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Editorial Board.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19923554 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 20, 2009 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Atherosclerosis: Should We Stop TWEAKing It?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923555 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 20, 2009 Category: Cardiology Authors: King VL Tags: Arterioscler Thromb Vasc Biol Source Type: journals

ApoAII Controversy Still in Rabbit?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923556 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 20, 2009 Category: Cardiology Authors: Shimano H Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Tissue Factor: Past, Present, and Future.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923557 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 20, 2009 Category: Cardiology Authors: Mackman N, Taubman M Tags: Arterioscler Thromb Vasc Biol Source Type: journals

What Is Wrong With the Allosteric Disulfide Bond Hypothesis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923558 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 20, 2009 Category: Cardiology Authors: Bach RR, Monroe D Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: NKT cells play a crucial role in the development of adipose tissue inflammation and glucose intolerance in diet-induced obesity. PMID: 19910631 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Ohmura K, Ishimori N, Ohmura Y, Tokuhara S, Nozawa A, Horii S, Andoh Y, Fujii S, Iwabuchi K, Onoé K, Tsutsui H Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Thiazolidinediones Reduce Pathological Neovascularization in Ischemic Retina Via an Adiponectin-Dependent Mechanism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data show that TZDs attenuate pathological retinal microvessel formation through APN-mediated modulation of TNF-alpha production. PMID: 19910632 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Higuchi A, Ohashi K, Shibata R, Sono-Romanelli S, Walsh K, Ouchi N Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Hemorphin 7 Reflects Hemoglobin Proteolysis in Abdominal Aortic Aneurysm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results suggest that circulating H7 peptides may reflect proteolysis of hemoglobin in the aneurysmal intraluminal thrombus and may be used as a biological marker of pathological vascular remodeling. PMID: 19910633 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Dejouvencel T, Féron D, Rossignol P, Sapoval M, Kauffmann C, Piot JM, Michel JB, Fruitier-Arnaudin I, Meilhac O Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Human Apolipoprotein A-II Determines Plasma Triglycerides by Regulating Lipoprotein Lipase Activity and High-Density Lipoprotein Proteome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: ApoA-II plays a crucial role in triglyceride catabolism by regulating LPL activity, at least in part, through HDL proteome modulation. PMID: 19910634 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Julve J, Escolà-Gil JC, Rotllan N, Fiévet C, Vallez E, de la Torre C, Ribas V, Sloan JH, Blanco-Vaca F Tags: Arterioscler Thromb Vasc Biol Source Type: journals

CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Diet-induced obesity increased CD11c in both AT and blood in mice and humans. CD11c plays an important role in T-cell accumulation and activation in AT, and contributes to insulin resistance associated with obesity. PMID: 19910635 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Wu H, Perrard XD, Wang Q, Perrard JL, Polsani VR, Jones PH, Smith CW, Ballantyne CM Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results suggest that apoCIII strongly inhibits hepatic uptake of VLDL and IDL overriding the opposite influence of apoE when both are present. The presence of apoCIII on dense VLDL is not associated with slow conversion to IDL, a lipoprotein lipase-dependent process; but when on light LDL, apoCIII is associated with enhanced conversion to dense LDL, a process involving hepatic lipase. PMID: 19910636 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Mendivil CO, Zheng C, Furtado J, Lel J, Sacks FM Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Claudin-5 as a Novel Estrogen Target in Vascular Endothelium.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We describe claudin-5 as a novel estrogen target in vascular endothelium and show in vivo (brain endothelium) and in vitro (brain and heart endothelium) effects of estrogen on claudin-5 levels. The estrogen-induced increase in junctional protein levels may lead to an improvement in vascular structural integrity and barrier function of vascular endothelium. PMID: 19910637 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Burek M, Arias-Loza PA, Roewer N, Förster CY Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our data show that loss of Tie1 results in lymphatic vascular abnormalities that precede the blood vessel phenotype. These findings indicate that Tie1 is involved in lymphangiogenesis and suggest differential requirements for Tie1 signaling in the 2 vascular compartments. PMID: 19910638 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: D'Amico G, Korhonen E, Waltari M, Saharinen P, Laakkonen P, Alitalo K Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Genetic Association and Interaction Analysis of USF1 and APOA5 on Lipid Levels and Atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our findings in these unique samples reinforce the roles of APOA5 and USF1 variants on cardiovascular phenotypes and suggest that both genes contribute to lipid levels and aortic atherosclerosis individually and possibly through epistatic effects. PMID: 19910639 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Laurila PP, Naukkarinen J, Kristiansson K, Ripatti S, Kauttu T, Silander K, Salomaa V, Perola M, Karhunen PJ, Barter PJ, Ehnholm C, Peltonen L Tags: Arterioscler Thromb Vasc Biol Source Type: journals

NADPH Oxidases: Functions and Pathologies in the Vasculature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reactive oxygen species are ubiquitous signaling molecules in biological systems. Four members of the NADPH oxidase (Nox) enzyme family are important sources of reactive oxygen species in the vasculature: Nox1, Nox2, Nox4, and Nox5. Signaling cascades triggered by stresses, hormones, vasoactive agents, and cytokines control the expression and activity of these enzymes and of their regulatory subunits, among which p22phox, p47phox, Noxa1, and p67phox are present in blood vessels. Vascular Nox enzymes are also regulated by Rac, ClC-3, Poldip2, and protein disulfide isomerase. Multiple Nox subtypes, simultaneously present...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Lassègue B, Griendling KK Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Obesity Genotype Score and Cardiovascular Risk in Women With Type 2 Diabetes Mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Obesity-predisposing variants may jointly affect CVD risk among women with diabetes. PMID: 19910641 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Loss of Stearoyl-CoA Desaturase-1 Attenuates Adipocyte Inflammation. Effects of Adipocyte-Derived Oleate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Loss of SCD1 attenuates adipocyte inflammation and its paracrine regulation of inflammation in macrophages and endothelial cells. The reduced oleate level is linked to the inflammation-modulating effects of SCD1 deficiency. PMID: 19910642 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Liu X, Miyazaki M, Flowers MT, Sampath H, Zhao M, Chu K, Paton CM, Joo DS, Ntambi JM Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Altered Plasma Fibrin Clot Properties Are Associated With In-Stent Thrombosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: IST patients tend to form dense fibrin clots resistant to lysis, and altered plasma fibrin clot features might contribute to the occurrence of IST. PMID: 19910643 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Undas A, Zalewski J, Krochin M, Siudak Z, Sadowski M, Pregowski J, Dudek D, Janion M, Witkowski A, Zmudka K Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Leptin Enhances the Potency of Circulating Angiogenic Cells Via Src Kinase and Integrin {alpha}v{beta}5. Implications for Angiogenesis in Human Obesity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results point to the ObR-Src kinase-alphavbeta5 cross talk as a distinct novel component of the network of specific interactions between integrins and cytokine receptors in angiogenesis. PMID: 19910644 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Heida NM, Leifheit-Nestler M, Schroeter MR, Müller JP, Cheng IF, Henkel S, Limbourg A, Limbourg FP, Alves F, Quigley JP, Ruggeri ZM, Hasenfuss G, Konstantinides S, Schäfer K Tags: Arterioscler Thromb Vasc Biol Source Type: journals

CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: CCL5 could participate in the inflammation of obese WAT by recruiting blood monocytes and exerting antiapoptotic properties on WAT macrophages. This specific role of CCL5 on macrophage survival with maintenance of their lipid scavenging function should be taken into account for future therapeutic strategies in obesity-related diseases. PMID: 19893003 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 5, 2009 Category: Cardiology Authors: Keophiphath M, Rouault C, Divoux A, Clément K, Lacasa D Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Fibulin-2 and Fibulin-5 Cooperatively Function to Form the Internal Elastic Lamina and Protect From Vascular Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Fibulin-2 and fibulin-5 cooperatively function to form the IEL during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury. The DKO mouse will serve as a unique animal model to test the effect of vessel integrity during various pathological insults. PMID: 19893004 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 5, 2009 Category: Cardiology Authors: Chapman SL, Sicot FX, Davis EC, Huang J, Sasaki T, Chu ML, Yanagisawa H Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Tyrosine sulfation of leukocyte adhesion molecules and chemokine receptors promotes atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19846834 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 24, 2009 Category: Cardiology Authors: Koltsova E, Ley K Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Dimorphisms in the Membrane-Spanning Domain of EPCR Impact Systemic Coagulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19846835 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 24, 2009 Category: Cardiology Authors: Esmon CT Tags: Arterioscler Thromb Vasc Biol Source Type: journals

The discovery of cellular immunity in the atherosclerotic plaque.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is now generally accepted that atherosclerosis is an inflammatory/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept. PMID: 19846836 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 24, 2009 Category: Cardiology Authors: Hansson GK, Jonasson L Tags: Arterioscler Thromb Vasc Biol Source Type: journals

The Molecular Mechanisms of HDL and Associated Vesicular Trafficking Mechanisms to Mediate Cellular Lipid Homeostasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HDL functions mainly as a cholesterol scavenger, facilitating transport of cholesterol to the liver for conversion to bile acids and secretion into the bile for elimination or recycling in the enterohepatic bile acid cycle. Because of its major function in cholesterol clearance, HDL is in general considered to be atheroprotective. From cell cholesterol can be removed by efflux especially to apoA-I and HDL as extracellular acceptors which transport the cholesterol to the liver for excretion. This process is called reverse cholesterol transport. In this context the ATP binding cassette transporter protein ABCA1 facilitat...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 24, 2009 Category: Cardiology Authors: Schmitz G, Grandl M Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: SCD1 ASO treatment in conjunction with dietary fish oil supplementation is an effective combination therapy to comprehensively combat the metabolic syndrome and atherosclerosis in mice. PMID: 19834103 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen TM, Zhu X, Duong MN, Brown AL, Lord C, Shah R, Davis MA, Kelley K, Wilson MD, Madenspacher J, Fessler MB, Parks JS, Rudel LL Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Familial Combined Hyperlipidemia Is Associated With Alterations in the Cholesterol Synthesis Pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our data indicate that both men and women with FCH have alterations in the cholesterol synthesis pathway, resulting in 51% higher levels of lathosterol (and additionally desmosterol in women). Plasma levels of the cholesterol precursor sterol squalene were only slightly increased (6%), suggesting enhanced conversion of squalene to lathosterol in this disorder. PMID: 19834104 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: van Himbergen TM, Otokozawa S, Matthan NR, Schaefer EJ, Buchsbaum A, Ai M, van Tits LJ, de Graaf J, Stalenhoef AF Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Molecular Imaging of the Initial Inflammatory Response in Atherosclerosis. Implications for Early Detection of Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Noninvasive ultrasound molecular imaging of endothelial activation can detect lesion-prone vascular phenotype before the appearance of obstructive atherosclerotic lesions. PMID: 19834105 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Kaufmann BA, Carr CL, Belcik JT, Xie A, Yue Q, Chadderdon S, Caplan ES, Khangura J, Bullens S, Bunting S, Lindner JR Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism. Results From the E3N Cohort Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In this large study, we found that route of estrogen administration and concomitant progestogens type are 2 important determinants of thrombotic risk among postmenopausal women using hormone therapy. Transdermal estrogens alone or combined with progesterone might be safe with respect to thrombotic risk. PMID: 19834106 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Canonico M, Fournier A, Carcaillon L, Olié V, Plu-Bureau G, Oger E, Mesrine S, Boutron-Ruault MC, Clavel-Chapelon F, Scarabin PY Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Adenosine Modulates HIF-1{alpha}, VEGF, IL-8, and Foam Cell Formation in a Human Model of Hypoxic Foam Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study provides the first evidence that A3, A2B, or mixed A3/A2B antagonists may be useful to block important steps in the atherosclerotic plaque development ado-induced. PMID: 19834107 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Gessi S, Fogli E, Sacchetto V, Merighi S, Varani K, Preti D, Leung E, Maclennan S, Borea PA Tags: Arterioscler Thromb Vasc Biol Source Type: journals

JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: JAK/STAT is a key regulator of Nox1 and Nox4 in human vascular SMCs. Inhibition of JAK/STAT pathway and the consequent Nox-dependent oxidative stress may be an efficient therapeutic strategy to reduce atherogenesis. PMID: 19834108 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Manea A, Irina Tanase L, Raicu M, Simionescu M Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Bone Marrow AT1 Augments Neointima Formation by Promoting Mobilization of Smooth Muscle Progenitors via Platelet-Derived SDF-1{alpha}Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The BM-AT1 receptor promotes neointima formation by regulating the mobilization and homing of BM-derived VPCs in a platelet-derived SDF-1alpha-dependent manner without affecting EPC-mediated reendothelialization. PMID: 19834109 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, Kato T, Matsui A, Hirai H, Ashihara E, Maekawa T, Iwai M, Horiuchi M, Ikeda K, Takahashi T, Okigaki M, Matsubara H Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Anthropometric Measures of Obesity and Risk of Venous Thromboembolism. The Tromso Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our findings indicate that WC is the preferable anthropometric measure of obesity to identify subjects at risk and to predict risk of VTE. PMID: 19834110 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Borch KH, Brækkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Chylomicronemia Elicits Atherosclerosis in Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48- and apo-B100-containing lipoproteins. PMID: 19815815 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 7, 2009 Category: Cardiology Authors: Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Effects of Cigarette Smoke Exposure on Clot Dynamics and Fibrin Structure. An Ex Vivo Investigation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Acute CSE changes clot dynamics and alters fibrin architecture. Both functional changes in fibrinogen and platelets appear to contribute to heightened thrombogenicity after acute CSE. PMID: 19815816 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 7, 2009 Category: Cardiology Authors: Barua RS, Sy F, Srikanth S, Huang G, Javed U, Buhari C, Margosan D, Ambrose JA Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Increased HDL Cholesterol and ApoA-I in Humans and Mice Treated With a Novel SR-BI Inhibitor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our data indicate that ITX5061 increases HDL-C levels by inhibition of SR-BI activity. This suggests that pharmacological inhibition of SR-BI has the potential to raise HDL-C and apoA-I levels without adverse effects on VLDL/LDL cholesterol levels in humans. PMID: 19815817 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 7, 2009 Category: Cardiology Authors: Masson D, Koseki M, Ishibashi M, Larson CJ, Miller SG, D King B, Tall AR Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Alzheimer Disease-Associated Peptide, Amyloid {beta}40, Inhibits Vascular Regeneration With Induction of Endothelial Autophagy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our present findings indicate that the initial progression of AD might be in part driven by Abeta40-induced endothelial autophagy and impairment of neurovascular regeneration, suggesting important implications for therapeutic approaches to AD. PMID: 19815818 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 7, 2009 Category: Cardiology Authors: Hayashi SI, Sato N, Yamamoto A, Ikegame Y, Nakashima S, Ogihara T, Morishita R Tags: Arterioscler Thromb Vasc Biol Source Type: journals

High-Density Lipoprotein-Based Contrast Agents for Multimodal Imaging of Atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lipoproteins, natural nanoparticles, have a well-recognized biological role and are highly suitable as a platform for delivering imaging agents. The ease with which both the exterior and interior of the particles can be modified permits the creation of multifunctional nanoparticles for imaging as well as the delivery of therapeutics. Importantly, their endogenous nature may make them biocompatible and biodegradable and allows them to avoid the recognition of the reticuloendothelial system. In particular, high-density lipoproteins (HDL) are of interest, because of their small size they can easily cross the endothelium a...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 7, 2009 Category: Cardiology Authors: Skajaa T, Cormode DP, Falk E, Mulder WJ, Fisher EA, Fayad ZA Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Increased PAFAH and Oxidized Lipids Are Associated With Inflammation and Atherosclerosis in Hypercholesterolemic Pigs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We demonstrated that an increase in PAFAH activity was associated with increased levels of lysophosphatidylcholine, oxidized LDL, and inflammation, resulting in accelerated atherosclerosis in hypercholesterolemic minipigs. The significant correlation between PLA2G7 RNA expression in plaque macrophages and plasma PAFAH activity suggest that the latter is a consequence, rather than a cause of macrophage accumulation. Our cell experiments suggest that oxidized LDL can induce PAFAH, resulting in accumulation of lysophosphatidylcholine that increases the inflammatory action of oxidized LDL. PMID: 19797705 [PubM...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: De Keyzer D, Karabina SA, Wei W, Geeraert B, Stengel D, Marsillach J, Camps J, Holvoet P, Ninio E Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Effect of Leptin on Vascular Calcification in Apolipoprotein E-Deficient Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Based on these observations, we conclude that leptin may increase cardiovascular risk by promoting osteogenic differentiation and thus vascular calcification. PMID: 19797706 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Zeadin M, Butcher M, Werstuck G, Khan M, Yee CK, Shaughnessy SG Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Exposure to shear stress induces an increase in expression of ephrinB2 in murine ES cells via VEGF-Notch signaling pathways. PMID: 19797707 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Masumura T, Yamamoto K, Shimizu N, Obi S, Ando J Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Hemostasis, Inflammation, and Fatal and Nonfatal Coronary Heart Disease. Long-Term Follow-Up of the Atherosclerosis Risk in Communities (ARIC) Cohort.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: von Willebrand factor and factor VIIIc are associated with an increased risk of cardiac death as compared to the risk of nonfatal MI. PMID: 19797708 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Kucharska-Newton AM, Couper DJ, Pankow JS, Prineas RJ, Rea TD, Sotoodehnia N, Chakravarti A, Folsom AR, Siscovick DS, Rosamond WD Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol deposition in arteries, but the mechanisms linking cholesterol accumulation in macrophage foam cells to inflammation are poorly understood. Macrophage cholesterol efflux occurs at all stages of atherosclerosis and protects cells from free cholesterol and oxysterol-induced toxicity. The ATP-binding cassette transporters ABCA1 and ABCG1 are responsible for the major part of macrophage cholesterol efflux to serum or HDL in macrophage foam cells, but other less efficient pathways such as passive efflux are also involved. Recent studies...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Yvan-Charvet L, Wang N, Tall AR Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Monocytes and macrophages play active roles in atherosclerosis, a chronic inflammatory disease that is a leading cause of death in the developed world. The prevailing paradigm states that, during human atherogenesis, monocytes accumulate in the arterial intima and differentiate into macrophages, which then ingest oxidized lipoproteins, secrete a diverse array of proinflammatory mediators, and eventually become foam cells, the key constituents of a vulnerable plaque. Yet monocytes are heterogeneous. In the mouse, one subset (Ly-6C(hi)) promotes inflammation, expands in hypercholesterolemic conditions, and selectively gi...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Swirski FK, Weissleder R, Pittet MJ Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Heme oxygenase-1 increases endothelial progenitor cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These findings suggest that HO-1 contributes to vascular repair by increasing circulating EPCs derived from the bone marrow. PMID: 19542024 [PubMed - indexed for MEDLINE] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Wu BJ, Midwinter RG, Cassano C, Beck K, Wang Y, Changsiri D, Gamble JR, Stocker R Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We describe a novel process that occurs during agLDL-macrophage interactions in which local release of free cholesterol causes local actin polymerization, promoting a pathological positive feedback loop for increased catabolism of agLDL and eventual foam cell formation. PMID: 19556523 [PubMed - indexed for MEDLINE] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Grosheva I, Haka AS, Qin C, Pierini LM, Maxfield FR Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Osteoprotegerin promotes fibrous cap formation in atherosclerotic lesions of ApoE-deficient mice--brief report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: OPG treatment promotes smooth muscle accumulation, collagen fiber formation, and development of fibrous caps but does not affect inflammatory properties of atherosclerotic lesions. Its effects may contribute to plaque stabilization. PMID: 19592469 [PubMed - indexed for MEDLINE] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Ovchinnikova O, Gylfe A, Bailey L, Nordström A, Rudling M, Jung C, Bergström S, Waldenström A, Hansson GK, Nordström P Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Sphingosine 1-phosphate: a regulator of arterial lesions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid that is critical in the development of blood vessels, and in the adult regulates vascular functions including vascular tone, endothelial integrity, and angiogenesis. Further, S1P may regulate arterial lesions in disease and after injury by controlling leukocyte recruitment and smooth muscle cell functions. PMID: 19592471 [PubMed - indexed for MEDLINE] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Daum G, Grabski A, Reidy MA Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: FMT-CT is a robust and observer-independent tool for noninvasive assessment of inflammatory murine atherosclerosis. Reporter-containing nanomaterials may have unique advantages over small molecule agents for in vivo imaging. PMID: 19608968 [PubMed - indexed for MEDLINE] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Estrogen receptor alpha expression in both endothelium and hematopoietic cells is required for the accelerative effect of estradiol on reendothelialization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We demonstrate that endothelial ER alpha plays a pivotal role in E2-mediated reendothelialization. However, endothelial targeting alone is not sufficient because the concomitant stimulation of a subpopulation of BM ER alpha is necessary. This cooperation should be taken into account in strategies aimed at optimizing in-stent reendothelialization. PMID: 19608969 [PubMed - indexed for MEDLINE] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2009 Category: Cardiology Authors: Toutain CE, Filipe C, Billon A, Fontaine C, Brouchet L, Guéry JC, Gourdy P, Arnal JF, Lenfant F Tags: Arterioscler Thromb Vasc Biol Source Type: journals