Effects of 8-Hydroxyisocapnolactone-2-3-diol and friedelin on mast cell degranulation
Conclusions These results exhibit the promising of 8-hydroxyisocapnolactone-2-3-diol is a potential parent structure for developing a MCs stabilizer. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 6, 2017 Category: Tropical Medicine Source Type: research

Antioxidant, anti-inflammatory and antinociceptive potential of Ternstroemia sylvatica Schltdl. & amp; Cham
Conclusions Our work confirms the value of Ternstroemia sylvatica as an important anti-inflammatory and analgesic plant, whose mechanism seems to be associated to its antioxidant effects, and supports its uses in the Mexican traditional medicine. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Efficient hepatoprotective activity of cranberry extract against CCl4-induced hepatotoxicity in Wistar albino rat model: Down-regulation of liver enzymes and strong antioxidant activity
Conclusion The resulting data evidenced that CBE exhibits promising hepatoprotective potential against the chemical induced hepatotoxicity, maintains homeostasis in liver enzymes, and can provide significant antioxidant defense against free radicals-induced oxidative stress. Graphical abstract (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Euclea undulata Thunb.: Review of its botany, ethnomedicinal uses, phytochemistry and biological activities
This study was aimed at reviewing the botany, ethnopharmacology and biological activities of E. undulata in southern Africa. Results presented in this study are based on review of literature using search engines such as Science Direct, Springerlink, Scopus, PubMed, Web of Science, BioMed Central and Google Scholar. Herbal medicine is prepared from the decoctions of the roots, bark and leaves, and extracts of these plant parts have demonstrated anticholinesterase, anti-inflammatory, antimicrobial, antimycobacterial, antiplasmodial, antioxidant and hypoglycaemic activities. Multiple classes of phytochemical compounds such a...
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Evaluating the effect of Myrtus communis on programmed cell death in hydatid cyst protoscolices
Conclusion The extract of M. communis at different concentrations could increase the activity of caspases 3 and 9 and caused programmed cell death in hydatid cyst protoscolices however, this effect was significant at high concentrations of the extract. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Effect of taurine on immune function in mice with T-cell lymphoma during chemotherapy
Conclusions Taurine can effectively enhance the immune function of mice with T-cell lymphoma during chemotherapy, reduce the toxicity of chemotherapy. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions
Conclusions Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective. However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Influence of light intensity and water content of medium on total dendrobine of Dendrobium nobile Lindl
Conclusions In brief, the moderately strong light intensity and water content of medium from low to medium can facilitate the growth and yield of D . nobile plants, while light intensity from moderately weak to weak can enhance the dendrobine content. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Bartonella infection in asymptomatic horses and donkeys from Tuscany, Central Italy
Conclusions The detected sero-prevalence suggests a common and frequent exposure of equids living in Central Italy to bartonellae and PCR results show that Bartonella sp. infection is possible both in horses and donkeys. At the best of our knowledge, this is the first report of B. henselae infection in donkeys. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Meningococcal disease, a clinical and epidemiological review
Publication date: Available online 28 October 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): Rodrigo Siqueira Batista, Andréia Patrícia Gomes, Jorge Luiz Dutra Gazineo, Paulo Sérgio Balbino Miguel, Luiz Alberto Santana, Lisa Oliveira, Mauro Geller Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Afri...
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Glypican-3-specific cytotoxic T lymphocytes induced by human leucocyte antigen-A*0201-restricted peptide effectively kill hepatocellular carcinoma cells in  vitro
Conclusions The GPC3 522–530 peptide contains antigen-determinant and its specific CTLs can effectively kill HCC in a HLA-A2-restricted and peptide-dependent manner. Our findings suggest that this peptide may be valuable for development of therapeutic vaccine. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Association of TNFA ( −308G/A), IFNG (+874 A/T) and IL-10 (−819 C/T) polymorphisms with protection and susceptibility to dengue in Brazilian population
Conclusions This research identifies the association of the IFNG (+874 A/T), TNFA (−308G/A), IL-10 (−819 C/T) genotypes as a factor for protection, susceptibility and severity to dengue. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Antioxidants: Friend or foe?
Publication date: Available online 28 October 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): R. Sarangarajan, S. Meera, R. Rukkumani, P. Sankar, G. Anuradha Reactive oxygen species are the intermediates that are formed during the normal metabolic process which are effectively neutralized by the antioxidant system of the body. Any imbalance in this neutralization process causes oxidative stress which has been implicated as one of the cause in diseases such as Alzheimer's disease, cardiovascular disorders, cancer etc. Research has enabled the use of antioxidants as therapeutic agents in the treatmen...
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease
Conclusions Our results have successfully explored the molecular mechanism of lupane triterpenoids via BACE1 inhibition, suggesting that lupeol in particular could be utilized as a useful therapeutic and preventive agent to mitigate Alzheimer's disease. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research

Regulating effect of glycyrrhetinic acid on bronchial asthma smooth muscle proliferation and apoptosis as well as inflammatory factor expression through ERK1/2 signaling pathway
Conclusion GA can inhibit the proliferation of bronchial smooth muscle cells and reduce the expression of inflammatory factors by inhibiting the phosphorylation of ERK1/2. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 5, 2017 Category: Tropical Medicine Source Type: research