AtivanThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you your search results in order of date.

Pages: 1 2 3 4 5 6

269 records returned

Propylene Glycol Accumulation in Critically Ill Patients Receiving Continuous Intravenous Lorazepam Infusions(December).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The continuous infusion rate and cumulative 24-hour lorazepam dose are strongly associated with and independently predict propylene glycol concentrations. Despite the absence of confirmed propylene glycol-associated adverse effects, clinicians should be aware that propylene glycol accumulation may occur with continuous-infusion lorazepam. PMID: 19920159 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Horinek EL, Kiser TH, Fish DN, Maclaren R Tags: Ann Pharmacother Source Type: journals

Mom Flies Over the Cuckoo’s NestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several weeks ago my mother, in her eighth or ninth year of Alzheimer’s Disease, and 63rd year of marriage, began wielding knives and trying to stab people, verbally threatening to kill my father, throwing dangerous glass objects and screaming bloody murder at her own image in the mirror—“I DON’T WANT YOU HERE, GET OUT!!!” My brother and I finally intervened and had her temporarily hospitalized in a psychiatric ward, hoping we could buy more time for her at home through stabilizing her on the right meds, and getting Dad more help. We chose a modern, upscale hospital in a New Jer...
Source: Psychology Today Food and Diet Center - November 7, 2009 Category: Nutrition Authors: Eliezer Sobel Tags: Aging Anxiety Cognition Depression Diet Happiness Health Memory Neuroscience Personality Psychiatry Resilience Stress admittance Ativan bruises catheter geriatric psychiatrist glass objects health care system heat o Source Type: consumer

Topiramate overdose: A case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 21-year-old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. On admission to the hospital he had a nonconvulsive status epilepticus and received 4 mg lorazepam i.v. He recovered rapidly despite an initial TPM concentration of 144.6 [mu]g/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication. (Source: Epilepsia)
Source: Epilepsia - November 3, 2009 Category: Neurology Authors: Christian Brandt, Heike Elsner, Nora Füratsch, Matthias Hoppe, Esther Nieder, Bernhard Rambeck, Alois Ebner, Theodor W. May Source Type: journals

What Evaluation is Appropriate for Complex Febrile Seizures?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Febrile seizures are the most common type of seizures in children. They affect about 2-5% of all children. Febrile seizures are characterized into two groups: simple febrile seizures and complex febrile seizures. Basically, if the child does not meet the criteria for a simple febrile seizure it is called a complex febrile seizure. The main characteristics are outlined below: Simple Febrile Seizure Complex Febrile Seizure Age 6-60 months < 6 months or > 60 months Duration < 15 minutes > 15 minutes Type Generalized Focal seizures tonic-clonic Tonic and/or clonic Partial se...
Source: PediatricEducation.org - November 2, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

Lorazepam: Delirium and difficulty separating from the ventilator: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

The effects of lorazepam on extrastriatal dopamine D2/3-receptors—A double-blind randomized placebo-controlled PET studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, lorazepam decreased [11C]FLB 457 binding in frontal and temporal cortex, suggesting that cortical GABA–dopamine interaction may be involved in the central actions of lorazepam in healthy volunteers. The correlation between lorazepam-induced sedation and D2/D3 receptor binding potential (BP) change further supports this hypothesis. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - October 30, 2009 Category: Psychiatry Authors: Harry Vilkman, Jaana Kajander, Sargo Aalto, Tero Vahlberg, Kjell Någren, Topias Allonen, Erkka Syvälahti, Jarmo Hietala Tags: Articles Source Type: journals

Caring for the Elderly in an Inpatient Setting: Managing Insomnia and PolypharmacyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article addresses these concerns by highlighting key points from the available literature. Insomnia may be a problem in the elderly because of their increased sensitivity to changes in environment among other factors. First, obtain a sleep history and a comprehensive medical and medication history to identify the cause. Next, treat the underlying cause with nonpharmacological interventions to restore restful and qualitative sleep. When nonpharmacological interventions are not successful, pharmacological means are indicated. Remember to start low, go slow, and treat for a short duration of time (less than 4 weeks) to a...
Source: Journal of Pharmacy Practice - October 21, 2009 Category: Drugs & Pharmacology Authors: Kim, J., Tofade, T. S., Peckman, H. Tags: Continuing Education Article Source Type: journals

Effects of Lorazepam and citalopram on human defensive reactions: ethopharmacological differentiation of fear and anxiety. - Perkins AM, Ettinger U, Davis R, Foster R, Williams SC, Corr PJ.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drugs that are clinically effective against generalized anxiety disorder preferentially alter rodent risk assessment behavior, whereas drugs that are clinically effective against panic disorder preferentially alter rodent flight behavior. The theoretical p... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 18, 2009 Category: Global & Universal Tags: Risk Perception and Communication, Warnings, Operating Instructions Source Type: info

ATIVAN (Lorazepam) Injection, Solution [Baxter Healthcare Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 14, 2009 Category: Drugs & Pharmacology Source Type: organizations

Review article: Convulsive and non-convulsive status epilepticus: An emergency medicine perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Status epilepticus (SE) is divided into convulsive and non-convulsive types; both are associated with significant morbidity and mortality. Although convulsive SE is easily recognized, non-convulsive SE remains an elusive diagnosis as physical signs are varied and subtle. Successful management depends on a comprehensive approach that involves diagnostic testing and pharmacological interventions while ensuring cerebral oxygenation and perfusion at all times. There are a limited number of well-designed studies to support the development of evidence-based recommendations for the management of SE, especially for the management ...
Source: Emergency Medicine Australasia - October 12, 2009 Category: Emergency Medicine Authors: Amish M Shah, Anita Vashi, Andy Jagoda Tags: Reviews Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study Examines Impact of Treatment on Prodromal Symptom Progression in YouthTargeted Naltrexone Reduces Alcohol Use Among Male Problem DrinkersRhabdomyolysis After Clozapine and Lithium TreatmentMetabolic Assessment of Adjunctive Aripiprazole in MDDCognitive Effects of Lorazepam in APOE [epsiv]4 CarriersProdromal Treatment StudiesElevated Rate of Adverse Events With QuetiapineA Case of Myopathy Associated With Valproic AcidNew Approvals: Saphris (Asenapine) for Schizophrenia, Bipolar DisorderNew Approval: Intuniv (Guanfacine) for ADHD (Source: The Brown University Psychopharmacology Update)
Source: The Brown University Psychopharmacology Update - October 5, 2009 Category: Psychiatry Source Type: journals

Lorazepam/olanzapine: Hypotension and unconsciousness: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 30, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Translocator Protein Blockade Reduces Prostate Tumor Growth.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These data suggest that blocking TSPO function in tumor cells induces cell death and denotes a survival role for TSPO in prostate cancer and provides the first evidence for the use of benzodiazepines in prostate cancer therapeutics. (Clin Cancer Res 2009;15(19):6177-84). PMID: 19789311 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 28, 2009 Category: Cancer & Oncology Authors: Fafalios A, Akhavan A, Parwani AV, Bies RR, McHugh KJ, Pflug BR Tags: Clin Cancer Res Source Type: journals

Alcohol and drugs in suspected impaired drivers in Ontario from 2001 to 2005Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: However, these data demonstrate that ‘‘drugged driving” does occur and that further, comprehensive investigation is needed to determine the frequency and type of drug use by Ontario drivers. (Source: Journal of Forensic and Legal Medicine)
Source: Journal of Forensic and Legal Medicine - September 25, 2009 Category: Forensic Medicine Authors: J-P.F.P. Palmentier, R. Warren, L.Y. Gorczynski Tags: Original Communications Source Type: journals

A clinical, radiological and outcome study of status epilepticus from IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to evaluate the clinical and radiological characteristics and the outcome of status epilepticus (SE). 117 consecutive patients with SE were evaluated including their demographics, history of epilepsy, antiepileptic drug (AED) default, comorbidities, SE type and duration. The study included 22 children, 77 adults and 18 elderly patients with SE. Blood counts, serum chemistry, ECG, cranial MRI, cerebrospinal fluid and EEG were done. Patients were treated with IV phenytoin, valproate, lorazepam or diazepam as per a fixed protocol and responses to first and second drugs were noted. Death dur...
Source: Journal of Neurology - September 16, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals

Successful Use of Dexmedetomidine for Sedation in a 24-Week Gestational Age Neonate (October).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Dexmedetomidine was an effective sedative and analgesic in a 24-week gestational age neonate treated for refractory agitation while on mechanical ventilation. Based on its documented efficacy for pain and sedation and its favorable adverse effect profile, dexmedetomidine warrants further study as first-line or adjunct therapy with narcotics for sedation in ventilated newborns. PMID: 19755621 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 14, 2009 Category: Drugs & Pharmacology Authors: O'Mara K, Gal P, Ransom JL, Wimmer Jr JE, Carlos RQ, Dimaguila MA, Davonzo C, Smith M Tags: Ann Pharmacother Source Type: journals

Ativan (lorazepam) Injection - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Manufacturer notification Area: Other Library Updates > SPC Changes Section 4.5 (interactions) has been updated. The following information is now included: Concomitant administration of lorazepam with valproate may result in increased plasma concentrations and reduced clearance of lorazepam. Lorazepam dosage should be reduced to approximately 50% when co-administered with valproate. Concurrent administration of lorazepam with probenecid may result in a more rapid onset or prolonged effect of lorazepam due to increased half lifee and decreased total clearance. Lorazepam dosage needs to be reduced by approximate...
Source: NeLM - SPC Changes - September 13, 2009 Category: Drugs & Pharmacology Source Type: organizations

Pharmacotherapy in pediatric critical illness: a prospective observational study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacotherapy is an under-evaluated element of critical care medicine. In order to better understand pharmacotherapy in pediatric critical illness, we evaluated a cohort of emergency admissions to a university-affiliated pediatric intensive care unit (PICU). A prospective, observational study was performed. Eligible patients were admitted to this medical-surgical ICU for at least 24 hours. The primary outcomes were the number of drug orders written, the number of different medications ordered, and the number of drug administrations. Multiple regression analyses were used to identify factors independently associated w...
Source: Paediatric Drugs - September 4, 2009 Category: Pediatrics Authors: McDonnell C, Hum S, Frndova H, Parshuram CS Tags: Paediatr Drugs Source Type: journals

Ativan - LorazepamEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article covers what Ativan is used for, warnings associated with the drug, major side effects, drug interactions, pregnancy and nursing, and withdrawal symptoms. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - September 1, 2009 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: consumer

[Haloperidol plus promethazine for agitated patients - a systematic review.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: All treatments evaluated are effective, but this review provides compelling evidence as to clear advantages of the haloperidol plus promethazine combination. PMID: 19784494 [PubMed - in process] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - August 31, 2009 Category: Psychiatry Authors: Huf G, Coutinho ES, Adams CE Tags: Rev Bras Psiquiatr Source Type: journals

Jackson Autopsy Fingers Propofol, Lorazepam as Cause of DeathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Los Angeles County coroner's office has officially determined that pop music legend Michael Jackson died of an overdose involving multiple drugs, specifically propofol and lorazepam. (Source: MedPage Today Product Alert)
Source: MedPage Today Product Alert - August 28, 2009 Category: Drugs & Pharmacology Source Type: news

Propofol Plus Sedative Killed Michael JacksonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute intoxication with the anesthetic propofol, coupled with the effect of the sedative drug Ativan, killed pop star Michael Jackson on June 25, the Los Angeles County Coroner's Office has announced. (Source: WebMD Health)
Source: WebMD Health - August 28, 2009 Category: Consumer Health News Source Type: news

Differential effects of lorazepam on sleep and activity in C57BL/6J and BALB/cJ strain mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the effects of two doses of lorazepam (0.5 and 1.5 mg kg(-1)) or saline alone (0.2 mL) on sleep and activity in C57BL/6 (n = 8) and BALB/c (n = 7) mice. Compared to saline, both doses of lorazepam significantly increased non-rapid eye movement (NREM) and reduced activity in both strains. In C57BL/6 mice, rapid eye movement (REM) was increased at both doses. In BALB/c mice, the 0.5 mg kg(-1) dose had no significant influence on REM, whereas REM was reduced significantly after the 1.5 mg kg(-1) dose. The results demonstrate significant differences between C57BL/6 and BALB/c mice in the effects of lorazepam on REM...
Source: Journal of Sleep Research - August 27, 2009 Category: Sleep Medicine Authors: Tang X, Yang L, Fishback NF, Sanford LD Tags: J Sleep Res Source Type: journals

From Diseased towards Human EaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Homoeopathic Links 2009; 22: 149-155DOI: 10.1055/s-0029-1185962SummaryA long-term difficult case involving multiple disease layers demonstrating clearly the need for a comprehensive case management approach and the use of more than one remedy. Treating episodic acute illness within the framework of chronic disease involves addressing the underlying miasmic influence. Different case management techniques and remedies illustrated, analyzed and compared. Appropriate usage of hand-triturated, high-potency (C 4, C 5) remedies. The treatment of addiction via the patient's trituration of the addictive substance (tauto...
Source: Homoeopathic Links - August 26, 2009 Category: Complementary Medicine Tags: MATERIA MEDICA AND CASES Source Type: journals

Jackson pleaded with doctor for powerful anesthetic, records showEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mixture of the sedatives Valium, lorazepam and midazolam, combined with propofol, was enough to kill the singer, a warrant affidavit unsealed Monday in Houston shows. A sleepless Michael Jackson spent his last hours pleading for a dose of a powerful anesthetic, his doctor told police, according to court records unsealed Monday. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - August 25, 2009 Category: Science Source Type: news

New to forum, 3rd day on suboxone...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: jamez70 Posted: Thu Aug 13, 2009 12:22 am Diary, I have had SEVERE SEVERE anxiety in my life. Let me try to describe it. Suddenly, out of nowhere, I have a severe panic attack without any real reason (no phobia). I try to go on.. That night, I have another one. I then become afraid to sleep in my bed, because I associate it with the panic attack. Then about 8 hours later, I have another one. Then I wonder "whats wrong with me? Do I have a tumor? Did I have a stroke?".. Then they keep coming and coming. Eventually, I enter a constant state of se...
Source: Suboxone Forum - August 12, 2009 Category: Addiction Source Type: forums

Catatonic syndrome associated with lead intoxication: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Possibly, lead intoxication results in changes in neurotransmitter system that leads to catatonia. Lorazepam improves patient's condition through changes in this system. (Source: Cases Journal)
Source: Cases Journal - August 10, 2009 Category: Journals (General) Source Type: journals

Lorazepam/temazepam: Sleep apnoea syndrome and respiratory insufficiency: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 10, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Successful treatment for refractory convulsive status epilepticus by parenteral lacosamideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of refractory convulsive status epilepticus (CSE) that was successfully controlled with lacosamide. The 38-year-old male patient was admitted for a series of complex partial seizures with secondary generalization leading to refractory CSE. During the transport to the hospital the patient was given 22.5 mg diazepam, 12.5 mg etomidate, and 5 mg midazolam without success. An additional dose of 4 mg lorazepam and a dose of 1,500 mg levetiracetam after admission were yet without clinical effect. A further treatment with lacosamide (300 mg via percutaneous gastric fistula) resulted in complete clinical remission...
Source: Epilepsia - August 7, 2009 Category: Neurology Authors: Christian Tilz, Roland Resch, Thomas Hofer, Christian Eggers Source Type: journals

Major issue, plz help!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: MACKENZY3376 Posted: Fri Jul 31, 2009 1:18 am DUDE!!! u cant do this alone all by urself. from my experience if i had been alone i would have killed myself. pleeease if nothing else-cant you go to a hospital or something? im not familiar with where you are or how in general the healthcare is and this might sound childish but if nothing else i would go to a hospital and tell them if they dont help you that you think you might commit suicide. you need help and i always try to put myself in the others shoes and if i didnt have the help from my parents or anyone...
Source: Suboxone Forum - July 31, 2009 Category: Addiction Source Type: forums

Evaluation of Adult Outpatient Magnetic Resonance Imaging Sedation Practices: Are Patients Being Sedated Optimally?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Many outpatients in MRI centres may be scanned before the peak effect of anxiolytics prescribed. A standard sedation protocol in such centres is associated with a more appropriate drug choice, as well as optimized monitoring and postprocedure care.Abrégé: But: Examiner l'utilisation d'anxiolytiques chez les patients adultes externes de centres d'imagerie par résonance magnétique afin de déterminer s'ils sont administrés de façon optimale eu égard à l'action des médicaments, au prescripteur des médicaments ainsi qu'au type de suivi postadministration.Matériel et méthodes: Les données sur l'utilisa...
Source: Canadian Association of Radiologists Journal - July 30, 2009 Category: Radiology Authors: Janel E. Middelkamp, Bruce B. Forster, Ciaran Keogh, Pamela Lennox, Kelly Mayson Tags: Magnetic Resonance Imaging Source Type: journals

Gabapentin Therapy for Pain and Irritability in a Neurologically Impaired InfantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 39-week gestational age, male infant with hypotonicity, functional short gut, and microduplication of chromosome 22 who was treated with gabapentin to control pain and irritability. During his hospitalization, the infant experienced multiple complications including respiratory distress, persistent pulmonary hypertension of the newborn, hypocalcemia, hypoglycemia, hyperbilirubinemia, gastroesophageal reflux, necrotizing enterocolitis, and cholestatic jaundice. Pain associated with related invasive procedures and surgeries was treated with intermittent and scheduled morphine. In addition to postoperative and pr...
Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy - July 27, 2009 Category: Drugs & Pharmacology Authors: A. Lauren HaneySandra S GarnerToby H Cox Source Type: journals

Magnitude of potentially inappropriate prescribing in Germany among older patients with generalized anxiety disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: GPs in Germany often prescribe medications that have been designated as potentially inappropriate to their elderly patients with GAD--especially those with comorbid depressive disorders. Further research is needed to ascertain whether there are specific subgoups of elderly patients with GAD for whom the benefits of these medications outweigh their risks. (Source: BMC Geriatrics)
Source: BMC Geriatrics - July 26, 2009 Category: Geriatrics Authors: Ariel BergerMarko MychaskiwEllen DukesJohn EdelsbergGerry Oster Source Type: journals

Ativan (lorazepam) injection - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.4 (special warnings and precautions for use) had been updated with the following information: The use of benzodiazepines, including lorazepam, may lead to physical and psychological dependence. Severe anaphylactic/anaphylactoid reactions have been reported with the use of benzodiazepines. Cases of angioedema involving the tongue, glottis or larynx have been reported in patients after taking the first or subsequent doses of benzodiazepines. Some patients taking benzodiazepines have had additional symptoms such as dyspnoea,...
Source: NeLM - SPC Changes - July 26, 2009 Category: Drugs & Pharmacology Source Type: organizations

Going off Meds, Part 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From June to late August of 2005 I tapered off all of my bipolar disorder medications - Zyprexa, Topamax, Trazodone, Prozac / Celexa, Ativan, Gabitril and Wellbutrin. This is the first of three articles telling why I decided to do this and how the process unfolded through an episode of agitated depression coupled with serious back pain. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 24, 2009 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: consumer

The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A 2,3 selective agonist, in comparison with lorazepam in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was a double-blind, five-way cross-over study to investigate the effects of three doses of SL65.1498 in comparison with placebo and lorazepam 2 mg in healthy volunteers. The objective was to select a dose level (expected to be therapeutically active), free of any significant deleterious effect. Psychomotor and cognitive effects were measured using a validated battery of measurements, including eye movements, body sway, memory tests, reaction-time assessments, and visual analogue scales. The highest dose of SL65.1498 showed slight effects on saccadic peak velocity and smooth pursuit performance, although to a muc...
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: de Haas, S., Franson, K., Schmitt, J., Cohen, A., Fau, J., Dubruc, C, van Gerven, J. Tags: Original papers Source Type: journals

[Epileptic seizures in critically ill patients]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
THE AIM OF THIS ARTICLE: To review the causes, clinical signs, pathophysiology, consequences, and treatment of seizures and status epilepticus in critically ill patients. Only 25% of people, who have seizures and status epilepticus, have epilepsy as well. In the intensive care settings, seizures and status epilepticus are a common neurologic complication, which is attributable to primary neurologic pathology (stroke, hemorrhage, tumor, central nervous system infection, head trauma) or secondary to critical illness (anoxic brain damage, intoxications, metabolic abnormalities) and clinical management. There are three mai...
Source: Medicina (Kaunas) - July 19, 2009 Category: Universities & Medical Training Authors: Stasiukyniene V, Pilvinis V, Reingardiene D, Janauskaite L Tags: Medicina (Kaunas) Source Type: journals

The Mothers Act Disease Mongering Campaign - Part IEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) The Mothers Act represents the ultimate example of disease mongering at its worst because the eight-year attempt to pass this federal legislation has evolved into profiteering never before exhibited so conspicuously.Disease mongering "is the selling of sickness that widens the boundaries of illness and grows the markets for those who sell and deliver treatments," according to Ray Moyniahan and David Henry in the April 11, 2006 paper in PLoS Med, titled, "The Fight against Disease Mongering." "It is exemplified most explicitly by many pharmaceutical industry -- funded disease-awareness campaigns -- more often ...
Source: NaturalNews.com - July 16, 2009 Category: Consumer Health Advice Source Type: news

Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In this pilot study, plasma tryptophan/LNAA and tyrosine/LNAA ratios were associated with transition to delirium in MV patients, suggesting that alterations of amino acids may be important in the pathogenesis of ICU delirium. Future studies evaluating the role of amino acid precursors of neurotransmitters are warranted in critically ill patients. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1573-6Authors P. P. Pandharipande, Vanderbilt Medical Center Division of Critical Care Medicine, Department of Anesthesiology 526 MAB, 1211 21st Avenue South Nashville TN 37212 US...
Source: Intensive Care Medicine - July 9, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

My journey to sobrietyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: Unsponsored Posted: Thu Jul 09, 2009 12:38 am Hello, I'm 23 years old and discovered oc , and binged for 8 months : 160mg- 320 mg OC a day. I believed that I could quit cold turkey in January but it was too hard with work and school.. So I decided to go on suboxone, which I have been taking for about 6 months. I am tapering off pretty quickly actually and it has been working out nicely. week 1 - 1.5 mg -> 1mg, gradual reduction (each pill slightly smaller than the other) week 2 - 1 mg - stabilize week 3 - 0.75 - >0.5 mg gradual reduction(each pill sl...
Source: Suboxone Forum - July 8, 2009 Category: Addiction Source Type: forums

Altering Intensive Care Sedation Paradigms to Improve Patient OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Providing sedation and comfort for intensive care patients has evolved in the last few years. New approaches to improving outcomes for intensive care unit (ICU) patients include providing analgesia before adding sedation and recognizing dangerous adverse effects associated with sedative medications, such as prolonged effects of midazolam, propylene glycol toxicity with lorazepam, propofol infusion syndrome, the deliriogenic effects of benzodiazepines and propofol, and bradycardia with dexmedetomidine. There are now reliable and valid ways to monitor pain and delirium in ICU patients. Dexmedetomidine reduces the incidence o...
Source: Critical Care Clinics - June 30, 2009 Category: Intensive Care Authors: Richard R. Riker, Gilles L. Fraser Source Type: journals

Chronic gamma-hydroxybutyric-acid use followed by gamma-hydroxybutyric-acid withdrawal mimic schizophrenia: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In our opinion, this original case illustrates the importance of considering gammahydroxybutyric- acid withdrawal delirium in the differential diagnosis of a first-break psychosis. In this case, the effects of chronic GHB use were incorrectly identified as the negative symptoms of schizophrenia prodrome. Likewise, severe gamma-hydroxybutyric-acid withdrawal syndrome was initially mistaken for acute positive symptoms of schizophrenia, until autonomic dysfunction manifested itself more clearly. (Source: Cases Journal)
Source: Cases Journal - June 30, 2009 Category: Journals (General) Source Type: journals

Catatonia: a syndrome appears, disappears, and is rediscovered.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Catatonia is the psychiatric syndrome of disturbed motor functions amid disturbances in mood and thought first described in 1874. It was quickly found in 10% to 38% of psychiatric populations. After it was tied to schizophrenia as a type in the psychiatric classification, its recognition became increasingly limited and by the 1980s questions were asked as to where the catatonics had gone. The decline is largely owing to the change in venue for psychiatric practice from asylum to office, the rejection of physical examination, and the dependence on item rating scales for diagnosis. In the 1970s, broad surveys again showe...
Source: Canadian Journal of Psychiatry - June 30, 2009 Category: Psychiatry Authors: Fink M Tags: Can J Psychiatry Source Type: journals

A Case of Alcohol Withdrawal Requiring 1,600 mg of Lorazepam in 24 Hours.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alcohol withdrawal continues to present significant morbidity and mortality in hospitalized medical/surgical patients. The authors present a case of a patient with delirium tremens requiring up to 1,600 mg/day of lorazepam and discuss alternative treatments for alcohol withdrawal. PMID: 19773714 [PubMed - in process] (Source: CNS Spectrums)
Source: CNS Spectrums - June 30, 2009 Category: Neurology Authors: Kahn DR, Barnhorst AV, Bourgeois JA Tags: CNS Spectr Source Type: journals

[CASE REPORTS] Recurring Episodes of Bell's Mania After Cerebrovascular AccidentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: Failure to recognize this patient’s syndrome as a form of catatonia could have had severe, even life-threatening, consequences. The use of neuroleptic medications in cases of delirium/mania with catatonic signs may result in marked clinical deterioration, whereas high-dose lorazepam can ameliorate catatonic signs. (Source: Psychosomatics)
Source: Psychosomatics - June 29, 2009 Category: Psychiatry & Psychology Authors: Bobo, W. V., Murphy, M. J., Heckers, S. H. Tags: Other Mood Disorders, Stroke, Delirium, Syndromes Secondary to General Medical Disorders CASE REPORTS Source Type: journals

From Diseased towards Human EaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Homoeopathic Links 2009; 22: 86-92DOI: 10.1055/s-0029-1185585SummaryLong-term difficult case involving multiple disease layers demonstrating clearly the need for a comprehensive case management approach and the use of more than one remedy. Treating episodic acute illness within the framework of chronic disease involves addressing the underlying miasmic influence. Different case management techniques and remedies illustrated, analyzed and compared. Appropriate usage of hand-triturated, high-potency (C4, C5) remedies. The treatment of addiction via the patient's trituration of the addictive substance (tautopathy). Following ...
Source: Homoeopathic Links - June 25, 2009 Category: Complementary Medicine Tags: MATERIA MEDICA AND CASES Source Type: journals

DigestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Safety of ramelteonThere is great interest in the role of melatonin agonists as treatments for insomnia. Ramelteon is already available in the USA, where it is used to reduce sleep latency associated with primary insomnia. Licensing in Europe has been delayed after the European Medicines Agency questioned its efficacy. Two studies now report on the safety of ramelteon over one year.The first study enrolled 1213 adults taking ramelteon 16mg (18-64 year age group) or 8mg (over-65 years) and were considered compliant if they took it at least three nights per week (J Clin Psychiatry 2009; pii:ej07m03834). In the younger group ...
Source: Progress in Neurology and Psychiatry - June 23, 2009 Category: Neurology Tags: Digest Source Type: journals

Role of Intravenous Levetiracetam in Acute Seizure Management of ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Status epilepticus is defined as a seizure lasting beyond 30minutes. Children with intractable epilepsy undergo frequent hospital admissions secondary to status epilepticus or because of acute exacerbation of seizures. Intravenous levetiracetam became available in August 2006 for use in patients aged above 16 years. There are insufficient data about the efficacy and safety of intravenous levetiracetam in children. We retrospectively analyzed data from children treated with intravenous levetiracetam for status epilepticus and acute exacerbation of seizures. We acquired data from our institution's electronic medical records ...
Source: Pediatric Neurology - June 17, 2009 Category: Neurology Authors: Batool F. Kirmani, Edwin D. Crisp, Saima Kayani, Hasan Rajab Tags: Original Articles Source Type: journals

Concomitant treatment with voriconazole and benzodiazepines like temazepam and lorazepam may lead to decreased serum voriconazole concentrationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - June 2, 2009 Category: Drugs & Pharmacology Tags: Research article Source Type: journals