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149 records returned

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear BodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Here we identify hnRNP L as a novel SNB component. We show that, compared with other identified Sam68-associated hnRNP proteins and hnRNP LL, this co-localisation within SNBs is specific to hnRNP L. Our data suggest that the novel Sam68-hnRNP L protein interaction may have a distinct role within SNBs. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - November 13, 2009 Category: Cytology Authors: Prabhakar RajanCaroline DalglieshCyril BourgeoisMonika HeinerKaveh EmamiEmma ClarkAlbrecht BindereifJames SteveninCraig RobsonHing LeungDavid Elliott Source Type: journals

Cbl-Associated Protein is tyrosine phosphorylated by c-Abl and c-Src kinasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This is the first demonstration of phosphorylation of CAP by any kinase. Our findings suggest that coordinated action of Src and Abl might regulate the function of CAP and reveal a functional role especially for the Src-mediated Tyr phosphorylation of CAP in cell spreading. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - November 5, 2009 Category: Cytology Authors: Inga FernowAna TomasovicAnn Siehoff-IckingRitva Tikkanen Source Type: journals

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study shows that clone cell libraries can be a powerful resource in systems biology research by making it possible to differentiate between various hypotheses in a consistent cellular background. Using our constructed clone library we profiled the cell signaling patterns to establish the role of HER2 in the crosstalk between EGFR and HER3 receptors in HME cells. Our results for HME cells show that the weak linkage between EGFR and HER3 pathways can lead to distinct downstream cellular signaling patterns in response to the ligands of these two receptors. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - October 31, 2009 Category: Cytology Authors: Yi ZhangLee OpreskoHarish ShankaranWilliam ChrislerH. Steven WileyHaluk Resat Source Type: journals

Novel association of APC with intermediate filaments identified using a new versatile APC antibodyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We introduce a versatile APC antibody that is useful for cell/tissue immunostaining, immunoblotting and immunoprecipitation. We also present evidence for interactions between APC and IFs, independent of actin filaments and microtubules. Our results suggest that APC associates with all three major components of the cytoskeleton, thus expanding potential roles for APC in the regulation of cytoskeletal integrity. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - October 20, 2009 Category: Cytology Authors: Yang WangYoshiaki AzumaDavid FriedmanRobert CoffeyKristi Neufeld Source Type: journals

Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein TprEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Using TIde, we show in the branched models under which conditions inhibitions in a certain pathway can affect a molecule concentrations in a different. In the signalling pathway we illuminate which inhibitions have an effect on the signalling characteristics of the last active kinase. Finally, we compare our set of best targets in the glycolysis model with a similar analysis showing the applicability of our tool. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - October 15, 2009 Category: Cytology Authors: Iris Ben-EfraimPhyllis FrosstLarry Gerace Source Type: journals

Defects in cellular sorting and retroviral assembly induced by GGA overexpressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data provide insights into the composition of structures induced by GGA overexpression and their ability to disrupt endosomal sorting and retroviral particle production. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - September 28, 2009 Category: Cytology Authors: Anjali JoshiKunio NagashimaEric Freed Source Type: journals

KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PTH mRNA is a target for the endonuclease PMR1. The PMR1 mediated decrease in PTH mRNA levels involves the PTH mRNA 3'-UTR ARE, KSRP and the exosome. This represents an unanticipated mechanism by which the decay of an ARE-containing mRNA is facilitated by KSRP and is dependent on both the exosome and an endoribonuclease. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - September 22, 2009 Category: Cytology Authors: Morris NechamaYong PengOsnat BellPaola BriataRoberto GherziDaniel SchoenbergTally Naveh-Many Source Type: journals

Development of a high-throughput method for the systematic identification of human proteins nuclear translocation potentialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our reporter-based system can rapidly screen gene products for their ability to be translocated to the nucleus. Large-scale applications of the system presented herein should provide invaluable information for a more complete biological atlas. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - September 21, 2009 Category: Cytology Authors: Trinh Xuan HoatNicolas BertinNoriko NinomiyaShiro FukudaKengo UsuiJun KawaiYoshihide HayashizakiHarukazu Suzuki Source Type: journals

CRK9 contributes to regulation of mitosis and cytokinesis in the procyclic form of Trypanosoma bruceiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CRK9 may play a role in mediating the segregation between the two kinetoplast/basal body pairs prior to cytokinetic initiation. Since such a segregation over a relatively significant distance is essential for cytokinetic initiation only in the procyclic but may not be in the bloodstream form, CRK9 could be specifically involved in regulating cytokinetic initiation in the procyclic form of T. brucei. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - September 20, 2009 Category: Cytology Authors: Stephane GourguechonChing Wang Source Type: journals

Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results showed that both the PLCdelta1PH-GFP and the GFP-Tubby domain are useful reporters of PtdIns(4,5)P2 changes in the plasma membrane, with distinct advantages and disadvantages. While the PLCdelta1PH-GFP is a more sensitive reporter, its Ins(1,4,5)P3 binding may compromise its accuracy to measure PtdIns(4,5)P2 changes. The Tubby domain is more accurate to report on PtdIns(4,5)P2 but its higher affinity and lower sensitivity may limit its utility when phospholipase C activation is only moderate. These studies also demonstrated that similar changes in PtdIns(4,5)P2 levels in the plasma membrane can d...
Source: BMC Cell Biology - Latest articles - September 20, 2009 Category: Cytology Authors: Zsofia SzentpeteryAndras BallaYeun KimMark LemmonTamas Balla Source Type: journals

Dynamic localisation of Ran GTPase during the cell cycleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results show that Ran interacts dynamically with chromatin, nuclear pore complexes and the mitotic spindle during the cell cycle. These interactions are dependent on the nucleotide-bound state of the protein. Our data indicate that Ran-GTP generated at chromatin is highly mobile and interacts dynamically with distal structures that are involved in nuclear transport and mitotic spindle assembly. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - September 17, 2009 Category: Cytology Authors: James HutchinsWilliam MoorePaul Clarke Source Type: journals

Anti-proliferative activity of silver nanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Here, we demonstrate that uptake of Ag-np occurs mainly through clathrin mediated endocytosis and macropinocytosis. Our results suggest that cancer cells are susceptible to damage with lack of recovery from Ag-np-induced stress. Ag-np is found to be acting through intracellular calcium transients and chromosomal aberrations, either directly or through activation of catabolic enzymes.The signalling cascades are believed to play key roles in cytoskeleton deformations and ultimately to inhibit cell proliferation. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - September 16, 2009 Category: Cytology Authors: P AshaRaniM HandeSuresh Valiyaveettil Source Type: journals

Downregulation of protease activated receptor expression and cytokine production in P815 cells by RNA interferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, siRNAs of PARs can modulate PAR expression and PAR related cytokine production in mast cells, confirming that PARs are likely to play a role in allergic reactions. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - September 6, 2009 Category: Cytology Authors: Liya QiaoHuiyun ZhangShandong WuShaoheng He Source Type: journals

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Acute ablation of Perk in INS 832/13 beta cells exhibited all of the major defects seen in Perk KO mice and revealed abnormal expression and redox state of key ER chaperone proteins. Dysregulation of ER chaperone/folding enzymes ERp72 and GRP78/BiP occurred early after ablation of PERK function suggesting that changes in ER secretory functions may give rise to the other defects including reduced insulin gene expression, secretion, and cell proliferation. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - September 3, 2009 Category: Cytology Authors: Daorong FengJianwen WeiSounak GuptaBarbara McGrathDouglas Cavener Source Type: journals

Direct observation of molecular arrays in the organized smooth endoplasmic reticulumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results provide evidence in favour of the hypothesis of endoplasmic reticulum sheet stabilization by intermembrane tethering. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - August 23, 2009 Category: Cytology Authors: Vladimir KorkhovBenoit Zuber Source Type: journals

Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These observations suggest that Arf6 is a key player in mammalian peroxisome biogenesis. In addition, they also lend strong support to and extend the concept that specific Arf isoform pairs may act in tandem to regulate exclusive trafficking pathways. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - August 16, 2009 Category: Cytology Authors: Erin AnthonioChantal BreesEveline Baumgart-VogtTsunaki HonguSofie HuybrechtsPatrick Van DijckGuy MannaertsYasunori KanahoPaul Van VeldhovenMarc Fransen Source Type: journals

All-trans retinoic acid promotes neural lineage entry by pluripotent embryonic stem cells via multiple pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: RA can promote neural lineage entry by ESCs in adherent monolayer culture systems. This effect depends on RA signaling and its crosstalk with the ERK and Wnt pathways. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - July 29, 2009 Category: Cytology Authors: Jianfeng LuLi TanPing LiHui GaoBo FangShoudong YeZhe GengPing ZhengHouyan Song Source Type: journals

Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Collectively, our results suggest that a novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle. This pathway is not involved in the regulation of cytokinesis, but instead may regulate centrosome duplication. The kinesin-like motor protein KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - July 27, 2009 Category: Cytology Authors: Takuji AokiShuji UedaTohru KataokaTakaya Satoh Source Type: journals

Mechanical strain induces involution-associated events in mammary epithelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Here, we show for the first time, that mechanical strain is able to induce weaning associated events in cultured mammary epithelial cells. These results were obtained using a new practical and affordable device specifically designed for such a purpose. We believe that our results indicate the relevance of mechanical stress among the early post-lactation events that lead to mammary gland involution. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - July 16, 2009 Category: Cytology Authors: Ana QuaglinoMarcelo SaliernoJesica PellegrottiNatalia RubinsteinEdith Kordon Source Type: journals

Evaluation of expression and function of the H+/myo-inositol transporter HMITEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Together, these data do not support a role for HMIT as a neuronal plasma membrane inositol transporter, as previously proposed. However, we observed that HMIT can transport inositol triphosphate, indicating unanticipated intracellular functions for this transporter that may be relevant to mood control. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - July 15, 2009 Category: Cytology Authors: Elena Di DanielSelina MokEmma MeadChiara MutinelliErika ZambelloLaura CaberlottoTheresa PellChristopher LangmeadAjit ShahGraham DuddyJames KewPeter Maycox Source Type: journals

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxy-Terminal Modulator ProteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that phosphorylation on Ser37/Ser38 of CTMP is important for the prevention of mitochondrial localization of CTMP, eventually leading to cell death by binding to Hsp70. In addition to its role in PKB inhibition, CTMP may therefore play a key role in mitochondria-mediated apoptosis by localizing to mitochondria. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - July 14, 2009 Category: Cytology Authors: Longzhen PiaoYuwen LiKeum-Jin YangKyeong Ah ParkHee Sun ByunMinho WonJanghee HongJeong-Lan KimGi Ryang KweonGang Min HurJeong Ho SeokJae Youl ChoTaehoon ChunDaniel HessDerek BrazilBrian HemmingsJongsun Park Source Type: journals

Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The ETA receptors predominate in the ET-1-induced activation of ERK1/2 in human VSMCs, which associates with increments in intracellular PKC, PKA and PI3K activities, but not Ca2+ signalling. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - July 2, 2009 Category: Cytology Authors: Qing-Wen ChenLars EdvinssonCang-Bao Xu Source Type: journals

Distinctive interactions of the Arabidopsis homolog of the 30 kD subunit of the cleavage and polyadenylation specificity factor (AtCPSF30) with other polyadenylation factor subunitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that the nuclear CPSF complex in plants is a dynamic one, and that the interactions between AtCPSF30 and other CPSF subunits are different from those existing in other eukaryotes. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - July 1, 2009 Category: Cytology Authors: Suryadevara RaoRandy DinkinsArthur Hunt Source Type: journals

Evidence for a mitochondrial localization of the retinoblastoma proteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although a few data regarding an unspecific cytosolic localization of Rb protein have been reported for some tumor cells, our results are the first evidence of a mitochondrial localization of Rb. The mitochondrial localization of Rb is observed in parallel with its classic nuclear location and paves the way for the study of potential as-yet-unknown roles of Rb at this site. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - June 24, 2009 Category: Cytology Authors: Ioana FerecatuNathalie Le FlochMarie BergeaudAida Rodriguez-EnfedaqueVincent RinchevalLisa OliverFrancois ValletteBernard MignotteJean-Luc Vayssiere Source Type: journals

Hydrophobic profiles of the tail anchors in SLMAP dictate subcellular targeting.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Thus the overall hydrophobicity of the two alternatively spliced TAs in SLMAP determines its subcellular targeting and TA2 predominantly directs SLMAP to the mitochondria where it may serve roles in the function of this organelle. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - June 18, 2009 Category: Cytology Authors: Joseph ByersRosa GuzzoMaysoon SalihBalwant Tuana Source Type: journals

Generation and characterization of human insulin-releasing cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have established three human insulin-releasing cell lines which maintain antigenic characteristics and insulin secretion profiles of the original tumors. These cell lines represent valuable tools for the study of molecular events underlying beta cell function and dysfunction. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - June 18, 2009 Category: Cytology Authors: Leticia LabriolaMaria PetersKarin KroghIvan StiglianoLeticia TerraCecilia BuchananMarcel MachadoElisa Bal de Kier JoffeLydia PuricelliMari Sogayar Source Type: journals

Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In embryonic stem cells where (anti-proliferative) p53 activity is not necessary, or even unfavorable, p53 is retained in the cytoplasm and prevented from activating its target genes. However, if its activity is beneficial or required, p53 is allowed to accumulate in the nucleus and activates its target genes, even in embryonic stem cells. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - June 16, 2009 Category: Cytology Authors: Valeriya SolozobovaAlexandra RolletschekChristine Blattner Source Type: journals

Characterization of sequences in Human TWIST required for nuclear localizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study demonstrates the presence of two putative NLS motifs in H-TWIST and suggests that these NLS sequences are functional. Furthermore, we identified and confirmed the interaction of TWIST with a novel protein candidate TCF-4. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - June 16, 2009 Category: Cytology Authors: Shalini SinghAnthony Gramolini Source Type: journals

Self-renewal and differentiation capabilities are variable between human embryonic stem cell lines I3, I6 and BG01VEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our comparative analysis provides further evidence for similarities and differences between three hESC lines in self-renewal, and spontaneous and directed differentiation. These differences may be associated with inherited variation in the sex, stage, quality and genetic background of embryos used for hESC line derivation, and/or changes acquired during passaging in culture. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - June 5, 2009 Category: Cytology Authors: Tahereh TavakoliXiangru XuEric DerbyYevgeniya SerebryakovaYvonne ReidMahendra RaoMark MattsonWu Ma Source Type: journals

The N-glycome of human embryonic stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The N-glycan phenotype of hESC was shown to reflect their differentiation stage. During differentiation, hESC-associated N-glycan features were replaced by differentiated cell-associated structures. The results indicated that hESC differentiation stage can be determined by direct analysis of the N-glycan profile. These results provide the first overview of the N-glycan profile of hESC and form the basis for future strategies to target stem cell glycans. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - June 2, 2009 Category: Cytology Authors: Tero SatomaaAnnamari HeiskanenMilla MikkolaCia OlssonMaria BlomqvistMinna TiittanenTaina JaatinenOlli AitioAnne OlonenJari HelinJukka HiltunenJari NatunenTimo TuuriTimo OtonkoskiJuhani SaarinenJarmo Laine Source Type: journals

The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behavioursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: FRAP experiments reveal that in contrast to HP1, SUV420H2 is strongly associated to pericentric heterochromatin. Then, the fraction of SUV420H2 captured and characterized by TAP/MS is a soluble fraction which may be in a stable association with HP1. Consequently, SUV420H2 may be recruited to heterochromatin in association with HP1, and stably maintained at its heterochromatin sites in an HP1-independent fashion. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - June 1, 2009 Category: Cytology Authors: Patricia SouzaPamela VolkelDave TrinelJulien VandammeClaire RosnobletLaurent HeliotPierre-Olivier Angrand Source Type: journals

Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Even though p53 and SMN are associated, the increased sensitivity of SMA fibroblasts to camptothecin does not occur through a p53-dependent mechanism. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - May 16, 2009 Category: Cytology Authors: Chia-Yen Wu, Ilsa Gomez-Curet, Vicky L Funanage, Mena Scavina and Wenlan Wang Source Type: journals

beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This data demonstrates the complexity of the interaction of various signaling pathways in the regulation of cell behavior during wound repair. Cell motility and the induction of collagen lattice contraction are not always coupled, and are likely regulated by different intracellular mechanisms. There is unlikely to be a single signaling pathway that acts as master regulator of fibroblast behavior in wound repair. beta-catenin plays dominant role regulating cell motility, while transforming growth factor beta plays a dominant role regulating the induction of collagen lattice contraction. Key words: beta-catenin...
Source: BMC Cell Biology - Latest articles - May 11, 2009 Category: Cytology Authors: Raymond Poon, Saeid Amini Nik, Jessica Ahn, Laura Slade and Benjamin A Alman Source Type: journals

Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different speciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results demonstrate that uPARAP/Endo180 expression by rat HSCs is strongly up-regulated during culture activation and identify this receptor as a feature common to culture-activated HSCs. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - May 11, 2009 Category: Cytology Authors: Seyed A Mousavi, Marita S Fonhus and Trond Berg Source Type: journals

Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that stimulation of PKC disrupts epithelial apical junctions via ROCK-II dependent activation of NM II, which increases contractility of perijunctional actin filaments. This mechanism is likely to be important for cancer cell dissociation and tumor metastasis. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - May 7, 2009 Category: Cytology Authors: Andrei I Ivanov, Stanislav N Samarin, Moshe Bachar, Charles A Parkos and Asma Nusrat Source Type: journals

Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatidsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The testis-specific isoform PFN3 showed major hallmarks of the well characterized "somatic" profilin isoforms, albeit with distinct binding affinities. PFN4, on the other hand, did not interact with actin or polyproline in vitro. Rather, it seemed to be specialized for phospholipid binding, possibly providing cellular functions which are distinct from actin dynamics regulation. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - May 6, 2009 Category: Cytology Authors: Martina Behnen, Kai Murk, Petri Kursula, Heike Cappallo-Obermann, Martin Rothkegel, Abraham L. Kierszenbaum and Christiane Kirchhoff Source Type: journals

Isolation and characterization of a spontaneously immortalized bovine retinal pigmented epithelial cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The tRPE cells are immortal, but still exhibit contact inhibition, serum dependence, monolayer growth and secrete an extra-cellular matrix. They retain the in-vivo morphology, gene expression and cell polarity. Additionally, the cells endocytose exogenous melanin, A2E and purified lipofuscin granules. This cell line may be a useful in-vitro research model for retinal maculopathies. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - May 4, 2009 Category: Cytology Authors: Thomas E Liggett, T DANIEL Griffiths and Elizabeth R Gaillard Source Type: journals

Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Compound 1 inhibited FGF-2 induced angiogenesis by binding to its cognate receptors and is an addition to the small number of natural product inhibitors of angiogenesis (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - April 23, 2009 Category: Cytology Authors: Sajjad Hussain, Mark Slevin, Nessar Ahmed, David West, Muhammad Iqbal Choudhary, Humera Naz and John Gaffney Source Type: journals

Centrosome proteins form an insoluble perinuclear matrix during muscle cell differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data provide new insights into the reorganization of centrosome proteins during muscular differentiation, at the structural and biochemical level. Because we observe that centrosome protein re-localization occurs early during differentiation, we believe that it is of functional importance for the reorganization of the cytoskeleton in the differentiation process. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - April 21, 2009 Category: Cytology Authors: Vlastimil Srsen, Xavier Fant, Rebecca Heald, Catherine Rabouille and Andreas Merdes Source Type: journals

Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: AhR pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of MMP-9. Our results provide insight into the mechanism and function of the AhR pathway and its impact on gastric cancer progression. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - April 16, 2009 Category: Cytology Authors: Tie-Li Peng, Jie Chen, Wei Mao, Xin Song and Min-Hu Chen Source Type: journals

A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NEDD4L isoforms that contain or lack a C2 domain target different intracellular locations. Additionally, whereas the C2-containing NEDD4L isoform is capable of shuttling between the plasma membrane and intracellular compartments in response to a calcium stimulus the C2-lacking isoform can not. Lastly, the C2-containing NEDD4L isoform affects the mobilization of ENaC subunits differently in response to a calcium stimulus. We have elucidated how a common genetic variant can underlie significant functional diversity in NEDD4L at the cellular level. We propose a model that describes how that functional variatio...
Source: BMC Cell Biology - Latest articles - April 13, 2009 Category: Cytology Authors: Nicholas F Garrone, Bonnie L Blazer-Yost, Robert B Weiss, Jean-Marc Lalouel and Andreas Rohrwasser Source Type: journals

GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic capacity in mouse seminiferous tubulesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings suggest that mRHBDD1 may be associated with mammalian spermatogenesis. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - April 10, 2009 Category: Cytology Authors: Yong Wang, Wei Song, Shuchun Li, Xin Guan, Shiying Miao, Shudong Zong, S. S. Koide and Linfang Wang Source Type: journals

Mimitin – a novel cytokine-regulated mitochondrial proteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Mimitin is a mitochondrial protein upregulated by proinflammatory cytokines at the transcriptional and protein levels, with MAP kinases involved in IL-1-dependent induction. Mimitin interacts with a microtubular protein (MAP1S), and some changes of mimitin gene expression modulate activity of apoptotic caspases 3/7, suggesting that this protein may indirectly participate in apoptosis. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - March 31, 2009 Category: Cytology Authors: Paulina Wegrzyn, Stephen J Yarwood, Nathalie Fiegler, Monika Bzowska, Aleksander Koj, Danuta Mizgalska, Stanisław Malicki, Magdalena Pajak, Aneta Kasza, Neli Kachamakova-Trojanowska, Joanna Bereta, Jacek Jura and Jolanta Jura Source Type: journals

Mimitin - a novel cytokine-regulated mitochondrial proteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Mimitin is a mitochondrial protein upregulated by proinflammatory cytokines at the transcriptional and protein levels, with MAP kinases involved in IL-1-dependent induction. Mimitin interacts with a microtubular protein (MAP1S), and some changes of mimitin gene expression modulate activity of apoptotic caspases 3/7, suggesting that this protein may indirectly participate in apoptosis. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - March 31, 2009 Category: Cytology Authors: Paulina Wegrzyn, Stephen J Yarwood, Nathalie Fiegler, Monika Bzowska, Aleksander Koj, Danuta Mizgalska, Stanislaw Malicki, Magdalena Pajak, Aneta Kasza, Neli Kachamakova-Trojanowska, Joanna Bereta, Jacek Jura and Jolanta Jura Source Type: journals

Transient in utero disruption of Cystic Fibrosis Transmembrane Conductance Regulator causes phenotypic changes in Alveolar Type II cells in adult ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Developmental changes due to transient disruption of CFTR in fetal lung reflect in altered ATII cell phenotype in the adult life. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - March 31, 2009 Category: Cytology Authors: Ashraf Gad, Delon L Callender, Erin Killeen, Joseph Hudak, Malgosia A Dlugosz, Janet E Larson, J Craig Cohen and Avinash Chander Source Type: journals

Characterization of the interaction between Actinin-Associated Lim Protein (ALP) and the rod domain of alpha-actininEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The internal region of ALP appeared to be largely unstructured but functional. The ZM motif defined part of the interaction surface between ALP and the alpha-actinin rod domain. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - March 27, 2009 Category: Cytology Authors: Tuula Klaavuniemi, Nanna Alho, Pirta Hotulainen, Annina Kelloniemi, Heli Havukainen, Perttu Permi, Sampo Mattila and Jari Ylanne Source Type: journals

Photo-activation of the hydrophobic probe iodonaphthylazide in cells alters membrane protein function leading to cell deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: INA is a photo-activable agent that induces apoptosis in various cancer cell lines. It reacts with membrane proteins to alter the normal physiological function resulting in apoptosis. This activity of INA maybe exploited for use as an anti-cancer agent. (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - March 26, 2009 Category: Cytology Authors: Mathias Viard, Himanshu Garg, Robert Blumenthal and Yossef Raviv Source Type: journals

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The assay is rapid ( (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - March 19, 2009 Category: Cytology Authors: Blanca Herrera and Gareth J Inman Source Type: journals

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The assay is rapid ( (Source: BMC Cell Biology - Latest articles)
Source: BMC Cell Biology - Latest articles - March 19, 2009 Category: Cytology Authors: Blanca Herrera and Gareth J Inman Source Type: journals

The cell nuclei of skeletal muscle cells are transcriptionally active in hibernating edible dormiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this study we demonstrate that skeletal muscle cells of the hibernating edible dormouse maintain their structural and functional integrity in full, even after months in the nest. A twofold explanation for that is envisaged: 1) the maintenance, during hibernation, of low-rate nuclear and mitochondrial activity counterbalancing myofibre wasting, 2) the intensive muscle stimulation (shivering) during periodic arousals in the nest, which would mimic physical exercise. These two factors would prevent muscle atrophy usually occurring in mammals after prolonged starvation and/or inactivity as a consequence of preva...
Source: BMC Cell Biology - Latest articles - March 14, 2009 Category: Cytology Authors: Manuela Malatesta, Federica Perdoni, Serafina Battistelli, Sylviane Muller and Carlo Zancanaro Source Type: journals