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The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population. (Source: BMC Cancer)
Source: BMC Cancer - November 20, 2009 Category: Cancer & Oncology Authors: Adela CastillejoTrinidad Mata-BalaguerCarla GuarinosMaria-Isabel CastillejoAna Martinez-CantoVictor-Manuel BarberaPaola MontenegroEnrique OchoaRafael LazaroCarmen Guillen-PonceAlfredo CarratoJose Soto Source Type: journals

The effect of low-level laser irradiation (Ga-Al-AsP - 660nm) on in vitro and in vivo melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: LLLT Irradiation should be avoided over melanomas as the combination of high irradiance (2.5W/cm2) and high dose (1050J/cm2) significantly increases melanoma tumor growth in vivo. (Source: BMC Cancer)
Source: BMC Cancer - November 20, 2009 Category: Cancer & Oncology Authors: Lucio FrigoJuliana LuppiGiovani FaveroDurvanei MariaSocrates PennaJan BjordalRene BensadounRodrigo Alvaro Lopes Martins Source Type: journals

Initial activation of EpCAM cleavage via cell-to-cell contactEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Activation of EpCAM's cleavage and oncogenic capacity is dependent on cellular interaction (juxtacrine) to provide for initial signals of regulated intramembrane proteolysis, which then support signalling via soluble EpEX (paracrine). (Source: BMC Cancer)
Source: BMC Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Sabine DenzelDorothea MaetzelBrigitte MackCarola EggertGabriele BaerrOlivier Gires Source Type: journals

Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: S. gallolyticus most likely plays an essential role in the oncogenic progression of normal colorectal mucosa to adenoma and to CRC. This promoting/propagating role of S. gallolyticus might take place by utilizing certain inflammatory, anti-apoptotic, and angiogenic factors of transformation including NF-kappaB and IL-8. (Source: BMC Cancer)
Source: BMC Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Ahmed AbdulamirRand HafidhLayla MahdiTarik AljebooriFatimah Abu bakar Source Type: journals

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative statesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Colon tumors show differential expression of miRNAs depending on mismatch repair status. miRNA expression in colon tumors has an epigenetic component and altered expression that may reflect a reversion to regulatory programs characteristic of undifferentiated proliferative developmental states. (Source: BMC Cancer)
Source: BMC Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Aaron SarverAmy FrenchPedro BorralhoVenugopal ThayanithyAnn ObergKevin SilversteinBruce MorlanShaun RiskaLisa BoardmanJulie CunninghamSubbaya SubramanianLiang WangTom SmyrkCecilia RodriguesStephen ThibodeauClifford Steer Source Type: journals

XPD Codon 312 and 751 Polymorphisms, and AFB1 Exposure, and Hepatocellular Carcinoma RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest that XPD Lys751Gln polymorphism is an important modulator of AFB1 related-HCC development in Guangxi population. (Source: BMC Cancer)
Source: BMC Cancer - November 17, 2009 Category: Cancer & Oncology Authors: Xi Dai LongYun MaYun Feng ZhouJin Guang YaoFu Zhi BanYong Zhi HuangBing Cheng Huang Source Type: journals

Doxorubicin Loaded Polymeric Nanoparticulate Delivery System to Overcome Drug Resistance in OsteosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Lipid-modified dextran nanoparticles loaded with doxorubicin showed pronounced anti-proliferative effects against osteosarcoma cell lines. These findings may lead to new treatment options for MDR osteosarcoma. (Source: BMC Cancer)
Source: BMC Cancer - November 16, 2009 Category: Cancer & Oncology Authors: Michiro SusaArun IyerKeinosuke RyuFrancis HornicekHenry MankinMansoor AmijiZhenfeng Duan Source Type: journals

Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among Men of African Descent: A case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A moderately significant association was observed between PCA risk and men possessing at least one variant GSTP1 105 Val allele (p = 0.049) among men of African descent. We also observed a 2.1-fold increase in PCA risk associated with men possessing the GSTP1 (Val/Val) and GSTM1 (*1/*1 + *1/*0) alleles. MDR analysis validated these findings; detecting GSTP1 105 Val (p = 0.001) as the best single factor for predicting PCA risk. Our findings emphasize the importance of utilizing a combination of traditional and advanced statistical tools to identify and validate single gene and multi-locus interactions in relati...
Source: BMC Cancer - November 16, 2009 Category: Cancer & Oncology Authors: Nicole LavenderMarnita BenfordTiva VanCleaveGuy BrockRick KittlesJason MooreDavid HeinLa Creis Kidd Source Type: journals

DNA-AP sites generation by Etoposide in whole blood cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that etoposide induces DNA damage specifically at DNA-AP sites in quiescent blood cells. This effect could be involved in the development of secondary malignancies associated with etoposide chemotherapy. (Source: BMC Cancer)
Source: BMC Cancer - November 16, 2009 Category: Cancer & Oncology Authors: Emilio RojasPatricia MussaliEfrain TovarMahara Valverde Source Type: journals

An informatics supported web-based data annotation and query tool to expedite translational research for head and neck malignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The SPORE Head and Neck Neoplasm Virtual Biorepository is a robust translational biomedical informatics tool that can facilitate basic science, clinical, and translational research. The Data Query Tool acts as a central source providing a mechanism for researchers to efficiently find clinically annotated datasets and biospecimens that are relevant to their research areas. The tool protects patient privacy by revealing only de-identified data in accordance with regulations and approvals of the IRB and scientific review committee. (Source: BMC Cancer)
Source: BMC Cancer - November 13, 2009 Category: Cancer & Oncology Authors: Waqas AminHyunseok KangAnn EgloffHarpreet SinghKerry TrentJennifer Ridge-HetrickRaja SeethalaJennifer GrandisAnil Parwani Source Type: journals

High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The RelA/p65 inhibitory effects of SAHA and VPA in vitro and the close relationship of class I HDACs and RelA/p65 in vivo suggest that treatment with HDIs could serve as a promising approach to suppress NF-kappaB activity which in turn may lead to enhanced apoptosis and chemosensitization of pancreatic cancers. (Source: BMC Cancer)
Source: BMC Cancer - November 13, 2009 Category: Cancer & Oncology Authors: Annika LehmannCarsten DenkertJan BudcziesAnn-Christin BuckendahlSilvia Darb-EsfahaniAurelia NoskeBerit MullerMarcus BahraPeter NeuhausManfred DietelGlen KristiansenWilko Weichert Source Type: journals

B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that B7-H4 gene polymorphism may contribute to the sporadic breast cancer risk and prognosis in Chinese Han women. (Source: BMC Cancer)
Source: BMC Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Jie ZhangMingyan ZhangWei JiangLihong WangZhenkun FuDalin LiDa PangDianjun Li Source Type: journals

A balanced t(5;17) (p15;q22-23) in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We report a novel t(5;17)(p15;q22-23) translocation in chondroblastoma without involvement of any of the two chromosomal regions in other cases studied. Our results indicate that the characteristic multinucleated giant cells in chondroblastoma do not have the same clonal origin as the mononuclear population, as they do not harbour the same translocation. We therefore hypothesise that they might be either reactive or originate from a distinct neoplastic clone, although the occurrence of two distinct clones is unlikely. Impairment of the CA10 gene might be pathogenetically relevant, as low expression was found i...
Source: BMC Cancer - November 10, 2009 Category: Cancer & Oncology Authors: Salvatore RomeoKaroly SzuhaiIsao NishimoriMarije IjszengaPauline Wijers-KosterAntonie TaminiauPancras Hogendoorn Source Type: journals

Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their compex MMP-9/NGAL in breast cancer diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL) expression is induced in many types of human cancer, while detection of its complex with matrix metalloproteinase-9 (MMP-9) is correlated with cancer disease status. We aim to evaluate the serum expression of MMP-9, NGAL and their complex (MMP-9/NGAL) during the diagnostic work-up of women with breast abnormalities and investigate their correlation with disease severity. Methods: The study included 113 women with non-palpable breast lesions undergoing vacuum-assisted breast biopsy for histological diagnosis, and 30 healthy women, wh...
Source: BMC Cancer - November 4, 2009 Category: Cancer & Oncology Authors: Xeni ProvatopoulouAntonia GounarisEleni KalogeraFlora ZagouriIoannis FlessasEvgenios GoussetisAfroditi NonniIoannis PapassotiriouGeorge Zografos Source Type: journals

Assessment of angiogenesis by CD105 antigen in epithelial salivary gland neoplasms with diverse metastatic behaviorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Immunostaining of CD105 in salivary gland tumors imply participation of angiogenesis in the development of malignant lesions, as well as some role for myoepithelial cells in the control of new vessel formation. In addition, suggest that ACC with positive CD105 vessels are at higher risk for metastasis. (Source: BMC Cancer)
Source: BMC Cancer - November 4, 2009 Category: Cancer & Oncology Authors: Sergio CardosoKelen Christine SouzaPaulo Rogerio FariaAna Lucia EisenbergFernando DiasAdriano Loyola Source Type: journals

Continuous 5-fluorouracil infusion plus long acting Octreotide in advanced well differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte Oncology Network.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Continuous/metronomic 5FU infusion plus LAR octreotide is well tolerated and shows activity in patients with well-differentiated neuroendocrine carcinoma. The potential synergism between metronomic chemotherapy and antiangiogenic drugs provides a rationale for exploring this association in the future.Trial registration: NCT00953394 (Source: BMC Cancer)
Source: BMC Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Maria BrizziAlfredo BerrutiAnna FerreroEnrica MilanesiMarco VolanteFederico CastiglioneNadia BiroccoSebastiano BombaciDavide PerroniBenedetta FerrettiOscar AlabisoLibero CiuffredaOscar BertettoMauro PapottiLuigi Dogliotti Source Type: journals

Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parametersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This described model will provide valuable guidance on prognosis after curative surgery for HCC in clinical practice. The adaptive nature allows easy accommodation for future new biomarker inputs, and it may serve as the foundation for future modeling and prediction for HCC prognosis after surgical treatment. (Source: BMC Cancer)
Source: BMC Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Ke HaoJohn LukNikki LeeMao MaoChunsheng ZhangMark FergusonJohn LambHongyue DaiIrene NgPak ShamRonnie Poon Source Type: journals

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results in thyroid cancer cells, namely those harbouring BRAFV600E mutation showed that BRAF signalling pathway provides important proliferation signals. We have shown that in thyroid cancer cells sorafenib induces apoptosis by affecting Mcl-1 and Bcl-2 in BRAFV600E mutated cells which was independent of BRAF. These results suggest that sorafenib may prove useful in the treatment of thyroid carcinomas, particularly those refractory to conventional treatment and harbouring BRAF mutations. (Source: BMC Cancer)
Source: BMC Cancer - October 31, 2009 Category: Cancer & Oncology Authors: Ana PretoJoana GoncalvesAna RebochoJoana FigueiredoAna MeirelesAna RochaHelena VasconcelosHugo SecaRaquel SerucaPaula SoaresManuel Sobrinho-Simoes Source Type: journals

High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results from this study support a potential involvement of Egr-1 in the progression from non-muscle invasive bladder cancers to muscle invasive bladder cancer. (Source: BMC Cancer)
Source: BMC Cancer - October 30, 2009 Category: Cancer & Oncology Authors: Frederikke Lihme EgerodAnnette BartelsNils FristrupMichael BorreTorben OrntoftMartin OleksiewiczNils BrunnerLars Dyrskjot Source Type: journals

The mannosylated extracellular domain of Her2/neu produced in P. pastoris induces protective antitumor immunity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Here we report on the efficacy of the extracellular domain of human Her2/neu produced in yeast P. pastoris, which confers mannosylation of the protein, to act as a potent anti-tumor vaccine against Her2/neu overexpressing tumors. Specific cellular and humoral responses were observed as well as efficacy. (Source: BMC Cancer)
Source: BMC Cancer - October 30, 2009 Category: Cancer & Oncology Authors: Alexios DimitriadisChrysanthi GontinouConstantin BaxevanisAvgi Mamalaki Source Type: journals

Cooperation of decay-accelerating factor and membrane cofactor protein in regulating survival of human cervical cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data indicated that combined DAF and MCP shRNA described in this study may offer an additional alternative to improve the efficacy of antibody-and complement-based cancer immunotherapy. (Source: BMC Cancer)
Source: BMC Cancer - October 30, 2009 Category: Cancer & Oncology Authors: Ling-Juan GaoShu-Yu GuoYou-Qun CaiPing-Qing GuYa-Juan SuHui GongYun LiuChen Chen Source Type: journals

Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: During induced differentiation of human EC cells, the Wnt signalling pathway is reprogrammed and canonical Wnt signalling induced. Specific species regulating non-canonical Wnt signalling conferred growth inhibition when targeted for repression in these EC cells. Notably, FZD7 repression significantly inhibited growth of human EC cells and is a promising therapeutic target for TGCTs. (Source: BMC Cancer)
Source: BMC Cancer - October 29, 2009 Category: Cancer & Oncology Authors: Grace SnowAllison KasperAlexander BuschElisabeth SchwarzKatherine EwingsThomas BeeMichael SpinellaEthan DmitrovskySarah Freemantle Source Type: journals

Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Results of our in vivo yeast-based approach correlate well with clinical data in five out of seven hMLH1 variants and the described model was thus shown to be useful for functional characterization of MLH1 variants in cancer patients found throughout the entire coding region of the gene. (Source: BMC Cancer)
Source: BMC Cancer - October 28, 2009 Category: Cancer & Oncology Authors: Matjaz VogelsangAleksandra CominoNeja ZupanecPetra HudlerRadovan Komel Source Type: journals

Comparison of breast cancer survival in two populations: Ardabil, Iran and British Columbia, CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings support the need for breast cancer screening programs (including regular clinical breast examinations and mammography), public education and awareness regarding early detection of breast cancer, and education of health care providers. (Source: BMC Cancer)
Source: BMC Cancer - October 28, 2009 Category: Cancer & Oncology Authors: Alireza SadjadiT. Gregory HislopChris BajdikMorteza BashashAnahita GhorbaniMehdi NouraieMasoud BabaeiReza MalekzadehParvin Yavari Source Type: journals

Association between an 8q24 locus and the risk of colorectal cancer in Japanese.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The polymorphism rs6983267 showed a significant association with CRC in a Japanese population. Further investigation of the biological mechanism of this association is warranted. (Source: BMC Cancer)
Source: BMC Cancer - October 26, 2009 Category: Cancer & Oncology Authors: Keitaro MatsuoTakeshi SuzukiHidemi ItoSatoyo HosonoTakakazu KawaseMiki WatanabeKohei ShitaraKoji KomoriYukihide KanemitsuTakashi HiraiYasuhi YatabeHideo TanakaKazuo Tajima Source Type: journals

TRPV6 alleles do not influence prostate cancer progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results show that the frequencies of trpv6 alleles in healthy control individuals and prostate cancer patients are not significantly different. Although expression of trpv6 transcripts correlates with aggressive potential of prostate cancer, the TRPV6 genotype does not correlate with the onset of prostate cancer, with the Gleason score and the tumour stage. (Source: BMC Cancer)
Source: BMC Cancer - October 26, 2009 Category: Cancer & Oncology Authors: Thorsten KesslerUlrich WissenbachRainer GrobholzVeit Flockerzi Source Type: journals

Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results highlight several genes that may play an important role across the spectrum of serous ovarian tumorigenesis. (Source: BMC Cancer)
Source: BMC Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Melissa MerrittPeter ParsonsTanya NewtonAdam MartynPenelope WebbAdele GreenDavid PapadimosGlen Boyle Source Type: journals

Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results indicate that high levels of fecal CK19 mRNA represent a potential marker for colorectal malignancy and for aggressive treatment of younger CRC patients. (Source: BMC Cancer)
Source: BMC Cancer - October 21, 2009 Category: Cancer & Oncology Authors: Chun-Chao ChangShung-Haur YangChih-Cheng ChienShu-Hung ChenShiann PanChia-Long LeeChih-Ming LinHsiao-Lun SunChi-Cheng HuangYih-Yiing WuRuey-Neng YangChi-Jung Huang Source Type: journals

Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Loss of prostasin expression in bladder transitional cell carcinomas is associated with epithelial-mesenchymal transition (EMT), and may have functional implications in tumor invasion and resistance to chemotherapy. (Source: BMC Cancer)
Source: BMC Cancer - October 21, 2009 Category: Cancer & Oncology Authors: Li-Mei ChenNicole VerityKarl Chai Source Type: journals

Retrospective analysis of 119 Chinese noninflammatory locally advanced breast cancer cases treated with intravenous combination of vinorelbine and epirubicin as a neoadjuvant chemotherapy: a median follow-up of 63.4 monthsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is a retrospective evaluation of the efficacy of neoadjuvant chemotherapy (NC) with a vinorelbine (V) and epirubicin (E) intravenous combination regimen and is aimed at identification of predictive markers for the long-term outcome in noninflammatory locally advanced breast cancer (NLABC). Methods: One-hundred-and-nineteen patients with NLABC were identified from September 2001 to May 2006. Analysis was performed in March 2008, with a median follow-up of 63.4 months (range, 9-76 months). All patients were diagnosed with invasive breast cancer using 14G core needle biopsy and treated with three cycles of VE befor...
Source: BMC Cancer - October 20, 2009 Category: Cancer & Oncology Authors: Ou HuangCanMing ChenJiaYi WuShuJie ChenXiaoSong ChenGuangYu LiuZhen HuJingSong LuJiong WuZhiMin ShaoZhenZhou ShenKunWei Shen Source Type: journals

Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: MiRNAs showing altered expression at different stages of CRC could be targets for CRC therapies and be further developed as potential diagnostic and prognostic analytes. The identified biological processes and signalling pathways collectively targeted by co-expressed miRNAs in CRC provide a basis for understanding the functional role of miRNAs in cancer. (Source: BMC Cancer)
Source: BMC Cancer - October 19, 2009 Category: Cancer & Oncology Authors: Greg ArndtLesley DosseyLara CullenAngela LaiRiki DrukerMichael EisbacherChunyan ZhangNham TranHongtao FanKathy RetzlaffAnton BittnerMitch Raponi Source Type: journals

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although the proper influence of sulfasalazine treatment on patient outcome was difficult to ascertain in these debilitated patients with a large tumor burden (median KPS=50), ISRCTN45828668 was terminated after its interim analysis. This study urges to exert cautiousness in future trials of Sulfasalazine for the treatment of malignant gliomas.Trial Registration: Current Controlled Trials ISRCTN45828668 (Source: BMC Cancer)
Source: BMC Cancer - October 18, 2009 Category: Cancer & Oncology Authors: Pierre RobeDidier MartinMinh Nguyen-KhacMaria ArtesiManuel DeprezAdelin AlbertSophie VanbelleStephane CalificeMarkus BredelVincent Bours Source Type: journals

NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Identification and analysis of MSX2 in hematopoietic cells implicates a modulatory role via NOTCH3-signaling in early T-cell differentiation. Our data suggest that reduction of NOTCH3-signaling by physiological downregulation of MSX2 expression during T-cell development is abrogated by ectopic expression of oncogenic NKLs, substituting MSX2 function. (Source: BMC Cancer)
Source: BMC Cancer - October 18, 2009 Category: Cancer & Oncology Authors: Stefan NagelLetizia VenturiniGrzegorz PrzybylskiPiotr GrabarczykCorinna MeyerMaren KaufmannKarin BattmerChristian SchmidtHans DrexlerMichaela ScherrRoderick MacLeod Source Type: journals

Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that OGF and OGFr are present in follicular-derived thyroid cancers, and that OGF serves in a tonically active inhibitory manner to maintain homeostasis of cell proliferation. These results may provide a biotherapeutic strategy in the treatment of these cancers. (Source: BMC Cancer)
Source: BMC Cancer - October 17, 2009 Category: Cancer & Oncology Authors: Patricia McLaughlinIan ZagonSunny ParkAndrea ConwayRenee DonahueDavid Goldenberg Source Type: journals

Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: IL1RN, MAL and MMP1 are prospective tumor diagnostic markers for HNSCC. MMP1 overexpression is the most promising marker, and its detection could help identify tumor cells in tissue or saliva. (Source: BMC Cancer)
Source: BMC Cancer - October 17, 2009 Category: Cancer & Oncology Authors: Benjamin LallemantAlexandre EvrardChristophe CombescureHeliette ChapuisGuillaume ChambonCaroline RaynalChristophe ReynaudOmar SabraDominique JoubertFrederic HollandeJean-Gabriel LallemantSerge LumbrosoJean-Paul Brouillet Source Type: journals

Predicting for activity of second-line trastuzumab-based therapy in Her2-positive advanced breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: In Her2-positive advanced breast cancer, the upfront use of trastuzumab is well established. Upon progression on first-line therapy, patients may be switched to lapatinib. Others however remain candidates for continued antibody treatment (treatment beyond progression). Here, we aimed to identify factors predicting for activity of second-line trastuzumab-based therapy. Methods: Ninety-seven patients treated with > 1 line of trastuzumab-containing therapy were available for this analysis. Her2-status was determined by immunohistochemistry and re-analyzed by FISH if a score of 2+ was gained. Time to progression (T...
Source: BMC Cancer - October 16, 2009 Category: Cancer & Oncology Authors: Rupert BartschCatharina De VriesUrsula PluschnigPeter DubskyZsuzsanna Bago-HorvathSimon GampenriederMargaretha RudasRobert MaderAndrea RottenfusserChristoph WiltschkeMichael GnantChristoph ZielinskiGuenther Steger Source Type: journals

Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The identification of pTyr proteins and signaling pathways associated with HCC metastasis could provide useful information for selecting new molecular intervention targets. Moreover, FER might serve as a novel drug target in future HCC therapy. (Source: BMC Cancer)
Source: BMC Cancer - October 15, 2009 Category: Cancer & Oncology Authors: Haiyu LiZhenggang RenXiaonan KangLan ZhangXuefei LiYan WangTongchun XueYuefang ShenYinkun Liu Source Type: journals

A 7 gene expression score predicts for radiation response in cancer cervixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have identified a 7 gene signature which could help identify patients with cervical cancer who can be treated with radiotherapy alone. However, this needs to be validated in a larger patient population. (Source: BMC Cancer)
Source: BMC Cancer - October 14, 2009 Category: Cancer & Oncology Authors: Thangarajan RajkumarNeelakantan VijayalakshmiKesavan SabithaSundersingh ShirleyGanesharaja SelvaluxmyMayil Vahanan BoseLavanya Nambaru Source Type: journals

Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We established 6 xenograft canine HSA tumors in nude mice and found that the expressions of angiogenic growth factors and their receptors in xenograft HSAs were similar to those in spontaneous HSA. Furthermore, we detected the expression of angiogenic homeobox genes; therefore, xenograft models may be useful in analyzing malignant growth in HSA. (Source: BMC Cancer)
Source: BMC Cancer - October 13, 2009 Category: Cancer & Oncology Authors: Atsushi KodamaHiroki SakaiSatoko MatsuuraMami MurakamiAtsuko MuraiTakashi MoriKouji MaruoTohru KimuraToshiaki MasegiTokuma Yanai Source Type: journals

Socioeconomic disparities in breast cancer survival: relation to stage at diagnosis, treatment and raceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Stage at diagnosis, first course treatment and race explained most of the socioeconomic disparity in breast cancer survival. Targeted interventions to increase breast cancer screening and treatment coverage in patients with lower SES could reduce much of socioeconomic disparity. (Source: BMC Cancer)
Source: BMC Cancer - October 13, 2009 Category: Cancer & Oncology Authors: Xue Qin Yu Source Type: journals

Combination of interferon-alpha and 5-fluorouracil inhibits endothelial cell growth directly and by regulation of angiogenic factors released by tumor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggested that IFN-alpha and 5-FU had direct growth inhibitory effects on endothelial cells, as well as anti-angiogenic effects through regulation of angiogenic factors released from HCC cells. Modulation of VEGF and Angs secretion by IFN-alpha and 5-FU may contribute to their anti-angiogenic and anti-tumor effects on HCC. (Source: BMC Cancer)
Source: BMC Cancer - October 11, 2009 Category: Cancer & Oncology Authors: Hiroshi WadaHiroaki NaganoHirofumi YamamotoTakehiro NodaMasahiro MurakamiShogo KobayashiShigeru MarubashiHidetoshi EguchiYutaka TakedaMasahiro TanemuraKoji UmeshitaYuichiro DokiMasaki Mori Source Type: journals

Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data suggest that even though VEGF-C/VEGFR3 pathway is primarily required for lymphangiogenesis and lymphatic metastasis, a very high level of VEGF-C can also stimulate angiogenesis, which is associated with increased tumor growth and a switch from a primary pattern of lymph node metastasis to an increased proportion of metastases at distant sites. (Source: BMC Cancer)
Source: BMC Cancer - October 11, 2009 Category: Cancer & Oncology Authors: Johanna TuomelaMaija ValtaJani SeppanenKati TarkkonenH. Kalervo VaananenPirkko Harkonen Source Type: journals

Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings suggest that the IHC analysis by Allred's method improves our ability to select patients for BRCA1 testing. (Source: BMC Cancer)
Source: BMC Cancer - October 9, 2009 Category: Cancer & Oncology Authors: GianMaria MioloVincenzo CanzonieriClelia De GiacomiLara Della PuppaRiccardo DolcettiDavide LombardiTiziana PerinSimona ScaloneAndrea VeronesiAlessandra Viel Source Type: journals

DNA damage induced by cis- and carboplatin as indicator for in vitro sensitivity of ovarian carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The measurement of DNA damage induced by cis- and carboplatin is an accurate method to determine the in vitro chemosensitivity of ovarian cancer cells towards these cytostatics, because of its quickness, sensitivity and low cell number needed. (Source: BMC Cancer)
Source: BMC Cancer - October 9, 2009 Category: Cancer & Oncology Authors: Florian UngerHermann KlasenGarri TchartchianRudy de WildeIrene Witte Source Type: journals

ST3Gal.I sialyltransferase relevance in bladder cancer tissues and cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ST3Gal.I plays the major role in the sialylation of the T antigen in bladder cancer. The overexpression of ST3Gal.I seems to be part of the initial oncogenic transformation of bladder and can be considered when predicting cancer progression and recurrence. (Source: BMC Cancer)
Source: BMC Cancer - October 6, 2009 Category: Cancer & Oncology Authors: Paula VideiraManuela CorreiaNadia MalagoliniHelio CrespoDario LigeiroFernando CalaisHelder TrindadeFabio Dall'Olio Source Type: journals

Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These drugs show great promise in vitro against a number of cancer cell lines and due to their polymeric nature will most likely be less toxic than currently used metal-containing drugs such as cisplatin. These drugs also offer several addition positive aspects. First, the reactants are commercially available so that additional synthetic steps are not needed. Second, synthesis of the polymer is rapid, occurring within about 15 seconds. Third, the interfacial synthetic system is already industrially employed in the synthesis of aromatic nylons and polycarbonates. Thus, the ability to synthesize large amounts of...
Source: BMC Cancer - October 6, 2009 Category: Cancer & Oncology Authors: Michael RonerCharles CarraherKimberly ShahiYuki AshidaGirish Barot Source Type: journals

The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PgP inhibitors increase uptake of doxorubicin in cells close to blood vessels, have little effect on drug uptake into cells at intermediate distances, and might have a paradoxical effect to decrease doxorubicin uptake into distal cells. This effect probably contributes to the limited success of PgP inhibitors in clinical trials. (Source: BMC Cancer)
Source: BMC Cancer - October 5, 2009 Category: Cancer & Oncology Authors: Krupa PatelIan Tannock Source Type: journals

miRNAs in lung cancer - Studying complex fingerprints in patient's blood cells by microarray experimentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings support the idea that neoplasia may lead to a deregulation of miRNA expression in blood cells of cancer patients compared to blood cells of healthy individuals. Furthermore, we provide evidence that miRNA patterns can be used to detect human cancers from blood cells. (Source: BMC Cancer)
Source: BMC Cancer - October 5, 2009 Category: Cancer & Oncology Authors: Andreas KellerPetra LeidingerAnne BorriesAnke WendschlagFrank WucherpfennigMatthias SchefflerHanno HuwerHans-Peter LenhofEckart Meese Source Type: journals

Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results implicate MGMT promoter methylation as a possible biomarker for oral and pharyngeal cancer prognosis. The critical role of MGMT in DNA repair suggests that defective DNA repair may be correlative in the observed association between MGMT promoter methylation and tumor recurrence. Follow-up studies should include further quantitative MSP-PCR measurements, global methylation profiling and detailed analysis of downstream DNA repair genes regulated by promoter methylation. (Source: BMC Cancer)
Source: BMC Cancer - October 5, 2009 Category: Cancer & Oncology Authors: Emanuela TaioliCamille RaginXiao-hong WangJiangying ChenScott LangevinAshley BrownSusanne GollinSeymour GarteRobert Sobol Source Type: journals

FRAGMATIC: A randomised phase III clinical trial investigating the effect of FRAGMin(R) Added to standard Therapy In patients with lung CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThis Cancer Research UK funded trial will be one of the biggest lung cancer trials ever conducted in the world and will be the first to determine whether the addition of LMWH to routine treatment will be advantages in terms of overall survival in patients with lung cancer. (Source: BMC Cancer)
Source: BMC Cancer - October 5, 2009 Category: Cancer & Oncology Authors: Gareth GriffithsSarah BurnsSimon NobleFergus MacbethDavid CohenTimothy Maughan Source Type: journals