Treatment for Covid-19 with SARS-CoV-2 neutralizing antibody BRII-196(Ambavirumab) plus BRII-198(Lomisivir): a retrospective cohort study
Monoclonal antibody therapy for Covid-19 springs up all over the world and get some efficiency. This research aims to explore the treating effect of BRII-196(Ambavirumab) plus BRII-198(Lomisivir) on Covid-19. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Qin Yalan, Hao Lingfang, Liu Xisong, Liang Run, Zhang Junjing and Zhang ’ An Tags: Research Source Type: research
Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital
Dialysis patients are at high risk for drug-related problems (DRPs), which have significant consequences for their morbidity, mortality, and quality of life. Improved clinical outcomes can be achieved by preve... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Aysel Pehlivanli, Sayeste Akkan Eren, Sule Sengul, Bilgen Basgut, Sehsuvar Erturk and A. Tanju Ozcelikay Tags: Research Source Type: research
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
This study was conducted to further investigate the molecular mechanisms of miRNA-dependent effect... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 28, 2024 Category: Drugs & Pharmacology Authors: Khalil Hajiasgharzadeh, Parviz Shahabi, Elham Karimi-Sales and Mohammad Reza Alipour Tags: Research Source Type: research
Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice
Browning of white adipose tissue (WAT) is become an appealing target for therapeutics in the treatment of obesity and related metabolic diseases. Dapagliflozin is widely used in the treatment of type 2 diabete... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Authors: Lin Xiang, Min Liu, Guangda Xiang, Ling Yue, Junxia Zhang, Xiaoli Xu and Jing Dong Tags: Research Source Type: research
Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan
This study aimed to evaluate the long-term risk of CKD and renal function declines using a combination of diuretics and SGLT2i. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Han-Jie Lin, Pin-Yang Shih, Stella Chin-Shaw Tsai, Wu-Lung Chuang, Tsai-Ling Hsieh, Heng-Jun Lin, Teng-Shun Yu, Fuu-Jen Tsai, Chiu-Ying Chen and Kuang-Hsi Chang Tags: Research Source Type: research
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
It has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both cancer- and immune cells. Therefore, we evaluated potential immunologic... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - March 5, 2024 Category: Drugs & Pharmacology Authors: Tove Selvin, Malin Berglund, Lena Lenhammar, Magnus Lindskog, Malin Jarvius, Rolf Larsson, Peter Nygren, M årten Fryknäs and Claes R Andersson Tags: Research Source Type: research
Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin
Radiation triggers salivary gland damage and excess iron accumulates in tissues induces cell injury. Flavonoids are found in some fruits and are utilized as potent antioxidants and radioprotective agents. This... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 27, 2024 Category: Drugs & Pharmacology Authors: Salwa Farid Ahmed, Eman M. F. El-Maghraby, Maha M. Rashad and Dina W. Bashir Tags: Research Source Type: research
Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions
This bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 27, 2024 Category: Drugs & Pharmacology Authors: Xu Zuo, Xin Zhao, Jinjin Shi and Tiandong Zhang Tags: Research Source Type: research
Preparation and evaluation of transdermal permeation of Huperzine A ethosomes gel in vitro
This study aimed to design and evaluate the transdermal permeation of Huperzine A ethosomes gel in vitro. Huperzine A ethosomes were prepared using the injection method, and their physical and chemical propert... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 26, 2024 Category: Drugs & Pharmacology Authors: Jiyu Wu, Renai Xu, Xiaowei Xu, Shiyuan Ye and Aifang Huang Tags: Research Source Type: research
The effect of oral supplementation of Paricalcitol on C-reactive protein levels in chronic kidney disease patients: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials
Previous studies investigating the effect of oral supplementation of paricalcitol on reactive protein levels in chronic kidney disease (CKD) patients reported inconsistent findings. In this systematic review a... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 23, 2024 Category: Drugs & Pharmacology Authors: Seyyed Mostafa Arabi, Mostafa Shahraki-Jazinaki, Mahla Chambari, Leila Sadat Bahrami, Sara Sabeti, Mohammaed Ibrahim Mohaildeen Gubari, Basil D. Roufogalis and Amirhossein Sahebkar Tags: Research Source Type: research
Pharmacovigilance study of BCR-ABL1 tyrosine kinase inhibitors: a safety analysis of the FDA adverse event reporting system
With the increased use of BCR-ABL1 tyrosine kinase inhibitors (TKIs) in cancer patients, adverse events (AEs) have garnered considerable interest. We conducted this pharmacovigilance study to evaluate the AEs ... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 23, 2024 Category: Drugs & Pharmacology Authors: Dehua Zhao, Xiaoqing Long and Jisheng Wang Tags: Research Source Type: research
New tricks for old drugs- praziquantel ameliorates bleomycin-induced pulmonary fibrosis in mice
Pulmonary fibrosis is a chronic progressive disease with complex pathogenesis, short median survival time, and high mortality. There are few effective drugs approved for pulmonary fibrosis treatment. This stud... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 14, 2024 Category: Drugs & Pharmacology Authors: Yanjun Zeng, Rui Hu, Wei Ma, Ying Ding, Yi Zhou, Xin Peng, Lixin Feng, Qingmei Cheng and Ziqiang Luo Tags: Research Source Type: research
Safinamide, an inhibitor of monoamine oxidase, modulates the magnitude, gating, and hysteresis of sodium ion current
Safinamide (SAF), an α-aminoamide derivative and a selective, reversible monoamine oxidase (MAO)-B inhibitor, has both dopaminergic and nondopaminergic (glutamatergic) properties. Several studies have explored... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 8, 2024 Category: Drugs & Pharmacology Authors: Te-Yu Hung, Sheng-Nan Wu and Chin-Wei Huang Tags: Research Source Type: research
Large variation in anti-factor Xa levels with nadroparin as thromboprophylaxis in COVID-19 and non-COVID-19 critically ill patients
Critically ill COVID-19 and non-COVID-19 patients receive thromboprophylaxis with the LMWH nadroparin. Whether a standard dosage is adequate in attaining the target anti-FXa levels (0.20 –0.50 IU/ml) in these g... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 6, 2024 Category: Drugs & Pharmacology Authors: Monique M.R. de Maat, Henk J. van Leeuwen, Lian Roovers, Sabine J.G.M. Ahlers, Jolanda Lambers and Marcel M.C. Hovens Tags: Research Source Type: research
Determination of the median lethal dose of zinc gluconate in mice and safety evaluation
This study... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 5, 2024 Category: Drugs & Pharmacology Authors: Yong-cai Wang, Xia Yang, Juan Xiao, Su-mei Wei, Ying Su, Xiu-qi Chen, Ting Huang and Qing-wen Shan Tags: Research Source Type: research
