BMC Endocrine DisordersThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Endogenous melatonin and oxidatively damaged guanine in DNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: A significant body of literature indicates that melatonin, a hormone primarily produced nocturnally by the pineal gland, is an important scavenger of hydroxyl radicals and other reactive oxygen species. Melatonin may also lower the rate of DNA base damage resulting from hydroxyl radical attack and increase the rate of repair of that damage. This paper reports the results of a study relating the level of overnight melatonin production to the overnight excretion of the two primary urinary metabolites of the repair of oxidatively damaged guanine in DNA. Methods: Mother-father-daughter(s) families (n=55) were recru...
Source: BMC Endocrine Disorders - October 17, 2009 Category: Endocrinology Authors: Zoreh DavanipourHenrik PoulsenAllan WeimannEugene Sobel Source Type: journals

Age-related increases in parathyroid hormone may be antecedent to both osteoporosis and dementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings of a statistically lower bone density and prolonged P300 in patients with high parathyroid hormone levels may suggest that increased parathyroid hormone levels coupled with prolonged P300 latency may become putative biological markers of both dementia and osteoporosis and warrant intensive investigation. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 12, 2009 Category: Endocrinology Authors: Eric BravermanThomas ChenAmanda ChenVanessa ArcuriMallory KernerAnish BajajJavier CarbajalDasha BravermanB William DownsKenneth Blum Source Type: journals

Clinical effectiveness and cost-effectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PEG is highly effective for improving patients' IGF-1 level. Signs and symptoms of disease improve but evidence is lacking about long term effects on improved signs and symptoms of disease, quality of life, patient compliance and safety. Economic evaluation indicated that if current standards (UK) for determining cost-effectiveness of therapies were to be applied to PEG it would be considered not to represent good value for money. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 7, 2009 Category: Endocrinology Authors: David MooreYaser AdiMartin ConnockSue Bayliss Source Type: journals

The consequences of delaying insulin initiation in UK type 2 diabetes patients failing oral hyperglycaemic agents: a modelling studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: UK type 2 diabetes patients are at increased risk of a large number of diabetes-related complications due to an unnecessary delay in insulin initiation. Despite clear guidelines recommending tight glycaemic control this failure to begin insulin therapy promptly is likely to result in needlessly reduced life expectancy and compromised quality of life. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 4, 2009 Category: Endocrinology Authors: Gordon GoodallEric SarpongRisa HayesWilliam Valentine Source Type: journals

The association between history of diabetic foot ulcer, perceived health and psychological distress: the Nord-Trondelag Health StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Perceived health and psychological well-being were significantly poorer among participants with diabetes and a history of foot ulcer compared to those without diabetes. Among people with diabetes, a history of foot ulcer had significant negative impact on perceived health but did not independently contribute to psychological distress. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - August 24, 2009 Category: Endocrinology Authors: Marjolein IversenKristian MidthjellGrethe TellTorbjorn MoumTruls OstbyeMonica NortvedtSverre UhlvingBerit Hanestad Source Type: journals

Actos Now for the Prevention of Diabetes (ACT NOW) StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: ACT NOW is designed to determine if pioglitazone can prevent/delay progression to diabetes in high risk IGT subjects, and to define the mechanisms (improved insulin sensitivity and/or enhanced beta cell function) via which pioglitazone exerts its beneficial effect on glucose metabolism to prevent/delay onset of T2DM.Trial Registration: clinical trials.gov identifier: NCT00220961 (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - July 28, 2009 Category: Endocrinology Authors: Ralph DeFronzoMaryAnn BanerjiGeorge BrayThomas BuchananStephen ClementRobert HenryAbbas KitabchiSunder MudaliarNicolas MusiRobert RatnerPeter ReavenDawn SchwenkeFrankie StentzDevjit Tripathy Source Type: journals

Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population. Methods: In 2001-2004, 1811 men and women (30-75 years) were randomly selected from the Vara population, south-western Sweden (81% participation rate). Of these, 1671 subjects with full information on basal morning and evening salivary cortisol and anthropometric measurements were included in this cross-sectional study. Differences between groups were examined by general linear model and ...
Source: BMC Endocrine Disorders - June 20, 2009 Category: Endocrinology Authors: Charlotte LarssonBo GullbergLennart RastamUlf Lindblad Source Type: journals

Randomised controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionGiven the extensive phenotypic characterization, this study will provide valuable insights into the mechanisms underlying the beneficial effects of aerobic exercise as well as the efficacy, feasibility and safety of such interventions in this age group. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - June 18, 2009 Category: Endocrinology Authors: Francis FinucaneJessica HortonLisa PurslowDavid SavageSoren BrageHerve BessonKenneth HortonEma De Lucia RolfeAlison SleighStephen SharpHelen MartinAvan Ahie SayerCyrus CooperUlf EkelundSimon GriffinNicholas Wareham Source Type: journals

Cost-effectiveness comparison between palpation- and ultrasound-guided thyroid fine-needle aspiration biopsiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Universal application of USG-FNA for all thyroid nodules is cost-effective and saves 138 Euros per additional accurate diagnosis of benign versus malignant thyroid nodular disease. Trial registration: ClinicalTrials.gov, NCT00571090 (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - May 16, 2009 Category: Endocrinology Authors: Ahmet Selcuk Can Source Type: journals

DreamTel; Diabetes risk evaluation and management tele-monitoring studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThe first phase will determine if the use of the Bluetooth enabled blood glucose devices which can transmit results electronically will lead to changes in A1c levels. It will also determine the feasibility of recruiting subjects to use this technology. In the second and third phases lasting 18 months, the Diabetes Risk Evaluation and Management Tele-monitoring (DreamTel) study will determine if the delivery of a diabetes intensification management program by the Home Care team supported by the Bluetooth enabled glucose meters leads to improvements in diabetes management. Protocol NCT00325624 (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - May 9, 2009 Category: Endocrinology Authors: Sheldon W Tobe, Joan Wentworth, Laurie Ironstand, Susan Hartman, Jacquie Hoppe, Judi Whiting, Janice Kennedy, Colin McAllister, Alex Kiss, Nancy Perkins, Lloyd Vincent, George Pylypchuk and Richard Z Lewanczuk Source Type: journals

Family history of diabetes and clinical characteristics in Greek subjects with type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study showed an excess maternal transmission of T2D in a sample of Greek diabetic patients. However, no different influence was found between maternal and paternal diabetes on the clinical characteristics of diabetic patients except for LDL-cholesterol levels and presence of hypertension. The presence of a family history of diabetes resulted to an early onset of the disease to the offspring. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - April 27, 2009 Category: Endocrinology Authors: Athanasia Papazafiropoulou, Alexios Sotiropoulos, Eystathios Skliros, Marina Kardara, Anthi Kokolaki, Ourania Apostolou and Stavros Pappas Source Type: journals

Graz Endocrine Causes Of Hypertension (GECOH) study: a diagnostic accuracy study of aldosterone to active renin ratio in screening for primary aldosteronismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Screening for PA with subsequent targeted treatment is of great potential benefit for hypertensive patients. In the GECOH study we will evaluate a standardised procedure for screening and diagnosing of this disease. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - April 7, 2009 Category: Endocrinology Authors: Stefan Pilz, Andreas Tomaschitz, Vinzenz Stepan, Barbara Obermayer-Pietsch, Astrid Fahrleitner-Pammer, Natascha Schweighofer, Horst R Portugaller, Harald Sourij, Harald Dobnig, Andreas Meinitzer and Thomas R Pieber Source Type: journals

Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPAR gamma agonist pioglitazoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We show opposite skeletal effects of PPAR alpha and gamma agonists in intact female rats. FENO resulted in significantly higher femoral BMD and lower medullary area, while PIO induced bone loss and impairment of the mechanical strength. This represents a novel skeletal effect of PPAR alpha activation. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 30, 2009 Category: Endocrinology Authors: Unni Syversen, Astrid K Stunes, Bjorn I Gustafsson, Karl J Obrant, Lars Nordsletten, Rolf Berge, Liv Thommesen and Janne E Reseland Source Type: journals

Clinical features, predictive factors and outcome of hyperglycaemic emergencies in a developing countryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HHS carry a higher case fatality rate than DKA and the predictive factors for hyperglycaemic emergencies' mortality in the Nigerian with DM include foot ulcers, hypokalaemia and being elderly. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 10, 2009 Category: Endocrinology Authors: Anthonia O Ogbera, Jacob Awobusuyi, Chioma Unachukwu and Olufemi Fasanmade Source Type: journals

Clinical features,predictive factors and outcome of hyperglycaemic emergencies in a developing country.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HHS carry a higher case fatality rate than DKA and the predictive factors for hyperglycaemic emergencies' mortality in the Nigerian with DM include foot ulcers, hypokalaemia and being elderly. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 10, 2009 Category: Endocrinology Authors: Anthonia O Ogbera, Jacob Awobusuyi, Chioma Unachukwu and Olufemi Fasanmade Source Type: journals

Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFκB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In type 2 diabetic patients, the anti-inflammatory effect of rosiglitazone is not reflected by changes in NFκB and PPARγ target genes in PBMCs in vivo. Furthermore, our results do not support that high insulin concentrations contribute to the pro-inflammatory profile in type 2 diabetic patients. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - February 25, 2009 Category: Endocrinology Authors: Marjolijn CE Bragt, Jogchum Plat, Marco Mensink, Patrick Schrauwen and Ronald P Mensink Source Type: journals

Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In summary, the zinc transporting system in beta-cells is influenced by the exposure to cytokines. Particularly ZnT8, which has been associated with the development of diabetes, seems to be cytokine sensitive. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - February 25, 2009 Category: Endocrinology Authors: Laerke Egefjord, Jens Ledet Jensen, Claus Heiner Bang-Berthelsen, Andreas Bronden Petersen, Kamille Smidt, Ole Schmitz, Allan Ertman Karlsen, Flemming Pociot, Fabrice Chimienti, Jorgen Rungby and Nils E Magnusson Source Type: journals

Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFkappaB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background Rosiglitazone not only improves insulin-sensitivity, but also exerts anti-inflammatory effects. We have now examined in type 2 diabetic patients if these effects are reflected by changes in mRNA expression in peripheral blood mononuclear cells (PBMCs) to see if these cells can be used to study these anti-inflammatory effects at the molecular level in vivo. Method Eleven obese type 2 diabetic patients received rosiglitazone (2x4 mg/d) for 8 weeks. Fasting blood samples were obtained before and after treatment. Ten obese control subjects served as reference group. The expression of NFkappaB-related genes and PPAR...
Source: BMC Endocrine Disorders - February 25, 2009 Category: Endocrinology Authors: Marjolijn C E Bragt, Jogchum Plat, Marco Mensink, Patrick Schrauwen and Ronald P Mensink Source Type: journals

Self-care coping strategies in people with diabetes: a qualitative exploratory studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients have different diabetes self-care coping strategies which are influenced by their self-care health value and consequently may affect their diet and exercise choices, frequency of blood glucose monitoring, and compliance with prescribed medication regimens. Particular attention should be paid to the patient's self-care coping strategy, and self-care protocols should be tailored to complement the different "ideal" patient types. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - February 20, 2009 Category: Endocrinology Authors: Margaret M Collins, Colin P Bradley, Tony O'Sullivan and Ivan J Perry Source Type: journals

Diabetes Mellitus: Indigenous naming, indigenous diagnosis and self-management in an African setting: the example from CameroonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The evolution of indigenous names for diabetes is an important factor that influences the subsequent self-diagnosis and management of diabetes in both biomedical and traditional health care settings.KeywordsIndigenous naming, diagnosis, self-monitoring, diabetes mellitus, Africa. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - February 19, 2009 Category: Endocrinology Authors: Paschal K Awah, Nigel C Unwin and Peter R Phillimore Source Type: journals

Extremely short duration high intensity interval training substantially improves insulin action in young healthy malesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The efficacy of a high intensity exercise protocol, involving only ~250 kcal of work each week, to substantially improve insulin action in young sedentary subjects is remarkable. This novel time-efficient training paradigm can be used as a strategy to reduce metabolic risk factors in young and middle aged sedentary populations who otherwise would not adhere to time consuming traditional aerobic exercise regimes. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - January 28, 2009 Category: Endocrinology Authors: John A Babraj, Niels BJ Vollaard, Cameron Keast, Fergus M Guppy, Greg Cottrell and James A Timmons Source Type: journals

Cardiovascular autonomic function tests in an African populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The test battery revealed cut-off values different from those measured in Caucasians. Further studies are recommended to assess whether these reference values are generally applicable to Africans. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - December 30, 2008 Category: Endocrinology Authors: Malvin Torsvik, Amanda Haegblom, Geir Egil Eide, Erich Schmutzhard, Kaare Vetvik and Andrea Sylvia Winkler Source Type: journals

The Edinburgh Type 2 Diabetes Study: study protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study will provide a wealth of epidemiological and biomarker data that should be invaluable in the identification of potentially modifiable, causal risk factors for diabetes-related cognitive impairment, liver dysfunction and vascular disease, which can be targeted for the development of preventive and therapeutic interventions. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - December 11, 2008 Category: Endocrinology Authors: Jackie F Price, Rebecca M Reynolds, Rory J Mitchell, Rachel M Williamson, F Gerald R Fowkes, Ian J Deary, Amanda J Lee, Brian M Frier, Peter C Hayes and Mark W J Strachan Source Type: journals

Association of angiotensin-converting enzyme inhibitor therapy and comorbidity in diabetes: results from the Vermont Diabetes Information SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ACE inhibitor use is associated with a lower likelihood of a history of cancer and peptic ulcers in patients with diabetes. These findings are limited by the cross sectional study design, self-report of comorbid diagnoses, and lack of information on the timing and duration of ACE inhibitor use. Further research is needed to confirm these associations and understand their mechanisms. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - December 5, 2008 Category: Endocrinology Authors: Maria E. Ramos-Nino, Charles D. MacLean and Benjamin Littenberg Source Type: journals

Pediatric reference intervals for thyroid hormone levels from birth to adulthood: a retrospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results corroborate those of previous studies showing that thyroid hormone levels change markedly during childhood, and that adult reference intervals are not universally applicable to children. Moreover, differences of our reference intervals compared to previous studies were observed, likely caused by different antibody characteristics of various analytical methods, different populations or undefined geographic covariates, e.g. iodine and selenium status. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - November 27, 2008 Category: Endocrinology Authors: Klaus Kapelari, Christine Kirchlechner, Wolfgang Hogler, Katharina Schweitzer, Irene Virgolini and Roy Moncayo Source Type: journals

The AQUA-FONTIS study: protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is caused by artefacts, is a form of beneficial adaptation, or is a disorder requiring treatment. Trials investigating substitution therapy of NTIS revealed contradictory results. The comparison of heterogeneous patient cohorts may be the cause for those inconsistencies.ObjectivesPrimary objective of this study is t...
Source: BMC Endocrine Disorders - October 13, 2008 Category: Endocrinology Authors: Johannes W Dietrich, Axel Stachon, Biljana Antic, Harald H Klein and Steffen Hering Source Type: journals

The AQUA-FONTIS Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is caused by artefacts, is a form of beneficial adaptation, or is a disorder requiring treatment. Trials investigating substitution therapy of NTIS revealed contradictory results. The comparison of heterogeneous patient cohorts may be the cause for those inconsistencies. Objectives: Primary objective of this study i...
Source: BMC Endocrine Disorders - October 13, 2008 Category: Endocrinology Authors: Johannes W Dietrich, Axel Stachon, Biljana Antic, Harald H Klein and Steffen Hering Source Type: journals

Randomized, controlled, parallel-group prospective study to investigate the clinical effectiveness of early insulin treatment in patients with latent autoimmune diabetes in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study seeks the best treatment for early LADA in terms of maintaining glycaemic control and maintaining natural insulin production.Trial registrationISRCTN63815121 (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - July 24, 2008 Category: Endocrinology Authors: Sinead Brophy, Helen Davies, Stephen Bain, Jeffrey W Stephens, Wei-yee Cheung, Kez Richards, Kathie Wareham, Charles Beaverstock, Janet Lloyd, Don Page, Meurig Williams, Ian Russell and Rhys Williams Source Type: journals

Randomized, controlled, parallel-group prospective study to investigate the clinical effectiveness of early insulin treatment in patients with latent autoimmune diabetes in adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study seeks the best treatment for early LADA in terms of maintaining glycaemic control and maintaining natural insulin production. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - July 24, 2008 Category: Endocrinology Authors: Sinead Brophy, Helen Davies, Stephen Bain, Jeffrey W Stephens, Wei-yee Cheung, Kez Richards, Kathie Wareham, Charles Beaverstock, Janet Lloyd, Don Page, Meurig Williams, Ian Russell and Rhys Williams Source Type: journals

Primary prevention of diabetes mellitus type 2 and cardiovascular diseases using a cognitive behavior program aimed at lifestyle changes in people at risk: design of a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionChanging behaviors is difficult, requires time, considerable effort and motivation. Combining the two counseling methods MI and PST, followed by booster sessions may result in sustained behavioral change. Trial registration: Current Controlled Trials ISRCTN59358434 (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - June 24, 2008 Category: Endocrinology Authors: Jeroen Lakerveld, Sandra D.M. Bot, Marijke J. Chinapaw, Maurits W. van Tulder, Patricia van Oppen, Jacqueline M. Dekker and Giel Nijpels Source Type: journals

Validation of ICD-9-CM coding algorithm for improved identification of hypoglycemia visitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The proposed algorithm improves on prior strategies to identify hypoglycemia visits in administrative data sets and will enhance the ability to study the epidemiology and design interventions for this important complication of diabetes care. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - April 1, 2008 Category: Endocrinology Authors: Adit A. Ginde, Phillip G. Blanc, Rebecca M. Lieberman and Carlos A. Camargo Jr. Source Type: journals

Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose toleranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The 2-year intervention up-regulated mitochondrial HSP expressions in middle-aged subjects with impaired glucose tolerance. These improvements, however, were not correlated directly with enhanced glucose tolerance. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 27, 2008 Category: Endocrinology Authors: Mika Venojarvi, Sirkka Aunola, Raivo Puhke, Jukka Marniemi, Helena Hamalainen, Jukka-Pekka Halonen, Jaana Lindstrom, Merja Rastas, Kirsti Hallsten, Pirjo Nuutila, Osmo Hanninen and Mustafa Atalay Source Type: journals

The role of Se, vitamin C, and zinc in benign thyroid diseases and of Se in malignant thyroid diseases: low Se levels are found in subacute and silent thyroiditis and in papillary and follicular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The Ho can be accepted for zinc levels whereas it has to be rejected for Se. Patients with benign or malignant thyroid diseases can present low Se levels as compared to controls. Low levels of vitamin C were found in some subgroups of patients. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - January 25, 2008 Category: Endocrinology Authors: Roy Moncayo, Alexander Kroiss, Manfred Oberwinkler, Fatih Karakolcu, Matthias Starzinger, Klaus Kapelari, Heribert Talasz and Helga Moncayo Source Type: journals

Study protocol: Insulin and its role in cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study could provide insights to the role of insulin, insulin resistance, IGF-1 in carcinogenesis although a precise role and the extent of influence cannot be determined. In future, cancer prevention and treatment strategies could revolve around insulin and insulin resistance. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 22, 2007 Category: Endocrinology Authors: K Harish, M Dharmalingam and M Himanshu Source Type: journals

Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Features of the somatic mutations suggest that they may confer a selective advantage and contribute to the molecular pathogenesis of parathyroid adenomas. Importantly, the statistically significant differences in mutation prevalence in oxyphil vs. chief cell adenomas also suggest that mtDNA mutations may contribute to the oxyphil phenotype. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 4, 2007 Category: Endocrinology Authors: Jessica Costa-Guda, Takehiko Tokura, Sanford I Roth and Andrew Arnold Source Type: journals

Association between erythrocyte Na+K+-ATPase activity and some blood lipids in Type 1 diabetic patients from Lagos, NigeriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It can be concluded that poor glycemic control evokes greater reduction in erythrocyte Na+K+-ATPase activity and promote enzyme-blood atherogenic lipid relationships in Type 1 diabetic Nigerian patients. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 1, 2007 Category: Endocrinology Authors: Bamidele A Iwalokun and Senapon O Iwalokun Source Type: journals

Brief Intervention in Type 1 diabetes - Education for Self-efficacy (BITES): Protocol for a randomised controlled trial to assess biophysical and psychological effectivenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionWe hope the trial will demonstrate feasibility of a pragmatic randomised trial of BITES and help quantify therapeutic effect. A follow up multi-centre trial powered to detect this effect could provide further evidence. Trial registration: Current Controlled Trials ISRCTN75807800 (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - September 14, 2007 Category: Endocrinology Authors: Jyothis T George, Abel P Valdovinos, Jonathan C Thow, Ian Russel, Paul Dromgoole, Sarah Lomax, David J Torgerson and Tony Wells Source Type: journals

Is annual surveillance of all treated hypothyroid patients necessary?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 18 monthly surveillance may be adequate in the long term follow-up of hypothyroid patients less than 60 years of age on a stable thyroxine dose of 100-150 micrograms/day where there are robust follow-up mechanisms in place. Implementing this strategy has potential for cost saving. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - July 2, 2007 Category: Endocrinology Authors: Ananth K Viswanath, Alison Avenell, Sam Philip, Shamsunder H Acharya, Graeme MacLennan, Katherine Dalziel, Olivia Pereira, Shirley A Copland, John S Bevan and Prakash Abraham Source Type: journals

A randomized, double-blind, placebo-controlled trial to assess safety and tolerability during treatment of type 2 diabetes with usual diabetes therapy and either Cycloset or placeboEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study will extend the current data on Cycloset safety, tolerability and efficacy in individuals with type 2 diabetes to include its effects in combination with thiazolodinediones, insulin secretagogues, metformin, alpha-glucosidase inhibitors and exogenous insulin regimens. Trial registration: clinical trials.gov NCT00377676 (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - June 25, 2007 Category: Endocrinology Authors: Richard E Scranton, J Michael Gaziano, Dean Rutty, Michael Ezrokhi and Anthony H Cincotta Source Type: journals

Accuracy of self-reported height measurements in parents and its effect on mid-parental target height calculationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Clinical determination of mid-parental height is an important part of the assessment of a child's growth, however our clinical impression has been that parents cannot be relied upon to accurately report their own heights. Therefore, we conducted this study to assess the accuracy of parental height self-reporting and its effect on calculated mid-parental target height for children presenting to a pediatric endocrinology office. Methods: All parents bringing their children for an initial evaluation to a pediatric endocrinology clinic over a period of nine months were questioned and then measured by a pediatric en...
Source: BMC Endocrine Disorders - April 2, 2007 Category: Endocrinology Authors: Ieva Braziuniene, Thomas A Wilson and Andrew H Lane Source Type: journals

The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study suggests a functional variant of UCP1 contributes to the variance of AIRg in an AA population; the plausibility of this unexpected association is supported by the novel finding that UCP1 is expressed in islets. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 30, 2007 Category: Endocrinology Authors: Michele M Sale, Fang-Chi Hsu, Nicholette D Palmer, Candace J Gordon, Keith L Keene, Hermina M Borgerink, Arun J Sharma, Richard N Bergman, Kent D Taylor, Mohammed F Saad and Jill M Norris Source Type: journals

A multinodular goiter as the initial presentation of a renal cell carcinoma harbouring a novel VHL mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the presence of a clear-cell tumor of the thyroid gland, screening for somatic mutations in the VHL gene in material derived from thyroid aspirates might provide additional information to immunocytochemical studies and therefore plays a contributory role to establish the final diagnosis. Moreover, in a near future, this piece of information might be useful to define a targeted therapy. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 26, 2006 Category: Endocrinology Authors: Maria João M Bugalho, Evelina Mendonça, Patrícia Costa, Jorge Rosa Santos, Eduardo Silva, Ana Luísa Catarino and Luís G Sobrinho Source Type: journals

Insulin versus oral agents in the management of Cystic Fibrosis Related Diabetes: a case based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Insulin alone may not be the only therapeutic option in managing CFRD. Oral hypoglycemic agents were equally effective in treating CFRD and may provide an alternative class of agents for patients reluctant in using insulin. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - June 21, 2006 Category: Endocrinology Authors: Gary M Onady and Leora J Langdon Source Type: journals

Reversible hypothyroidism and Whipple's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This is the first ante-mortem case report studying the possible involvement of the thyroid gland by Whipples disease. Despite the normalization of her thyroid function test biochemically after antibiotic therapy, there is diminished thyroid reserve thus requiring close and regular monitoring. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - May 10, 2006 Category: Endocrinology Authors: Huy A Tran Source Type: journals

Neurocognitive function in children with compensated hypothyroidism: lack of short term effects on or off thyroxinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this small, short term study, thyroxin therapy could not be shown to affect neuropsychological function in children with compensated hypothyroidism. These children may have attention problems but appear to have normal verbal and visual processing, motor speed/coordination and achievement. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 20, 2006 Category: Endocrinology Authors: Naghma J Aijaz, Evelyn M Flaherty, Thomas Preston, Stacey Storch Bracken, Andrew H Lane and Thomas A Wilson Source Type: journals

Echocardiographic assessment of subclinical left ventricular eccentric hypertrophy in adult-onset GHD patients by geometric remodeling: an observational case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Though the lack of significant differences in resting LV morphology and function, about 25% of GHD patients in this study showed high LVMi (as eccentric LV hypertrophy), not dissimilarly to overweight controls. This finding, which prognostic role is already known in obese and hypertensive patients, is worthy to be investigated in GHD patients through wider controlled trials. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - February 28, 2006 Category: Endocrinology Authors: Cesare de Gregorio, Lorenzo Curto, Antonino Recupero, Patrizia Grimaldi, Barbara Almoto, Marilena Venturino, Domenico Cento, Maria Carola Narbone, Francesco Trimarchi, Sebastiano Coglitore and Salvatore Cannavo Source Type: journals

Agrarian diet and diseases of affluence – Do evolutionary novel dietary lectins cause leptin resistance?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The global pattern of varying prevalence of diseases of affluence, such as obesity, cardiovascular disease and diabetes, suggests that some environmental factor specific to agrarian societies could initiate these diseases.Presentation of the hypothesisWe propose that a cereal-based diet could be such an environmental factor. Through previous studies in archaeology and molecular evolution we conclude that humans and the human leptin system are not specifically adapted to a cereal-based diet, and that leptin resistance associated with diseases of affluence could be a sign of insufficient adaptation to such a diet...
Source: BMC Endocrine Disorders - December 10, 2005 Category: Endocrinology Authors: Tommy Jönsson, Stefan Olsson, Bo Ahrén, Thorkild C Bøg-Hansen, Anita Dole and Staffan Lindeberg Source Type: journals

Amiloride derivatives enhance insulin release in pancreatic islets from diabetic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Islets from diabetic mice show some mis-regulation of intracellular pH, and their secretory capacity is consistently enhanced by DMA/amiloride. Thus, amiloride derivatives show promise as potential therapeutic agents for type 2 diabetes. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - December 8, 2005 Category: Endocrinology Authors: Subhadra C Gunawardana, W Steven Head and David W Piston Source Type: journals

The spectrum of thyroid dysfunction in an Australian hepatitis C population treated with combination Interferon-α2β and RibavirinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Ninety three percent of HCV treated patients have intact thyroid function at the end of treatment. The predominant TD is hypothyroidism. The predominant pattern of thyrotoxicosis (TTX) is that of thyroiditis although the number is small. Graves' like disease was not observed. People with pre-existing thyroid auto-antibodies should be closely monitored for thyroid dysfunction, particularly hypothyroidism. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 12, 2005 Category: Endocrinology Authors: Huy A Tran, Tracey L Jones and Robert G Batey Source Type: journals

Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CETP TaqI B and APOE HhaI polymorphism may not be associated with type II diabetes mellitus in North Indian population, however CETP TaqI B polymorphism may be associated with hypertension along with T2DM. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - July 1, 2005 Category: Endocrinology Authors: Manjusha Dixit, Sandeep Bhattacharya and Balraj Mittal Source Type: journals