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Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in PakistanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU). Methods: H. pylori infection established by both rapid urease test and histology were studied. The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out. Results: ...
Source: BMC Gastroenterology - November 20, 2009 Category: Gastroenterology Authors: Javed YakoobShahab AbidZaigham AbbasWasim JafriZubair AhmadRashida AhmedMuhammad Islam Source Type: journals

Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This population-based study has great potential to characterize the relationship between gastrointestinal symptoms and endoscopic findings in China. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - November 19, 2009 Category: Gastroenterology Authors: Xiaoyan YanRui WangYanfang ZhaoXiuqiang MaJiqian FangHong YanXiaoping KangPing YinYuantao HaoQiang LiJohn DentJoseph SungDuowu ZouSaga JohanssonKatarina HallingWenbin LiuJia He Source Type: journals

A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptomEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In conclusion, the Bacillus coagulans-based product was effective in improving the quality of life and reducing gastrointestinal symptoms in adults with post prandial intestinal gas-related symptoms and no GI diagnoses.Trial Registration:ClinicalTrials.gov Identifier: NCT00881322 (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - November 18, 2009 Category: Gastroenterology Authors: Douglas KalmanHoward SchwartzPatricia AlvarezSamantha FeldmanJohn PezzulloDiane Krieger Source Type: journals

Effects of esomeprazole treatment for gastroesophageal reflux disease on quality of life in 12- to 17-year-old adolescents: an international health outcomes studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: GERD had a negative effect on QOL in adolescents. After esomeprazole treatment, statistically and clinically significant improvements occurred in all domains of the QOLRAD for these adolescents.Trial Registration: D9614C00098; ClinicalTrials.gov Identifier NCT00241501 (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - November 18, 2009 Category: Gastroenterology Authors: Thirumazhisai GunasekaranVasundhara ToliaRichard CollettiBenjamin GoldBarry TraxlerMarta IlluecaJoseph Crawley Source Type: journals

The effect of psychological stress on iron absorption in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results demonstrate that PS can decrease iron absorption in rats, which might be related to regulation expression of iron transporters. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - November 13, 2009 Category: Gastroenterology Authors: Jianbo ChenHui ShenChengjie ChenWanyin WangSiyu YuMin ZhaoMin Li Source Type: journals

Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We found augmented serum concentration of TGF-beta and an increase in the percentage of fibrotic tissue in the liver of BDI patients. Contrary to expected results the 6-fold increase in Smad7 expression did not inhibit the expression of TGF-beta, collagens, and PAI-1. We also observed greater expression of Col I and Col III mRNA in BDI patients and significant correlations between their expression and TGF-beta concentration and Smad7 mRNA expression. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 31, 2009 Category: Gastroenterology Authors: Maria del Pilar Alatorre-CarranzaAlejandra Miranda-DiazIrinea Yanez-SanchezOscar Pizano-MartinezJose M Hermosillo-SandovalMonica Vazquez-del MercadoSebastian Hernandez-HoyoRicardo Abundis-MartinezMary Fafutis-MorrisJorge Segura-OrtegaVidal Delgado-Rizo Source Type: journals

A comparison of diagnostic tests for lactose malabsorption - which one is the best?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The agreement between commonly used methods for the diagnosis of LM was unsatisfactory. A lactose breath test with measurement of H2 + CH4x2 in expired air had the best diagnostic properties. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 31, 2009 Category: Gastroenterology Authors: Oistein HovdePer Farup Source Type: journals

Cholecystectomy and sphincterotomy in patients with mild acute biliary pancreatitis in Sweden 1988 - 2003: a nationwide register studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cholecystectomy during index stay slightly prolongs this stay, but drastically reduces readmissions for biliary indications. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 22, 2009 Category: Gastroenterology Authors: Birger SandzenMarkku HaapamakiHans StenlundErik NilssonMikael Oman Source Type: journals

Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Variation in genes involved in the innate immune response may play a role in the predisposition to colorectal cancer (CRC). Several polymorphisms of the CARD15 gene (caspase activating recruitment domain, member 15) have been reported to be associated with an increased susceptibility to Crohn disease. Since the CARD15 gene product and other CARD proteins function in innate immunity, we investigated the impact of germline variation at the CARD4, CARD8 and CARD15 loci on the risk for sporadic CRC, using a large patient sample from Northern Germany. Methods: A total of 1044 patients who had been operated with spor...
Source: BMC Gastroenterology - October 19, 2009 Category: Gastroenterology Authors: Nikolaus MockelmannWitigo von SchonfelsStephan BuchOliver von KampenBence SiposJan Hendrik EgbertsPhilip RosenstielAndre FrankeMario BroschSebastian HinzChristian RoderHolger KalthoffUlrich FolschMichael KrawczakStefan SchreiberClemens Dieter BroringJurge Source Type: journals

Importance of duodenal bulb biopsies in children for diagnosis of celiac disease in clinical practiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The lesion in celiac disease in children can be patchy with duodenal bulb mucosa being the only area showing histological changes. The recommendations regarding the site of biopsies should be revised to include biopsies not only from distal duodenum but also from bulb to improve the diagnostic yield. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 15, 2009 Category: Gastroenterology Authors: Mohsin RashidAndrea MacDonald Source Type: journals

The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 15, 2009 Category: Gastroenterology Authors: Xiaoxiang GuanHui ZhaoJiangong NiuDongfeng TanJaffer AjaniQingyi Wei Source Type: journals

Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Polymorphisms in NQO1, IL-10 and PTPN11, in combination with HP status, could be used to identify individuals who are at increased risk of developing IM and therefore GC. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 12, 2009 Category: Gastroenterology Authors: Feng ZhuMarie LohJeffrey HillSumarlin LeeKing Xin KohKin Wai LaiManuel Salto-TellezBarry IacopettaKhay Guan YeohRichie SoongThe Singapore Gastric Cancer Consortium (sgcc) Source Type: journals

Systematic review and meta-analysis on the adverse events of rimonabant treatment: Considerations for its potential use in hepatologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Rimonabant is associated with an increased risk of adverse events. Despite of an increasing interest for its use on fatty liver, the security profile and efficacy it is needs to be carefully assessed before its recommendation. At present the use of rimonabant on fatty liver cannot be recommended. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 8, 2009 Category: Gastroenterology Authors: Norberto Chavez-TapiaFelix Tellez-AvilaGiorgio BedogniLory CroceFlora MasuttiClaudio Tiribelli Source Type: journals

Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Animal experiments have shown a protective effect of vitamin C on the formation of gallstones. Few data in humans suggest an association between reduced vitamin C intake and increased prevalence of gallstone disease. The aim of this study was to assess the possible association of regular vitamin C supplementation with gallstone prevalence. Methods: An observational, population-based study of 2129 subjects aged 18-65 years randomly selected from the general population in southern Germany was conducted. Abdominal ultrasound examination, completion of a standardized questionnaire, compilation of anthropometric dat...
Source: BMC Gastroenterology - October 7, 2009 Category: Gastroenterology Authors: Thomas WalcherMark HaenleMartina KronBirgit HayRichard MasonDaniel WalcherGerald SteinbachPeter KernIsolde PiechotowskiGuido AdlerBernhard BoehmWolfgang KoenigWolfgang KratzerEmil Study group Source Type: journals

Hepatitis B Virus Inhibition in Mice by Lentiviral Vector Mediated Small Interference RNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma. The major challenges for current therapies are the low efficacy of current drugs and the occurrence of drug resistant HBV mutations. RNA interference (RNAi) of virus-specific genes offers the possibility of developing a new anti-HBV therapy. Recent reports have shown that lentiviral vectors based on HIV-1 are promising gene delivery vehicles due to their ability to integrate transgenes into non-dividing cells. Herein, a lentivirus-based RNAi system was developed to drive expression and delivery of HBV-specific short i...
Source: BMC Gastroenterology - October 5, 2009 Category: Gastroenterology Authors: Lei DengGuoqiang LiLisen XiAihong YinYun GaoWei YouXuehao WangBeicheng Sun Source Type: journals

Limitations of the MELD score in predicting mortality or need for removal from waiting list in patients awaiting liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The long term prediction of mortality or removal from waiting list in patients awaiting liver transplantation might be better assessed by the CTP score than the MELD score. This might have implications for the development of new improved scoring systems. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - September 24, 2009 Category: Gastroenterology Authors: Daniel GotthardtKarl Heinz WeissMelanie BaumgartnerAlexandra ZahnWolfgang StremmelJan SchmidtThomas BrucknerPeter Sauer Source Type: journals

The roles of tumor necrosis factor-alpha in colon tight junction protein expression and intestinal mucosa structure in a mouse model of acute liver failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TNF-alpha affects the structure of the intestinal mucosa, decreases expression of ZO-1, and affects the morphology of the colon in a mouse model of ALF. It also may participate in the pathophysiological mechanism of SBP complicated to ALF. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - September 21, 2009 Category: Gastroenterology Authors: Hongli SongSa LvPei Liu Source Type: journals

Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The NO - cGMP system plays a key role in the regulation of sinusoidal tonus and liver blood flow with phosphodiesterase-5 (PDE-5) terminating the dilatory action of cGMP. We, therefore, investigated the effects of PDE-5 inhibitors on hepatic and systemic hemodynamics in rats. Methods: Hemodynamic parameters were monitored for 60 min. after intravenous injection of sildenafil and vardenafil [1, 10 and 100 ug/kg (sil1, sil10, sil100, var1, var10, var100)] in anesthetized rats. Results: Cardiac output and heart rate remained constant. After a short dip, mean arterial blood pressure again increased. Systemic vascu...
Source: BMC Gastroenterology - September 17, 2009 Category: Gastroenterology Authors: Leonie HalverscheidPeter DeibertRene SchmidtHubert BlumTorsten DunkernBenedikt PannenWolfgang Kreisel Source Type: journals

Mapping of HNF4alpha target genes in intestinal epithelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The HNF4alpha regulation of the Cdx-2 promoter unravels a transcription factor network also including HNF1alpha, all of which are transcription factors involved in intestinal development and gene expression. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - September 16, 2009 Category: Gastroenterology Authors: Mette BoydSimon BressendorffJette MollerJorgen OlsenJesper Troelsen Source Type: journals

Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Results did not indicate robust cancer-preventive effects of BB. Blueberry influenced ACF occurrence in distal colon and tumor progression in duodenum, in gender-specific fashion. Data indicate the potential for slowing tumor progression (adenomatous polyp to adenocarcinoma) by BB. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - September 15, 2009 Category: Gastroenterology Authors: Frank SimmenJulie FrankXianli WuRijin XiaoLeah HenningsRonald Prior Source Type: journals

Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe - a Hungarian nationwide observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Infliximab (IFX) has proven to be an effective addition to the therapeutic arsenal for refractory, fistulizing, and steroid dependent Crohn's disease (CD), with efficacy in the induction and maintenance of clinical remission of CD. Our objective in this study is to report the nationwide, multicenter experience with IFX induction therapy for CD in Hungary. Methods: During a 6-year-period, beginning in 2000, a total of 363 CD patients were treated with IFX as induction therapy (5mg/kg IFX infusions given at week 0, 2 and 6) at eleven centers in Hungary in this observational study. Data analysis included patient d...
Source: BMC Gastroenterology - September 9, 2009 Category: Gastroenterology Authors: Pal MihellerPeter LakatosGabor HorvathTamas MolnarTamas SzamosiZsofia CeglediAgnes SalamonJozsef CzimmerGyorgy RumiKaroly PalatkaMaria PappZsolt JakabAndrea SzaboAndras GelleyLaszlo LakatosZsolt BartaCsaba BalazsIstvan RaczMargit ZeherZoltan DobronteIstva Source Type: journals

Stromal regulatory T-cells are associated with a favorable prognosis in gastric cancer of the cardiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Recent evidence suggests that CD4+CD25+FoxP3+ regulatory T-cells (Treg) may be responsible for the failure of host anti-tumor immunity by suppressing cytotoxic T-cells. Methods: In 52 cases of patients with intestinal type gastric cancer of the cardia we performed immunohistochemical analysis for tumor infiltrating lymphocytes (TIL) using tissue microarrays. The interrelationship between TIL subpopulations (CD3+, CD8+, CD20+, CD68+, GranzymeB+, FoxP3+) at various sites and NED-survival was investigated (median follow-up: 61 months). Results: Intraepithelial infiltration with TIL including Treg was generally low...
Source: BMC Gastroenterology - September 3, 2009 Category: Gastroenterology Authors: Matthias HaasArno DimmlerWerner HohenbergerGerhard GrabenbauerGerald NiedobitekLuitpold Distel Source Type: journals

Using an oblique incident laser beam to measure the optical properties of stomach mucosa/submucosa tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The absorption coefficients, the reduced scattering coefficients, the optical penetration depths, the diffusion coefficients, the diffuse reflectance and the shifts of diffuse reflectance of tissue samples at 635, 730, 808, 890 and 980 nm wavelengths vary with a change of wavelength. There were significant differences in the optical properties for tissue samples at five different wavelengths (P0.01). (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - August 27, 2009 Category: Gastroenterology Authors: Hua-Jiang WeiDa XingBo-Hua HeHuai-Min GuGuo-Yong WuXue-Mei Chen Source Type: journals

Nationwide epidemiological study of severe gallstone disease in TaiwanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This population-based study found a substantial increase in the rate of admission for severe gallstone disease among those aged 20-39. Concurrently, the incidences of biliary pancreatitis and acute cholangitis have risen among those aged [greater than or equal to]60. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - August 21, 2009 Category: Gastroenterology Authors: John HuangChia-Hsuin ChangJiun-Ling WangHsu-Ko KuoJou-Wei LinWen-Yi ShauLee Po-Huang Source Type: journals

Toll like receptor four (tlrfour) polymorphisms in Tunisian patients with crohn's disease: genotype-phenotype correlationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: this study reported the absence of association between CD and TLRfour gene in the Tunisian population, but this gene could play a role in clinical expression of the disease. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - August 6, 2009 Category: Gastroenterology Authors: Lilia ZouitenMaher KharratSami KarouiMeriem SerghiniMonia FekihSamira MatriLamia KallelJalel BoubakerAzza FilaliHabiba Chaabouni Source Type: journals

Small intestinal bacterial overgrowth mimicking acute flare as a pitfall in patients with Crohn's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: SIBO represents a frequently ignored yet clinically relevant complication in CD, often mimicking acute flare. Because symptoms of SIBO are often difficult to differentiate from those caused by the underlying disease, targeted work-up is recommended in patients with corresponding clinical signs and predisposing factors. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 29, 2009 Category: Gastroenterology Authors: Jochen KlausUlrike SpaniolGuido AdlerRichard MasonMax ReinshagenChristian von Tirpitz C Source Type: journals

Physical Activity and Diet Behaviour in Colorectal Cancer Patients Receiving Chemotherapy: Associations with Quality of LifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings provide insight into lifestyle behaviours of CRC survivors currently receiving systemic chemotherapy, and the differences in perceived QOL as affected by severity of disease and treatment setting. Prospective studies in a larger sample of CRC survivors on chemotherapy are needed to confirm lifestyle behaviour patterns and identify factors related to quality of life that are unique to this population, especially receiving metastatic treatment. Furthermore, the appropriateness of national diet and exercise guidelines for survivors being treated with palliative intent needs to be addressed. (Source...
Source: BMC Gastroenterology - July 26, 2009 Category: Gastroenterology Authors: Lynette StephensonD Gwyn BebbRaylene ReimerS Nicole Culos-Reed Source Type: journals

The pancreatic zymogen granule membrane protein, GP2, binds Escherichia coli type 1 FimbriaeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: GP2 binds to Type 1 fimbria, a bacterial adhesin that is commonly expressed by members of the Enterobacteriacae family. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 22, 2009 Category: Gastroenterology Authors: Su YuAnson Lowe Source Type: journals

Gastroesophageal reflux leads to esophageal cancer in a surgical model with miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Surgically induced gastroesophageal reflux produced esophageal squamous cell carcinoma, but not esophageal adenocarcinoma, in mice. Dominant negative p53 mutation, heterozygous loss of INK4a/Arf, antacid treatment, iron supplementation, or gastrectomy failed to promote esophageal adenocarcinoma in these mice. Further studies are needed in order to develop a mouse model of esophageal adenocarcinoma. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 22, 2009 Category: Gastroenterology Authors: Jing HaoBa LiuChung S. YangXiaoxin Chen Source Type: journals

Symptoms and signs in individuals with serology positive for celiac disease but normal mucosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Individuals with positive CD serology but normal mucosa often have CD-like symptoms and a family history of CD. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 21, 2009 Category: Gastroenterology Authors: Jonas LudvigssonLena BrandtScott Montgomery Source Type: journals

Visceral obesity and the risk of Barrett's esophagus in Japanese patients with non-alcoholic fatty liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In Japanese patients with NAFLD, obesity tended to be associated with the risk of BE, and this risk appeared to be mediated for the most part by abdominal visceral adiposity. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 20, 2009 Category: Gastroenterology Authors: Tomoyuki AkiyamaMasato YonedaMasahiko InamoriHiroshi IidaHiroki EndoKunihiro HosonoKyoko YonedaKoji FujitaTomoko KoideChikako TokoroHirokazu TakahashiAyumu GotoYasunobu AbeHiroyuki KirikoshiNoritoshi KobayashiKensuke KubotaSatoru SaitoAtsushi Nakajima Source Type: journals

Interrelationship between TP53 gene deletion, protein expression and chromosome 17 aneusomy in gastric adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We suggest that TP53 deletion and chromosome 17 aneusomy is a common event in GC and other TP53 alterations, as mutation, may be implicated in the distinct carcinogenesis process of diffuse and intestinal types. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 19, 2009 Category: Gastroenterology Authors: Andre KhayatAdriana GuimaraesDanielle CalcagnoAline SeabraEleonidas LimaMariana LealMario FariaSilvia RabenhorstPaulo AssumpcaoSamia DemachkiMarilia SmithRommel Burbano Source Type: journals

Quality of life following liver transplantation: a comparative study between Familial Amyloid Neuropathy and liver disease patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It is concluded that liver transplantation has a less beneficial impact in FAP patient's physical quality of life, probably because they are not so much disabled by their disease at the moment of liver transplantation. The lesser improvement in mental quality of life of FAP patients may be due to their particular psychological profile and greater expectations towards transplantation. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 14, 2009 Category: Gastroenterology Authors: Diogo Telles-CorreiaHelena Cortez-PintoAntonio BarbosaInes MegaEstela Monteiro Source Type: journals

TNF-alpha induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PC induces a prolonged inhibition of TNF-alpha-induced pro-inflammatory signalling. This inhibition may be caused by a shift of the TNF-alpha receptors at the surface to lipid rafts. Our results may offer a potential molecular explanation for the positive role of PC seen in clinical studies for the treatment of ulcerative colitis. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 12, 2009 Category: Gastroenterology Authors: Irina TreedeAnnika BraunPetia JeliaskovaThomas GieseJoachim FullekrugGareth GriffithsWolfgang StremmelRobert Ehehalt Source Type: journals

Early effects of oral administration of lafutidine with mosapride compared with lafutidine alone on intragastric pH valuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In H. pylori negative healthy male subjects, an oral dose of lafutidine 10 mg with mosapride 5 mg more rapidly increased intragastric pH than lafutidine 10 mg alone. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 8, 2009 Category: Gastroenterology Authors: Hiroshi IidaMasahiko InamoriYuichi NozakiHiroki EndoKunihiro HosonoTomoyuki AkiyamaYasunari SakamotoHirokazu TakahashiTomoko KoideChikako TokoroYasunobu AbeAtsushi Nakajima Source Type: journals

The galactose elimination capacity and mortality in 781 Danish patients with newly-diagnosed liver cirrhosis: a cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Despite its biologic plausibility, the association between liver function and mortality of patients with chronic liver disease is not well supported by data. Therefore, we examined whether the galactose elimination capacity (GEC), a physiological measure of the total metabolic capacity of the liver, was associated with mortality in a large cohort of patients with newly-diagnosed cirrhosis. Methods: By combining data from a GEC database with data from healthcare registries we identified cirrhosis patients with a GEC test at the time of cirrhosis diagnosis in 1992-2005. We divided the patients into 10 equal-sized...
Source: BMC Gastroenterology - June 29, 2009 Category: Gastroenterology Authors: Peter JepsenHendrik VilstrupPeter OttSusanne KeidingPer AndersenNiels Tygstrup Source Type: journals

Increasing prevalence and high incidence of celiac disease in elderly people: A population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of celiac disease was high in elderly people, but the symptoms were subtle. Repeated screening detected five biopsy-proven cases in three years, indicating that the disorder may develop even in the elderly. Increased alertness to the disorder is therefore warranted. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 28, 2009 Category: Gastroenterology Authors: Anitta VilppulaKatri KaukinenLiisa LuostarinenIlkka KrekelaHeikki PatrikainenRaisa ValveMarkku MakiPekka Collin Source Type: journals

Assessment of safety and feasibility of a new technical variant of gastropexy for percutaneous endoscopic gastrostomy: an experience with 453 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Gastropexy with the technical variant described here is easy to be performed and was feasible and safe in the present study. PEG performed by the Introducer Technique with this type of gastropexy was associated with low rates of wound infection even without the use of prophylactic antibiotics. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 25, 2009 Category: Gastroenterology Authors: Paulo CampoliDaniela CardosoMarilia TurchiFlavio EjimaOrlando Mota Source Type: journals

Trends in esophageal cancer and body mass index by race and gender in the state of MichiganEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The disparity between African American males and white males is not explained by ecological-level trends in BMI. Further research to identify the factors responsible for this disparity, possibly including anatomic fat distribution, are required. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 22, 2009 Category: Gastroenterology Authors: Eric KortEric SevensmaTimothy Fitzgerald Source Type: journals

Gluten sensitivity enteropathy in patients with recurrent aphthous stomatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A significant minority (e.g. 2.83%) of RAS patients have GSE. This could be compared with the 0.96% prevalence of GSE in the general population of Iran. This study suggests that evaluation for celiac disease is appropriate in patients with RAS. Additionally, the unresponsiveness to conventional anti-aphthae treatment could be an additional risk indicator. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 16, 2009 Category: Gastroenterology Authors: Ramin ShakeriFarhad ZamaniRasoul SotoudehmaneshAfsaneh AmiriMehdi MohamadnejadFereydoun DavatchiAli Mohammadi KarakaniReza MalekzadehFarhad Shahram Source Type: journals

Treatment of malignant gastric outlet obstruction with stents: an evaluation of the reported variables for clinical outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Available reports do not provide sufficient relevant information of the clinical outcome of duodenal stenting. In future studies, these relevant issues should be addressed to allow improved evaluation of the effect of stent treatment. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 16, 2009 Category: Gastroenterology Authors: Lene LarssenAsle MedhusTruls Hauge Source Type: journals

Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Primary defects in LPL and C-II are rare in survivors of acute hypertriglyceridaemic pancreatitis; lipase activity measurements should be restricted to those having their first episode during chilhood (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 16, 2009 Category: Gastroenterology Authors: Inmaculada Coca-PrietoPedro ValdivielsoGunilla OlivecronaMaria Jose ArizaJose RiojaPilar Font-UgaldeCarlota Garcia-AriasPedro Gonzalez-Santos Source Type: journals

Intra-abdominal pressure alterations after large pancreatic pseudocyst transcutaneous drainageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The drainage of large pancreatic pseudocyst reduces IAP. Moreover, the IAP seems to rise shortly after the drainage again, but in a way that it remains inferior to the initial value. More chronic changes to the IAP are related to abdominal cavity's properties and have to be further studied. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 6, 2009 Category: Gastroenterology Authors: Theodossis PapavramidisVassilis DurosAntonis MichalopoulosVassilis PapadopoulosDaniel ParamythiotisNick Harlaftis Source Type: journals

The clinicopathologic observation, c-KIT gene mutation and clonal status of gastrointestinal stromal tumor in the sacrumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In summary, we showed that tumor material, phenotypically identical with GISTs was found in the sacrum. It is difficult to differentiate GISTs from other spindle cell tumors, hence the need for immunohistochemistry, the examination of c-KIT gene amplification and sequencing. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 6, 2009 Category: Gastroenterology Authors: Li GongYan-Hong LiHua-Dong ZhaoJian-Ye ZhaoWei Zhang Source Type: journals

Mortality with upper gastrointestinal bleeding and perforation: effects of time and NSAID useEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Upper gastrointestinal bleed or perforation still carries a finite risk of death. Differences in study architecture, population characteristics, risk factors, definition of mortality, and reporting of outcomes impose limitations on interpreting effect size. Data published since 1997 suggest that mortality in patients suffering from an upper gastrointestinal bleed or perforation has fallen to 1 in 13 overall, but remains higher at about 1 in 5 in those exposed to NSAID or aspirin. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 5, 2009 Category: Gastroenterology Authors: Sebastian StraubeMartin TramerR Andrew MooreSheena DerryHenry McQuay Source Type: journals

Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These observations indicate that lafutidine inhibits the vagal afferent signalling of a gastric acid insult, which may reflect an inhibitory action on acid-induced gastric pain. The ability of lafutidine to decrease intragastric acidity following exposure to excess HCl cannot be explained by its antisecretory activity but appears to reflect dilution and/or emptying of the acid load into the duodenum. This profile of actions emphasizes the notion that H2 receptor antagonists can protect the gastric mucosa from acid injury independently of their ability to suppress gastric acid secretion. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 2, 2009 Category: Gastroenterology Authors: Martin EdelsbrunnerMotoko NakanoPeter Holzer Source Type: journals

Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Here, we have demonstrated that DIM induces G1 and G2/M phase cell cycle arrest in HT-29 cells, and this effect may be mediated by reduced CDK activity. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - May 29, 2009 Category: Gastroenterology Authors: Hyun Ju ChoiDo Young LimJung Han Yoon Park Source Type: journals

Efficacy of a 7-day course of furazolidone, levofloxacin, and lansoprazole after failed Helicobacter pylori eradication.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: An empiric salvage-regimen including levofloxacin, furazolidone and lansoprazole is very effective in the eradication of Helicobacter pylori, particularly in patients that have failed one prior eradication therapy. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - May 26, 2009 Category: Gastroenterology Authors: Jaime EisigFernando SilvaRicardo BarbutiTomas Navarro-RodriguezPeter MalfertheinerJoaquim MoraesSchlioma Zaterka Source Type: journals

Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: H. pylori seropositivity is inversely associated with the risk of ESCC in Taiwan, and COX-2 -1195 polymorphism plays a role in modifying the influence between H. pylori and ESCC, especially in lower third esophagus. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - May 23, 2009 Category: Gastroenterology Authors: Huang-Ming HuChao-Hung KuoChien-Hung LeeI-Chen WuKa-Wo LeeJang-Ming LeeYih-Gang GoanShah-Hwa ChouEin-Long KaoMing-Tsang WuDeng-Chyang Wu Source Type: journals