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Aspirin and clopidogrel use in the early postoperative period following on-pump and off-pump coronary artery bypass graftingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Early postoperative clopidogrel combined with aspirin may be safe and beneficial compared with perioperative aspirin treatment alone, in both on-pump and off-pump coronary artery bypass grafting. However, a possibility of selection bias calls for randomized controlled trials to confirm our findings. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - November 20, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Dae Hyun Kim, Constantine Daskalakis, Scott C. Silvestry, Mital P. Sheth, Andrew N. Lee, Suzanne Adams, Sam Hohmann, Sofia Medvedev, David J. Whellan Tags: Perioperative Management Source Type: journals

Aspirin kills 400% more people than H1N1 swine fluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) The CDC now reports that nearly 4,000 Americans have been killed by H1N1 swine flu. This number is supposed to sound big and scary, motivating millions of people to go out and pay good money to be injected with untested, unproven H1N1 vaccines. But let's put the number in perspective: Did you know that more than four times as many people are killed each year by common NSAID painkillers like aspirin?The July 1998 issue of The American Journal of Medicine explains it as follows:"Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for nonsteroidal anti-inflammatory dr...
Source: NaturalNews.com - November 20, 2009 Category: Consumer Health Advice Source Type: news

Clinical trials update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE-I, European CRT survey, German pre-SCD II registry, and MADIT-CRTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the European Society of Cardiology held in Barcelona in 2009. The AAA study does not support the routine use of aspirin for the prevention of vascular events in patients with asymptomatic atherosclerosis. RELY suggests that dabigatran may be more effective than warfarin for the prevention of stroke in patients with atrial fibrillation. Rolofylline was not superior to placebo in improving outcomes in patients with acute heart failure enrolled in the PROTE...
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Cleland, J. G.F., Coletta, A. P., Yassin, A., Buga, L., Torabi, A., Clark, A. L. Tags: MEETING REPORT Source Type: journals

Low-dose aspirin therapy shows no CVD benefit for Type 2 diabeticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a Chinese study show that low-dose aspirin therapy appears to convey no benefits for primary or secondary cardiovascular disease prevention for Type 2 diabetes patients. (Source: MedWire News - Diabetes)
Source: MedWire News - Diabetes - November 19, 2009 Category: Endocrinology Source Type: news

AHA: Low Bleeding Rates Observed in Dabigatran Dose-Ranging Trial (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ORLANDO (MedPage Today) -- The oral anticoagulant dabigatran did not appear to markedly increase major bleeding rates among post-MI patients who were already being treated with aspirin and clopidogrel (Plavix), researchers said here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

New mechanism identified for beneficial effects of aspirin in cardiovascular diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New data in humans shows that all doses of aspirin used in clinical practice increase nitric oxide. Nitric oxide is released from the blood vessel wall and may decrease the development and progression of plaques leading to heart attacks and strokes. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 19, 2009 Category: Science Source Type: news

Use of Heparin in Women With Early and Late Miscarriages With and Without ThrombophiliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data support the notion that LMWH is efficacious in patients with recurrent abortions and thrombophilia. We demonstrated the same effect of LMWH in women with unexplained abortions without thrombophilia. The potential mechanism of action of LMWH in early and late abortions warrants further study. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Monien, S., Kadecki, O., Baumgarten, S., Salama, A., Dorner, T., Kiesewetter, H. Tags: Articles Source Type: journals

Utility of the PFA-100 Instrument and the Novel Multiplate Analyzer for the Assessment of Aspirin and Clopidogrel Effects on Platelet Function in Patients With Cardiovascular DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated the utility of the PFA-100 and the Multiplate analyzer for the assessment of aspirin and clopidogrel effects on platelet function in patients with cardiovascular disease. Platelet function was determined with the PFA-100 using collagen+epinephrine (CEPI) and collagen+adenosine-5’-diphosphate (CADP) cartridges, and with whole blood impedance aggregometry using the Multiplate ASPI and ADP+PG tests (aggregation triggered with arachidonic acid and ADP+ prostaglandin E1, respectively). Four study groups were identified from the 154 patients enrolled: patients without antiplatelet therapy, patients wit...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Mueller, T., Dieplinger, B., Poelz, W., Haltmayer, M. Tags: Articles Source Type: journals

Investigational oral antiplatelet agent ticagrelor (Brilinta®) filed for approval in USEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: PharmaTimes Area: News AstraZeneca has submitted a New Drug Application with the FDA for its investigational oral antiplatelet therapy ticagrelor (Brilinta®) for the reduction of major adverse cardiac events in patients with acute coronary syndrome. The filing includes data from the 18,624-patient PLATO study, the phase III head-to-head trial comparing ticagrelor plus aspirin with clopidogrel plus aspirin (see NeLM link). Ticagrelor is the first in a new class of drugs, the CPTPs (cyclo-pentyl-triazolo-pyrimidines) and is chemically distinct from the thienopyridines. It was filed for approval with regulators in E...
Source: NeLM - Cardiovascular Medicine - November 19, 2009 Category: Cardiology Source Type: organizations

CASCADE: No Significant Benefit of Clopidogrel in Reducing Graft Disease After CABGEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dual antiplatelet therapy did not significantly reduce vein graft intimal hyperplasia compared with aspirin alone over 12 months. Heartwire (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 18, 2009 Category: Cardiology Tags: Cardiology Source Type: info

On This Day in Science History - November 19 - John VaneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
November 19th marks the passing of John Vane. Vane was a British biochemist who spent his career studying prostaglandins. Prostaglandins are compounds that regulate many different functions in the body. Vane developed a test called teh dynamic bioassay that identified and measured the substances that make up blood and other fluids of the body. Using this test, he discovered prostaglandins are produced by several tissues and organs and their effect was short ranged, typically affecting the area near where they were produced. One of the experiments he performed found that aspirin inhibited the production of prostaglandin tha...
Source: About.com Chemistry - November 18, 2009 Category: Chemistry Source Type: consumer

AHA: Aspirin alone good enough to prevent vein graft diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Orlando, Fla.—The addition of clopidogrel to aspirin did not lead to a significant reduction in vein graft intimal hyperplasia during the first year after CABG, according to the CASCADE trial presented Monday during the late-breaking clinical trials session at the 2009 American Heart Association conference. (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - November 17, 2009 Category: Cardiology Tags: Latest News Source Type: news

CASCADE: No significant benefit of clopidogrel in reducing graft disease after CABGEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dual antiplatelet therapy did not significantly reduce vein graft intimal hyperplasia compared with aspirin alone over 12 months. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

Acetaminophen: Good painkiller can be deadly if overusedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
You may believe acetaminophen, the aspirin-free pain reliever found in Tylenol, is one of the safest painkillers on the market. And used properly, it is. But acetaminophen is also the leading cause of acute liver failure in the United States because taking just slightly more than the maximum reco... (Source: Wash Post Health)
Source: Wash Post Health - November 17, 2009 Category: Consumer Health News Authors: Post Tags: Acetaminophen: Good painkiller can be deadly if overused Source Type: news

CASCADE: No added benefit with clopidogrel for saphenous vein grafts after CABGEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The addition of clopidogrel to aspirin failed to significantly reduce intimal hyperplasia in the saphenous vein grafts of patients who underwent coronary artery bypass graft compared with aspirin alone. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 17, 2009 Category: Internal Medicine Source Type: news

CASCADE: No added benefit with clopidogrel for saphenous vein grafts after CABGEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The addition of clopidogrel to aspirin failed to significantly reduce intimal hyperplasia in the saphenous vein grafts of patients who underwent coronary artery bypass graft compared with aspirin alone. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 17, 2009 Category: Cardiology Source Type: news

Health Care Services Provided During Physician Office Visits for Hypertension: Differences by SpecialtyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to compare differences by physician specialty in the provision of health care services during office visits for hypertension. The authors examined office visits for US physicians by using data from the National Ambulatory Medical Care Survey for 2003 to 2005. Of more than 274 million hypertension visits, 35.5%, 43.9%, 8.5%, and 12.1% visits were made to general practitioners/family physicians, internists, cardiologists, and other specialties, respectively. Visitors to cardiologists were more likely to have coronary heart disease and heart failure than visitors to other physicians. While presc...
Source: The Journal of Clinical Hypertension - November 17, 2009 Category: Cardiology Authors: Jing Fang, Nora L. Keenan, Carma Ayala Source Type: journals

Addition of cilostazol reduces biological aspirin resistance in aspirin users with ischaemic stroke: a double-blind randomized clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although this was a negative study, our findings disclosed a trend toward enhanced antiplatelet effects when cilostazol was added to aspirin in ischaemic stroke patients. Combination of aspirin and cilostazol might be a treatment option in the ischaemic stroke patients with AR. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 17, 2009 Category: Neurology Authors: J.-H. Lee, J.-K. Cha, S. J. Lee, S.-W. Ha, S. U. Kwon Source Type: journals

Letter by Kan et al regarding Article, "randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart failure (WATCH) trial".Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19917893 [PubMed - in process] (Source: Circulation)
Source: Circulation - November 17, 2009 Category: Cardiology Authors: Kan LP, Chu KM, Lin GM Tags: Circulation Source Type: journals

Aspirin without Plavix as good after heart bypassEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ORLANDO, Florida (Reuters) - Aspirin alone proved as effective as aspirin plus the blood clot preventer Plavix in keeping coronary artery bypass grafts open during the first year after surgery, according to a study released on Monday. (Source: Reuters: Health)
Source: Reuters: Health - November 16, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

Aspirin Without Plavix As Good After Heart BypassEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aspirin alone proved as effective as aspirin plus the blood clot preventer Plavix in keeping coronary artery bypass grafts open during the first year after surgery, according to a study released on Monday. Source: Reuters Health Related MedlinePlus Topics: Blood Thinners, Coronary Artery Bypass Surgery, Pain Relievers (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 16, 2009 Category: Consumer Health News Source Type: consumer

Aspirin/nicorandil/ticlopidine/cilostazol: Cholestatic-type liver injury treated with ursodeoxycholic acid/plasma exchange and cilostazol-related increase in pulse rate: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Aspirin Lengthens Survival in Patients With Nonmetastatic Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aspirin therapy inhibits the development of pre-cancerous colon adenomas. Does it also offer protection after colorectal cancer develops? Journal Watch (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 16, 2009 Category: Consumer Health News Tags: Internal Medicine Source Type: news

New Mechanism Identified For Beneficial Effects Of Aspirin In Cardiovascular DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On Sunday, November 15, 2009, Florida Atlantic University (FAU) researcher Charles H. Hennekens, M.D., the first Sir Richard Doll Research Professor in the Charles E. Schmidt College of Biomedical Science will present at the American Heart Association's Annual Scientific Sessions meeting in Orlando, FL, the first data in humans to show that all doses of aspirin used in clinical practice increase nitric oxide. (Source: Cardiovascular / Cardiology News From Medical News Today)
Source: Cardiovascular / Cardiology News From Medical News Today - November 16, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

Treatment disparities and effect on late mortality in patients with diabetes presenting with acute myocardial infarction: observations from the ACACIA registry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Patients with diabetes have a higher risk than non-diabetic patients of late mortality following an acute MI, yet receive fewer guideline-recommended medications and early invasive procedures. Increased application of proven pharmacotherapies and an early invasive management strategy in patients with diabetes presenting with ACS might improve their outcomes. STUDY PROTOCOL NUMBER (SANOFI-AVENTIS): PML-0051. PMID: 19912085 [PubMed - in process] (Source: Med J Aust)
Source: Med J Aust - November 16, 2009 Category: Journals (General) Authors: Hung J, Brieger DB, Amerena JV, Coverdale SG, Rankin JM, Astley CM, Soman A, Chew DP Tags: Med J Aust Source Type: journals

Aspirin is associated with reduced cardiovascular and all-cause mortality in type 2 diabetes in a primary prevention setting: The Fremantle Diabetes Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions - Regular low-dose aspirin may reduce all-cause and CVD mortality in a primary prevention setting in type 2 diabetes. All-cause mortality reductions appear greatest in men and those aged >/=65 years. The present observational data support recommendations that aspirin should be used in primary CVD prevention in all but the lowest risk patients. PMID: 19918016 [PubMed - as supplied by publisher] (Source: Diabetes Care)
Source: Diabetes Care - November 16, 2009 Category: Endocrinology Authors: Ong G, Davis TM, Davis WA Tags: Diabetes Care Source Type: journals

AHA: Ticagrelor bests Plavix in STEMI patients, includes mortality reductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Orlando, Fla.—STEMI patients who received both aspirin and the new reversible oral antiplatelet drug ticagrelor (Brilinta; AstraZeneca) had few cardiac events and less mortality than patients on aspirin and the popular irreversible antiplatelet medication clopidogrel (Plavix; Bristol-Myers Squibb), based on the results of the PLATO STEMI trial, presented during Sunday’s late-breaking clinical trial session at the American Heart Association conference. (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - November 15, 2009 Category: Cardiology Tags: Latest News Source Type: news

Combined warfarin–aspirin therapy: what is the evidence for benefit and harm and which patients should (and should not) receive it?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this review are to describe the characteristics of patients who are receiving combined warfarin–aspirin therapy, to summarize the evidence for the therapeutic benefit and harm of combined warfarin–aspirin, and to provide practical guidelines as to which patients should (or should not) receive such treatment. Content Type Journal ArticleDOI 10.1007/s11239-009-0413-4Authors Marco P. Donadini, McMaster University and St Joseph’s Healthcare Department of Medicine Hamilton ON L8N 4A6 CanadaJames D. Douketis, McMaster University and St Joseph’s Healthcare Department of Medicine Room F-544, 50 Cha...
Source: Journal of Thrombosis and Thrombolysis - November 14, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Are antidepressants just a crutch?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently I evaluated a new patient, a young woman who wondered whether medication might ease her depression. She was in therapy elsewhere, and although seeing me was her idea, she was apprehensive about adding an antidepressant. I did end up recommending one, at which point she asked: "Aren't antidepressants just a crutch?"I relish this question. It is asked in anxiety, hesitation, and doubt, yet carries within it its own hopeful answer."Why yes," I answered with a smile. "Antidepressants are exactly that, just a crutch." I pointed out that antidepressants, and all psychiatric medications, are symptomatic...
Source: Psychology Today Depression Center - November 14, 2009 Category: Psychiatry & Psychology Authors: Steven Reidbord, MD Tags: Depression Psychiatry antidepressant antidepressants bad genes crutch crutches definitive treatment depressive symptoms exact nature family dynamics foot infection fractured leg genetic vulnerabilities hesitation leg bone m Source Type: consumer

Drug-Eluting Stent Fracture: Promise and Performance⁎Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All promise outruns performance.—Ralph Waldo Emerson () The saga of drug-eluting stents (DES) continues from their hyperbolic introduction into clinical practice in 2003 through a period of scrupulous clinical safety introspection, emerging as the principal device therapy for percutaneous coronary intervention with renewed enthusiasm in today's era of prolonged oral dual antiplatelet therapy. Clinicians, researchers, industry, and regulatory agencies have gained wisdom from the many lessons taught in the global introduction of DES into clinical practice. As clinicians and scientists, we benefit from an organized cogniti...
Source: Journal of the American College of Cardiology - November 12, 2009 Category: Cardiology Authors: Andrew J. Carter Tags: Interventional Cardiology: Editorial Comment Source Type: journals

Nano Bubble Gum For Enhancing Drug Delivery In GutEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Of the many characteristic traits a drug can have, one of the most desirable is the ability for a drug to be swallowed and absorbed into the bloodstream through the gut. Some drugs, like over-the-counter aspirin, lend themselves to this mode of delivery and are trivial to take. They can be pressed into a pill and swallowed. Other drugs cannot be swallowed and must be administered instead through more complicated routes. Insulin, for instance, must be injected. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 12, 2009 Category: Science Source Type: news

Prothrombotic and Hemorrhagic Effects of AspirinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the prothrombotic effects described in recent observational studies are likely produced by a direct effect of aspirin, whose putative mechanism involving COX 2 inhibition remains poorly understood. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 12, 2009 Category: Hematology Authors: Aguejouf, O., Eizayaga, F., Desplat, V., Belon, P., Doutremepuich, C. Tags: Articles Source Type: journals

Use of Aspirin Versus Clopidogrel Plus Aspirin After Coronary Artery Bypass Graft SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aspirin and clopidogrel together reduce the risk of recurrent thrombosis-related events in patients with acute coronary syndromes or stent revascularization and may reduce thrombosis-induced saphenous vein graft failure. In this retrospective, observational study, 4297 patients were assigned to 2 groups after coronary artery bypass graft surgery, based on medications prescribed at hospital discharge: aspirin only (n = 3318) or aspirin plus clopidogrel (n = 979). At 4-year follow-up, unadjusted survival was similar between the 2 groups (aspirin—clopidogrel, 87.9% vs aspirin-only, 88.8%, P = .43). After statistical adj...
Source: Clinical and Applied Thrombosis/Hemostasis - November 12, 2009 Category: Hematology Authors: Sanon, S., Lee, V.-V., Elayda, M., Wilson, J. M. Tags: Articles Source Type: journals

Influence of antiplatelet pre-treatment on the risk of intracranial haemorrhage in acute ischaemic stroke after intravenous thrombolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pre-treatment with AP is associated with an increased risk of PH after intravenous thrombolysis in patients with acute ischaemic stroke. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 12, 2009 Category: Neurology Authors: L. Dorado, M. Millán, N. Pérez de la Ossa, C. Guerrero, M. Gomis, E. López-Cancio, A. C. Ricciardi, A. Dávalos Source Type: journals

No Benefits of Aspirin for Primary Prevention in Diabetics, Meta-Analysis SuggestsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Most guideline documents recommend aspirin for primary prevention in people with diabetes, but a new meta-analysis has found no benefit of the widely used drug across a range of different cardiovascular end points. The results speak to the need for dedicated randomized trials, investigators say. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 11, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Aspirin: Intracranial haemorrhage in elderly patients: 3 case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Aspirin/enoxaparin sodium: Retroperitoneal haematoma in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Aspirin/warfarin: Spontaneous suprachoroidal haemorrhage in an elderly patient with ARMD: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Self-medication with over-the-counter drugs and complementary medications in South Australia's elderly populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Participants seemed to self-medicate in accordance with approved indications, suggesting they were informed consumers, actively looking after their own health. However, use of analgesics and aspirin are associated with an increased risk of adverse drug events in the elderly. Future work should examine how self-medication contributes to polypharmacy and increases the risk of adverse drug reactions. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - November 11, 2009 Category: Complementary Medicine Authors: Lynn Yeen GohAgnes VitrySusan SempleAdrian EstermanMary Luszcz Source Type: journals

The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report we demonstrate for the first time that, when administered in combination, TGZ and ASA can produce a strong synergistic effect in growth inhibition and G1 arrest in lung cancer CL1-0 and A549 cells. Examination by colony formation assay revealed an even more profound synergy. In Western blot, combined TGZ and ASA also could downregulate Cdk2, E2F-1, cyclin B1, cyclin D3 protein, and the ratio of phospho-Rb/Rb. Importantly, apoptosis was synergistically induced by the combination treatment, as evidenced by caspase-3 activation and PARP cleavage. The involvement of PI3K/Akt inhibition and p27 upregulation, as w...
Source: Molecular Carcinogenesis - November 11, 2009 Category: Molecular Biology Authors: Kun-Huang Yan, Chih-Jung Yao, Hwan-You Chang, Gi-Ming Lai, Ann-Lii Cheng, Shuang-En Chuang Source Type: journals

No benefits of aspirin for primary prevention in diabetics, meta-analysis suggestsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Most guideline documents recommend aspirin for primary prevention in people with diabetes, but a new meta-analysis has found no benefit of the widely used drug across a range of different cardiovascular end points. The results speak to the need for dedicated randomized trials, investigators say. (Source: theHeart.org)
Source: theHeart.org - November 10, 2009 Category: Cardiology Source Type: info

No clear benefit of aspirin for primary CV prevention in diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a meta-analysis published in the British Medical Journal show no clear benefit of aspirin therapy for primary prevention of cardiovascular events in individuals with diabetes. (Source: MedWire News - Diabetes)
Source: MedWire News - Diabetes - November 10, 2009 Category: Endocrinology Source Type: news

Enhancing Drug Delivery In Gut Using Nano Bubble GumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Of the many characteristic traits a drug can have, one of the most desirable is the ability for a drug to be swallowed and absorbed into the bloodstream through the gut. Some drugs, like over-the-counter aspirin, lend themselves to this mode of delivery and are trivial to take. They can be pressed into a pill and swallowed. Other drugs cannot be swallowed and must be administered instead through more complicated routes. Insulin, for instance, must be injected. (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - November 10, 2009 Category: Biochemistry Tags: Medical Devices / Diagnostics Source Type: news

Enhancing Drug Delivery In Gut Using Nano Bubble GumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Of the many characteristic traits a drug can have, one of the most desirable is the ability for a drug to be swallowed and absorbed into the bloodstream through the gut. Some drugs, like over-the-counter aspirin, lend themselves to this mode of delivery and are trivial to take. They can be pressed into a pill and swallowed. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Medical Devices / Diagnostics Source Type: news

Colchicine for the Primary and Secondary Prevention of Pericarditis: An Update(December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Despite limitations in study designs, current evidence suggests a role for colchicine in the secondary prophylaxis for recurrent pericarditis. The evidence for use of colchicine as primary prophylaxis in PPS is indeterminate; therefore, colchicine cannot be recommended routinely. While colchicine should be recommended for the prevention of recurrent pericarditis, questions regarding the optimal regimen and long-term safety profile need to be further elucidated. PMID: 19903861 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 10, 2009 Category: Drugs & Pharmacology Authors: Kuo IF, Pearson GJ, Koshman SL Tags: Ann Pharmacother Source Type: journals

Clopidogrel Benefit Roughly Equal for Women and Men (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unlike aspirin, clopidogrel (Plavix) appears to work about as well in women as it does in men, according to a large meta-analysis. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 9, 2009 Category: Cardiology Source Type: news

Asasantin Retard (dipyridamole 200 mg and aspirin 25 mg) - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC, includes change to: Section 4.4 (Special Warnings and Special Precautions for Use) - A small number of cases have been reported in which unconjugated dipyridamole was shown to be incorporated into gallstones to a variable extent (up to 70% by dry weight of stone). These patients were all elderly, had evidence of ascending cholangitis and had been treated with oral dipyridamole for a number of years. There is no evidence that dipyridamole was the initiating factor in causing gallstones to form in these patients. It is possi...
Source: NeLM - Cardiovascular Medicine - November 9, 2009 Category: Cardiology Source Type: organizations

Evidence of benefit with aspirin for prophylaxis in people with diabetes is uncertainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: BMJ Area: News A meta-analysis of trial data found that in people with diabetes, there was no unequivocal evidence of benefit for primary prevention with low-dose aspirin in reducing major cardiovascular events. The evidence on harms was inconsistent. Low-dose aspirin is generally recommended in guidelines as primary prevention of major cardiovascular events in people with diabetes, although this is based mainly on extrapolation of the results of trials in other high-risk populations. There is limited evidence relating directly to people with diabetes. The aim of this meta-analysis was to identify trial...
Source: NeLM - Cardiovascular Medicine - November 9, 2009 Category: Cardiology Source Type: organizations

No clear benefit of aspirin for primary CV prevention in diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a meta-analysis published in the British Medical Journal show no clear benefit of aspirin therapy for primary prevention of cardiovascular events in individuals with diabetes. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 9, 2009 Category: Cardiology Source Type: news