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Journal Scan: Baseline Heart Rate, Antihypertensive Treatment, and Prevention of Cardiovascular Outcomes in ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) (J Am Coll Cardiol 2009;54:1154-1161.)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors reported data from the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) study, a randomized trial of atenolol ± bendroflumethiazide (atenolol-based) versus amlodipine ± perindopril (amlodipine-based) regimen for treatment of untreated or undertreated hyp. . . (Source: Cardiosource)
Source: Cardiosource - November 6, 2009 Category: Cardiology Source Type: organizations

Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This review concluded that the magnitude of heart rate reduction was statistically significantly associated with the survival benefit of beta-blockers in heart failure, but the dose of beta-blocker was not. The majority of the review process and the synthesis were well conducted. Despite the absence of a validity assessment, the conclusions appear likely to be reliable. [Included studies assessed metoprolol, carvedilol, bisoprolol, bucindolol, nebivolol and atenolol. ] CRD Commentary: The review question was clear and was supported by specific inclusio...
Source: NeLM - Disease Focused Reviews - November 6, 2009 Category: Internal Medicine Source Type: organizations

The challenge of analyzing beta-blocker drugs in sludge and wastewater.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, different approaches were used to assess and overcome the severe effects of interference from the sample matrix from different types of sludges and wastewater on the analysis of nine beta-blockers and the beta sympathomimetic clenbuterol. The partitioning of the target compounds into sludge was investigated in wastewater treatment plants (WWTPs) in both Canada and Germany to evaluate whether this is an important mechanism for removal from sewage. Due to ion suppression in the electro spray interface, absolute recoveries were for certain compounds even lower than 20%. By using surrogate standards, acceptable ...
Source: Analytical and Bioanalytical Chemistry - October 28, 2009 Category: Chemistry Authors: Scheurer M, Ramil M, Metcalfe CD, Groh S, Ternes TA Tags: Anal Bioanal Chem Source Type: journals

Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heartEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vasodilator-stimulated phosphoprotein (VASP) is a major substrate for cyclic nucleotide-dependent kinases that has been implicated in cardiac pathology, yet many aspects of VASP's molecular regulation in cardiomyocytes are incompletely understood. In these studies, we explored the role of VASP, both in signaling pathways in isolated murine myocytes, as well as in a model of cardiac hypertrophy in VASPnull mice. We found that the β-adrenergic agonist isoproterenol promotes the rapid and reversible phosphorylation of VASP at Ser157 and Ser239. Forskolin and the cAMP analog 8-(4-chlorophenylthio)-cAMP promote a similar p...
Source: AJP: Heart and Circulatory Physiology - October 26, 2009 Category: Cardiology Authors: Sartoretto, J. L., Jin, B. Y., Bauer, M., Gertler, F. B., Liao, R., Michel, T. Tags: ARTICLES Source Type: journals

FDA approves Twynsta® (telmisartan plus amlodipine) a new single pill combination that delivers powerful and consistent blood pressure reductions throughout 24 hoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Twynsta® delivers very powerful blood pressure (BP) reductions of up to 40/29 mmHg1 and a 24-hour BP response rate of up to 98%2 for hypertensive patients at risk of cardiovascular (CV) events Twynsta® combines the proven evidence base in CV outcomes of telmisartan and amlodipine3-9in a convenient single pill Twynsta® achieves superior BP reductions compared to amlodipine 10mg and is significantly better tolerated with 71% less peripheral oedema.10160 or DBP >10019 References: 1 Data on file, Boehringer Ingelheim. 2 Littlejohn TW III et al. Telmisartan and amlodipine combination therapy is p...
Source: Boehringer Ingelheim RSS-Newsfeed - October 19, 2009 Category: Research Source Type: organizations

Intracoronary intermedin 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and {beta}-adrenoreceptor-mediated nitric oxide releaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, IMD1–47 primarily augmented coronary blood flow and cardiac function through the involvement of calcitonin-related receptor complexes and β2-adrenoreceptor-mediated NO release. The intracellular signaling involved cAMP-dependent activation of kinases and the opening of K+ channels. (Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - October 15, 2009 Category: Physiology Authors: Grossini, E., Molinari, C., Mary, D. A. S. G., Uberti, F., Caimmi, P. P., Vacca, G. Tags: ARTICLES Source Type: journals

Atenolol/chloroquine/dextropropoxyphene: Cardiotoxicity: 2 case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 12, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Cardiovascular autonomic dysfunction in a novel rodent model of polycystic kidney disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to define the relationship between hypertension and autonomic function in a new rodent model of polycystic kidney disease (PKD). Using measures of heart rate and systolic blood pressure variability (HRV, SBPV), and time domain analysis of cardiac and sympathetic baroreflex function, we compared the Lewis PKD model (LPK) to a Lewis control. Systolic BP and SBPV were significantly higher in LPK vs. Lewis (168+/-7 vs. 131+/-8mm Hg, P</=0.01, total power: 11+/-3.1 vs. 1.3+/-0.3mm Hg/Hz(2), P</=0.05). LPK has a higher resting HR (437+/-17 vs. 330+/-11 beats per minute [bpm], P</=0.001) associated with ...
Source: Autonomic Neuroscience - October 11, 2009 Category: Neuroscience Authors: Harrison JL, Hildreth CM, Callahan SM, Goodchild AK, Phillips JK Tags: Auton Neurosci Source Type: journals

Intravenous Lipid Emulsion as Antidote (review)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Available data, though limited, suggest that ILE may be beneficial in treating life-threatening cardiotoxicity induced by highly lipophilic drugs. Physicians managing these cases should follow established guidelines and consult at an early stage with a poison center. (66 references) COMMENT: This thoughtful review is well worth reading. Although ILE is not yet ready for routine use in the early stages of resuscitation, many toxicologists would recommend it as a last-ditch effort when a lipophilic drug has caused cardiovascular collapse not improved by standard treatment. The strongest statement to this ...
Source: The Poison Review - October 2, 2009 Category: Toxicology Authors: Leon Tags: Medical antidote intravenous lipid emulsion Source Type: info

Gas chromatography-mass spectrometry method for determination of metoprolol in the patients with hypertension.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A sensitive and efficient method was developed for determination of metoprolol in human plasma by gas chromatography-mass spectrometry (GC-MS). Metoprolol and atenolol (internal standard, IS) were extracted from human plasma with a mixture of ethylacetate and diethylether at basic pH with liquid-liquid extraction. Calibration curves were linear over the concentration range 15-500 ng/ml. Intra- and inter-day precision values for metoprolol in human plasma were less than 6.4, and accuracy (relative error) was better than 8.8%. The analytical recovery of metoprolol from human plasma averaged 91.20%. The limits of detectio...
Source: Talanta - September 30, 2009 Category: Chemistry Authors: Yilmaz B, Arslan S, Akba V Tags: Talanta Source Type: journals

Atenolol: Hyperkalaemia: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 30, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Amlodipine achieves greater reduction in carotid BP than atenololEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The calcium channel blocker amlopidine achieves greater reduction in systolic cartotid blood pressure in patients with hypertension than the beta blocker atenolol, study results show. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - September 28, 2009 Category: Cardiology Source Type: news

Atenolol Hepatotoxicity: Report of a Complicated Case (October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Despite the fact that beta-blocker-induced hepatotoxicity is probably extremely rare, it must be suspected and the drug therefore discontinued. PMID: 19776295 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 22, 2009 Category: Drugs & Pharmacology Authors: Dumortier J, Guillaud O, Gouraud A, Pittau G, Vial T, Boillot O, Scoazec JY Tags: Ann Pharmacother Source Type: journals

Beta-blocker use challenged as first-line antihypertensive therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study results show that for patients with hypertension uncomplicated by coronary heart disease, amlodipine is superior to atenolol treatment in preventing cardiovascular events and procedures even in patients with high heart rates. (Source: MedWire News - Hypertension)
Source: MedWire News - Hypertension - September 21, 2009 Category: Cardiology Source Type: news

Beta-blocker use challenged as first-line antihypertensive therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study results show that for patients with hypertension uncomplicated by coronary heart disease, amlodipine is superior to atenolol treatment in preventing cardiovascular events and procedures even in patients with high heart rates. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - September 21, 2009 Category: Cardiology Source Type: news

Effect Of Antihypertensive Drug Therapy On Short-Term Heart Rate Variability In Newly Diagnosed Essential Hypertension.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY 1. Abnormalities of cardiac autonomic regulation are a potential mechanism for morbidity despite blood pressure (BP) lowering in hypertension. Analysis of short-term (5 min) heart rate variability provides a noninvasive probe of autonomic regulation of SA node automaticity. 2. We hypothesized that antihypertensive drug therapy would be associated with an increase in 5 min overall HRV along with a decrease in blood pressure (BP), at 8 weeks follow up in subjects with newly diagnosed, never treated essential hypertension. 3. 150 subjects [84 males; 66 females; aged 48 +/- 10 years (mean +/- SD)] with newly diagno...
Source: Clinical and Experimental Pharmacology and Physiology - September 20, 2009 Category: Drugs & Pharmacology Authors: Pavithran P, Prakash ES, Dutta TK, Madanmohan T Tags: Clin Exp Pharmacol Physiol Source Type: journals

Baseline Heart Rate, Antihypertensive Treatment, and Prevention of Cardiovascular Outcomes in ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: There was no evidence that the superiority of amlodipine-based over atenolol-based therapy for patients with hypertension uncomplicated by coronary heart disease was attenuated with higher baseline heart rate. These data suggest that, in similar hypertensive populations without previous or current coronary artery disease, higher baseline heart rate is not an indication for preferential use of beta-blocker–based therapy. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - September 16, 2009 Category: Cardiology Authors: Neil R. Poulter, Joanna E. Dobson, Peter S. Sever, Björn Dahlöf, Hans Wedel, Norm R.C. Campbell, ASCOT Investigators Tags: Hypertension Source Type: journals

Glucagon treatment for bradycardia and a junctional rhythm caused by excessive beta-blockadeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 68-year-old female with a history of coronary artery disease and hypertension presented with a 3h history of lightheadedness and chest discomfort. She was transported to hospital by the emergency medical service. On her arrival she was talking and in obvious discomfort. Her heart rate was 36min−1 and her blood pressure was 72/40mm Hg. The initial physical examination was otherwise unremarkable. The patient's husband informed us of her current medications. These included 50mg oral atenolol twice daily. There had been no recent changes in her medications and there was no suggestion that the patient had taken an overdose....
Source: Resuscitation - September 10, 2009 Category: Emergency Medicine Authors: Michael J. Bindon, Kevin Barlotta Tags: Letters to the Editor Source Type: journals

Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The highly lipophilic β1-selective β-blocker metoprolol, known to prevent ventricular fibrillation via central nervous system-mediated vagal activation, may be especially beneficial to DCM patients showing a family history of frequent sudden cardiac death, such as those with a deletion mutation K210 in the TNNT2 gene. (Source: Cardiovascular Research)
Source: Cardiovascular Research - September 9, 2009 Category: Cardiology Authors: Zhan, D.-Y., Morimoto, S., Du, C.-K., Wang, Y.-Y., Lu, Q.-W., Tanaka, A., Ide, T., Miwa, Y., Takahashi-Yanaga, F., Sasaguri, T. Tags: ORIGINAL ARTICLES Source Type: journals

Comparison of Office, Ambulatory, and Home Blood Pressure Antihypertensive Response to Atenolol and HydrochlorthiazideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J Clin Hypertens (Greenwich). Office, home, and ambulatory blood pressure (BP) demonstrate variable associations with outcomes. The authors sought to compare office BP (OBP), home BP (HBP), and ambulatory BP (ABP) for measuring responses to hydrochlorothiazide (HCTZ), atenolol, and their combination. After completing washout, eligible patients were randomized to atenolol 50 mg or HCTZ 12.5 mg daily. Doses were doubled after 3 weeks and the alternate drug was added after 6 weeks if BP was >120/70 mm Hg (chosen to allow maximum opportunity to assess genetic associations with dual BP therapy in the parent study). OBP (in trip...
Source: The Journal of Clinical Hypertension - September 9, 2009 Category: Cardiology Authors: Amber L. Beitelshees, Yan Gong, Kent R. Bailey, Stephen T. Turner, Arlene B. Chapman, Gary L. Schwartz, John G. Gums, Eric Boerwinkle, Julie A. Johnson Source Type: journals

Gingival overgrowth secondary to amlodipine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 66-year-old Asian woman attended for optimization of blood pressure control. Prescribed medication included atenolol (50 mg once daily), bendrofluazide (2.5 mg once daily) and amlodipine (5 mg once daily). She complained of gingival overgrowth, occurring several months after starting amlodipine (Figure 1). PMID: 19749649 [PubMed - as supplied by publisher] (Source: British Journal of Hospital Medicine)
Source: British Journal of Hospital Medicine - September 8, 2009 Category: Internal Medicine Authors: Dubrey SW, Grocott-Mason R Tags: Br J Hosp Med (Lond) Source Type: journals

Use of atenolol in pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: National Teratology Information Service (NTIS) Area: Evidence > Drugs in Pregnancy SUMMARY: Atenolol is a cardioselective (beta1 selective) beta adrenoceptor blocking drug licensed for the treatment of hypertension, angina pectoris, cardiac dysrhythmia, and for early intervention in the acute phase of myocardial infarction. To date, use of atenolol during pregnancy has not been conclusively associated with an increased risk of structural fetal malformations. Some recent studies have suggested a possible increased risk of congenital heart defects associated with antihypertensive therapy including beta adrenoceptor ...
Source: NeLM - Drugs in Pregnancy - September 3, 2009 Category: OBGYN Source Type: organizations

Regulation of VASP phosphorylation in cardiac myocytes: Differential regulation by cyclic nucleotides and modulation of protein expression in heart.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vasodilator-stimulated phosphoprotein (VASP) is a major substrate for cyclic nucleotide-dependent kinases that has been implicated in cardiac pathology, yet many aspects of VASP's molecular regulation in cardiomyocytes are incompletely understood. In these studies, we explored the role of VASP both in signaling pathways in isolated murine myocytes as well as in a model of cardiac hypertrophy in VASPnull mice. We found that the beta adrenergic agonist isoproterenol promotes the rapid and reversible phosphorylation of VASP at Ser157 and Ser239. Forskolin and the cAMP analog 8-CPT-cAMP promote a similar pattern of VASP ph...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 3, 2009 Category: Physiology Authors: Sartoretto JL, Jin BY, Bauer M, Gertler FB, Liao R, Michel T Tags: Am J Physiol Heart Circ Physiol Source Type: journals

Procaterol Inhibits Lung Fibroblast MigrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Fibroblasts are important cells that are involved in modulation of fibrosis after injuries. In some uncontrollable inflammatory processes, excess fibroblasts migrate around the small airway. The pathogenesis of chronic obstructive pulmonary disease is related to fibrosis around the small airways. The aim of the current study was to investigate the effect of procaterol, a second-generation beta (2)-agonist, on migration of human fetal lung fibroblasts (HFL-1) induced by human plasma fibronectin (HFn). Using the blindwell chamber technique, 10−8 M procaterol inhibited migration of HFL-1 (contro...
Source: Inflammation - September 3, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Production and Secretion of Adiponectin from 3T3-L1 Adipocytes: Comparison of Antihypertensive Drugs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionIn this comparative model, telmisartan, and to a lesser extent, losartan, increased production and secretion of adiponectin from 3T3-L1 adipocytes compared to the other antihypertensive drugs.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.171. PMID: 19730415 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 2, 2009 Category: Cardiology Authors: Brody R, Peleg E, Grossman E, Sharabi Y Tags: Am J Hypertens Source Type: journals

Survival among patients with left ventricular systolic dysfunction treated with atenolol.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metoprolol succinate, carvedilol, and bisoprolol are approved for use in heart failure. Other beta-blockers have been found to be inferior (metoprolol tartrate) or have not been studied (atenolol). The authors compared all-cause mortality following treatment with either atenolol, carvedilol, or metoprolol tartrate for 974 patients with left ventricular function < or =40%. The unadjusted mortality at 6 months was lower with atenolol (3.2%) and carvedilol (4.2%) when compared with metoprolol tartrate (7.5%, P< or =.039). However, patients with atenolol were older but had less prior heart failure. After adjustment f...
Source: Congestive Heart Failure - August 31, 2009 Category: Cardiology Authors: Kapoor JR, Heidenreich PA Tags: Congest Heart Fail Source Type: journals

Frequency and Risk Factors for Posttransplant Diabetes Mellitus in Iranian Renal Transplant PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was performed to determine the prevalence of and risk factors for PTDM among Iranian renal transplant recipients. In this cross-sectional study, 300 patients were studied in 2007. It included questionnaires with clinical data and blood samples. PTDM was defined as DM without a pretransplant history. The 184 (61.3%) male and 116 (38.7%) female patients of overall mean age of 41.2 ± 13.5 years were 67.4 ± 48.6 months after the procedure. PTDM was observed in 24 patients (8%). The mean interval to develop PTDM was 19.9 ± 31.5 months. The mean age of PTDM patients was significantly higher than non-PTDM patients: ...
Source: Transplantation Proceedings - August 31, 2009 Category: Transplant Surgery Authors: S. Ossareh, S. Naseem, M.A. Faraji, M. Bahrami Asl, A. Yousefnejad Tags: Kidney Transplantation Source Type: journals

Quiz Page September 2009: Long-standing High-Renin Hypertension and HypokalemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 43-year-old white woman was evaluated for uncontrolled hypertension, progressive weakness, and fatigue. High blood pressure (BP) was diagnosed at the age of 28 years during the first trimester of pregnancy. A caesarean section was performed at week 37 for intrauterine growth retardation and preeclampsia. From 1993 through 2007, her BP was poorly controlled, first on atenolol and indapamide therapy, and then on candesartan and nebivolol therapy. Canrenoate was not tolerated because of nausea and abdominal pain. Her course also has been notable for persistent hypokalemia, with potassium values ranging from 2.8 to 3.2 mEq/L...
Source: American Journal of Kidney Diseases - August 26, 2009 Category: Urology & Nephrology Tags: Frontmatter Source Type: journals

Impact of Heart Rate on Central Aortic Pressures and Hemodynamics: Analysis From the CAFE (Conduit Artery Function Evaluation) Study: CAFE-Heart RateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: When comparing beta-blocker–based treatments with other BP-lowering strategies, HR reduction with beta-blockers is a major mechanism accounting for less effective central aortic pressure reduction per unit change in brachial pressure. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - August 13, 2009 Category: Cardiology Authors: Bryan Williams, Peter S. Lacy, CAFE and the ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Investigators Tags: Arterial Reflections and Stiffness Source Type: journals

Effect of Nebivolol and Atenolol on Brachial Artery Flow-Mediated Vasodilation in Patients with Coronary Artery DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s10557-009-6187-2Authors John P. Lekakis, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceAthanassios Protogerou, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceChristos Papamichael, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceGeorgia Vamvakou, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceIgnatios Ikonomidis, Athens University Department of Clinical Therapeuti...
Source: Cardiovascular Drugs and Therapy - August 12, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol compared to respective monotherapies in healthy subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate any influence on olmesartan plasma pharmacokinetics from amlodipine or atenolol. We analysed pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol compared to respective monotherapies in two separate studies. In one study, 18 subjects received once daily treatment for 7 days with olmesartan medoxomil 20 mg alone or with amlodipine 5 mg or amlodipine 5 mg alone. In the other study, atenolol 50 mg once daily replaced amlodipine. Concentration vs. time profiles for olmesartan monotherapy were similar to combination therapy. Mean olmesarta...
Source: Fundamental and Clinical Pharmacology - July 30, 2009 Category: Drugs & Pharmacology Authors: Juliane Bolbrinker, Matthias Huber, Jürgen Scholze, Reinhold Kreutz Source Type: journals

Head dizzyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: HHH Posted: Wed Jul 29, 2009 11:04 pm For the past month ive been fealing really dizzy and with every step i take walking it feals like my brain is rocking against my head. Every time i move my eyes i can hear something like fluid in my right ear. I though it was fluid in my ear and went to doc and got antibiotics but its still there. I was on every pain pill there is for 10 years. Ive been on suboxone for 7 months. Im down to 4mg a day. Im also on 50mg of atenolol for high blood pressure. I know that its not my BP med because i just was put on 25mg more and...
Source: Suboxone Forum - July 29, 2009 Category: Addiction Source Type: forums

Serial evaluation of electrocardiographic left ventricular hypertrophy for prediction of risk in hypertensive patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Regression of ECG LVH by Cornell product and/or Sokolow-Lyon voltage criteria during antihypertensive therapy is associated with lower likelihoods of CV morbidity and mortality, all-cause mortality, and new-onset diabetes, independent of blood pressure lowering and treatment modality in essential hypertension. These findings suggest that antihypertensive therapy targeted at regression or prevention of ECG LVH may improve prognosis. (Source: Journal of Electrocardiology)
Source: Journal of Electrocardiology - July 26, 2009 Category: Cardiology Authors: Peter M. Okin Tags: Session VI: Left Ventricular Hypertrophy: ECG-LVM Discrepancies - Co-Chairs: Ljuba Bacharova/Ian Rowlandson Source Type: journals

Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological ResponseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The expression of several genes not previously identified as part of the adrenergic signaling pathway changed in response to a single oral dose of atenolol. Variation in these genes could contribute to unexplained differences in response to [beta]-blockers. (Source: Archives of Drug Information)
Source: Archives of Drug Information - July 20, 2009 Category: Drugs & Pharmacology Authors: Utkarsh Kohli, Britney L. Grayson, Thomas M. Aune, Laxmi V. Ghimire, Daniel Kurnik, C. Michael Stein Source Type: journals

Investigation of enantiomeric separation of basic drugs by capillary electrophoresis using clindamycin phosphate as a novel chiral selectorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study clindamycin phosphate belonging to the group of lincomycin antibiotics is first used as a novel chiral selector for the enantiomeric separations of several racemic basic drugs, which possess high separability, consisting of nefopam, citalopram, tryptophan, chlorphenamine and propranolol. Other basic drugs giving partial enantioseparation include tryptophan methyl ester, metoprolol and atenolol. Clindamycin phosphate possesses advantages such as high solubility and low viscosity in the water and very weak UV absorption. In the course of this work we observed that both migration time and enantioseparation were ...
Source: Electrophoresis - July 19, 2009 Category: Biochemistry Authors: Bin Chen, Yingxiang Du, Ping Li Source Type: journals

Antihypertensive drugs and central blood pressureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Recent evidence suggests that central blood pressure is a more important determinant of cardiovascular risk than brachial pressure. Interestingly, antihypertensive drugs exert different effects on brachial and central pressure. Traditional β-blockers, such as atenolol, appear to have an adverse impact on central pressure, despite lowering brachial pressure. This may help to explain the results of recent large outcome studies using atenolol. Further research is required to clarify whether other antihypertensive agents lower central pressure beyond the effects observed on brachial pressure. Conten...
Source: Current Hypertension Reports - July 14, 2009 Category: Primary Care Tags: Current Hypertension Reports Source Type: journals

“In-house” pharmacological management for computed tomography coronary angiography: heart rate reduction, timing and safety of different drugs used during patient preparationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We retrospectively evaluated the effect, timing and safety of different pharmacological strategies during 64-slice CT coronary angiography (CT-CA). From the institutional database of CT-CA we enrolled 560 consecutive patients with suspected coronary artery disease. The type of drug preparation (group 1 = no treatment; group 2 = oral metoprolol; group 3 = other; group 4 = intravenous (IV) atenolol; group 5 = IV atenolol + nitrates; NR = non-responders), timing, and adverse effects were recorded. Heart rate (HR) during different preparation phases was recorded. Four adverse effects were record...
Source: European Radiology - July 14, 2009 Category: Radiology Tags: European Radiology Source Type: journals

Effect of Metformin on Weight Gain During Antihypertensive Treatment With a beta-Blocker in Chinese Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionsCombination therapy of nitrendipine and atenolol may significantly increase BW and fasting BG in overweight or obese patients with hypertension. Metformin may prevent BW gain and improve BG levels in hypertensive patients who received combination therapy of nitrendipine and atenolol.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.93American Journal of Hypertension 2009; doi:10.1038/ajh.2009.93. PMID: 19574961 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - July 1, 2009 Category: Cardiology Authors: Zhang JL, Zheng X, Zou DJ, Qiu JL, Zhao XX, Qin YW Tags: Am J Hypertens Source Type: journals

Hydrochlorothiazide and Atenolol Combination Antihypertensive Therapy: Effects of Drug Initiation Order.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For combination antihypertensive therapy with thiazide diuretics and beta-blockers, the effect of the order of initiation of the drugs on the outcome has not been tested. Patients with uncomplicated hypertension were randomized to receive either hydrochlorothiazide (HCTZ) or atenolol monotherapy, followed by addition of the alternative drug. Blood pressure (BP) responses were evaluated by race and order of drug initiation. A total of 368 participants received combination therapy. Among the participants, blacks showed a greater BP-lowering effect than whites did with HCTZ monotherapy (-13.0/-7.4 mm Hg vs. -8.0/-4.2 mm H...
Source: Clinical Pharmacology and Therapeutics - June 30, 2009 Category: Drugs & Pharmacology Authors: Johnson JA, Gong Y, Bailey KR, Cooper-Dehoff RM, Chapman AB, Turner ST, Schwartz GL, Campbell K, Schmidt S, Beitelshees AL, Boerwinkle E, Gums JG Tags: Clin Pharmacol Ther Source Type: journals

Combination pharmacotherapy in the treatment of experimental cardiac arrestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The administration of a drug combination of epinephrine + atenolol + levosimendan, when given during CPR, in a pig model of cardiac arrest, results in improved 48-hour survival and improves postresuscitation cardiac function. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - June 30, 2009 Category: Emergency Medicine Authors: Theodoros Xanthos, Eleni Bassiakou, Eleni Koudouna, Georgios Rokas, Sotirios Goulas, Ismene Dontas, Evaggelia Kouskouni, Despina Perrea, Lila Papadimitriou Tags: Original Contributions Source Type: journals

Exercise Tolerance After Beta Blockade in Recent Cardiac Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study showed little adverse effect on exercise tolerance by beta blockade in recently transplanted patients. Atenolol seemed to be safe in this context. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - June 30, 2009 Category: Transplant Surgery Authors: F. Buendía Fuentes, L. Almenar Bonet, L. Martínez-Dolz, M.J. Sancho-Tello de Carranza, J. Moro López, J. Agüero Ramón-Llin, I. Sánchez-Lázaro, J.M. Sánchez-Gómez, R. Raso Raso, J. Navarro Manchón, A. Salvador Sanz Tags: Thoracic Transplantation Source Type: journals

Sertraline-Induced Rhabdomyolysis in an Elderly Patient with Dementia and Comorbidities (July/August).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy. PMID: 19567656 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 29, 2009 Category: Drugs & Pharmacology Authors: Gareri P, Segura-García C, De Fazio P, De Fazio S, De Sarro G Tags: Ann Pharmacother Source Type: journals

Catecholaminergic automatic activity in the rat pulmonary vein: electrophysiological differences between cardiac muscle in the left atrium and pulmonary veinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ectopic activity in cardiac muscle within pulmonary veins (PVs) is associated with the onset and the maintenance of atrial fibrillation in humans. The mechanism underlying this ectopic activity is unknown. Here we investigate automatic activity generated by catecholaminergic stimulation in the rat PV. Intracellular microelectrodes were used to record electrical activity in isolated strips of rat PV and left atrium (LA). The resting cardiac muscle membrane potential was lower in PV [–70 ± 1 (SE) mV, n = 8] than in LA (–85 ± 1 mV, n = 8). No spontaneous activity was recorded in PV or LA under basal ...
Source: AJP: Heart and Circulatory Physiology - June 28, 2009 Category: Cardiology Authors: Doisne, N., Maupoil, V., Cosnay, P., Findlay, I. Tags: ARTICLES Source Type: journals

Postmyocardial infarction remodeling and coronary reserve: effects of ivabradine and beta blockade therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, 1) Iva has advantages over Aten in postinfarction therapy that are not due to differential effects of the drugs on heart rate, and 2) age limits growth factor upregulation, angiogenesis, and arteriogenesis in the postinfarcted heart. (Source: AJP: Heart and Circulatory Physiology)
Source: AJP: Heart and Circulatory Physiology - June 28, 2009 Category: Cardiology Authors: Christensen, L. P., Zhang, R.-l., Zheng, W., Campanelli, J. J., Dedkov, E. I., Weiss, R. M., Tomanek, R. J. Tags: ARTICLES Source Type: journals

Beta blockers for peripheral arterial disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Currently, there is no evidence to suggest that beta blockers adversely affect walking distance in people with intermittent claudication. Beta blockers should be used with caution if clinically indicated, especially in patients with critical ischaemia where acute lowering of blood pressure is contraindicated. PMID: 19359199 [PubMed - in process] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - June 27, 2009 Category: Surgery Authors: Paravastu SC, Mendonca DA, da Silva A Tags: Eur J Vasc Endovasc Surg Source Type: journals

Combination of amlodipine and enalapril in hypertensive patients with coronary diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The fixed combination of enalapril and amlodipine, as well as isolated amlodipine, was effective in the normalization of BP in pts with CAD and SAH stages I and II, adding blockage of the renin-angiotensin system.FUNDAMENTO: Pacientes (pts) con enfermedad coronaria (EAC) estable pueden beneficiarse con una menor presión arterial (PA), de acuerdo con estudios recientes. OBJETIVO: Evaluar la eficacia y la tolerancia de la combinación fija amlodipino + enalapril, comparada a el amlodipino en la normalización de la PA diastólica (PAD) (< 85 mmHg), en pts con EAC y HAS. MÉTODOS: Estudio doble ciego, randomizado...
Source: Arquivos Brasileiros de Cardiologia - June 25, 2009 Category: Cardiology Source Type: journals

Fractal properties of human heart period variability: physiological and methodological implications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fractal frequency scaling of heart period variability is used as a concise index of overall cardiac control. However, no prior study has assessed within-individual reproducibility of fractal indices of heart period, or reported how the estimated indices respond to autonomic blockade. Therefore, we examined fractal properties of the heart period from ten young, healthy individuals during three separate experimental sessions under control (saline) conditions and twice under combined autonomic blockade (atenolol and atropine sulfate) conditions. Under each condition, R-R intervals were recorded with the subject in the sup...
Source: The Journal of Physiology - June 14, 2009 Category: Physiology Authors: Tan CO, Cohen MA, Eckberg DL, Taylor JA Tags: J Physiol Source Type: journals

Wide Disparity Found in Drug Prices for Diabetes PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
July 11, 2009 (Newswise) - New research from Mount Sinai School of Medicine has found that the price in New York and New Jersey of the medications most commonly prescribed for patients with diabetes varies widely depending on where you shop. Researchers found that the combined cost of a 30-day supply of the ten medications most used by diabetics varied from a low of $428.35 at Medco by Mail up to $641.90 at Rite Aid. The study is of out-of-pocket costs for people who do not have prescription drug insurance. Ronald Tamler, MD, PhD, MBA, Assistant Professor of Medicine, Division of Endocrinology and Diabetes, and Clifton...
Source: Diabetes News from dLife.com - June 11, 2009 Category: Consumer Health News Authors: dlife Source Type: info

Case Study: A 64-Year-Old Female Presents With Chest Pain of 3 Hours' Duration and an ECG Consistent With Acute Anterior MIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This 64-year-old with a history of hypertension, managed with atenolol 100 mg daily, presented with 3 hours of chest pain and electrocardiographic (ECG) evidence of an acute anterior MI. She underwent immediate percutaneous coronary intervention (PCI) of an occluded left anterior descending artery. . . . (Source: Cardiosource)
Source: Cardiosource - June 10, 2009 Category: Cardiology Source Type: organizations

Pulse pressure and risk of cardiovascular outcomes in patients with hypertension and coronary artery disease: an INternational VErapamil SR-trandolapril STudy (INVEST) analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In CAD patients with hypertension, PP (on anti-hypertensive treatment) is a weaker predictor of cardiovascular outcomes than SBP, DBP, or MAP. (Source: European Heart Journal)
Source: European Heart Journal - June 1, 2009 Category: Cardiology Authors: Bangalore, S., Messerli, F. H., Franklin, S. S., Mancia, G., Champion, A., Pepine, C. J. Tags: Prevention and epidemiology Source Type: journals