Effects of oral administration of ondansetron, a 5-HT < sub > 3 < /sub > receptor antagonist, on anxiety-related behaviors and colonic hypercontractility in repeated stress-induced mice
CONCLUSIONS: Oral administration of ondansetron prevented increased FPO but did not affect anxiety-related behavior in repeated stress model. Colonic hypercontractility in the stressed mice was related to increased responses to cholinergic-induced contractions, which involved 5-HT3 receptors. Our findings suggest the modulatory roles of 5-HT3 receptors to mediate stress-induced colonic dysfunction.PMID:38642511 | DOI:10.1016/j.autneu.2024.103178 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - April 20, 2024 Category: Neuroscience Authors: Affan Waemong Sarunnuch Sattayachiti Dania Cheaha Nipaporn Konthapakdee Source Type: research
Localization of sensory nerve terminals containing calcitonin gene-related peptide (CGRP) on striated muscle fibers in the rat esophagus: Evidence for triple innervation via motor endplates
CONCLUSIONS: This study suggests that the CGRP-varicose nerve endings containing SP and TRPV1 in motor endplates are sensory, and a few esophageal striated muscle fibers are triply innervated. The nerve endings may detect acetylcholine-derived acetic acid from the vagal motor nerve endings and NO from esophageal intrinsic nerve terminals in the motor endplates to regulate esophageal motility.PMID:38636284 | DOI:10.1016/j.autneu.2024.103177 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - April 18, 2024 Category: Neuroscience Authors: Hirofumi Kuramoto Mana Yabe Ryo Morishita Ryoichi Yoshimura Hiroshi Sakamoto Source Type: research
Localization of sensory nerve terminals containing calcitonin gene-related peptide (CGRP) on striated muscle fibers in the rat esophagus: Evidence for triple innervation via motor endplates
CONCLUSIONS: This study suggests that the CGRP-varicose nerve endings containing SP and TRPV1 in motor endplates are sensory, and a few esophageal striated muscle fibers are triply innervated. The nerve endings may detect acetylcholine-derived acetic acid from the vagal motor nerve endings and NO from esophageal intrinsic nerve terminals in the motor endplates to regulate esophageal motility.PMID:38636284 | DOI:10.1016/j.autneu.2024.103177 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - April 18, 2024 Category: Neuroscience Authors: Hirofumi Kuramoto Mana Yabe Ryo Morishita Ryoichi Yoshimura Hiroshi Sakamoto Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Hepatic interoception in health and disease
Auton Neurosci. 2024 Mar 29;253:103174. doi: 10.1016/j.autneu.2024.103174. Online ahead of print.ABSTRACTThe liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific ...
Source: Autonomic Neuroscience - April 5, 2024 Category: Neuroscience Authors: Hans-Rudolf Berthoud Heike M ünzberg Christopher D Morrison Winfried L Neuhuber Source Type: research
Small fiber neuropathy in children, adolescents, and young adults with chronic orthostatic intolerance and postural orthostatic tachycardia syndrome: A retrospective study
CONCLUSION: Our data suggest a link between OI and POTS and small fiber neuropathy. Small fiber neuropathy was found by skin biopsy in over half of the patients tested. OI and Postural orthostatic tachycardia patients with small fiber neuropathy expressed multiple markers suggesting an underlying autoimmune or inflammatory process. Future research will be done to evaluate the symptomatic implication of SFN and whether immune or pharmacologic manipulation can alter patient symptoms.PMID:38537312 | DOI:10.1016/j.autneu.2024.103163 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - March 27, 2024 Category: Neuroscience Authors: Jeffrey P Moak Carolyn B Ramwell Heather Gordish-Dressman Sangeeta D Sule Elizabeth Bettini Source Type: research
Small fiber neuropathy in children, adolescents, and young adults with chronic orthostatic intolerance and postural orthostatic tachycardia syndrome: A retrospective study
CONCLUSION: Our data suggest a link between OI and POTS and small fiber neuropathy. Small fiber neuropathy was found by skin biopsy in over half of the patients tested. OI and Postural orthostatic tachycardia patients with small fiber neuropathy expressed multiple markers suggesting an underlying autoimmune or inflammatory process. Future research will be done to evaluate the symptomatic implication of SFN and whether immune or pharmacologic manipulation can alter patient symptoms.PMID:38537312 | DOI:10.1016/j.autneu.2024.103163 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - March 27, 2024 Category: Neuroscience Authors: Jeffrey P Moak Carolyn B Ramwell Heather Gordish-Dressman Sangeeta D Sule Elizabeth Bettini Source Type: research
