Women's reproductive risk score and healthy lifestyle modification in cardiovascular disease: findings from the UK Biobank.
This study was performed to construct a reproductive risk score (RRS) to measure reproductive status, examine the association between RRS and CVD, and explore the modification effect of healthy lifestyle on the association in women in the UK Biobank cohort. (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Ninghao Huang, Nan Li, Zhenhuang Zhuang, Zimin Song, Wenxiu Wang, Xue Dong, Wendi Xiao, Yueying Li, Yimin Zhao, Tao Huang Source Type: research
Association between Progression of coronary artery calcification and development of kidney failure with replacement therapy: Findings from KNOW-CKD Study
High coronary artery calcification (CAC) burden is a significant risk factor for adverse cardiovascular and kidney outcomes. However, it is unknown whether changes in the coronary atherosclerotic burden can accompany changes in kidney disease progression. Here, we evaluated the relationship between CAC progression and the risk of kidney failure with replacement therapy (KFRT). (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Sue Kyung Park, Kyu Beck Lee, Ji Yong Jung, Jong Cheol Jeong, Kook-Hwan Oh, Shin-Wook Kang, Seung Hyeok Han, KNOW-CKD (KoreaN Cohort Study for Outcomes in Patients With Chronic Kidne Source Type: research
Dietary n-3 alpha-linolenic and n-6 linoleic acids modestly lower serum lipoprotein(a) concentration but differentially influence other atherogenic lipoprotein traits: a randomized trial
Lipoprotein(a) [Lp(a)] is a causal, genetically determined cardiovascular risk factor. Limited evidence suggests that dietary unsaturated fat may increase serum Lp(a) concentration by 10 –15%. Linoleic acid may increase Lp(a) concentration through its endogenous conversion to arachidonic acid, a process regulated by the fatty acid desaturase (FADS) gene cluster. We aimed to compare the Lp(a) and other lipoprotein trait-modulating effects of dietary alpha-linolenic (ALA) and linole ic acids (LA). Additionally, we examined whether FADS1 rs174550 genotype modifies Lp(a) responses. (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Petrus Nuotio, Maria A. Lankinen, Topi Meuronen, Vanessa D. de Mello, Taisa Sallinen, Kirsi A. Virtanen, Jussi Pihlajam äki, Markku Laakso, Ursula Schwab Source Type: research
The current landscape for diabetes treatment: Preventing diabetes-associated CV risk
Despite the risk of atherosclerosis has progressively declined over the past few decades, subjects with type 2 diabetes mellitus (T2DM) continue to experience substantial excess of atherosclerotic cardiovascular disease (ASCVD)-related events. Therefore, there is urgent need to treat ASCVD disease in T2DM earlier, more intensively, and with greater precision. Many factors concur to increase the risk of atherosclerosis, and multifactorial intervention remains the basis for effective prevention or reduction of atherosclerotic events. (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Angela Dardano, Cristina Bianchi, Monia Garofolo, Stefano Del Prato Source Type: research
Impact of NF- κB Signaling and Sirtuin-1 Protein for Targeted Inflammatory Intervention
This study uncovers the structural intricacies of the NF-κB proteins and highlights the key role of SIRT1 in NF-kB signaling pathway regulation. Particularly the Rel Homology Domain (RHD), elucidating interactions and the regulatory mechanisms involving inhibitory proteins like IκB and p100 within the NF-κB signaling cascade. Disruption of the pathway is important in uncontrolled inflammation and immune disorders. This study extensively describes the role connections of canonical and non-canonical signaling pathways of NF-κB with inflammatory and cellular responses. SIRT1 belongs to the class III histone deacetylase, v...
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Sagar Das Tuhin Mukherjee Satyajit Mohanty Nikita Nayak Payel Mal Sumel Ashique Radheshyam Pal Sourav Mohanto Himanshu Sharma Source Type: research
Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204
Front Physiol. 2024 Apr 4;15:1327794. doi: 10.3389/fphys.2024.1327794. eCollection 2024.ABSTRACTRedox processes can modulate vascular pathophysiology. The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress adaptation, and structural remodeling. However, both protective and deleterious vascular effects have been reported for PDIA1, depending on the cell type and underlying vascular condition. Further understanding of this question is hampered by the poorly studied mechanisms underlyi...
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Leonardo Y Tanaka Sandeep Kumar Lucas F Gutierre Celso Magnun Daniela Kajihara Dong-Won Kang Francisco R M Laurindo Hanjoong Jo Source Type: research
Enrichment of type 1 innate lymphoid cells in the course of human atherosclerotic plaque development suggests contribution to atherogenesis
DISCUSSION: The high abundance of ILC1s in the early stages and further significant enrichment in later stages, suggest they may participate in the initiation and development of atherogenesis, and thus, may represent a novel target to prevent or treat atherosclerosis.PMID:38638438 | PMC:PMC11024276 | DOI:10.3389/fimmu.2024.1354617 (Source: Atherosclerosis)
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Kartika R Pertiwi Marcel B M Teunissen Gabrielle Krebbers Martine C M Willems Laurens Huisman Cindy Poelen Allard C van der Wal Onno J de Boer Source Type: research
Endovascular Treatment of a Contained Rupture of a Penetrating Aortic Ulcer in a Young Patient
Cureus. 2024 Mar 18;16(3):e56428. doi: 10.7759/cureus.56428. eCollection 2024 Mar.ABSTRACTPenetrating aortic ulcer (PAU) is a component of acute aortic syndromes (AASs), encompassing a range of potentially life-threatening aortic conditions such as dissection, intramural hematoma (IMH), and PAU itself. Ruptured PAU constitutes an emergency requiring surgical intervention. Here, we present a case involving a 47-year-old male patient admitted to our emergency department due to severe abdominal pain, malaise, and tenderness of the abdominal wall, which commenced abruptly several hours prior. An emergency CT scan revealed a la...
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Alexander T Daskalov Source Type: research
Biomechanics-mediated endocytosis in atherosclerosis
Front Cardiovasc Med. 2024 Apr 4;11:1337679. doi: 10.3389/fcvm.2024.1337679. eCollection 2024.ABSTRACTBiomechanical forces, including vascular shear stress, cyclic stretching, and extracellular matrix stiffness, which influence mechanosensitive channels in the plasma membrane, determine cell function in atherosclerosis. Being highly associated with the formation of atherosclerotic plaques, endocytosis is the key point in molecule and macromolecule trafficking, which plays an important role in lipid transportation. The process of endocytosis relies on the mobility and tension of the plasma membrane, which is sensitive to bi...
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Jinxuan Wang Jianxiong Xu Tianhu Liu Chaoping Yu Fengcheng Xu Guixue Wang Shun Li Xiaozhen Dai Source Type: research
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
CONCLUSIONS: By identifying and integrating the most gene-rich single-cell subclusters of atherosclerosis to date with a coronary artery disease framework of GRNs, GRN39 was identified and independently validated as being critical for the transformation of contractile SMCs into an osteogenic phenotype promoting advanced-stage, symptomatic atherosclerosis.PMID:38639096 | DOI:10.1161/CIRCRESAHA.123.323184 (Source: Atherosclerosis)
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Giuseppe Mocci Katyayani Sukhavasi Tiit Örd Sean Bankier Prosanta Singha Uma Thanigai Arasu Olayinka Oluwasegun Agbabiaje Petri M äkinen Lijiang Ma Chani J Hodonsky Redouane Aherrahrou Lars Muhl Jianping Liu Sonja Gustafsson Byambajav Byandelger Ying Wa Source Type: research
Identification of Critical Genes Differentiating Stable and Unstable Atherosclerotic Plaques: A Bioinformatic and Computational Analysis
CONCLUSION: The present study used several datasets to identify key genes associated with stable and unstable atherosclerotic plaque.PMID:38639275 | DOI:10.2174/0115701611282362240409035233 (Source: Atherosclerosis)
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Maryam Mahjoubin-Tehran Raul D Santos Wael Almahmeed Khalid Al-Rasadi Amirhossein Sahebkar Source Type: research
A Video-based Automated Tracking and Analysis System of Plaque Burden in Carotid Artery Using Deep Learning: A Comparison with Senior Sonographers
CONCLUSION: Our findings have indicated that the RVM model can be used in ultrasound carotid video. The RVM model can automatically segment and quantify atherosclerotic plaque burden at the same diagnostic level as senior sonographers. The application of AI to carotid videos offers more precise and effective methods to evaluate carotid atherosclerosis in clinical practice.PMID:38639284 | DOI:10.2174/0115734056296233240401061756 (Source: Atherosclerosis)
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Wenjing Gao Mengmeng Liu Jinfeng Xu Shaofu Hong Jiayi Chen Chen Cui Siyuan Shi Yinghui Dong Di Song Fajin Dong Source Type: research
Independent Relationship of Lipoprotein(a) and Carotid Atherosclerosis With Long-Term Risk of Cardiovascular Disease
CONCLUSIONS: Higher Lp(a) concentrations are independently associated with long-term ASCVD risk and may exaggerate cardiovascular risk when concomitant with atherosclerotic plaque.PMID:38639362 | DOI:10.1161/JAHA.123.033488 (Source: Atherosclerosis)
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Yue Qi Youling Duan Qiuju Deng Na Yang Jiayi Sun Jiangtao Li Piaopiao Hu Jun Liu Jing Liu Source Type: research
Is aortic knob width a novel predictor of mortality in hemodialysis patients?
CONCLUSIONS: Age, male gender, aortic calcification, and hypertension are the primary risk factors for increased aortic knob width in hemodialysis patients. Aortic knob width greater than 37.98 mm, which can be measured simply and rapidly using posterior-anterior chest radiography, may be a predictor of mortality.GRAPHICAL ABSTRACT: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-10.jpg.PMID:38639520 | DOI:10.26355/eurrev_202404_35909 (Source: Atherosclerosis)
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: B Kaya B Mete M Balal N Seyrek I Karayaylali Source Type: research
Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages
Geroscience. 2024 Apr 19. doi: 10.1007/s11357-024-01139-7. Online ahead of print.ABSTRACTCerebral microhemorrhages (CMHs, also known as cerebral microbleeds) are a critical but frequently underestimated aspect of cerebral small vessel disease (CSVD), bearing substantial clinical consequences. Detectable through sensitive neuroimaging techniques, CMHs reveal an extensive pathological landscape. They are prevalent in the aging population, with multiple CMHs often being observed in a given individual. CMHs are closely associated with accelerated cognitive decline and are increasingly recognized as key contributors to the path...
Source: Atherosclerosis - April 19, 2024 Category: Cardiology Authors: Anna Csiszar Anna Ungvari Roland Patai Rafal Gulej Andriy Yabluchanskiy Zoltan Benyo Illes Kovacs Peter Sotonyi Angelia C Kirkpartrick Calin I Prodan Eric M Liotta Xin A Zhang Peter Toth Stefano Tarantini Farzaneh A Sorond Zoltan Ungvari Source Type: research
