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Case report Extrapulmonary tuberculosis following allogeneic stem cell transplantation – a difficult and late diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 54-year old man after reduced intensity conditioning regimen allogeneic stem cell transplantation, without known personal or family history of tuberculosis, who presented knee joint, skin and bone marrow involvement by a Mycobacterium tuberculosis infection. A delay from the onset of the first symptoms to the confirmed diagnosis of tuberculosis was about 2 months in this case. Despite this delay, our patient successfully recovered after 4-tuberculostatics followed by 2-tuberculostatics therapy. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Case report Insulinoma in a patient with long lasting type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, insulinoma must be taken into consideration as a reason for hypoglycaemia in type 2 diabetes, however the coincidence of these two diseases is extremely rare. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Eotaxin (CCL11), TARC [thymus and activation-regulated chemokine (CCL17)], MCP-1 (CCL2) and CCR-1, CXCR-1, CXCR-2 expression in dermatitis herpetiformis and bullous pemphigoidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our research leads to the assumption that chemokines may play a role in the activating and recruiting eosinophils and neutrophils and suggest that difference in chemokine expression pattern may contributes to variations of the cellular infiltration and tissue damage in DH and BP patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Pica: a frequent symptom in iron deficiency anemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: As a result, pica is a frequent finding in IDA, and patients with and without pica have similar characteristics. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Assessment of selected oxidative stress parameters in patients with Wilson’s diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Higher erythrocyte activities of the antioxidative enzymes and total serum antioxidative status in patients with Wilson’s disease confirm activation of the antioxidative system in this group of patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Transvaginal doppler sonography for assessment the response to radiotherapy in locally advanced squamous cervical cancer: a preliminary studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TVS is useful for estimation of uterine cervix during radiation therapy due to locally advanced cervical cancer, but its usefulness in prediction of progression of the cancer is rather low. The value of the assessment of RI in descending branches of uterine arteries in monitoring the treatment of the cervical cancer was not confirmed. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research The ERCC2 K751 polymorphism is associated with breast cancer riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that not only G/G and T/T in our patients was not associated with breast cancer risk but also there is a relation between presence of G/T and increasing of breast cancer risk. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Lung parenchymal involvement and sputum bacteriology in tuberculous pelurisy: correlation with pleural fluid biochemical parametersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We concluded that degree of inflammation in TP might be affected by simultaneous pulmonary parenchymal changes and sputum bacteriology. It might be suggested that TP might be a different manifestation of pulmonary TB rather than an extra-pulmonary disease. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Effect of treadmill-based gait training on the stationary balance of elderly individualsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of the present study indicate that a specific exercise program, such as treadmill-based gait training, which is a dynamic activity, can improve stationary balance in successful elderly women. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Evaluation of bone mineral density and bone turnover markers in Egyptian children with juvenile rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: JRA patients had lower BMD, higher frequency of low BMD (more prominent in the femoral neck) and higher OPG and RANKL levels compared with healthy children; suggesting that they may be at risk of developing premature osteoporosis and fractures later in life. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Variability in the response to dexamethasone treatment in term neonates with respiratory failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Improvement in lung function and mechanics and a decrease in doses of pressors could be detected within 12 h of initiation of dexamethasone therapy. Changes observed in this study can be useful in designing future randomized controlled trials. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Inflammatory process modulation in children with cystic fibrosis submitted to aerobic trainingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We may infer that aerobic exercise training maintained the inflammatory process stable and increased exercise capacity in patients with CF. Thus, the measurement of systemic inflammatory response may be a variable to determine whether a proposed training program will trigger greater inflammation. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Biochemical markers of endothelial dysfunction in pediatric nephrotic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Endothelial dysfunction is related to the activity of the disease and it is reversible. Modulation of endothelial function in NS may offer a novel strategy to reduce progressive renal insult. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Effect of N-acetylcysteine on microalbuminuria in patients with acute respiratory distress syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NAC improves global hypoxemia in the patients with acute lung injury. Improvement of oxidant/antioxidant balance by NAC increases the survival of patients with ARDS who are under oxidative crisis. Although limitations of this study do not let us to reach a conclusive decision but the impact of microalbominuria as a predictive of survival in ARDS patients receiving NAC seems essential. Conducting larger clinical trials are recommended. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Captopril and losartan modify mitogen-induced proliferative response and expression of some differentiation antigents on peripheral blood mononuclear cells in chronic uraemic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our in vitro results seem to indicate that captopril and losartan interfere with immune cells and depress some functions of immune cells in chronic uremic patients and healthy subjects. It is very difficult at present to establish significance of these in vitro immunosuppresive effects of captopril and losartan reflects their in vivo action. Its significance for clinical implications necessitates further extensive studies. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research The effect of treatment on lipid peroxidation in patients with subarachnoid haemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Surgical and pharmacological treatment of SAH patients restored prooxidant-antioxidant balance. Evaluation of TBARS and CD level, in SAH patients’ peripheral blood may help to monitor the therapy efficiency in normalization of CNS oxygen metabolism. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Patients with diabetes mellitus with ischemic stroke have a higher hemoglobin A1c level and a higher serum low-density lipoprotein cholesterol level than diabetics without ischemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Diabetics should have their hemoglobin A1c level reduced to < 7.0% and their serum LDL cholesterol reduced to < 70 mg/dl. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Value of C-reactive protein and IL-6 measurements in type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In type I diabetes there is an increase in the inflammatory markers, hs-CRP and IL-6 denoting subclinical chronic inflammation. These markers correlate significantly with conventional risk factors for vascular disease, namely hypertension, dyslipidemia, high body mass index and glycemic control. Type 1 diabetes patients with a positive family history of type 2 diabetes mellitus have higher hs-CRP and IL-6 levels indicating that they are more prone to cardiovascular complications. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research N-Terminal pro-Brain Natriuretic Peptide in decompansated ventricular septal defectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NT-proBNP is elevated in VSDs with cardiac decompensation, it is correlated to clinical score and echocardiography parameters. It reflects pressure and volume loads to the pulmonary artery and right ventricle and may help to identify children with VSD and pulmonary hypertension that demands early intervention. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Prevalence of Behçet’s syndrome in patients presenting with venous thrombosis: prospective study in a cardiovascular outpatient clinicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It is important to keep in mind the differentital diagnosis of Behçet’s syndrome in a cardiovascular outpatient clinic. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Short period of exercise causes rapid increase of serum interleukin 6 with no effect on its soluble receptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In healthy males, brief exercise causes significant increase of plasma IL-6 concentration that depends on hemodynamic effects of exercise, whereas the plasma concentration of IL-6 circulating receptor remains stable. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Co-administration of ezetimibe and a statin in management of dyslipidemias: a meta-analysis of clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Ezetimibe coadministered with statins is effective in reducing LDL-C in patients who do not attain target LDL-C levels while on statin monotherapy. Simultaneous administration of a statin plus ezetimibe regimen in patients who are treatment-naI¨ve is also efficient at reducing plasma LDL-C. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Do plasma leptin levels predict diastolic dysfunction in patients with hypertension?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We suggested that leptin levels didn’t predict diastolic dysfunction in patients with hypertension. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Clinical research Study of T-cell stimulation and cytokine release induced by Staphylococcal enterotoxin type B and monophosphoryl lipid AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that MPL is a suitable adjuvant that probably leads to more sustained effect of SEB. Because the results of our cytokine assay indicate that the level of IFN-g compared with IL-4, SEB + MPL could be a candidate for tumor therapy. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Basic research The effects of palmvitee on d-aminolevulinic acid-induced hyperbilirubinaemia in suckling ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Palmvitee administration confers protective effect against hyperbilirubinaemia. However, this administration could lead to a decreased hepatic glucuronidation activity in the hyperbilirubinaemic rat neonates induced by ALA. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Basic research Down-regulation of intrahepatic CD16+ and CD56+ immune cells in chronic Hepatitis C virus infection and HCV-related hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data show that CHC is associated with defects in NK cells and CD56+ lymphocytes that correlate with the degree of inflammatory activity and stage of hepatic fibrosis. The reduced CD16+ Kupffer cells in chronic HCV infection and HCC stress the important role of these cells in antiviral and antitumor immunity. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Basic research Neural differentiation of periodontal ligament stem cells induced by neurotrophic Schwann cells factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PDLSCs could be induced to differentiate into a Schwann cell phenotype by indirect co-culture with heterogeneic Schwann cells, such neural differentiation began as early as 24 h after co-culture, but the most apparent neural differentiation of PDLSCs appeared 14 days later. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Basic research Role of nitric oxide in the plasma lipid profile in the rabbitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that NO donors, used routinely in cardiovascular disease therapy, may increase the levels of HDL and decrease harmful lipoprotein levels and, hence, decrease the risk of hypercholesterolemia and atherosclerosis. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Review paper Role of cyclooxygenase-2 in cervical cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Concurrent radiation and chemotherapy is a standard treatment of patients with cervical cancer in FIGO stages IB2-IVA. Chemotherapy given in the same time as irradiation improved survival significant, but not involves all patients. Cancer recurrence is the most common treatment failure in patients with advanced tumor. Further improvement in the treatment of advanced cases is essential. The increasing knowledge about new biologic markers and better ability to predict risk of cancer recurrence is very important for construction of more effective treatment strategies. Currently, there is considerable interest of role of cyclo...
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Review paper Neural stem cell therapy in neurological diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. These cells commonly subject to dividing, migration, deterioration or death. Comparing to all other tissues in the body, central nervous system has a considerably limited capacity to regenerate. Recent knowledge on neural stem cells has brought novel approaches as to the use of stem cells in the treatment of some neurodegenerative disorders such as Parkinson, Alzheimer disease and amyotrophic lateral sclerosis, as well as in the management of spinal co...
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

Review paper Cholesterol-lowering therapy and cell membranes. Stable plaque at the expense of unstable membranes?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current guidelines encourage ambitious long term cholesterol lowering with statins, in order to decrease cardiovascular disease events. However, by regulating the biosynthesis of cholesterol we potentially change the form and function of every cell membrane from the head to the toe. As research into cell morphology and membrane function realises more dependencies upon cholesterol rich lipid membranes, our clinical understanding of long term inhibition of cholesterol biosynthesis is also changing. This review of non-cardiovascular research concerning such membrane effects raises important new issues concerning the clinical ...
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

REVIEW PAPER Role of Periodontal Infection in Cardiovascular Disease: A Current PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oral pathogens play a causal role in Cardiovascular Disease (CVD) that is largely driven by inflammation and host immune response. Clinico-epidemiological and animal studies provide a strong link between periodontal disease (PD) and CVD, both of which are highly prevalent, complex disease processes with common risk factors. Genes involved in inflammation, matrix degeneration and immune response have been implicated in the initiation and progression of both diseases. Recent studies have promoted the discovery of novel pathways and lead molecules thus providing opportunities for developing effective vaccine candidates to con...
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - July 23, 2009 Category: Journals (General) Source Type: journals

Surgical revascularization of myocardium in population of young women. Is it a group of increased operative risk?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Occurrence of myocardial infarction and advanced atheromatosis of coronary arteries in premenopausal women is unusual. Surgical revascularization of myocardium as an established method of ischaemic heart disease (IHD) management is more often used in this subset of patients. In recent years there have been some studies indicating better outcome of female patients after cardiac surgery, especially in the long term, but it is generally believed that women are more exposed to complications and have poorer prognosis after myocardial revascularization procedures compared with males, especially in the youngest groups. It seems t...
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - July 23, 2009 Category: Journals (General) Source Type: journals

BASIC RESEARCH SDF1/CXCR4 signalling promotes mobility of myeloma cells by activation and redistribution of cell surface adhesion moleculesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Taken together, it is highlighted that SDF-1/CXCR4 is a critical regulator of MM migration, providing the framework for the inhibitors of this pathway to be used in future clinical trials to abrogate MM trafficking. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - July 23, 2009 Category: Journals (General) Source Type: journals

In vitro osteogenesis of rat adipose-derived stem cells: comparison with bone marrow stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of our study suggest that ADSCs may have an inferior potential for osteogenesis compared with BMSCs. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - July 23, 2009 Category: Journals (General) Source Type: journals

CLINICAL RESEARCH Transplantation of bone marrow stromal mesenchymal cells in the treatment of acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cell therapy with BMSCs seems effective in the early stages of AMI, preventing LVEF worsening and remodelling. Injected cells give origin to muscular and endothelial cells. It is necessary to clarify whether new cells directly derive from injected cells, or originate from resident or circulating cells by stimulation or chemotaxis. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - July 23, 2009 Category: Journals (General) Source Type: journals

Association of the QRS duration on the resting electrocardiogram with the severity of coronary artery disease in 2,196 patients undergoing coronary angiography for suspected coronary artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of a QRS duration ł 120 ms on the resting ECG increased with increasing severity of obstructive CAD. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - July 23, 2009 Category: Journals (General) Source Type: journals

Preprocedural C-reactive protein predictive value in angiographic in-stent restenosis after coronary stent placement in patients with stable anginaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Preprocedural CRP may not predict in-stent restenosis, but strict control of diabetes may improve the outcome after elective coronary stenting. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - July 23, 2009 Category: Journals (General) Source Type: journals

LIST OF REVIEWERS – Vol. 4, 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

EDITORIAL A medium of science communication in our timesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

REVIEW PAPERS Ambulatory blood pressure as a predictor of cardiovascular riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypertension is one of the most common primary diagnoses and a known risk factor for cardiovascular disease, stroke and kidney disease. Like many other physiological variables, blood pressure is characterized by long- and short-term variability. Thus, blood pressure measured over extended periods of time, i.e. ambulatory monitoring, is more representative of the actual value than a single office reading. In longitudinal studies, ambulatory blood pressure (ABP) is found to predict future cardiovascular risk better than conventional blood pressure. Not only blood pressure values but also the pattern predicts cardiovascular r...
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

Phosphoinositide 3-kinase alterations in the thyroid gland – a review studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The phosphoinositide 3-kinase (PI3K) pathway has become a subject of great interest of researchers in biomedicine worldwide. Recent studies have shown that PI3K plays a crucial role in various cellular functions: cell cycle progression, cell survival, adhesion and motility, angiogenesis, glucose homeostasis, cell size and organ size control. The phosphoinositide 3-kinase pathway alterations (PIK3CA gene mutations and/or amplification) have been observed in various human tumours. In the majority of diagnosed cases, mutations are localized in one of the three “hot spots” in the gene, responsible for coding cataly...
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

BASIC RESEARCH Protective effect of N-acetylcysteine on cyclosporine A-induced changes in lipid hydroperoxide levels and renal dysfunction in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Depletion of antioxidants and increased lipid hydroperoxides play an important role in cyclosporine-induced renal damage. N-acetylcysteine supplementation significantly reduced cyclosporine induced structural and functional impairment of the kidneys. Concurrent use of antioxidant N-acetylcysteine may be of therapeutic value to minimize cyclosporine-induced nephrotoxicity. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

Continuous use of gonadotropin-releasing hormone (GnRH)-agonist maintains high luteinizing hormone concentrations at the time of oocyte retrieval in women undergoing GnRH-agonist long protocol assisted reproductive technology treatment and stimulation with recombinant follicle-stimulating hormoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Continuous administration of GnRH-agonist until oocyte retrieval maintains high LH concentrations and does not negatively affect ART outcome. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

Sensitivity of Candida albicans isolates to caspofungin – comparison of microdilution method and E-test procedureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Caspofungin demonstrated an excellent potency against C. albicans isolates and the E-test method appears to be useful for determination of in vitro caspofungin activity against these pathogens. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

CLINICAL RESEARCH Comparison of left ventricular ejection fraction by single photon computed tomographic myocardial perfusion imaging versus coronary computed tomography angiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Measurement of left ventricular (LV) ejection fraction by coronary computed tomography angiography (CTA) vs. single photon computed tomographic myocardial perfusion imaging (MPI) needs to be investigated. Material and methods: Myocardial perfusion imaging and CTA were performed in 292 patients because of chest pain or dyspnea. The patients included 178 men and 114 women, mean age 66 ±11 years. Results: The mean LV ejection fraction was 61 ±12% for the MPI tests and 65 ±11% for CTA (p (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

Hypocalciuria in pre-eclampsia and gestational hypertension due to decreased fractional excretion of calciumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest that hypocalciuria in pre-eclampsia is associated with decreased fractional excretion of calcium, suggesting a mechanism which may involve increased tubular reabsorption of calcium. Urinary calcium to creatinine ratio may be a useful potential screening test for pre-eclampsia. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

Haptoglobin polymorphism correlated with coronary artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Unlike blood donors, the Hp2FF/Hp2FF haptoglobin subtype was the least frequent among CAD patients, which may implicate this subtype in the development of CAD, a disease with a high mortality rate which consequently reduces the proportion of these individuals in populations. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

Glutathione peroxidase, superoxide dismutase and catalase activities in hepatic tissue from children with glycogen storage diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Oxidative stress could play a role in the pathogenesis of glycogen storage disease. These preliminary results are encouraging to conduct more extensive clinical studies using adjuvant antioxidant therapy. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals

The interaction between endothelin-1 and C-reactive protein and their impact on long-term prognosis after percutaneous coronary interventionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We could not demonstrate a relationship between pre-procedural ET-1 or hs-CRP levels and MACE at 24 months after successful PCI with single stent implantation to single de novo lesions. This study also could not show any correlation between ET-1 and hs-CRP levels in PCI patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - April 22, 2009 Category: Journals (General) Source Type: journals