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Protocol for the "Michigan Awareness Control Study": A prospective, randomized, controlled trial comparing electronic alerts based on bispectral index monitoring or minimum alveolar concentration for the prevention of intraoperative awarenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The incidence of intraoperative awareness with explicit recall is 1-2/1000 cases in the United States. The Bispectral Index monitor is an electroencephalographic method of assessing anesthetic depth that has been shown in one prospective study to reduce the incidence of awareness in the high-risk population. In the B-Aware trial, the number needed to treat in order to prevent one case of awareness in the high-risk population was 138. Since the number needed to treat and the associated cost of treatment would be much higher in the general population, the efficacy of the Bispectral Index monitor in preventing awa...
Source: BMC Anesthesiology - November 5, 2009 Category: Anesthesiology Authors: George MashourKevin TremperMichael Avidan Source Type: journals

Noninvasive cardiac output and blood pressure monitoring cannot replace an invasive monitoring system in critically ill patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although the noninvasive CO measurement appears promising, the noninvasive blood pressure assessment is clearly less reliable than the invasively measured blood pressure. Therefore, according to the present data application of the Nexfin HD monitoring system in the ICU cannot be recommended generally. Whether such a tool might be reliable in certain critically ill patients remains to be determined. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - October 11, 2009 Category: Anesthesiology Authors: John StoverReto StockerRenato LenherrThomas NeffSilvia CottiniBernhard ZollerMarkus Bechir Source Type: journals

Population pharmacokinetics of remifentanil in infants and children undergoing cardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Remifentanil dosage adjustments are required during and after CPB due to marked changes in the V of the drug. Simulations indicate that a targeted blood concentration of 14 ng/mL is achieved and maintained in 50% of typical patients by administration of an initial dose of 18 ug remifentanil followed by an infusion of 3.7 ug/min before, during and post-CPB, supplemented with a bolus dose of 25 ug given at the start of CPB. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - July 26, 2009 Category: Anesthesiology Authors: Wai Johnn SamGregory HammerDavid Drover Source Type: journals

Role of potassium and calcium channels in sevoflurane-mediated vasodilation in the foeto-placental circulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Sevoflurane appears to block chorionic arterial KCa++ and KATP channels. Sevoflurane also blocks voltage-operated calcium channels, and exerts a net vasodilatory effect in the in vitro foeto-placental circulation. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - June 10, 2009 Category: Anesthesiology Authors: James JarmanChrisen MaharajBrendan HigginsRachel FarragherChristopher LaffeyNoel FlynnJohn Laffey Source Type: journals

Efficacy of sub-Tenon's block using an equal volume of local anaesthetic administered either as a single or as divided doses. A randomised clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Single injection of local anaesthesia for sub-Tenon's block with mixture of lignocaine with adrenaline, bupivacaine and hyaluronidase was found to be superior to provide akinesia of ocular muscles compared to divided dose given by two injections. No difference in groups in terms of haemorrhage, chemosis, patient's satisfaction and intraocular pressure was found.Trial registrationTrial registration no-ISRCTN73431052 (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 26, 2009 Category: Anesthesiology Authors: Ehtesham I Khan, Jawad Mustafa, John McAdoo and George Shorten Source Type: journals

Efficacy of Sub-Tenon's block using an equal volume of local anaesthetic administered either as a single or as divided doses.a randomised clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Single injection of local anaesthesia for sub-Tenon's block with mixture of lignocaine with adrenaline, bupivacaine and hyaluronidase was found to be superior to provide akinesia of ocular muscles compared to divided dose given by two injections. No difference in groups in terms of haemorrhage, chemosis, patient's satisfaction and intraocular pressure was found. Trial Registration:ISRCTN73431052 (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 26, 2009 Category: Anesthesiology Authors: Ehtesham I Khan, Jawad Mustafa, John McAdoo and George Shorten Source Type: journals

Nitrous oxide may not increase the risk of cancer recurrence after colorectal surgery: a follow-up of a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Colorectal-cancer recurrence risks were not greatly different in patients who were randomly assigned to 65% nitrous oxide or nitrogen during surgery. Our results may not support avoiding nitrous oxide use to prevent recurrence of colorectal cancer.Implications StatementThe risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery.Trial RegistrationCurrent Controlled Clinical Trials NCT00781352 http://www.clinicaltrials.gov (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - February 3, 2009 Category: Anesthesiology Authors: Edith Fleischmann, Corinna Marschalek, Katja Schlemitz, Jarrod E Dalton, Thomas Gruenberger, Friedrich Herbst, Andrea Kurz and Daniel I Sessler Source Type: journals

Nitrous oxide may not increase the risk of cancer recurrence after colorectal surgery: a follow-up of a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Colorectal-cancer recurrence risks were not greatly different in patients who were randomly assigned to 65% nitrous oxide or nitrogen during surgery. Our results may not support avoiding nitrous oxide use to prevent recurrence of colorectal cancer. Implications Statement: The risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery. Trial Registration: Current Controlled Clinical Trials NCT00781352 (www.clinicaltrials.gov) Word Count: 262 (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - February 3, 2009 Category: Anesthesiology Authors: Edith Fleishmann, Corinna Marschalek, Katja Schlemitz, Jarrod Dalton, Thomas Gruenberger, Herbst Friedrich, Andrea Kurz and Daniel Sessler Source Type: journals

Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of this study demonstrate the feasibility of recording contact heat evoked potentials with EEG during continuous and simultaneous fMRI. The combined use of the two methods can lead to identification of distinct patterns of brain activity indicative of pain and pro-nociceptive sensitisation in healthy subjects and chronic pain patients. Further studies are required for the technique to progress as a useful tool in clinical trials of novel analgesics. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - December 17, 2008 Category: Anesthesiology Authors: Katherine Roberts, Anastasia Papadaki, Carla Goncalves, Mary Tighe, Duncan Atherton, Ravikiran Shenoy, Donald McRobbie and Praveen Anand Source Type: journals

Arteriovenous extracorporeal lung assist allows for maximization of oscillatory frequencies: a large-animal model of respiratory distressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this animal model of ARDS, maximization of oscillatory frequencies with subsequent minimization of VT leads to hypercapnia that can only be reversed by adding av-ECLA. When combined with a recruitment strategy, these high frequencies do not impair oxygenation. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - November 14, 2008 Category: Anesthesiology Authors: Ralf M Muellenbach, Julian M Kuestermann, Markus Kredel, Amelie Johannes, Ulrike Wolfsteiner, Frank Schuster, Christian Wunder, Peter Kranke, Norbert Roewer and Jorg Brederlau Source Type: journals

Pharmacokinetics and pharmacodynamics of fenoldopam mesylate for blood pressure control in pediatric patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Fenoldopam is a rapid-acting, effective agent for intravenous control of blood pressure in children. The effective dose range is significantly higher in children undergoing anesthesia and surgery (0.8-1.2 mcg/kg/min) than as labeled for adults (0.05- 0.3 mcg/kg/min). The PK and side-effect profiles for children and adults are similar. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - October 6, 2008 Category: Anesthesiology Authors: Gregory B Hammer, Susan T Verghese, David R Drover, Myron Yaster and Joseph R Tobin Source Type: journals

Determination of the efficacy and side-effect profile of lower doses of intrathecal morphine in patients undergoing total knee arthroplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Both 200 μg and 300 μg provided comparable postoperative analgesia, which was superior to that provided by 100 μg IT morphine in patients undergoing total knee arthroplasty. Based on these findings, we recommend that 200 μg IT morphine be used in these patients.Trial registrationClinicalTrials.gov Identifier NCT00695045 (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - September 24, 2008 Category: Anesthesiology Authors: Patrick Hassett, Bilal Ansari, Pachaimuthu Gnanamoorthy, Brian Kinirons and John G Laffey Source Type: journals

Determination of the efficacy and side-effect profile of lower doses of intrathecal morphine in patients undergoing total knee arthroplasty.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Both 200mcg and 300mcg provided comparable postoperative analgesia, which was superior to that provided by 100mcg IT morphine in patients undergoing total knee arthroplasty. Based on these findings, we recommend that 200mcg IT morphine be used in these patients. Trial registration: ClinicalTrials.gov Identifier NCT00695045 (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - September 24, 2008 Category: Anesthesiology Authors: Patrick Hassett, Bilal Ansari, Pachaimuthu Gnanamoorthy, Brian Kinirons and John G Laffey Source Type: journals

Desflurane consumption during automated closed-circuit delivery is higher than when a conventional anesthesia machine is used with a simple vaporizer-O2-N2O fresh gas flow sequenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Agent consumption with an automated closed-circuit anesthesia machine is higher than with a conventional anesthesia machine when the latter is used with a specific vaporizer-FGF sequence. Agent consumption during automated delivery might be further reduced by optimizing the algorithm(s) that manages the initial FGF or by tolerating some N2 in the circuit to minimize the need for intermittent flushing. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - July 17, 2008 Category: Anesthesiology Authors: Sofie De Cooman, Nathalie De Mey, Bram BC Dewulf, Rik Carette, Thierry Deloof, Maurice Sosnowski, Andre M De Wolf and Jan FA Hendrickx Source Type: journals

Desflurane consumption during automated closed-circuit delivery is higher than when a conventional anesthesia machine is used with a simple vaporizer-O2-N2O fresh gas flow sequence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Agent consumption with an automated closed-circuit anesthesia machine is higher than with a conventional anesthesia machine when the latter is used with a specific vaporizer- FGF sequence. Agent consumption during automated delivery might be further reduced by optimizing the algorithm(s) that manages the initial FGF or by tolerating some N2 in the circuit to minimize the need for intermittent flushing. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - July 17, 2008 Category: Anesthesiology Authors: Sofie De Cooman, Nathalie De Mey, Bram BC Dewulf, Rik Carette, Thierry Deloof, Maurice Sosnowski, Andre M De Wolf and Jan FA Hendrickx Source Type: journals

A prospective study to evaluate the accuracy of pulse power analysis to monitor cardiac output in critically ill patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The agreement between lithium dilution cardiac output and the pulse power algorithm in the PulseCO monitor remains acceptable for up to four hours in critically ill patients. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - February 18, 2008 Category: Anesthesiology Authors: Maurizio Cecconi, Jayne Fawcett, R Michael Grounds and Andrew Rhodes Source Type: journals

Can modern infrared analyzers replace gas chromatography to measure anesthetic vapor concentrations?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: M-CAiOV compact gas IR analyzers are well compensated for carrier gas cross-sensitivity and are linear over the range of concentrations studied. IR and GC cannot be used interchangeably, because the deviations between GC and IR mount up to A+/- 20%, and because individual analyzers differ unpredictably in their performance. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - February 8, 2008 Category: Anesthesiology Authors: Jan FA Hendrickx, Hendrikus JM . Lemmens, Rik Carette, Andre M De Wolf and Lawrence J Saidman Source Type: journals

A new analgesic method, two-minute sciatic nerve press, for immediate pain relief: a randomized trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background Current analgesics have drawbacks such as delays in acquisition, lag-times for effect, and side effects. We recently presented a preliminary report of a new analgesic method involving a two-minute sciatic nerve press, which resulted in rapid and short-term relief of pain associated with dental and renal diseases. The present study investigated whether this technique was effective for pain associated with other disease types, and whether the relief was effective for up to one hour. Methods This randomized, placebo-controlled, parallel-group trial was conducted in four hospitals in Anhui Province, China. Patients...
Source: BMC Anesthesiology - January 25, 2008 Category: Anesthesiology Authors: Jiman He, Bin Wu, Xianrong Jiang, Fenglin Zhang, Tao Zhao and Wenlon Zhang Source Type: journals

Evaluation of a new arterial pressure-based cardiac output device requiring no external calibrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Several techniques have been discussed as alternatives to the intermittent bolus thermodilution cardiac output (COPAC) measurement by the pulmonary artery catheter (PAC). However, these techniques usually require a central venous line, an additional catheter, or a special calibration procedure. A new arterial pressure-based cardiac output (COAP) device (FloTracTM, VigileoTM; Edwards Lifesciences, Irvine, CA, USA) only requires access to the radial or femoral artery using a standard arterial catheter and does not need an external calibration. We validated this technique in critically ill patients in the intensiv...
Source: BMC Anesthesiology - November 9, 2007 Category: Anesthesiology Authors: Christopher Prasser, Sylvia Bele, Cornelius Keyl, Stefan Schweiger, Benedikt Trabold, Matthias Amann, Julia Welnhofer and Christoph Wiesenack Source Type: journals

Quality of life after stay in surgical intensive care unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ASA-PS, age, type of surgery, ICU LOS and SAPS II could be seen as determinants of HRQOL. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - July 24, 2007 Category: Anesthesiology Authors: Fernando J Abelha, Cristina C Santos, Paula C Maia, Maria A Castro and Henrique Barros Source Type: journals

Increased permeability-oedema versus atelectasis in pulmonary dysfunction after trauma and surgery: a prospective cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Trauma and surgery may be complicated by pulmonary dysfunction, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), but the mechanisms are incompletely understood. Methods: We evaluated lung capillary protein permeability non-invasively with help of the 67Ga-transferrin pulmonary leak index (PLI) technique and extravascular lung water (EVLW) by the transpulmonary thermal-dye dilution technique in consecutive, mechanically ventilated patients in the intensive care unit within 24 h of direct, blunt thoracic trauma (n=5, 2 with ARDS), and within 12 h of indirect trauma by transhiatal oesophage...
Source: BMC Anesthesiology - July 9, 2007 Category: Anesthesiology Authors: A.B. Johan Groeneveld Source Type: journals

Gabapentin and postoperative pain; A qualitative and quantitative systematic review, with focus on procedure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Gabapentin is an antiepileptic drug used in a variety of chronic pain conditions. Increasing numbers of randomized trials indicate that gabapentin is effective as a postoperative analgesic. This procedure-specific systematic review aims to analyse the 24-hour postoperative effect of gabapentin on acute pain in adults. Methods: Medline, The Cochrane Library and Google Scholar were searched for double-blind randomized placebo controlled trials of gabapentin for postoperative pain relief compared with placebo, in adults undergoing a surgical procedure. Qualitative analysis of postoperative effectiveness was evalu...
Source: BMC Anesthesiology - July 7, 2007 Category: Anesthesiology Authors: Ole Mathiesen, Steen Moiniche and Jorgen B Dahl Source Type: journals

Drotrecogin alfa (activated) in severe sepsis:A systematic review and new cost-effectiveness analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The evidence supporting the clinical and economic attractiveness of drotrecogin alfa is not conclusive and further research appears to be indicated. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - June 25, 2007 Category: Anesthesiology Authors: Vania Costa and James M Brophy Source Type: journals

Immediate and short-term pain relief by acute sciatic nerve press: a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes a new manipulation: a 2-minute sciatic nerve press, for rapid short-term relief of pain brought on by various dental and renal diseases. Methods: this randomized, single-blind, placebo-controlled trial ran in three hospitals in Anhui Province, China, with an enrollment of 66 out of 111 solicited patients aged 16 to 74 years. Patients were recruited sequentially, by specific participating physicians at their clinic visits to three independent hospitals. The diseases in enrolled dental patients included dental caries, periodontal diseases and dental trauma. Renal diseases in recruits included kidney infe...
Source: BMC Anesthesiology - May 16, 2007 Category: Anesthesiology Authors: Jiman He, Bin Wu, Wenlong Zhang and Guangping Ten Source Type: journals

Prevalence and impact of alcohol and other drug use disorders on sedation and mechanical ventilation: a retrospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of AOD among medical ICU patients undergoing MV is high. Patients with AOD receive higher doses of sedation than their non-AOD counterparts to achieve similar RASS scores but do not undergo longer duration of MV. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 14, 2007 Category: Anesthesiology Authors: Marjolein de Wit, Sau Yin Wan, Sujoy Gill, Wendy I Jenvey, Al M Best, Judith Tomlinson and Michael F Weaver Source Type: journals

Severe upper airway obstruction due to delayed retropharyngeal hematoma formation following blunt cervical traumaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Retropharyngeal hematoma with life-threatening airway compromise can develop hours or days after a precipitating injury. Clinicians should be alert to the potential for this delayed airway collapse, and should also be prepared to rapidly secure the airway in this patient population likely to have concomitant cervical spinal or head injuries. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 12, 2007 Category: Anesthesiology Authors: Laurie W Lazott, John A Ponzo, Rudolph B Puana, Katie S Artz, David P Ciceri and William C Culp Source Type: journals

Efficacy and safety of a two-step method of skin preparation for peripheral intravenous catheter insertion - a prospective multi-centre randomised trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have developed a two-step procedure for preparing the skin before peripheral venous catheter (PVC) insertions. This procedure involves two successive swabbings with wipes soaked in alcoholic antiseptic. We investigated whether this two-step procedure was as effective and safe as the standard four-step procedure -- washing with detergent, rinsing, drying, applying antiseptic -- by carrying out a multicentre randomised equivalence study comparing the frequency of precursor signs of infection at the site of insertion for the two skin preparation procedures. The study was carried out over an eight-month period, and 248 PVC ...
Source: BMC Anesthesiology - January 31, 2007 Category: Anesthesiology Authors: Nathalie L van der Mee-Marquet and The Bloodstream Infection Study Group of the RHC Source Type: journals

Efficacy and safety of a two-step method of skin preparation for peripheral intravenous catheter insertion: a prospective multi-centre randomised trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have developed a two-step procedure for preparing the skin before peripheral venous catheter (PVC) insertions. This procedure involves two successive swabbings with wipes soaked in alcoholic antiseptic. We investigated whether this two-step procedure was as effective and safe as the standard four-step procedure – washing with detergent, rinsing, drying, applying antiseptic – by carrying out a multicentre randomised equivalence study comparing the frequency of precursor signs of infection at the site of insertion for the two skin preparation procedures. The study was carried out over an eight-month period, and 248 PV...
Source: BMC Anesthesiology - January 31, 2007 Category: Anesthesiology Authors: Nathalie L van der Mee-Marquet and the Bloodstream infection Study Group of the Relais Régional d'Hygiène Hospitalière du Centre Source Type: journals

Effects of epidural lidocaine analgesia on labor and delivery: A randomized, prospective, controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Epidural analgesia with 1% lidocaine does not prolong the active-first and second stages of labor and does not increase vacuum-assisted or cesarean delivery rate. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - December 18, 2006 Category: Anesthesiology Authors: Shahram - Nafisi Source Type: journals

Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room – implications for the treatment of PONV and related clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Almost all trials showed a considerable and consistently high rate of recurrence of emetic symptoms after placebo highlighting the need for a consequent antiemetic treatment. Future (placebo) controlled efficacy trials may use the presented empirical estimates for defining clinically relevant effects and for statistical power considerations. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - December 13, 2006 Category: Anesthesiology Authors: Leopold HJ Eberhart, Silke Frank, Henning Lange, Astrid M Morin, André Scherag, Hinnerk Wulf and Peter Kranke Source Type: journals

High throughput modular chambers for rapid evaluation of anesthetic sensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This system enabled assessment of inhaled anesthetic responsiveness with a higher precision than that previously reported. It is broadly adaptable for delivering an inhaled therapeutic (or toxin) to a population while monitoring its vital signs, motor reflexes, and providing precise control over environmental conditions. This system is also amenable to full automation. Data presented in this manuscript prove the utility of the controlled environment chambers and should allow for subsequent phenotyping of mice with targeted mutations that are expected to alter sensitivity to induction or emergence from anesthes...
Source: BMC Anesthesiology - November 10, 2006 Category: Anesthesiology Authors: Yi Sun, Jingqiu Chen, Gregory Pruckmayr, James E Baumgardner, David M Eckmann, Roderic G Eckenhoff and Max B Kelz Source Type: journals

Neuroaxial anesthesia in a patient with progressive systemic sclerosis : Case presentation and review of the literature on systemic sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Systemic sclerosis is a complex disease that involves multiple organ systems. Every aspects of anesthetic care may be altered or hindered by the pathogenesis of disease. Although the choice of regional or general anesthesia is unclear, to choose combined spinal epidural anesthesia may be useful. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - October 17, 2006 Category: Anesthesiology Authors: Gulcan Erk, Vildan Taspinar, Ferah Donmez and Dilsen Ornek Source Type: journals

The impact of administration of tranexamic acid in reducing the use of red blood cells and other blood products in cardiac surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on the analysis of 4191 patients who underwent a primary cardiac operation, administration of tranexamic acid decreased the number of patients exposed to a transfusion or returned to theatre for bleeding in our institute. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - August 30, 2006 Category: Anesthesiology Authors: Alain Vuylsteke, Palanikumar Saravanan, Caroline Gerrard and Fay Cafferty Source Type: journals

The impact of administration of tranexamic acid in reducing the use of red blood cells and other blood products in cardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Based on the analysis of 4191 patients who underwent a primary cardiac operation, administration of tranexamic acid decreased the number of patients exposed to a transfusion or returned to theatre for bleeding in our institute. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - August 30, 2006 Category: Anesthesiology Authors: Alain Vuylsteke, Palanikumar Saravanan, Caroline Gerrard and Fay Cafferty Source Type: journals

Sustained inflation and incremental mean airway pressure trial during conventional and high-frequency oscillatory ventilation in a large porcine model of acute respiratory distress syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: To compare the effect of a sustained inflation followed by an incremental mean airway pressure trial during conventional and high-frequency oscillatory ventilation on oxygenation and hemodynamics in a large porcine model of early acute respiratory distress syndrome. Methods: Severe lung injury (Ali) was induced in 18 healthy pigs (55.3 +/- 3.9 kg, mean +/- SD) by repeated saline lung lavage until PaO2 decreased to less than 60 mmHg. After a stabilisation period of 60 minutes, the animals were randomly assigned to two groups: Group 1 (Pressure controlled ventilation; PCV): FIO2 = 1.0, PEEP = 5 cmH2O, VT = 6 ml/...
Source: BMC Anesthesiology - June 22, 2006 Category: Anesthesiology Authors: Ralf M Muellenbach, Markus Kredel, Bernd Zollhoefer, Christian Wunder, Norbert Roewer and Joerg Brederlau Source Type: journals

Do distribution volumes and clearances relate to tissue volumes and blood flows? A computer simulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The kinetics of anesthetic gases can be adequately described by a mammilary compartmental model. Therefore, concepts that are traditionally thought of as being applicable to the kinetics of intravenous agents can be equally well applied to anesthetic gases. Distribution volumes and clearances cannot be equated to tissue volumes and blood flows respectively. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - June 13, 2006 Category: Anesthesiology Authors: Jan F.A. Hendrickx, Hendrikus J.M. Lemmens and Steven L. Shafer Source Type: journals

Do distribution volumes and clearances relate to tissue volumes and blood flows? A computer simulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The kinetics of anesthetic gases can be adequately described by a mammilary compartmental model. Therefore, concepts that are traditionally thought of as being applicable to the kinetics of intravenous agents can be equally well applied to anesthetic gases. Distribution volumes and clearances cannot be equated to tissue volumes and blood flows respectively. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - June 13, 2006 Category: Anesthesiology Authors: Jan F.A. Hendrickx, Hendrikus J.M. Lemmens and Steven L. Shafer Source Type: journals

Acupuncture is a feasible treatment for post-thoracotomy pain: results of a prospective pilot trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The rate of data completion met our predefined criterion for determining a randomized trial to be feasible (at least 75% of patients tolerated the intervention and provided evaluable data). This novel intervention is acceptable to patients undergoing thoracotomy and does not interfere with standard preoperative care. There was no evidence of important adverse events. We are now testing the hypothesis that acupuncture significantly adds to standard perioperative pain management in a randomized trial. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - May 3, 2006 Category: Anesthesiology Authors: Andrew J Vickers, Valerie W Rusch, Vivek T Malhotra, Robert J Downey and Barrie R Cassileth Source Type: journals

High frequency oscillatory ventilation and prone positioning in a porcine model of lavage-induced acute lung injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: If ventilator induced lung injury is ameliorated by a lower Pmean, a combined treatment approach using HFOV and prone positioning might result in further lung protection. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - April 3, 2006 Category: Anesthesiology Authors: Joerg Brederlau, Ralf Muellenbach, Markus Kredel, Clemens Greim and Norbert Roewer Source Type: journals

Effect of valdecoxib pretreatment on pain and secondary hyperalgesia: a randomized controlled trial in healthy volunteers [ISRCTN05282752, NCT00260325]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We demonstrated that a single, oral dose of valdecoxib when does not attenuate secondary hyperalgesia induced by heat/capsaicin in a cutaneous sensitization pain model in healthy volunteers. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 10, 2006 Category: Anesthesiology Authors: David Burns, Lindsay Hill, Michael Essandoh, Tomasz M Jarzembowski, H Gregg Schuler and Piotr K Janicki Source Type: journals

Effect of propofol and etomidate on normoxic and chronically hypoxic pulmonary arteryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Propofol and etomidate have relaxant properties in PA from human and normoxic rat. The relaxant effect is specifically accentuated in PA from CH rat, mainly via an effect on the pharmacomechanical coupling. Etomidate appears to be more efficient than propofol at identical concentration, but, taking into account clinical concentrations, etomidate is less potent than propofol, which effect was in the range of clinical doses. Although these findings provide experimental support for the preferential use of etomidate for haemodynamic stability in patients suffering from PAHT, the clinical relevance of the observatio...
Source: BMC Anesthesiology - March 3, 2006 Category: Anesthesiology Authors: Nazinigouba Ouédraogo, Boutchi Mounkaïla, Huguette Crevel, Roger Marthan and Etienne Roux Source Type: journals

Randomised controlled trial of cervical radiofrequency lesions as a treatment for cervicogenic headache [ISRCTN07444684]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We did not find evidence that radiofrequency treatment of cervical facet joints and upper dorsal root ganglions is a better treatment than the infiltration of the greater occipital nerve, followed by TENS for patients fulfilling the clinical criteria of cervicogenic headache. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - February 16, 2006 Category: Anesthesiology Authors: Sara RS Haspeslagh, Hans A Van Suijlekom, Inge E Lamé, Alfons GH Kessels, Maarten van Kleef and Wim EJ Weber Source Type: journals

A randomized, controlled trial of spinal endoscopic adhesiolysis in chronic refractory low back and lower extremity pain [ISRCTN 16558617]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Spinal endoscopic adhesiolysis with targeted delivery of local anesthetic and steroid is an effective treatment in a significant number of patients with chronic low back and lower extremity pain without major adverse effects. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - July 6, 2005 Category: Anesthesiology Authors: Laxmaiah Manchikanti, Mark V Boswell, Jose J Rivera, Vidya Sagar Pampati, Kim S Damron, Carla D McManus, Doris E Brandon and Sue R Wilson Source Type: journals

"Anxiebo", placebo, and postoperative painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionPostoperative pain remains a significant clinical problem. Increased pain intensity with increased demand for opioid medication, and/or a relative unresponsiveness to pain treatment was reported both when the analgesia was administered by means of conventional nurse injection regimes and patient-controlled analgesia (PCA). Both the quality of the analgesia, and the sensitivity of postoperative models for assessing analgesic efficacy could be significantly influenced.The findings could be explained by increased penetration of an algesic anxiety-related nocebo influence (which we chose to call "anxiebo") relative t...
Source: BMC Anesthesiology - June 27, 2005 Category: Anesthesiology Authors: Paul Svedman, Martin Ingvar and Torsten Gordh Source Type: journals

Inhibition of sarcoplasmic Ca2+-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individualsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Inhibition of the SERCA activity by CPA enhances halothane- and caffeine-induced contractures especially in MHS and MHE skeletal muscle and may help for the diagnostic assignment of MH susceptibility. The status of SERCA activity may play a significant but so far unknown role in the genesis of malignant hyperthermia. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - June 9, 2005 Category: Anesthesiology Authors: Frank Schuster, Rainer Müller, Edmund Hartung, Norbert Roewer and Martin Anetseder Source Type: journals

Hypothermia in a surgical intensive care unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The prevalence of patient hypothermia on ICU arrival was high. Hypothermia at time of admission to the ICU was not an independent factor for mortality or for staying longer in ICU. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - June 6, 2005 Category: Anesthesiology Authors: Fernando J Abelha, Maria A Castro, Aida M Neves, Nuno M Landeiro and Cristina C Santos Source Type: journals

Carbon monoxide production from five volatile anesthetics in dry sodalime in a patient model: halothane and sevoflurane do produce carbon monoxide; temperature is a poor predictor of carbon monoxide productionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All modern volatile anesthetics produce CO in desiccated sodalime. Sodalime temperature increase is a poor predictor of CO production. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - June 2, 2005 Category: Anesthesiology Authors: Christiaan Keijzer, Roberto SGM Perez and Jaap J De Lange Source Type: journals