the shortcomings
of medical journals which are primarily related to inexperience, bias, and commercialism. The issues discussed include the
uncertain mission of the traditional medical journal in the modern digital age, the inherent inexperience of voluntary editorial
boards, the weaknesses and capricious nature of decisions made by the peer-review process, the uneven value of most journal
articles, the bias in what gets submitted and published in journals, the misunderstanding about t...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Autoimmunity and heart diseases: pathogenesis and diagnostic criteriaEmail this article to a colleague.
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Abstract Autoimmunity may evolve in predisposed individuals following an exogenous trigger. Autoimmunity is affected by genetic, immune,
hormonal, and environmental factors. Immune mechanisms in heart diseases are complex and often not completely understood.
Several cardiac disorders are believed to be mediated by an immune reaction. Both humoral and cellular immunity are associated
with the development of myocarditis, dilated cardiomyopathy, heart failure, rheumatic fever, and atherosclerosis. Here the
diagnostic criteria and autoimmune aspects of autoimmune-mediated cardiac disorders are reviewed. New diag...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Prophylaxis with α-lipoic acid against lipopolysaccharide-induced brain injury in ratsEmail this article to a colleague.
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Conclusion The results indicate that α-LA treatment effectively protected the brain tissue against endotoxin-induced oxidative stress.
Administration of LA could be a useful adjunct to clinical application in the management of septic shock.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0015-zAuthors
Anna Gorąca, Medical University of Łódź Chair of Experimental and Clinical Physiology, Department of Cardiovascular Physiology Mazowiecka 6/8 92-215 Łódź PolandKatarzyna Asłanowicz-Antkowiak, Medical University of Łódź Chair of Experimental and Clinical Physiology, ...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
The roles of the RAG1 and RAG2 “non-core” regions in V(D)J recombination and lymphocyte developmentEmail this article to a colleague.
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Abstract The enormous repertoire of the vertebrate specific immune system relies on the rearrangement of discrete gene segments into
intact antigen receptor genes during the early stages of B-and T-cell development. This V(D)J recombination is initiated by
a lymphoid-specific recombinase comprising the RAG1 and RAG2 proteins, which introduces double-strand breaks in the DNA adjacent
to the coding segments. Much of the biochemical research into V(D)J recombination has focused on truncated or “core” fragments
of RAG1 and RAG2, which lack approximately one third of the amino acids from each. However, geneti...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 31, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Virulence factor genotypes of
Helicobacter pylori
affect cure rates of eradication therapyEmail this article to a colleague.
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Abstract The cure rates of Helicobacter pylori infection by using a combination of a proton pump inhibitor (PPI) and antimicrobial agents are mainly influenced by bacterial
susceptibility to antimicrobial agents and the magnitude of acid inhibition during the treatment. Currently used empirical
triple therapies do not reliably produce a ≥80% cure rate on an intention-to-treat basis. Therefore, tailored regimens based
on relevant microbiological findings and pharmacogenomics are recommended for attaining an acceptable ≥95% cure rate. Recently,
virulence factors of H. pylori, such as cagA and vacA, are rep...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 14, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
The use of bibliometric indicators to help peer-review assessmentEmail this article to a colleague.
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We present an analysis of the data
of 600 research teams evaluated in 2007–2008.
Content Type Journal ArticleCategory Varia - ScientometricsDOI 10.1007/s00005-009-0004-2Authors
Nicole Haeffner-Cavaillon, Département d’Evaluation Scientifique INSERM Paris Cedex 13 FranceClaude Graillot-Gak, Département d’Evaluation Scientifique INSERM Paris Cedex 13 France
Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - February 14, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Biological activity of dendritic cells generated from cord blood CD34+ hematopoietic progenitors in IL-7- and IL-13-conditioned culturesEmail this article to a colleague.
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Conclusions This study indicates that FST713 medium allows the generation of limited numbers of more mature DCs, while FST3 medium leads
to the production of immature DCs in high numbers.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0005-1Authors
Bożenna Mytar, Jagiellonian University Medical College Department of Clinical Immunology, Polish-American Institute of Pediatrics Cracow PolandMałgorzata Stec, Jagiellonian University Medical College Department of Clinical Immunology, Polish-American Institute of Pediatrics Cracow PolandKazimierz Węglarczyk, Jagiellonian Univ...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 14, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
The use and misuse of journal metrics and other citation indicatorsEmail this article to a colleague.
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This article reviews the nature and use of the journal impact factor and other common bibliometric measures for assessing
research in the sciences and social sciences based on data compiled by Thomson Reuters. Journal impact factors are frequently
misused to assess the influence of individual papers and authors, but such uses were never intended. Thomson Reuters also
employs other measures of journal influence, which are contrasted with the impact factor. Finally, the author comments on
the proper use of citation data in general, often as a supplement to peer review. This review may help government policymakers,
unive...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 14, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
Rank-normalized journal impact factor as a predictive toolEmail this article to a colleague.
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Abstract Citation data accumulated on articles from the top and bottom 25 of impact factor (IF)-ranked international journals are compared
using 59 international geoscience journals from 1998 and 378 Polish geological papers from 1989–1994. There is a minor risk
of being uncited when results are published in high-IF periodicals as the average non-citation rate is 0.88 over a 10-year
period in this not very rapidly developing scientific discipline. Similarly, the established error levels in the prognosis
of expected citation success versus failure based on the extreme IF quartiles as an evaluation tool is l...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 14, 2009 Category: Allergy & Immunology Tags: Archivum Immunologiae et Therapiae Experimentalis Source Type: journals
