Breakthrough in the scientific world: Lab-grown red blood cells used in transfusions
Sampreeti Sri Sai Kale, Rohith Kode, Sai Kiran Kuchana, LV Simhachalam Kutikuppala1Asian Journal of Transfusion Science 2023 17(1):143-144 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Sampreeti Sri Sai Kale Rohith Kode Sai Kiran Kuchana LV Simhachalam Kutikuppala1 Source Type: research

A modified approach in testing the ether eluate to overcome the hurdle in reading the results
Sanmukh Ratilal Joshi, Mayuri Vekariya, Manisha RajaparaAsian Journal of Transfusion Science 2023 17(1):141-142 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Sanmukh Ratilal Joshi Mayuri Vekariya Manisha Rajapara Source Type: research

Herniation of blood bag during component preparation
John Gnanaraj, Esha Toora, Abhishekh BasavarajegowdaAsian Journal of Transfusion Science 2023 17(1):139-140 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: John Gnanaraj Esha Toora Abhishekh Basavarajegowda Source Type: research

A case report on para-Bombay blood group
AG Krishnaveni, S VasanthAsian Journal of Transfusion Science 2023 17(1):136-138 Rare blood group detection is important as the incidence of these blood groups is very low. These rare blood groups need a transfusion of blood from the same group of people; sometimes, it is not available in blood banks. It is important to detect them in the field of transfusion medicine so that the right transfusion at the right time and for the right patient is ensured. We had one patient who was identified as blood group O in a private laboratory and the patient came to our hospital for anemia during the second trimester of pregnancy whos...
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: AG Krishnaveni S Vasanth Source Type: research

ABO incompatibility: A cause for neonatal alloimmune thrombocytopenia
Ripal J Shah, V Harimoorthy, Geeta KhatwaniAsian Journal of Transfusion Science 2023 17(1):133-135 ABO antibodies are naturally occurring antibodies. The ABO antibodies found in the Group O individuals include anti-A and anti-B. In Group O individuals, it tends to be predominantly immunoglobulins G (IgG), although immunoglobulins M and IgA components are also present. Infants of Group O mothers are at higher risk for hemolytic disease of the fetus and new-born than those born to mothers with Group A or B because IgG readily cross the placenta. At the same time, abnormal high concentration of ABO antibody in mother can lea...
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Ripal J Shah V Harimoorthy Geeta Khatwani Source Type: research

Platelet count in impedance-based hematology analyzer: Beware of trap!
Vani Krishnamurthy, Archana Shivamurthy, Pradeep V KumarAsian Journal of Transfusion Science 2023 17(1):131-132 Among the blood counts, platelet count is most often reported with inconsistency. Many of the analyzers work on electrical impedance principle for red blood cell (RBC) and platelet counting. However, with this technology, factors such as fragmented RBCs, microcytes, cytoplasmic fragments of leukemic cells, lipid particles, fungal yeast forms, and bacteria are known to interfere with platelet count and give spuriously elevated platelet counts. A 72-year-old male was admitted for the treatment of dengue infection ...
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Vani Krishnamurthy Archana Shivamurthy Pradeep V Kumar Source Type: research

Emergency ABO-incompatible living donor liver transplantation in Wilson disease-induced acute liver failure
We report the clinical outcome of an emergency ABO incompatible-liver transplantation (LT) for an 8-year-old child with Wilson's disease-induced acute liver failure. The pretransplant anti-A antibody titer was 1:64, and hence he underwent three cycles of conventional plasma exchange as pretransplant liver supportive treatment for deranged coagulopathy and liver function followed by one cycle of immunoadsorption (IA) prior to LT. The posttransplant immunosuppression consisted of rituximab, tacrolimus, mycophenolate mofetil, and corticosteroid. The patient had anti-A isoagglutinin rebound with elevated aminotransf...
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Joseph J Valamparampil Deepti Sachan Naresh Shanmugam Srinivas Mettu Reddy Mohamed Rela Source Type: research

Clinical significant anti-P1 antibody with wide thermal amplitude: A tale of successful blood management
Nallagondla Thulasiram, Dibyajyoti Sahoo, Abhishekh BasavarajegowdaAsian Journal of Transfusion Science 2023 17(1):125-127 The P blood group system was introduced in 1927 by Landsteiner and Levine. About 75% of the population possesses P1 phenotype. P2 simply implies P1 negative and there is no P2 antigen. Individuals with P2 may have anti-P1 antibodies in there serum are cold-reacting antibodies which are clinically insignificant and occasionally active at 20°C or higher temperatures. However, in certain cases, anti-P1 is clinically significant and may cause acute intravascular hemolytic transfusio...
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Nallagondla Thulasiram Dibyajyoti Sahoo Abhishekh Basavarajegowda Source Type: research

A conservative approach in finding compatible blood for a patient with sickle cell disease having multiple alloantibodies
CONCLUSION: The new approach on using the saved TS consumed less of the patient's blood specimen, and the use of the tube method in screening and eliminating a large chunk of incompatible blood units has proved economical if compared with the use of the only gel-IgG-cards device in the entire maneuvering. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Sanmukh Ratilal Joshi Mayuri M Vekariya Manisha M Rajapara Source Type: research

Effectiveness of therapeutic plasma exchange in case of rare neurological disorder Isaacs syndrome
Parmatma Prasad Tripathi, Sangeeta Kumari, Nandita Prabhat, Divjot Singh Lamba, Rekha Hans, Manoj Kumar Goyal, Vivek Lal, Ratti Ram SharmaAsian Journal of Transfusion Science 2023 17(1):117-120 Isaacs syndrome is a disease characterized by nerve hyperexcitability and pseudomyotonia and treated with immunomodulatory and symptomatic therapy approaches. Here, we report a case of anti-(leucine-rich glioma-inactivated 1) antibody-positive patient diagnosed as Isaacs syndrome and accomplished a nearly complete response to only four sessions of therapeutic plasma exchange (TPE). Our experience suggests that TPE along with other ...
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Parmatma Prasad Tripathi Sangeeta Kumari Nandita Prabhat Divjot Singh Lamba Rekha Hans Manoj Kumar Goyal Vivek Lal Ratti Ram Sharma Source Type: research

New horizons for reduction of blood use: Patient blood management
Karim Shamsasenjan, Somayeh Gharehdaghi, Elham Khalaf-Adeli, Ali Akbar PourfathollahAsian Journal of Transfusion Science 2023 17(1):108-116 A countrywide study over the eras indicates overuse of blood transfusion can have considerable risks to patients accompanied by significant costs of blood transfusion for patients, hospitals, and health-care systems. Besides, more than 30% of the world's population is anemic. Typically, blood transfusion helps continue suitable oxygen transfer in anemia, i.e., more and more documented as a threatening factor with several adverse outcomes including long hospitaliz...
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Karim Shamsasenjan Somayeh Gharehdaghi Elham Khalaf-Adeli Ali Akbar Pourfathollah Source Type: research

Addressing concerns and suggestions of blood donors: An assured way for donor motivation, recruitment, and retention
Sreethu Chand, R Amita, Debasish GuptaAsian Journal of Transfusion Science 2023 17(1):103-107 The World Health Organization and National Blood Transfusion Council, Government of India, advocate regular repeat nonremunerated voluntary blood donors as the safest of all donors to meet the blood requirements of the country. Recruitment and retention of individuals as voluntary blood donors requires the adoption of novel and varied strategies protecting the voluntary nonremunerated nature of blood donation. In this review article, we are focusing on how addressing the donor suggestions and concerns has created a win&#82...
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Sreethu Chand R Amita Debasish Gupta Source Type: research

Transfusion reactions in neonates and pediatrics: How and why are they different ?
This article provides a brief articulation of the transfusion reactions in neonatal and pediatric populations describing how they are different from adults. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Abhishekh Basavarajegowda Nishad Plakkal Source Type: research

Comparative study between chronic automated red blood cell exchange and manual exchange transfusion in patients with sickle cell disease: A single center experience from Saudi Arabia
CONCLUSION: Compared to MET, aRBCX was more effective in reducing HbS, with fewer hospital visits and better disease control. Although more pRBCs were transfused, the ferritin level was better controlled in the aRBCX group without increasing alloimmunization risk. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Nour Al Mozain Yasmin Elobied Amal Al-Omran Alhanouf Aljaloud Alanoud Bin Omair Reema Bin Tuwaim Sara Alkhalifah Esraa S Altawil Sheena Abraham Lejardine Rose Salcedo Aljoyce Parena Farrukh Shah M Tayyeb Ayyoubi Daniela Hermelin Farjah Al Gahtani Mervat A Source Type: research

Altered color of plasma component & #8211; Unnecessary wastage of a precious resource
CONCLUSION: Plasma component with altered color restricts its issue to the patient and also for use in fractionation. In our study, many of the altered color plasma units were safe to transfuse, but the decision regarding transfusion was debatable on consultation with the treating doctor. Further studies with a large sample size are recommended for the use of these plasma components. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - March 1, 2023 Category: Hematology Authors: Dhara Darshan Patel Mamta C Shah Nidhi M Bhatnagar Tarak Rameshbhai Patel Sangita D Shah Shital Soni Source Type: research