A Comprehensive Review on the Role of Interleukin-40 as a Biomarker for Diagnosing Inflammatory Diseases
Autoimmune Dis. 2024 Mar 1;2024:3968767. doi: 10.1155/2024/3968767. eCollection 2024.ABSTRACTInterleukins are a group of proteins that have a wide range of complex functions and are believed to be involved in several diseases and conditions. In particular, interleukin-40 (IL-40) is a recently identified cytokine associated with B cells that was first introduced by Catalan et al. in 2017. This cytokine has several roles in the body, including functioning in the formation of B cells in the bone marrow, IgA production, and expression in the intestinal microbiome. Moreover, IL-40 appears to be involved in numerous autoimmune a...
Source: Autoimmune Diseases - March 11, 2024 Category: Allergy & Immunology Authors: Feryal Dabbagh-Gorjani Source Type: research

The Increasing Level of DKK-1 as a New Bone Formation Factor in Patients with Early Spondyloarthritis
This study aimed at determining the serum DKK-1 profile in patients with SpA and investigating its relationship with SpA progression. Supported by analyzing the BMD data which aims to affirm the potential of DKK-1 as a biomarker for early diagnosis of SpA, this research may become the early study to produce a robust tool to diminish the fatal impacts in SpA. This cross-sectional study included patients with SpA using ASAS 2010 criteria from Dr. Soetomo General Hospital, Indonesia. Collected data included patients' general characteristics, disease duration, disease activity using ASDAS-CRP and ASDAS-ESR, serum DKK-1 levels,...
Source: Autoimmune Diseases - June 1, 2023 Category: Allergy & Immunology Authors: Yuliasih Yuliasih Aghnia Permatasari Lita Diah Rahmawati Mohammad Imam Wahyudi Nabilatun Nisa' Source Type: research