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This page shows you the latest news and research items in this category.

Treatment of Experimental Aspergillosis with Amphotericin B
JOHN H. EVANS a n d ROGER D. BAKER (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 27, 2013 Category: Respiratory Medicine Source Type: news

Fulminating disseminated aspergillosis complicating peritoneal dialysis in eclampsia
Ross DA, Anderson DC, Macnaughton MC, Stewart WK (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 27, 2013 Category: Respiratory Medicine Source Type: news

Cutaneous aspergillosis
van Burik JA, Colven R, Spach DH (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 27, 2013 Category: Respiratory Medicine Source Type: news

Invasive aspergillosis in children
Golladay ES, Baker SB (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 27, 2013 Category: Respiratory Medicine Source Type: news

Primary invasive aspergillosis of the hand
Jones NF, Conklin WT, Albo VC (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 27, 2013 Category: Respiratory Medicine Source Type: news

Cutaneous aspergillosis
Isaac M (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 27, 2013 Category: Respiratory Medicine Source Type: news

Cutaneous aspergillosis: a report of six cases
Galimberti R, Kowalczuk A, Hidalgo Parra I, Gonzalez Ramos M, Flores V (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 27, 2013 Category: Respiratory Medicine Source Type: news

Etanercept: Primary cutaneous aspergillosis: case report
(Source: Reactions)
Source: Reactions - February 26, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Voriconazole therapeutic drug monitoring: retrospective cohort study of the relationship to clinical outcomes and adverse events
Conclusions: Voriconazole therapeutic drug levels were not associated with improvement in clinical outcomes among patients with proven or probable invasive fungal disease. We also did not find an association between supratherapeutic drug levels and hepatoxicity or encephalopathy. It is possible that the utility of voriconazole therapeutic drug monitoring to improve clinical efficacy or decrease adverse events may be limited to a subset of high-risk patients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 26, 2013 Category: Infectious Diseases Authors: Helen ChuRupali JainHu XiePaul PottingerDavid Fredricks Source Type: research

Surgery for pulmonary aspergillosis
Kilman JW, Ahn C, Andrews NC, Klassen K (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 21, 2013 Category: Respiratory Medicine Source Type: news

Cerebral aspergillosis: report of two cases
Venugopal PV, Venugopal TV, Thiruneelakantan K, Subramanian S, Shetty BM (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 18, 2013 Category: Respiratory Medicine Source Type: news

Pulmonary aspergillosis and the importance of oxalate crystal recognition in cytology specimens.
Lee SH, Barnes WG, Schaetzel WP. (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 18, 2013 Category: Respiratory Medicine Source Type: news

Invasive aspergillosis in acute leukemia: correlation with nose cultures and antibiotic use
Aisner J, Murillo J, Schimpff SC, Steere AC (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 18, 2013 Category: Respiratory Medicine Source Type: news

[Bronchopulmonary and encephalomeningeal aspergillosis in a 20-day-old newborn]
AKKOYUNLU A, YUCEL FA (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 15, 2013 Category: Respiratory Medicine Source Type: news

[Hospital infection of bronchopulmonary aspergillosis in infants and small children]
Brass K (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 15, 2013 Category: Respiratory Medicine Source Type: news

Pulmonary aspergillosis complicating aplastic phase in hematologic patients
Capnist G, Chisesi T, Battista R, Dini E (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 14, 2013 Category: Respiratory Medicine Source Type: news

Minireview: host defence in invasive aspergillosis
Summary Aspergillus is a saprophytic fungus, which mainly becomes pathogenic in immunosuppressed hosts. A failure of host defences results in a diverse set of illnesses, ranging from chronic colonisation, aspergilloma, invasive disease and hypersensitivity. A key concept in immune responses to Aspergillus species is that host susceptibility determines the morphological form, antigenic structure and physical location of the fungus. Traditionally, innate immunity has been considered as a first line of defence and activates adaptive immune mechanisms by the provision of specific signals; innate and adaptive immune responses a...
Source: Mycoses - February 14, 2013 Category: Research Authors: Cornelia Lass‐Flörl, Emmanuel Roilides, Jürgen Löffler, Doris Wilflingseder, Luigina Romani Tags: Review article Source Type: research

Aspergillosis of the nervous system
Beal MF, O'Carroll CP, Kleinman GM, Grossman RI (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 12, 2013 Category: Respiratory Medicine Source Type: news

Cerebral aspergillosis
Shapiro K, Tabaddor K (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 12, 2013 Category: Respiratory Medicine Source Type: news

Voriconazole-associated hyponatremia: a successful management with therapeutic monitoring.
Abstract Voriconazole is a second generation triazole antifungal agent and the first choice therapy for invasive aspergillosis (IA)(1).… PMID: 23403435 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - February 12, 2013 Category: Microbiology Authors: Xu RA, Lin GY, Hu LF, Shi DW, Ye XL, Liu YJ, Pan XF, Zhang CH, Zhang XH Tags: Antimicrob Agents Chemother Source Type: research

Update of multicenter noncomparative study of caspofungin (CAS) in adults with invasive aspergillosis (IA) refractory (R) or intolerant (I) to other antifungal agents: analysis of 90 patients
Maertens J, Raad I Petrikkos G et al (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 11, 2013 Category: Respiratory Medicine Source Type: news

[Non-CF Bronchiectasis with Focus on Allergic Bronchopulmonary Aspergillosis]
Rademacher J, Ringshausen FC (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 11, 2013 Category: Respiratory Medicine Source Type: news

Performance of two Aspergillus IgG EIA assays compared with the precipitin test in chronic and allergic aspergillosis
Baxter CG, Denning DW, Jones AM, Todd A, Moore CB, Richardson MD (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 11, 2013 Category: Respiratory Medicine Source Type: news

Amphotericin B nasal spray as prophylaxis against aspergillosis in patients with neutropenia
Meunier-Carpentier F, Snoeck R, Gerain J, Muller C, Klastersky J (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia
Gerson SL, Talbot GH, Hurwitz S, Strom BL, Lusk EJ, Cassileth PA (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Fulminant aspergillosis of the nose and paranasal sinuses: a new clinical entity
McGill TJ, Simpson G, Healy GB (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Recognition and successful management in pulmonary aspergillosis in leukemia
Sinclair AJ, Rossof AH, Coltman CA Jr (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

An outbreak of aspergillosis in children with acute leukemia
Mahoney DH Jr, Steuber CP, Starling KA, Barrett FF, Goldberg J, Fernbach DJ (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis
Steinbach WJ, Stevens DA (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Voriconazole for invasive aspergillosis in oncohematological patients: a single-center pediatric experience
Cesaro S, Strugo L, Alaggio R, Cecchetto G, Rigobello L, Pillon M, Cusinato R, Zanesco L (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Increase in aspergillosis and severe mycotic infection in patients with leukemia and MDS: comparison of the data from the Annual of the Pathological Autopsy Cases in Japan in 1989, 1993 and 1997
Kume H, Yamazaki T, Abe M, Tanuma H, Okudaira M, Okayasu I (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Invasive pulmonary aspergillosis in acute leukemia. The contribution of CT to early diagnosis and aggressive management
Kuhlman JE, Fishman EK, Burch PA, Karp JE, Zerhouni EA, Siegelman SS (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Radiologic-pathologic correlation of the CT halo sign in invasive pulmonary aspergillosis
Hruban RH, Meziane MA, Zerhouni EA, Wheeler PS, Dumler JS, Hutchins GM (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Favorable outcome of invasive aspergillosis in patients with acute leukemia
Burch PA, Karp JE, Merz WG, Kuhlman JE, Fishman EK (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Invasive pulmonary aspergillosis in adult acute leukemia: clinical clues to its diagnosis
Gerson SL, Talbot GH, Lusk E, Hurwitz S, Strom BL, Cassileth PA (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Pulmonary cavitation and massive hemoptysis in invasive pulmonary aspergillosis. Influence of bone marrow recovery in patients with acute leukemia
Albelda SM, Talbot GH, Gerson SL, Miller WT, Cassileth PA (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 7, 2013 Category: Respiratory Medicine Source Type: news

Treatment of invasive aspergillosis: relation of early diagnosis and treatment to response
Aisner J, Wiernik PH, Schimpff SC (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 6, 2013 Category: Respiratory Medicine Source Type: news

Allergic bronchopulmonary mycosis due to fungi other than Aspergillus: a global overview.
Abstract Abstract Allergic bronchopulmonary mycosis (ABPM) is a hypersensitivity-mediated disease of worldwide distribution. We reviewed 143 reported global cases of ABPM due to fungi other than aspergilli. The commonest etiologic agent was Candida albicans, reported in 60% of the cases, followed by Bipolaris species (13%), Schizophyllum commune (11%), Curvularia species (8%), Pseudallescheria boydii species complex (3%) and rarely, Alternaria alternata, Fusarium vasinfectum, Penicillium species, Cladosporium cladosporioides, Stemphylium languinosum, Rhizopus oryzae, C. glabrata, Saccharomyces cerevisiae and Trich...
Source: Critical Reviews in Microbiology - February 5, 2013 Category: Microbiology Authors: Chowdhary A, Agarwal K, Kathuria S, Gaur SN, Randhawa HS, Meis JF Tags: Crit Rev Microbiol Source Type: research

Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis
Viscoli C, Machetti M, Gazzola P, De Maria A, Paola D, Van Lint MT, Gualandi F, Truini M, Bacigalupo A (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 4, 2013 Category: Respiratory Medicine Source Type: news

CT of invasive pulmonary aspergillosis in children with cancer
Taccone A, Occhi M, Garaventa A, Manfredini L, Viscoli C (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 4, 2013 Category: Respiratory Medicine Source Type: news

The radiological spectrum of invasive aspergillosis in children: a 10-year review
Thomas KE, Owens CM, Veys PA, Novelli V, Costoli V (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 4, 2013 Category: Respiratory Medicine Source Type: news

Bayesian Development of a Dose-Response Model for Aspergillus fumigatus and Invasive Aspergillosis
Leleu C, Menotti J, Meneceur P, Choukri F, Sulahian A, Garin YJ, Denis JB, Derouin F (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 4, 2013 Category: Respiratory Medicine Source Type: news

Enhancing Angiogenesis in Invasive Aspergillosis: A Novel Therapeutic Approach
Ito JI (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 4, 2013 Category: Respiratory Medicine Source Type: news

Proangiogenic growth factors potentiate in situ angiogenesis and enhance antifungal drug activity in murine invasive aspergillosis
Ben-Ami R, Albert ND, Lewis RE, Kontoyiannis DP (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 4, 2013 Category: Respiratory Medicine Source Type: news

The Pharmacodynamics and Dose-Response Relationships of Liposomal Amphotericin B against Different Azole-Resistant Aspergillus fumigatus Isolates in a Murine Model of Disseminated Aspergillosis.
Abstract The management of invasive aspergillosis (IA) has become more complicated due to the emergence of acquired azole resistance in Aspergillus fumigatus, which is associated with treatment failure and a mortality rate of 88%. Treatment with liposomal amphotericin B (L-AmB) may be a useful alternative to improve therapeutic outcome in azole-resistant IA.Four clinical A. fumigatus isolates obtained from patients with proven IA were studied in a non-neutropenic murine model of infection: a wild-type isolate without mutations in the cyp51A-gene and three azole-resistant isolates harbouring a M220I, TR(34)/L98H and...
Source: Antimicrobial Agents and Chemotherapy - February 4, 2013 Category: Microbiology Authors: Seyedmousavi S, Melchers WJ, Mouton JW, Verweij PE Tags: Antimicrob Agents Chemother Source Type: research

Experimental Evidence that Granulocyte Transfusions are Efficacious in Treatment of Neutropenic Hosts with Pulmonary Aspergillosis.
Conclusion:Our present results provide an experimental basis for enthusiasm for PMN transfusions in the therapy of aspergillosis in man. PMID: 23380731 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - February 4, 2013 Category: Microbiology Authors: Martinez M, Chen V, Tong AJ, Hamilton K, Clemons KV, Stevens DA Tags: Antimicrob Agents Chemother Source Type: research

An unusual presentation of invasive aspergillosis after lung transplantation
Cattelan AM, Loy M, Tognon S, Rea F, Sasset L, Cadrobbi P (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 1, 2013 Category: Respiratory Medicine Source Type: news

Hospital construction-associated outbreak of ocular aspergillosis after cataract surgery
Tabbara KF, al Jabarti AL (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 1, 2013 Category: Respiratory Medicine Source Type: news

Major variations in Aspergillus fumigatus arising within aspergillomas in chronic pulmonary aspergillosis
Summary Aspergillomas develop from progressive layers of mycelial growth on the walls of pulmonary cavities over months. Aspergillomas are characteristic of chronic pulmonary aspergillosis and are a risk factor for azole resistance. We investigated genotypic and phenotypic alterations in Aspergillus fumigatus recovered from aspergillomas. Aspergillomas were removed from three patients (two at surgery, one at autopsy) and dissected. Overall 92 colonies of A. fumigatus were isolated. Microsatellite typing was conducted to determine genetic type. Itraconazole, voriconazole and posaconazole susceptibilities were performed. The...
Source: Mycoses - February 1, 2013 Category: Research Authors: S. J. Howard, A. C. Pasqualotto, M. J. Anderson, H. Leatherbarrow, A. M. Albarrag, E. Harrison, L. Gregson, P. Bowyer, D. W. Denning Tags: Original Article Source Type: research

Serum galactomannan assay for the diagnosis of invasive aspergillosis in children with haematological malignancies
Summary Diagnostic efficacy of Galactomannan (GM) assay for invasive aspergillosis (IA) is variably reported. Data from developing countries are scant. Children with haematological malignancies and fever were enrolled prospectively. Blood sample for GM was drawn on the day of admission; levels were measured with Platellia Aspergillus enzyme immunoassay. Diagnostic criteria were adapted from EORTC‐MSG‐2002. Proven, probable and possible episodes were considered as the disease group. One hundred febrile episodes in 78 patients were evaluated. The mean age was 6.1 years. Majority (75%) episodes were in patients with acu...
Source: Mycoses - February 1, 2013 Category: Research Authors: Ajaya K. Jha, Deepak Bansal, Arunaloke Chakrabarti, M. R. Shivaprakash, Amita Trehan, Ram K. Marwaha Tags: Original article Source Type: research