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Angptl3 variation in type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: ANGPTL3 is involved in the regulation of lipid metabolism and has recently been implicated in the pathogenesis of T2D in mice. We investigated the effect of common variation of this gene on T2D risk and risk factors, as well as the association with the protein serum levels. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: K.D. Salpea, J.A. Cooper, P.J. Talmud, S.E. Humphries Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Role of coagulation factors in coronary thrombosis in young individuals—a hospital based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Myocardial infarction (MI) is a leading cause of death and disability worldwide, with genetic and environmental predisposition. Majority of myocardial infarctions occur in individuals >65 years old, but is being increasingly seen in individuals with age (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S. Dayakar, S. Komandur, M.d. Sadhnani, V. Bhupesh Kumar, P. Sreedhar, Sudhir Naik, P. Seshargiri Rao, P.C. Rath, Narsa Raju, K. Manoj Agarwal, B. Shyamala Sesikeran Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Apolipoprotein a1 gene polymorphism (g-75a and c+83t) in myocardial infarction—a pilot study in the north indian populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rationale of study: Coronary artery disease is assuming epidemic proportion in India as well as globally . Assessment of metabolic and lifestyle risk factors of atherosclerosis and interventions in these has, however, been ineffective in completely predicting or controlling the development of atherosclerotic process, suggesting that specific genetic predisposition should be considered . Since HDL and its Apolipoprotein A1 is mainly responsible for reverse cholesterol transport , we tried to study whether genetic polymorphism in ApoA1 gene (G-75A and C+83T) could be playing a role in occurrence of Myocardial Infarction. (So...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: R. Dawar, A. Gurtoo, R. Singh Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Hepatic gene expression in prague hereditary hypercholesterolemic (phhc) ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prague hereditary hypercholesterolemic (PHHC) rat develops hypercholesterolemia after feeding cholesterol without an addition of cholic acid. The hypercholesterolemia is due to accumulation of cholesterol-rich VLDL and IDL in circulation. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M. Zimolova, J. Kovar, R. Bohuslavova, V. Stranecky, R. Ivanek, M. Jirsa, R. Poledne Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Differential effects of radial artery injury and limb ischaemia on circulating cd133+/cd34+ progenitor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study rationale: Bone marrow derived progenitor cells increase after cardiovascular events, but may be reduced with atherosclerosis. They may be mobilised from the bone marrow in response to cytokines and ischaemia. We used a novel model of transient endothelial injury in healthy volunteers to contrast acute effects of mechanical injury with those of ischaemia/reperfusion on CD34+/133+ circulating progenitor cells. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: L.M. Tilling, M.V. Holmes, A. Verma Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

The kif6 719arg allele is associated with increased risk of coronary heart disease among males in the welcome trust case control consortium study of coronary heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carriers of the KIF6 719Arg allele, compared with noncarriers, have a higher risk of coronary heart disease (CHD) in several prospective studies and in the placebo groups of two randomized trials of pravastatin. In these trials, pravastatin treatment ameliorated the risk associated with 719Arg allele. In the Welcome Trust Case-Control Consortium (WTCCC) CHD study, although no association was observed between the 719Arg allele and CHD, a significant association between the 719Arg allele and CHD was observed in a sex-differentiated test. In order to investigate this sex-differentiated association, we analyzed the association...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: D. Shiffman, C.M. Rowland, J. Thompson, A.S. Hall, J.J. Devlin, N.J. Samani Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Consideration of ethnicity in coronary risk prediction using crpEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rationale: CRP cut-points for the evaluation of CHD risk are mainly based on studies in Europeans. We evaluated CRP concentration in populations of differing geographical and ancestral background to consider the implications for risk prediction in non-European populations. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: T. Shah, P. Newcombe, J. Addo, J.P. Casas, L. Smeeth, J. Whittaker, A.D. Hingorani Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Identification of genes associated with qt interval using the 50k cardio-metabolic snp chip: results from the whitehall ii studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The QT interval on an electrocardiogram is a measure of the total time from ventricular depolarization to repolarization. QT interval, a heritable quantitative trait, and its prolongation by drugs, cardiac disease and electrolyte abnormalities are associated with the risk of developing ventricular arrhythmias and sudden cardiac death. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S. Shah, F. Drenos, T. Shah, J. Palmen, C. Vezzili, R. Sofat, M. Kumari, M. Kivamaki, J. Pallas, P. MacFarlane, J. Whittaker, P.J. Talmud, S.E. Humphries, A.D. Hingorani Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Genotypes at matrix metalloprotinase (mmp) loci for mmp7, mmp9 and mmp12 are associated with carotid imt and presence of plaquesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the study was to determine the association between metalloproteinase (MMP) polymorphisms with intima-media thickness in the common carotid (IMTcc) and presence of plaques in the common carotid and femoral bifurcations. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: A. Panayiotou, N. Georgiou, M. Griffin, D. Bond, T. Tyllis, S.E. Humphries, A.N. Nicolaides Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Co-segregation of el and hl variants with high plasma hdl-c levels in families with hyperalphalipoprotaeinemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rational and results: To identify genetic causes of hyperalphalipoproteinemia and their pattern of inheritance, four candidate genes – CETP, SR-B1, EL and HL – were sequenced in 41 individuals with plasma HDL-c levels above the 95th percentile for age and gender. In 2 subjects, heterozygosity for a frameshift mutation (p.L130fsX165) and a missense change (p.R476W) in EL was identified. In 2 other individuals, we identified heterozygosity for 2 HL missense changes (p.Q369R and p.S289F). In co-segregation studies, 2 out of 12 carriers of the p.L130fsX165 did not show High HDL-c phenotype while 5 out of 17 non-carriers in...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M.M. Motazacker, A.G. Holleboom, R. Franssen, J. Azevedo, G.K. Hovingh, J.J.P. Kastelein, J.A. Kuivenhoven Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

DOWN-REGULATION OF ACE EXPRESSION IN HUVECS USING siRNA RESULTS IN DOWN-REGULATION OF UCP2 EXPRESSION: A POTENTIAL MECHANISM OF THE CLINICAL BENEFIT OF ACE-INHIBITORS?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: An intrinsic deficiency of fatigue-resistance and endurance performance of skeletal muscle is responsible for much of the symptomatic limitation attributed to chronic heart failure (CHF). This impaired performance is caused, in part, by defects in muscle metabolic efficiency. Angiotensin-converting enzyme (ACE) inhibitors are known to improve the condition of patients. We have used a cell approach and small interfering (si)RNAs to explore the hypothesis that reducing ACE activity leads to diminution of expression of the uncoupling protein-2 (UCP2). We also evaluated the effect of down-regulation of UCP2 on the ...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: C.G. Maubaret, R. Heads, S. Dhamrait, H. Montgomery, S.E. Humphries Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Pro-protein convertase subtilisin/kexin type9 (pcsk9) variant database: preliminary analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to place all published PCSK9 variants in a publicly available database and assess the potential biological significance of each variant. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S.E. Leigh, T. Jakubcova, R.A. Whittall, S.E. Humphries Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

−203a/c polymorphism of cholesterol 7alpha-hydroxylase (cyp7a1) gene and diurnal variation in cyp7a1 activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The −203A/C polymorphism of cholesterol 7alpha-hydroxylase (CYP7A1) gene, the key regulatory enzyme in bile salt synthesis, affects responsiveness of serum cholesterol to dietary fat and cholesterol. However, no relationship between enzyme activity and this polymorphism has been demonstrated so far. Therefore, we studied whether this polymorphism can affect the diurnal variation of CYP7A1 activity. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: J. Kovar, M. Zimolova, M. Lenicek, L. Vitek, M. Jirsa, R. Poledne Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Local polymorphisms influence stk39 gene expression but are not associated with blood pressureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Blood pressure (BP) has significant heritability, but the genes responsible remain largely unknown. Single nucleotide polymorphisms (SNPs) in the STK39 gene were recently associated with hypertension by genome-wide association in an Amish population; in vitro data from transient transfection experiments using reporter constructs suggested that altered STK39 expression might mediate the effect. However, other large studies have not implicated STK39 in hypertension. We determined whether reported SNPs influenced STK39 expression in vivo, or were associated with BP in a large British Caucasian cohort. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: C. Kay, M.S. Cunnington, P. Avery, M. Santibanez-Koref, B. Keavney Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Fto polymorphism is associated with myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Myocardial infarction (MI) is the most common cause of death in industrial countries. All general MI risk factors have some genetic components and the proportion of genetic predisposition is between 30 and 60%. FTO gene (“fat mass and obesity related gene”, DNA demethylase) and its variants have been described primarily like important determinant of body weight. Further, FTO SNP increases general mortality independent of fatness in men. The association between FTO SNP rs17817449 and risk of MI development on middle European Caucasians was analysed. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: J.A. Hubáèek, V. Adámková, V. Stanìk, R. Poledne, M. Aschermann, J. Matoušková, M. Pìnièka, J. Veselka, J. Pitha Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Pharmacogenetics of statin treatment: impact of apoa5, apoe, cyp7a1 and hepatic lipase variantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Statins are drugs of choice in patients with high cholesterol levels and at increased CVD risk. There exists a significant inter-individual variability of statin efficacy that is likely to have a genetic basis. Apolipoproteins (APO) A5 and E, cholesterol 7-α-alpha-hydroxylase (CYP7A1) and hepatic lipase (HL) genes are the candidates that may play a role in modifying the therapeutic response to statins. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: J.A. Hubáèek, V. Adámková, R. Èeška, M. Vrablík Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Lrp5 variants are associated with triglyceride levels and type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background and aims: The LDL-receptor related protein 5 (LRP5) gene is located on chromosome 11q13, a region that has been linked to type 1 diabetes (T1D). Lrp5−/− mice develop glucose intolerance, and increased cholesterol levels. The aim of this study was to evaluate the effect of LRP5 SNPs on lipid parameters and cardiovascular and T2D disease risk in a large prospective study. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M. Guardiola, G. Ken-Dror, S.E. Humphries, P.J. Talmud Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Coronary artery disease susceptibility locus on chromosome 9p21Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, expression of ANRIL as well as of splice-variants appears to be cell-type-specific. Recent evidence suggests that expression may be haplotype-specific . Analysis of all possible transcripts using the tiling arrays will provide a full picture of ANRIL expression in cell-types relevant to CAD, as well as uncovering haplotype-specific effects, and provide further clues as to the functional role of ANRIL in CAD. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: L.D. Beeton, B. Burch, K. Russell, S. Salvage, P. Chivers, K.E. Webb Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

The common functional arg399gln variant in the dna repair enzyme xrcc1 is associated with elevated levels of micronucleus chromosomal dna damage and shorter telomere length in patient with atherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: DNA repair is a key factor for maintaining genomic stability, including telomere maintenance. Telomere shortening and chromosomal DNA damage in circulating leucocytes have been shown to be associated with coronary artery disease (CAD). (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: C. Federici, S. Manfredi, M. Del Fiandra, K. Salpea, C. Maubaret, S.E. Humphries, M.G. Andreassi Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Risk prediction in coronary heart disease and other conditions: current uncertainties and future opportunitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Risk prediction models are used to estimate individuals’ likelihood of future disease. Taking into account factors such as personal and family history, lifestyle, physical examination findings, and genetic and molecular biomarkers, risk prediction models apply a mathematical algorithm to estimate the risk of developing a particular outcome. Many models already exist, for conditions such as cardiovascular disease, type 2 diabetes and breast cancer. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: T.H.S. Dent, C.F. Wright Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Gene expression profiling in mononuclear cells demonstrates up-regulation of pro-inflammatory and adhesion related genes coronary artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined expression of genes in circulating mononuclear cells to discover disease specific pathways. Mononuclear cells were extracted from whole blood of patients with coronary artery disease (CAD; n=44) and healthy control subjects (n=44) by Ficoll gradient and superoxide production was measured using EPR spectroscopy. Total RNA was isolated for gene expression profiling (Illumina, Human WG-6 v3.0 chip). Ingenuity Pathway Analysis (IPA) was used to visualise networks of differentially expressed genes (n=12 per group). Serum samples were analysed using multiplexing technology (Luminex xMAP). Of 1644 differentially expre...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: C. Delles, M.U. Moreno, C. Taurino, U. Neisius, W.M. Miller, J.D. McClure, M.W. McBride, A.F. Dominiczak Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Angptl4 e40k and t266m: effects on plasma triglyceride and hdl levels, angptl4 levels and chd riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the association of two ANGPTL4 coding SNPs and five tagging SNPs with CHD traits in 2772 individuals from the Northwick Park Heart Study II (NPHSII). We also examined the effect of the seven variants, which are in strong linkage disequilibrium, on plasma Angplt4 levels (n=722). In NPHSII the T266M (rs1044250, MAF=30%) and E40K variants (MAF=2%) were significantly associated with TG-lowering (−10.4%, PC encoding the N terminus of Angptl4 were associated with significantly lower Angptl4 levels (P=0.0008 and 0.0002, respectively). T266M and 12574 C>T encoding the C terminus of Angptl4 were associated with signif...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M.C. Smart, C. Ehnholm, M. Jauhiainen, M. Robciuc, J.A. Cooper, F. Drenos, S.E. Humphries, P.J. Talmud Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Association of telomere length with type 2 diabetes, oxidative stress and ucp2 gene variationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Type 2 diabetes (T2D) is characterised by high oxidative stress, which potentially leads to accelerated telomere shortening and consequent premature cell senescence, implicated in the disease development. Therefore, we studied the association of leukocyte telomere length (LTL) with the presence of T2D, as well as the effect on the patients’ LTL of plasma oxidative stress and of variation in UCP2, a gene involved in the mitochondrial production of reactive oxygen species. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M.C. Smart, C. Ehnholm, M. Jauhiainen, M. Robciuc, J.A. Cooper, F. Drenos, S.E. Humphries, P.J. Talmud Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Association of variants in candidate genes influencing electrolyte transport and the autonomic nervous system with blood pressure variationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rationale: While heritability of hypertension is estimated to be as high as 60%, identifying the responsible genes is proving challenging. Our strategy was to perform a candidate gene association study with dense tagging SNP coverage of multiple genes selected based on known involvement in two pathways important to BP regulation; electrolyte transport and the autonomic nervous system. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. McCarthy, C. Vangjeli, G. Cavaller, N. Delanty, E. O’Brien, B. Harvey, A. Stanton Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

A field synopis of pharmacogenetic studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rationale for the study: Differences in drug efficacy and/or adverse effects make an important contribution to ill-health. Studying the genetic basis could reduce this by clarifying mechanisms of drug action/metabolism to inform drug development, and lead to genotype-based predictive tests of efficacy or toxicity (pharmacogenetics). The reliable identification of loci for drug response appears less advanced than for susceptibility loci for common disease. We wished to identify blocks to progress to guide future research. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M.V. Holmes, T. Shah, C. Vickery, L. Smeeth, A.D. Hingorani, J.P. Casas Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Apolipoprotein e (apoe) genotype and ischaemic stroke: integration of evidence from a literature based meta-analysis and a phenome scan of effects on blood lipids and other biomarkers of cardiovascular riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rationale: APOE genotype exhibits approximately linear relationship with LDL-cholesterol concentration and CHD risk but the relationship of APOE genotype with risk of ischemic stroke is less well defined. We evaluated the association of APOE genotype with stroke risk and to assess if the observed effect is consistent with effects on LDL-cholesterol, other lipid fractions or biomarkers of cardiovascular risk. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: APOE Collaboration Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Association between fto polymorphism, adiposity peak and adiposity rebound in the northern finland birth cohort 1966Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the association between the FTO SNP rs9939609 and both age and BMI at AP and AR using longitudinal data from the Northern Finland Birth Cohort 1966. AP and AR were derived from random effects models fitted at >0–1.5 years and >1.5–13 years (N=2782 infants and N=3413 children with minimum three measurements per age window). Additionally, correlations between derived parameters and BMI at age 31 were studied. Age at AP correlated weakly with BMI at AR (r=0.18) but not at 31 (r=0.02), whereas age at AR correlated inversely with BMI at AR (r=−0.50) and at 31 (r=−0.44). BMI at AP and BMI at AR pr...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: U. Sovio, N.J. Timpson, N.M. Warrington, L. Briollais, D. Mook-Kanamori, M. Kaakinen, A.J. Bennett, J. Molitor, M.I. McCarthy, M.-R. Jarvelin Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Association study of coronary artery disease (cad) using humancvd 50k chipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Recent GWAS studies have identified several novel susceptibility loci for CAD , but it seems that only common variants can be detected using this approach . Moreover, novel loci identified using GWAS appear to explain only a small amount of the expected contribution to CAD risk. Use of high-density arrays involving multiple single nucleotide polymorphisms (SNPs) in candidate genes for cardiovascular disease, including both common and low frequency variants, may help to elucidate the genetic contribution to CAD risk. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: A. Goel, R. Clarke, J.C. Hopewell, T. Kyriakou, S.C. Heath, S. Parish, S. Barlera, M.G. Franzosi, S. Rust, D. Bennett, A. Silveira, A. Malarstig, F.R. Green, M. Lathrop, B. Gigante, K. Leander, U. Faire, U. Seedorf, A. Hamsten, R. Collins, H. Watkins, M. Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Functional analysis of regulatory lpl snpsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to determine novel functional variation in LPL. Using a prospective cohort of 3012 healthy, Caucasian, middle-aged men (NPHSII), variation in LPL was examined using a tagSNP approach comprising 22 SNPs. Association with triglyceride levels was analysed by a number of statistical tests to identify SNPs with the highest likelihood of association. Candidate SNPs and those in high LD were examined for functionality. Electrophoretic mobility shift assay (EMSA) was initially performed to identify SNPs that had the potential to alter transcription factor binding sites. Those that altered DNA–protein in...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: A.J.P. Smith, F. Drenos, J. Palmen, W. Putt, P.J. Talmud, S.E. Humphries Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Anril, the non coding rna present in the chromosome 9 cad associated locus, has multiple splice variants and a potential regulatory role in cdkn2b expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Genome-wide association studies have identified a region on chromosome 9 associated with CAD risk and aneurysms. Discovery of a large antisense noncoding RNA (ANRIL) transcribed from the chromosome 9 locus and with the potential to regulate neighbouring genes CDKN2A/B, raises the possibility that the risk variants have primary effects on ANRIL expression leading to tissue and variant-specific effects on the magnitude and balance of CDKN2A/B transcripts. The aims of this study were to (i) determine the expressed ANRIL transcripts and (ii) investigate a potential regulatory role for ANRIL on CDKN2A/B expression. ...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: T. Kyriakou, A. Pal, J. Peden, F. Green, A. Gloyn, M. McCarthy, H. Watkins Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Gpihbp1 variants contribute to lipid levels in familial combined hyperlipidemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Familial combined hyperlipidemia (FCHL) is a complex genetic disorder, which predisposes to premature atherosclerosis. In mice, deficiency of glycosylphosphatidylinositol (GPI)-anchored high-density lipoprotein-binding protein (GPIHBP1) causes severe chylomicronemia. GPIHBP1 binds lipoprotein lipase and triglyceride-rich lipoproteins on the luminal surface of endothelial cells. Data examining the role of GPIHBP1 variation in human dyslipidemia are sparse. We therefore performed re-sequencing and association analyses to determine the contribution of GPIHBP1 variation to the aetiology of FCHL in white-British families. The e...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: H.E. Ringham, M.M. Town, S.D. Horswell, C.C. Shoulders Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

CAD RELATED VARIATION ON CHROMOSOME 10q11 IS ASSOCIATED WITH CIRCULATING SDF-1ALPHA LEVEL AND CAROTID INTIMA-MEDIA THICKNESS AND ATHEROSCLEROSISEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated whether this locus has an influence on plasma SDF-1alpha level and also examined whether it has effect on carotid intima-media thickness and development of carotid atherosclerosis. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S. Kiechl, R.C. Laxton, Q. Xiao, J. Willeit, Q. Xu, S. Ye Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Follow your heart: post-myocardial infarction careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Follow Your Heart group is a three-way partnership between HEART UK, the PCCS and Pfizer, and has been financially supported by Pfizer. Background: Clinical guidelines are vital to clinical practice; minimising variation, raising standards, increasing efficiency and improving health outcomes for patients. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: J. Morrell, on behalf of the Follow Your Heart Steering Committee Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Comparison of a point of care cholesterol device and laboratory analysis in the prediction of cardiovascular diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Based on the Department of Health Vascular Risk Assessment Programme we undertook a pilot scheme to screen a South Asian population attending the Shri Swami Narayan Temple. This screening included lipid measurements using point of care testing equipment (Cholestech LDX, Hayward, USA) and a routine laboratory method. We compared the risk assigned using the Joint British Societies’ 2 (JBS 2) cardiovascular disease (CVD) chart. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. Rao, N. Johri, L. Robertson, D. Harvey, B. Persaud, D.P. Mikhailidis, M. Thomas, D. Nair Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Body fat distribution in men and women of south asian origin: an observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Mortality from IHD in South Asian men and women are 1.5 times that of the native population in the UK. Alterations in body fat content and particularly body fat distribution are associated with adverse metabolic effects and increased cardiovascular risk. Increased visceral fat in South Asians may not be apparent from their BMI. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. Rao, N. Johri, D. Harvey, L. Robertson, M. Thomas, D.P. Mikhaildis, D. Nair Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Blood pressure and lipids improvement after very low energy diet (vled) or low energy diet (led) in obese patients with knee osteoarthritis: a randomised controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Weight reduction improves cardiac risk factor profiles but there are few recently published RCTs on the effects of formula diets. Methods: Comparing cardiac risk factors after 8 and 16 weeks following ‘very low energy diet’ (VLED) or ‘low energy diet’ (LED) in obese (BMI>30) patients with knee osteoarthritis. Patients were included in strata of 24, randomised via minimisation with allocation concealment to: either 8 weeks on ‘VLED’ (420–554kcal/d) or 8 weeks on a ‘LED’ (810kcal/d) both formula Cambridge diets. The second phase was 8 weeks fixed-energy diet program with food; 1200kcal includin...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: P. Christensen, H. Bliddal, B.F. Riecke, A.R. Leeds, A. Astrup, R. Christensen Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

All-cause and cardiovascular mortality in treated patients with severe hypertriglyceridaemia: a long-term prospective registry studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: To examine all-cause and cardiovascular disease (CVD) mortality in patients with severe hypertriglyceridaemia. Design: Prospective registry study. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: H.A.W. Neil, J. Cooper, D.J. Betteridge, N. Capps, I.F.W. McDowell, P.N. Durrington, M. Seed, S.E. Humphries Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Is small dense ldl a more important determinant of the plasma glycated ldl in type 2 diabetes than glycaemic control?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The research to date has focused on oxidation of LDL rather than glycation as the modification leading to atherosclerotic cardiovascular diseases. We have recently reported that, in non-diabetic people, small dense LDL (SD-LDL) is preferentially glycated both in vivo and in vitro. The relative contribution of SD-LDL and glycaemia in determining circulating levels of glycated LDL in diabetes is unknown. We investigated the distribution of apoB and glyc-apoB in apoB-containing lipoproteins isolated from 48 patients with type 2 diabetes and 11 healthy volunteers. LDL, LDL1, LDL2 and LDL3 were isolated from a further 63 patien...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. Younis, R. Sharma, H. Soran, P. Pemberton, V. Charlton-Menys, M. Elsweidy, P. Durrington Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Apolipoprotein b provides a more consistent goal of statin treatment than ldl-c and non-hdl-cEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Controversy surrounds whether apolipoproteins are the best discriminator of CHD risk and for monitoring response to statin treatment. There is one apolipoprotein B (apo B) molecule in each LDL particle while the cholesterol content of the low density lipoprotein (LDL) can vary considerably. This is particularly so in patients with combined dyslipidemia and hypertriglyceridemia. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: H. Soran, V. Charlton-Menys, S. Dissanayake, N. Younis, M. France, P.N. Durrington Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Achievement of ldl-c levels with three different drug strategies after failure of simvastatin 40mgEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: NICE lipid guidelines recommend simvastatin (S) 40mg as initial therapy, after lifestyle changes, in most patients requiring treatment. When desirable levels have not been met, increasing the dose, switching to a more potent statin or adding ezetimibe (E) can be considered. The addition of E to S was compared with switching to atorvastatin (A) or rosuvastatin (R) in a randomised, double-blind trial. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: T. McCormack, M. Blagden, R. Chipperfield, P. Harvey, R. Gaunt, S. Griffiths, P. Robinson Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by weight lossEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background and aims: The observation that high intakes of dietary cholesterol can increase plasma cholesterol in a number of species has led to the belief that the intake of dietary cholesterol, in humans, should be restricted. However, energy-restricted diets, that may contain a relatively high proportion of fat and cholesterol, have been shown to produce neutral or in some cases favourable effects on plasma cholesterol. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N.L. Harman, A.R. Leeds, B.A. Griffin Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Plasma pcsk9 levels are low in healthy subjects carrying the pcsk9 p.r46l variant and in p.d374y familial hypercholesterol-emia patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Loss of function mutations in PCSK9 (p.R46L) cause low plasma LDL-C levels, while gain of function mutations (p.D374Y) cause familial hypercholesterolemia (FH), but their relationship with plasma levels of PCSK9 is unclear. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S.E. Humphries, D. Neely, R.A. Whittall, J. Troutt, R.J. Konrad, M. Scartezini, Ka Wah Li, J.A. Cooper, J. Acharya, H.A.W. Neil Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Glycation of ldl is an important atherogenic modification and opposed by paraoxonase-rich hdlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Foam cells, central to atherogenesis, do not form when monocyte-macrophages are exposed to unmodified LDL. Chemical modification of LDL must first occur. Oxidative modification has attracted most interest, but glycated LDL present in the circulation at much higher concentration than oxidized LDL, even in non-diabetic people, equally stimulates foam cell formation. We have recently reported that in patients with and without type 2 diabetes LDL glycation occurs predominantly in SD-LDL and that presence of SD-LDL is a more important determinant of its plasma concentration than glycaemia. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. Younis, H. Soran, R. Sharma, P. Pemberton, V. Charlton-Menys, M. France, M. Elsweidy, P. Durrington Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Insulin like growth factor binding protein-1 phosphorylation status in subjects with and without ischemic heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Insulin like growth factor binding protein-1 (IGFBP-1) modulates the activity of IGF-1. It exists in plasma as phosphorylated and less phosphorylated forms. We wished to study the serum levels of these forms of IGFBP-1, using a novel assay, in subjects with and without ischemic heart disease (IHD). (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: A. Borai, C. Livingstone, M. Ghayour, A. Abuosa, G. Ferns Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Exploring the genetic architecture of lipid traits in whitehall ii healthy men and women using the 50k-snp cardio-metabolic chipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: GWASs have revolutionised complex disease genetics, but while broad in genome coverage, they lack depth. We have used a 50K SNP-CHIP covering ∼2100 genes involved in cardio-metabolic processes, providing a complementary in-depth approach. (Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S.E. Humphries, P.J. Talmud, F. Drenos, S. Shah, S. Palmen, T. Shah, M. Kumari, M. Kivimaki, J. Pallas, J.P. Casas, J. Whittaker, A. Hingorani Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Atherosclerosis)
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Source Type: journals

Levels of lipids and apolipoproteins in three culturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: There is a complex pattern of differences amongst the cultures. There are also important similarities in the differences between the genders. Swedes have the highest levels of LDL-C (3.77mmol/L), apoB (1.27g/L) and HDL-C (1.53mmol/L) but the lowest levels of triglyceride (1.47mmol/L for the Swedes vs. 1.55mmol/L and 1.93mmol/L for the Americans and Iranians, respectively, all p (Source: Atherosclerosis)
Source: Atherosclerosis - September 22, 2009 Category: Cardiology Authors: Amirreza Solhpour, Sahar Parkhideh, Nizal Sarrafzadegan, Sedigheh Asgary, Ken Williams, Ingmar Jungner, Are Aastveit, Göran Walldius, Allan Sniderman Tags: Epidemiology, Biomarkers and Nutrition Source Type: journals

Reactive Oxygen Species and Antioxidants in the Pathophysiology of Cardiovascular Disease: Does the Actual Knowledge Justify a Clinical Approach?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is evidence that reactive oxygen species (ROS) are related to the development of cardiovascular disease (CVD). Results from many studies support the hypothesis that ROS released from various sources or dysfunctional mitochondrial respiratory chain play a role in the development of atherosclerosis and its complications. This phenomenon is due to ROS-mediated signalling pathways that are involved in the modulation of several vascular mechanisms. Various animal models have demonstrated that ROS have a causal role in atherothrombosis and other vascular diseases. Oxidative stress is being proposed as the unifying mech...
Source: Atherosclerosis - September 18, 2009 Category: Cardiology Authors: De Rosa S, Cirillo P, Paglia A, Sasso L, Di Palma V, Chiariello M Tags: Curr Vasc Pharmacol Source Type: journals

The Rationale for Comparative Studies of Accelerated Atherosclerosis in Rheumatic Diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The inflammatory pathogenesis of atherosclerosis is now well-established, owing to in vitro and in vivo studies and the application of high sensitivity assays for C-reactive protein (CRP) in the general population and specific groups at risk for cardiovascular disease (CVD). In view of the complexity of inflammation-induced atherosclerosis, the rationale for comparative studies of atherogenesis in rheumatic diseases with diverse inflammatory pathogenesis seems obvious; they are human in vivo models to study inflammatory mechanisms involved in atherosclerosis and the impact of treatment. Factors implicated in atherogene...
Source: Atherosclerosis - September 18, 2009 Category: Cardiology Authors: Gasparyan AY, Stavropoulos-Kalinoglou A, Mikhailidis DP, Toms TE, Douglas KM, Kitas GD Tags: Curr Vasc Pharmacol Source Type: journals