BMC Clinical Pathology - Latest articlesThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

30 records returned

CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on gene expression analysis, we identify CD9 and vimentin as candidate markers for distinguishing between ccRCC and chRCC. In difficult cases and particularly when the amount of diagnostic tissue is limited, vimentin and CD9 staining could serve as a useful adjunct in the differential diagnosis of ccRCC and chRCC. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - November 18, 2009 Category: Pathology Authors: Ariel WilliamsJohn HigginsHongjuan ZhaoBorje LjunbergJames Brooks Source Type: journals

Experiences from treatment-predictive KRAS testing; high mutation frequency in rectal cancers from females and concurrent mutations in the same tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The demonstration of a particularly high KRAS mutation frequency among female rectal cancer patients suggests that this subset is the least likely to respond to anti-EGFR therapies, whereas the observation of concurrent KRAS mutations imply that repeated KRAS targeting may occur during tumor progression in a subset of colorectal cancers. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - October 14, 2009 Category: Pathology Authors: Mats JonssonAnna EkstrandThomas EdeklingJakob EberhardDorthe GrabauDavid BorgMef Nilbert Source Type: journals

Matrix metalloproteinases in subjects with type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our MMP analysis of serum from a limited number of patients with type 1 diabetes suggest that such analysis is potentially useful as markers in studies of people at risk of progression to chronic kidney disease. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - September 15, 2009 Category: Pathology Authors: Sedegheh GharagozlianKatja SvennevigHans-Jacob BangstadJan-Olof WinbergSvein Olav Kolset Source Type: journals

pRb2/p130 protein expression and RBL2mutation analysis in Burkitt lymphoma from UgandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The majority of endemic BL cases from Uganda express pRb2, but somatic RBL2 mutations affecting the protein's nuclear localization signal appear to be rare. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - August 18, 2009 Category: Pathology Authors: Sam KalungiSolrun SteineHenry WabingaLeif BostadAnders Molven Source Type: journals

Improved Methodology for Assessment of mRNA Levels in Blood of Patients with FMR1 Related Disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our observations demonstrate that, through the use of an appropriate internal control and the direct analysis of multiple sites of target mRNA, samples that do not conform to the conventional rRNA criteria can still be utilized to obtain biologically/clinically relevant data. Although, this strategy clearly has application for improved assessment of FMR1 mRNA toxicity in blood, it may also have more general implications for gene expression studies in fresh and archival tissues. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - June 9, 2009 Category: Pathology Authors: David GodlerDanuta LoeschRichard HugginsLavinia GordonHoward SlaterFreya GehlingTrent BurgessKH Andy Choo Source Type: journals

Mitochondrial mosaics in the liver of 3 infants with mtDNA defectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Histoenzymatic COX staining of a liver biopsy is fast and yields crucial data about the pathogenesis; it indicates whether mtDNA should be assayed. Each time a mitochondrial disorder is suspected and muscle data are non-diagnostic, a liver biopsy should be recommended. Mosaics are probably more frequent than observed until now. A novel pathogenic mutation in POLG is reported.Tentative explanations for the mitochondrial mosaics are, in one patient, unequal partition of mutated mitochondria during mitoses, and in two others, an interaction between products of several genes required for mtDNA maintenance. (Source...
Source: BMC Clinical Pathology - Latest articles - June 5, 2009 Category: Pathology Authors: Frank RoelsPatrick VerlooFrancois EyskensBaudhuin FrancoisSara SenecaBoel De PaepeJean-Jacques MartinValerie MeersschautMarleen PraetEmmanuel ScalaisMarc EspeelJoel SmetGert Van GoethemRudy Van Coster Source Type: journals

Validation of human papillomavirus genotyping by signature DNA sequence analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Laboratory staff must be familiar with the limitations of the consensus PCR primers, the locations of the signature sequence in the L1 gene for some HPV genotypes, and HPV genotype sequence variants in order to perform accurate HPV genotyping. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - May 22, 2009 Category: Pathology Authors: Sin Hang LeeVeronica VigliottiJessica VigliottiSuri Pappu Source Type: journals

Performance of the Genotype® MTBDRPlus assay in the diagnosis of tuberculosis and drug resistance in Samara, Russian FederationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: High sensitivity, short turnaround times and the potential for screening large numbers of specimens rapidly, make the GenoType® MTBDRplus assay suitable as a first-line screening assay for drug resistant TB. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - March 10, 2009 Category: Pathology Authors: Vladyslav Nikolayevskyy, Yanina Balabanova, Tatyana Simak, Nadezhda Malomanova, Ivan Fedorin and Francis Drobniewski Source Type: journals

Performance of the Genotype(R) MTBDRPlus assay in the diagnosis of tuberculosis and drug resistance in Samara, Russian FederationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: High sensitivity, short turnaround times and the potential for screening large numbers of specimens rapidly, make the GenoType(R) MTBDRplus assay suitable as a first-line screening assay for drug resistant TB. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - March 10, 2009 Category: Pathology Authors: Vladyslav Nikolayevskyy, Yanina Balabanova, Tatyana Simak, Nadezhda Malomanova, Ivan Fedorin and Francis Drobniewski Source Type: journals

Molecular analysis of Mycobacterium isolates from extrapulmonary specimens obtained from patients in MexicoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 1) We describe the Mycobacterium species diversity in specimens derived from extrapulmonary sites in symptomatic patients in Mexico; 2) Nontuberculous mycobacteria were found in a considerable number of patients; 3) Genotypic rifampicin resistance in M. tuberculosis complex infections in lymph nodes was not found. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - March 9, 2009 Category: Pathology Authors: Cosme Alvarado-Esquivel, Nora Garcia-Corral, David Carrero-Dominguez, Jose Antonio Enciso-Moreno, Teodoro Gurrola-Morales, Leopoldo Portillo-Gomez, Rudi Rossau and Wouter Mijs Source Type: journals

Derivation and internal validation of an equation for albumin-adjusted calciumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A locally derived and internally validated albumin-adjusted calcium equation differed from previously published equations and resulted in important differences in classification of calcium status in hypoalbuminemic patients. Individual laboratories should determine their own linear regression equation for calcium on albumin rather than relying on published formulas. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - November 27, 2008 Category: Pathology Authors: Matthew T James, Jiango Zhang, Andrew W Lyon and Brenda R Hemmelgarn Source Type: journals

Serum S100B levels after meningioma surgery: a comparison of two laboratory assaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although a generally linear relationship exists between serum S100B concentrations measured by ELISA and a commercially available kit, ELISA values tended to be higher than commercial kit measurements particularly at concentrations over 0.7ug/L, which are suggestive of brain injury. International standardization of commercial kits is required before the predictive validity of S100B for brain damage can be effectively assessed in clinical practice. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - September 19, 2008 Category: Pathology Authors: Sharon Einav, Eyal Itshayek, Jeremy D Kark, Haim Ovadia, Carolyn F Weiniger and Yigal Shoshan Source Type: journals

Comparison of DNA histograms by standard flow cytometry and image cytometry on sections in Barrett's adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The purpose of this study was to compare DNA histograms obtained by standard flow cytometry (FC) and high fidelity image cytometry on sections (ICS) in normal gastrointestinal mucosa and Barrett's adenocarcinoma (BAC). Methods: Archival formalin-fixed paraffin-embedded tissue blocks of 10 normal controls from 10 subjects and 42 BAC tissues from 17 patients were examined. DNA FC was performed using standard techniques and ICS was carried out by Automated Cellular Imaging System (ACIS). DNA ploidy histograms were classified into diploid with peak DNA index (DI) at 0.9-1.1, and aneuploid with peak DI >1.1. DI valu...
Source: BMC Clinical Pathology - Latest articles - May 30, 2008 Category: Pathology Authors: Qin Huang, Chenggong Yu, Xiaoqi Zhang and Raj K. Goyal Source Type: journals

Population-based study of diagnostic assays for Borrelia infection: comparison of purified flagella antigen assay (IdeiaTM, Dako Cytomation) and recombinant antigen assay (Liaison(R), DiaSorin)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Diagnostic assays based on flagella antigen seem to show more false-positive IgM and false-negative IgG results than assays based on recombinant antigens. The latter may reduce the number of presumably false-positive IgM results and identify more IgG-positive subjects, but this system also produces more false-positive IgG results. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - April 18, 2008 Category: Pathology Authors: Eskild Petersen, Martin Tolstrup, Francesco Capuano and Svend Svend Ellermann-Eriksen Source Type: journals

Testing for hereditary thrombophilia: a retrospective analysis of testing referred to a national laboratoryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this real-world setting, testing for inherited thrombophilia is frequently at odds with the recommendations of the CAP consensus conference. There is a need for wider dissemination of concise thrombophilia testing guidelines. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - April 2, 2008 Category: Pathology Authors: Brian R Jackson, Kyland Holmes, Amit Phansalkar and George M Rodgers Source Type: journals

The calcium-binding protein S100P in normal and malignant human tissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on our observations, S100P is widely expressed in both normal and malignant tissues. The high expression in some tumors suggests that it may represent a potential target molecule for future diagnostic and therapeutic applications. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - February 18, 2008 Category: Pathology Authors: Seppo Parkkila, Pei-wen Pan, Aoife Ward, Adriana Gibadulinova, Ingrid Oveckova, Silvia Pastorekova, Jaromir Pastorek, Alejandra Rodriguez Martinez, Henrik O Helin and Jorma Isola Source Type: journals

Preservation of biomolecules in breast cancer tissue by a formalin-free histology systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the utilization of a formalin-free fixation and processing system for tissue detection of two important biopredictors in breast cancer a estrogen receptor and HER2 a at the RNA and protein levels. Methods: Parallel sections of 62 cases of breast cancer were fixed in an alcohol-based molecular fixative and in formalin. Molecular fixative samples were processed by a novel formalin-free microwave-assisted processing system that preserves DNA, RNA and proteins. Formalin-fixed samples were processed using the conventional method. Estrogen receptor was assessed by immunohistochemistry and real-time PCR. HER2 was ass...
Source: BMC Clinical Pathology - Latest articles - January 29, 2008 Category: Pathology Authors: Mehdi Nassiri, Sharon Ramos, Hajir Zohourian, Vladimir Vincek, Azorides R Morales and Mehrdad Nadji Source Type: journals

Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Overall analytical precision (mean median CV, ~ 9%) and total between-person variation (median CV, ~ 50-70%) appear well suited to enable use of metabolomics markers in human clinical trials and epidemiological studies, including studies of the effect of caloric intake and balance on long-term cancer risk. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - November 12, 2007 Category: Pathology Authors: Yevgeniya I Shurubor, Wayne R Matson, Walter C Willett, Susan E Hankinson and Bruce S Kristal Source Type: journals

Low specificity of HIV-testing on sputum specimens kept at ambient temperatures for 4 to 7 days: a blinded comparisonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: HIV testing on sputum using the OraQuick HIV1/2(R) assay has high sensitivity and specificity, and holds promise for application in tuberculosis surveys. Its performance under conditions that may occur during surveys in resource-poor countries is however unknown. We assessed, in a blinded comparison with HIV serum testing, the sensitivity and specificity of the OraQuick(R) assay for detecting HIV antibody in sputum specimens kept at ambient temperature for up to 7 days, with and without decontaminant. Methods: Paired sputum and blood specimens from consecutively diagnosed smear-positive tuberculosis patients w...
Source: BMC Clinical Pathology - Latest articles - September 19, 2007 Category: Pathology Authors: Saidi M Egwaga, Timothy M Chonde, Mecky I Matee, Sayoki G Mfinanga, Prosper E Ngowi, Fred Lwilla and Frank GJ Cobelens Source Type: journals

An exfoliation and enrichment strategy results in improved transcriptional profiles when compared to matched formalin fixed samples.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The exfoliation / enrichment technique represents a superior alternative in tissue procurement and RNA recovery relative to formalin fixed tissue. None of the deleterious effects associated with formalin fixation are encountered in the exfoliated/ enriched samples because of the absence of its use in this protocol. The exfoliation/ enrichment technique also represents an economical alternative that will yield comparable results to cells enriched by laser capture microdissection from frozen tissue sections. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - August 3, 2007 Category: Pathology Authors: Wilfrido D Mojica, Leighton Stein and Lesleyann Hawthorn Source Type: journals

Cell cycle regulators in relation to HPV in cervical carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: 1) Aberrations involving p27 KIP1, cyclin E, CDK4, p16INK4A are considered early events in HPV 16 and 18-associated cervical carcinoma, whereas cyclin D1 and p53 pathway abnormalities are considered late events. 2) Immunohistochemical tests for p16INK4A and cyclin E, could help in early diagnosis of cervical carcinoma. 3) Only FIGO stage p53, cyclin D1, p27 KIP1and Ki-67 are independent prognostic factors that might help in predicting outcome of cervical cancer patients. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - May 24, 2007 Category: Pathology Authors: Abeer A Bahnassy, Abdel-Rahman N Zekri, Maha Saleh, Mohammad Lotayef, Manar Moeir and Osama Shawki Source Type: journals

Rosai-Dorfman Disease: A previously unreported association with Sickle Cell DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Rosai-Dorfman Disease, (RDD) otherwise known as Sinus Histiocytosis with Massive Lymphadenopathy, is an uncommon, benign systemic histio-proliferative disease characterised by massive lymphadenopathy particularly in the head and neck region, and often associated with extra nodal involvement.[2] Sickle cell disease (SCD) is a common disorder predominantly in people of African origin. Although RDD is more common in Africans, [2] this is the first case presentation of a child with SCD and RDD. The child first presented with severe anemia of unknown cause at the age of six weeks and has since had recurrent infectio...
Source: BMC Clinical Pathology - Latest articles - April 2, 2007 Category: Pathology Authors: Claire Stebbing, Jon van der Walt, Ghada Ramadan and Baba Inusa Source Type: journals

Tissue Harvester with Functional Valve (THFV): Shidham's device for reproducibly higher specimen yield by fine needle aspiration biopsy with easy to perform stepsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we report a device overcoming these limitations. Methods: Tissue Harvester with Functional Valve (THFV) was evaluated as a part of a phase 1 National Institute of Health (NIH) research grant under Small Business Technology Transfer (STTR) Program. Working prototypes of the device were prepared. Each of the four cytopathologists with previous cytopathology fellowship training and experience in performing FNAB evaluated 5 THFV and 5 hypodermic needles resulting in 40 specimens (20 with THFV, 20 with hypodermic needles). A piece of fresh cattle liver stuffed in latex glove was used as the specimen. Based on thes...
Source: BMC Clinical Pathology - Latest articles - March 7, 2007 Category: Pathology Authors: Vinod B. Shidham, Ashwini W. Pandit, R.Nagarjun Rao, Zainab Basir and Anjani Shidham Source Type: journals

Concurrent development of testicular seminoma and choriocarcinoma of the superior mediastinum, presented as cervical mass: a case report and implications about pathogenesis of germ-cell tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The pathogenesis of concurrent germ cell tumours in the same patient remains an area of controversy. Although the genetic instability of the pluripotent germ cell offers an adequate explanation, the possibility of metastasis from the primary, less differentiated tumour to a distant location as a more mature subtype cannot be excluded. Possible development of a metastatic site of different histology and thus biological behaviour (e.g choriocarcinoma) should be anticipated. Furthermore, urologists, pathologists and medical oncologists should be meticulous in the original pathological diagnosis in these patients, ...
Source: BMC Clinical Pathology - Latest articles - November 20, 2006 Category: Pathology Authors: Giannis Mountzios, George Pavlakis, Evangelos Terpos, George Sakorafas, Kyriakos Revelos, Aristotelis Bamias, Nikolaos Nikolaou, Pantelis Papasavas, Jean-Charles Soria and Meletios-Athanasios Dimopoulos Source Type: journals

Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - October 30, 2006 Category: Pathology Authors: Panagiotis A Konstantinopoulos, Bruce J Dezube and Liron Pantanowitz Source Type: journals

Primary histologic diagnosis using automated whole slide imaging: a validation studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results indicated that the image information contained in current whole slide images is sufficient for pathologists to make reliable diagnostic decisions and compose complex diagnostic reports. This is a very positive result; however, this does not mean that WSI is as good as a microscope. Virtually every slide had focal areas in which image quality (focus and dynamic range) was less than perfect. In some cases, there was evidence of over-compression and regions made "soft" by less than perfect focus. We expect systems will continue to get better, image quality and speed will continue to improve, but that f...
Source: BMC Clinical Pathology - Latest articles - April 27, 2006 Category: Pathology Authors: John R Gilbertson, Jonhan Ho, Leslie Anthony, Drazen M Jukic, Yukako Yagi and Anil V Parwani Source Type: journals

Protection of early phase hepatic ischemia-reperfusion injury by cholinergic agonistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Pharmacological modulation of the cholinergic pathway provides a means to modulate cytokine production and to delay IR-induced heaptocellular injury. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - February 15, 2006 Category: Pathology Authors: Elahé T Crockett, James J Galligan, Bruce D Uhal, Jack Harkema, Robert Roth and Kinnari Pandya Source Type: journals

Real-time PCR complements immunohistochemistry in the determination of HER-2/neu status in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data show that the results obtained for the gene amplification of HER-2/neu by real-time PCR on the LightCycler® instrument is comparable to results obtained by FISH. These results therefore suggest that real-time PCR analysis, using the LightCycler®, is a viable alternative to FISH for reassessing breast tumors which receive an IHC score of 2+, and that a combined IHC and real-time PCR approach for the determination of HER-2 status in breast cancer patients may be an effective and efficient strategy. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - January 18, 2006 Category: Pathology Authors: Andreea Nistor, Peter H Watson, Norman Pettigrew, Karim Tabiti, Angelika Dawson and Yvonne Myal Source Type: journals

Inclusion of MUC1 (Ma695) in a panel of immunohistochemical markers is useful for distinguishing between endocervical and endometrial mucinous adenocarcinoma*Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A panel of immunohistochemical markers including MUC1, p16, ER, PR, and vimentin is recommended, when there is morphological and clinical doubt as to the primary site of endocervical or endometrial origin. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - January 12, 2006 Category: Pathology Authors: Thaer Khoury, Dongfeng Tan, Jianmin Wang, Marilyn Intengan, Jun Yang, Sadir Alrawi, Peisha Yan and James C Byrd Source Type: journals

Lymph node infarction – a rare complication associated with disseminated intra vascular coagulation in a case of dengue feverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Global infarction of the lymph node may mask the underlying pathology. Any malignancy especially lymphoma may coexist or follow lymph node infarction, therefore the patient needs constant surveillance. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - December 12, 2005 Category: Pathology Authors: I Satish Rao, Anand C Loya, KS Ratnakar and VR Srinivasan Source Type: journals