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Derivation and validation of murine histologic alterations resembling asthma, with two proposed histologic grade parameters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A definition of murine histologic alterations resembling asthma in the BALB/c OVA mouse was developed and validated. The definition will be of use in experiments involving this model to ensure that all mice said to have undergone an asthmatic attack did indeed reveal allergic pulmonary inflammation. Proposed grading criteria should be further evaluated with additional studies using physiologic measures of attack severity and increased airway resistance. (Source: BMC Immunology)
Source: BMC Immunology - October 30, 2009 Category: Allergy & Immunology Authors: Mitchell WachtelGoutam ShomeMhairi SutherlandJohn McGlone Source Type: journals

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Selenium status may affect immune defense and tissue homeostasis through its effect on selenoprotein expression and the trafficking of tissue macrophages. (Source: BMC Immunology)
Source: BMC Immunology - October 28, 2009 Category: Allergy & Immunology Authors: Bradley CarlsonMin-Hyuk YooYasuyo SanoAniruddha SenguptaJin Young KimRobert IronsVadim GladyshevDolph HatfieldJin Mo Park Source Type: journals

The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that the inhibitory effects of LILRB4 do not result from a failure to upregulate co-stimulatory proteins. In addition to the high level expression that can render antigen presenting cells tolerogenic, there may be a role for lower level expression and activity of LILRB2 and LILRB4 in response to TLR signalling during an immune response to bacterial infection. (Source: BMC Immunology)
Source: BMC Immunology - October 27, 2009 Category: Allergy & Immunology Authors: Damien BrownDes JonesKatie AndersonNicolas LapaqueRobin BuerkiJohn TrowsdaleRachel Allen Source Type: journals

Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, induced susceptibility of host resistance is associated with an impaired innate immune response following infection with L. monocytogenes in C57BL/6 Se-deficient mice. (Source: BMC Immunology)
Source: BMC Immunology - October 23, 2009 Category: Allergy & Immunology Authors: Chengmin WangHaijing WangJing LuoYi HuLei WeiMingxing DuanHongxuan He Source Type: journals

Modulation of pathogen-induced CCL20 secretion from human HT-29 intestinal epithelial cells by commensal bacteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study is the first to demonstrate that a commensal strain can attenuate CCL20 secretion by HT-29 IECs. Collectively, the data indicate that M. paratuberculosis may mediate mucosal damage and that B. infantis can exert immunomodulatory effects on IECs that mediate host responses to flagellin and flagellated enteric pathogens. (Source: BMC Immunology)
Source: BMC Immunology - October 7, 2009 Category: Allergy & Immunology Authors: Shomik SibartieAnn O'HaraJude RyanAine FanningJim O'MahonyShaun O'NeillBarbara SheilLiam O'MahonyFergus Shanahan Source Type: journals

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: - We provide an extended list of putative Fas ligand interaction partners, confirming previously identified interactions, but also introducing several additional SH3 domain proteins that might be important regulators of Fas ligand function. (Source: BMC Immunology)
Source: BMC Immunology - October 5, 2009 Category: Allergy & Immunology Authors: Matthias VossMarcus LettauOttmar Janssen Source Type: journals

Prerequisites for cytokine measurements in clinical trials with multiplex immunoassaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All together we show parameters which are essential for measurement of cytokines in the context of clinical trials. (Source: BMC Immunology)
Source: BMC Immunology - September 27, 2009 Category: Allergy & Immunology Authors: Wilco de JagerKatarzyna BourcierGer RijkersBerent PrakkenVicki Seyfert-Margolis Source Type: journals

Control of CD56 expression and tumor cell cytotoxicity in human Vgamma2Vdelta2 T cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The ability to express CD56 was not predicted by TCR sequence or by the strength of signal received by the TCR. For gammadelta T cells, cytotoxic effector function is acquired when cytotoxic precursors within the population are stimulated to proliferate and express CD56. (Source: BMC Immunology)
Source: BMC Immunology - September 20, 2009 Category: Allergy & Immunology Authors: Elizabeth UrbanHaishan LiCheryl ArmstrongChiara FocaccettiCristiana CairoC. David Pauza Source Type: journals

Ethanol inhibits LPS-induced signaling and modulates cytokine production in peritoneal macrophages in vivo in a model for binge drinkingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Overall, the effects of ethanol on signalling in vivo were similar to those reported for in vivo exposure to ethanol and/or lipopolysaccharide. However, inhibition of the activation of NF-kappaB was not detected as translocation of p65 to the nucleus but was detected using transgenic reporter mice. The observation that ethanol given 24 hr before dosing with LPS modulated production of some cytokines indicates a persistent effect which does not require continued presence of ethanol. (Source: BMC Immunology)
Source: BMC Immunology - September 17, 2009 Category: Allergy & Immunology Authors: Stephen PruettRuping Fan Source Type: journals

Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite its low resolution, our approach permits comparison of molecular surface features in the absence of crystal structure data. Our results illustrate diversity of surface features of innate immunity receptors and provide hints for function of NLRs whose specific role in innate immunity is yet unknown. (Source: BMC Immunology)
Source: BMC Immunology - September 2, 2009 Category: Allergy & Immunology Authors: Andrei IstominAdam Godzik Source Type: journals

Endogenous Fms-like Tyrosine Kinase-3 Ligand levels are not altered in mice after a severe burn and infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that the beneficial effects of Flt3L treatments after burn injury are not due to correction of a burn-associated Flt3L deficiency but rather, are likely due to supplementary stimulation of dendritic cell production and immune responses to infection. (Source: BMC Immunology)
Source: BMC Immunology - August 27, 2009 Category: Allergy & Immunology Authors: Julia BohannonWeihua CuiTracy Toliver-Kinsky Source Type: journals

Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study underpins a novel role for IL-21 in the differentiation of pseudo-mature lytic NK cells in a synergistic context with IL-15, and identifies a potential strategy to expand functional NK cells for immunotherapy. (Source: BMC Immunology)
Source: BMC Immunology - August 26, 2009 Category: Allergy & Immunology Authors: Giuseppina BonannoAndrea MariottiAnnabella ProcoliMaria CoralloGiovanni ScambiaLuca PierelliSergio Rutella Source Type: journals

The Toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recoveryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results demonstrate that activation of TRIF/type I IFN responses is important in both the pathogenesis and resolution of NTHi-induced OM. (Source: BMC Immunology)
Source: BMC Immunology - August 4, 2009 Category: Allergy & Immunology Authors: Anke LeichtleMichelle HernandezKwang PakNicholas WebsterStephen WassermanAllen Ryan Source Type: journals

Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although DNA prime adenoviral vector boost immunizations belong to the strongest inducers of cytotoxic T cell responses in different animal models and humans, the CD8+ T cell responses can be further improved by targeting the DNA encoded antigen to DEC205 in the presence of synergistic TLR ligands CpG and Poly I:C. (Source: BMC Immunology)
Source: BMC Immunology - August 2, 2009 Category: Allergy & Immunology Authors: Claudius GrossmannMatthias TenbuschGodwin NchindaVladimir TemchuraGhulam NabiGeoffrey StoneRichard KornbluthKlaus Uberla Source Type: journals

Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The T-Lux mouse provides a novel, efficient model for tracking in vivo aspects of the CD4+ T cell response to antigen, providing an attractive approach for studies directed at immunotherapy or vaccine design. (Source: BMC Immunology)
Source: BMC Immunology - August 2, 2009 Category: Allergy & Immunology Authors: Joseph ChewningKari DuggerTandra ChaudhuriKurt ZinnCasey Weaver Source Type: journals

In vitro, but not in vivo, reversibility of peritoneal macrophages activation during experimental acute pancreatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Peritoneal macrophages adopt a pro-inflammatory activation early during acute pancreatitis. Treatment with M2 cytokines could revert in vitro the pancreatitis-induced activation of macrophages but fails to modulate its activation in vivo. This treatment has only a moderate effect in reducing the systemic inflammation associated to acute pancreatitis. Hydrolitic enzymes presents in ascitic fluid could be involved in the degradation of cytokines, strongly reducing its utility to modulate peritoneal macrophages in pancreatitis. (Source: BMC Immunology)
Source: BMC Immunology - July 30, 2009 Category: Allergy & Immunology Authors: Sabrina Gea-SorliDaniel Closa Source Type: journals

Enrichment and analysis of secretory lysosomes from lymphocyte populationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The provided protocol is readily applicable to enrich and isolate intact secretory vesicles from individual cell populations. It can be used to compare SL of normal and transformed cell lines or primary cell populations from healthy donors and patients with lysosomal storage or transport diseases, or from corresponding mutant mice. A subsequent proteome analysis allows the characterization of molecules involved in lysosomal maturation and cytotoxic effector function at high-resolution. (Source: BMC Immunology)
Source: BMC Immunology - July 28, 2009 Category: Allergy & Immunology Authors: Hendrik SchmidtChristoph GelhausRalph LuciusMelanie NebendahlMatthias LeippeOttmar Janssen Source Type: journals

Sequence determinants of innate immune activation by short interfering RNAsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data presented favour a model of TLR7/8 activation by siRNAs, in which the two strands are denatured in the endosome, and single-stranded, U-rich RNA species activate TLR7/8. These findings have relevance to the design of siRNAs, particularly for in vivo or clinical applications. (Source: BMC Immunology)
Source: BMC Immunology - July 23, 2009 Category: Allergy & Immunology Authors: Amber GoodchildNicole NopperAndrew KingTram DoanMarcel TanudjiGreg ArndtMichael PoidingerLaurent RivoryToby Passioura Source Type: journals

The effect of caffeic acid Phenethyl Ester on the functions of human monocyte-derived dendritic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicated that CAPE inhibited cytokine and chemokine production by MoDCs which might be related to the NF-kappa B signaling pathway. This study provided a new insight into the mechanism of CAPE in immune response and the rationale for propolis in the treatment of asthma and other allergic disorders. (Source: BMC Immunology)
Source: BMC Immunology - July 15, 2009 Category: Allergy & Immunology Authors: Li-Chieh WangYu-Li LinYu-Chih LiangYao-Hsu YangJyh-Hong LeeHsin-Hui YuWen-Mein WuBor-Luen Chiang Source Type: journals

The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Thus, our results suggest a non-redundant role for SLY1 in integrating signals from both receptors in early T cell progenitors in the thymus. (Source: BMC Immunology)
Source: BMC Immunology - July 14, 2009 Category: Allergy & Immunology Authors: Bernhard ReisKlaus PfefferSandra Beer-Hammer Source Type: journals

The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our analysis of signal transduction events demonstrate a functional interaction of epithelial cells with PMNs in response to Candida infection involving divergent signalling events that differentially govern hBD-2 and hBD-3 expression. (Source: BMC Immunology)
Source: BMC Immunology - June 12, 2009 Category: Allergy & Immunology Authors: Nadine SteubesandKarlheinz KiehneGabriele BrunkeRene PahlKarina ReissKarl-Heinz HerzigSabine SchubertStefan SchreiberUlrich FolschPhilip RosenstielAlexander Arlt Source Type: journals

Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The upregulation of chemokines and CCRs may facilitate DC migration from the infection site to the lymph nodes, whereas the increase of TRAIL may induce lymphocyte apoptosis. These findings may explain the increased lung infiltrations and lymphoid depletion in SARS patients. Further explorations of the biological significance of these findings are warranted. (Source: BMC Immunology)
Source: BMC Immunology - June 8, 2009 Category: Allergy & Immunology Authors: Helen LawChung Yan CheungSin Fun SiaYuk On ChanJs PeirisYu Lung Lau Source Type: journals

Increased levels of soluble CD226 in sera accompanied by decreased membrane CD226 expression on peripheral blood mononuclear cells from cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: As a cellular membrane triggering receptor, CD226 is involved in the NK cell- or CTL-mediated lysis of tumor cells of different origin, including freshly isolated tumor cells and tumor cell lines. Here, we evaluated soluble CD226 (sCD226) levels in sera, and membrane CD226 (mCD226) expression on peripheral blood mononuclear cells (PBMC) from cancer patients as well as normal subjects, and demonstrated the possible function and origin of the altered sCD226, which may provide useful information for understanding the mechanisms of tumor escape and for immunodiagnosis and immunotherapy. Results: Soluble CD226 level...
Source: BMC Immunology - June 2, 2009 Category: Allergy & Immunology Authors: Zhuwei XuTao ZhangRan ZhuangYun ZhangWei JiaChaojun SongKun YangAngang YangBoquan Jin Source Type: journals

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Bone marrow cell derived arginase I is the predominant source of allergen-induced lung arginase but is not required for allergen-induced inflammation, airway hyperresponsiveness or collagen deposition. (Source: BMC Immunology)
Source: BMC Immunology - June 1, 2009 Category: Allergy & Immunology Authors: Kathryn NieseAnn CollierAmanda HajekStephen CederbaumWilliam O'BrienMarsha Wills-KarpMarc RothenbergNives Zimmermann Source Type: journals

Different levels of humoral immunoreactivity to different wheat cultivars gliadin are present in patients with celiac disease and in patients with multiple myeloma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Results obtained showed different content of immunogenic gliadin epitopes in various species of wheat.They also point for new effort to elucidate is there a need to develop new standard antigen, the representative mixture of gliadin isolated from local wheat species used for bread production in corresponding geographic region for ELISA diagnostic tests. (Source: BMC Immunology)
Source: BMC Immunology - May 31, 2009 Category: Allergy & Immunology Authors: Aleksandra Konic-RisticDejan DodigRadmilo KrsticSvetislav JelicIvan StankovicAleksandra NinkovicJelena RadicIrina BesuBranka Bonaci-NikolicNjegica JojicMilica DjordjevicDragan PopovicZorica Juranic Source Type: journals

High-sensitive and rapid detection of Mycobacterium tuberculosis infection by IFN-gamma release assay among HIV-infected individuals in BCG-vaccinated areaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: An accurate test for Mycobacterium tuberculosis infection is urgently needed in immunosuppressed populations. The aims of this study were to investigate the diagnostic power of enzyme-linked immunospot (ELISPOT)-based IFN-gamma release assay in detecting active and latent tuberculosis in HIV-infected population in bacillus Calmette-Guerin (BCG)-vaccinated area. A total of 100 HIV-infected individuals including 32 active tuberculosis patients were recruited. An ELISPOT-based IFN-gamma release assay, T-SPOT.TB, was used to evaluate the M. tuberculosis ESAT-6 and CFP-10 specific IFN-gamma response. Tuberculin skin...
Source: BMC Immunology - May 28, 2009 Category: Allergy & Immunology Authors: Weimin JiangLingyun ShaoYing ZhangShu ZhangChengyan MengYunya XuLingli HuangYun WangYing WangXinhua WengWenhong Zhang Source Type: journals

Efficient isolation of highly purified tonsil B lymphocytes using RosetteSep with allogeneic human red blood cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: RosetteSep reagent can be used in combination with allogeneic human red blood cells to reproducibly isolate tonsil B lymphocytes to high levels of purity with no change in phenotype or loss of cells. This method provides considerable time and cost savings compared to other methods. (Source: BMC Immunology)
Source: BMC Immunology - May 27, 2009 Category: Allergy & Immunology Authors: Jonathan ZuccoloTammy UnruhJulie Deans Source Type: journals

T cells cooperate with palmitic acid in induction of beta cell apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results imply that stimulated T cells produce cytokines that cooperate with saturated free fatty acids in beta cell destruction during diabetes pathogenesis. (Source: BMC Immunology)
Source: BMC Immunology - May 22, 2009 Category: Allergy & Immunology Authors: Tamara CvjeticaninIvana StojanovicGordana TimotijevicStanislava Stosic-GrujicicDjordje Miljkovic Source Type: journals

A kinase dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Altogether, our findings indicate that mTOR kinase activity is indispensable for the early development of mouse embryos. Moreover, a single wild type mTOR allele is sufficient to maintain normal postnatal growth and lymphocyte development and proliferation. (Source: BMC Immunology)
Source: BMC Immunology - May 20, 2009 Category: Allergy & Immunology Authors: Boris Shor, Druie Cavender and Crafford Harris Source Type: journals

Respiratory burst function of ovine neutrophilsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study successfully adapted a commonly used method of measuring human neutrophil respiratory burst function to characterise different aspects of ovine neutrophil respiratory burst function. This improved understanding of ovine neutrophils will facilitate the validitation of ovine biomedical models of human pathologies in which neutrophils have been implicated. (Source: BMC Immunology)
Source: BMC Immunology - May 8, 2009 Category: Allergy & Immunology Authors: John-Paul Tung, John F Fraser, Peter Wood and Yoke Lin Fung Source Type: journals

Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite our data showing FcR-dependent stimulation of DC in vitro, Ab-mediated immunity to C. burnetii in vivo is FcR-independent. We also found that passive immunity to this pathogen is independent of complement. (Source: BMC Immunology)
Source: BMC Immunology - May 8, 2009 Category: Allergy & Immunology Authors: Jeffrey G Shannon, Diane C Cockrell, Kazue Takahashi, Gregory L Stahl and Robert A Heinzen Source Type: journals

Interplay between the heterotrimeric G-protein subunits G-alpha-q and G-alpha-i2 sets the threshold for chemotaxis and TCR activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that G-alpha-i2 confers migration signals in the presence of CXCL12 whereas G-alpha-q exerts a tonic inhibition on both basal and stimulated migrational responses. This is compatible with the notion that the level of G-alpha-q activation contributes to determining the commitment of the T cell either to migration or activation through the TCR. (Source: BMC Immunology)
Source: BMC Immunology - May 8, 2009 Category: Allergy & Immunology Authors: Jacob Ngai, Marit Inngjerdingen, Torunn Berge and Kjetil Tasken Source Type: journals

Interplay between the heterotrimeric G-protein subunits Galphaqand Galphai2sets the threshold for chemotaxis and TCR activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data suggest that Gαi2 confers migration signals in the presence of CXCL12 whereas Gαq exerts a tonic inhibition on both basal and stimulated migrational responses. This is compatible with the notion that the level of Gαq activation contributes to determining the commitment of the T cell either to migration or activation through the TCR. (Source: BMC Immunology)
Source: BMC Immunology - May 7, 2009 Category: Allergy & Immunology Authors: Jacob NgaiMarit InngjerdingenTorunn BergeKjetil Tasken Source Type: journals

Association of IL-10 and IL-10R beta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that IL-10 and IL-10R beta genes have a synergistic effect on the risk of GvHD. (Source: BMC Immunology)
Source: BMC Immunology - May 4, 2009 Category: Allergy & Immunology Authors: Jyrki Sivula, Hannu Turpeinen, Liisa Volin and Jukka Partanen Source Type: journals

Bos taurus genome sequence reveals the assortment of immunoglobulin and surrogate light chain genes in domestic cattleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The bovine kappa gene locus is compact and simple which may reflect the preferential use of the lambda chain in cattle. The relative orientation of variable and joining genes in both loci are consistent with a deletion mechanism in VJ-joining. The orientation of some variable genes cannot be determined from the data available. The number of functional variable genes is moderate when compared to man or mouse. Thus, post-recombinatorial mechanisms might contribute to the generation of the bovine pre-immune antibody repertoire. However, the heavy chains probably contribute more to recombinational immunoglobulin r...
Source: BMC Immunology - April 30, 2009 Category: Allergy & Immunology Authors: Anna Ekman, Mikael Niku, Jenni Liljavirta and Antti Iivanainen Source Type: journals

Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: TM-N49 is a potent stimulus for skin edema, mast cell activation and accumulation. (Source: BMC Immunology)
Source: BMC Immunology - April 28, 2009 Category: Allergy & Immunology Authors: Ji-Fu Wei, Xiao-Long Wei, Ya-Zhen Mo and Shao-Heng He Source Type: journals

Differential intracellular fate of Burkholderia pseudomallei 844 and Burkholderia thailandensis UE5 in human monocyte-derived dendritic cells and macrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data presented showed that while both strains were similar in their ability to survive and replicate in human MoDCs, only Bp-844 could readily replicate in human Mfs. Both bacteria induced similar host cellular responses, particularly with regard to their ability to bias T cell differentiation toward a Th1 phenotype. (Source: BMC Immunology)
Source: BMC Immunology - April 27, 2009 Category: Allergy & Immunology Authors: Jaruek Charoensap, Pongsak Utaisincharoen, Anneke Engering and Stitaya Sirisinha Source Type: journals

Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data indicate Selective inhibition of DPP-IV does not impair T dependent immune responses to antigenic challenge. (Source: BMC Immunology)
Source: BMC Immunology - April 9, 2009 Category: Allergy & Immunology Authors: Kalpit A Vora, Gene Porter, Roche Peng, Yan Cui, Kellyann Pryor, George Eiermann and Dennis Zaller Source Type: journals

Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Up regulation of MEF2 family, HDACs, and H2AV during cell differentiation and inflammation sheds new lights onto regulation events on transcriptional and epigenetic level controlling these processes. Data generated will serve as a source for further investigation of macrophages differentiation pathways and related biological responses. (Source: BMC Immunology)
Source: BMC Immunology - April 2, 2009 Category: Allergy & Immunology Authors: Young-Sook Baek, Stefan Haas, Holger Hackstein, Gregor Bein, Maria HERNANDEZ Santana, Hans Lehrach, Sascha Sauer and Harald Seitz Source Type: journals

The Drosophila cell adhesion molecule Neuroglian regulates Lissencephaly-1 localisation in circulating immunosurveillance cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The Drosophila cellular adhesion molecule Neuroglian is expressed in haemocytes and its activity is required for the encapsulation of L. boularli eggs. At the cell periphery of haemocytes Neuroglian may be involved in cell-cell interactions, while at the cell centre Neuroglian regulates the localisation of the nucleokinesis complex protein lissencephaly-1. (Source: BMC Immunology)
Source: BMC Immunology - March 25, 2009 Category: Allergy & Immunology Authors: Michael J Williams Source Type: journals

Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings reveal a heretofore unrecognized hierarchical interaction between the IFNgamma and CCL3, which demonstrate that IFNgamma is crucial for CCL3-mediated neutrophil recruitment in vivo (Source: BMC Immunology)
Source: BMC Immunology - March 19, 2009 Category: Allergy & Immunology Authors: Cynthia A. Bonville, Caroline M. Percopo, Kimberly D. Dyer, Jiliang Gao, Calman Prussin, Barbara Foster, Helene F. Rosenberg and Joseph B. Domachowske Source Type: journals

Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated Kinase-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We identified a novel mechanism for MMP-9 expression in response to injury signals, which is mediated by PAK1 activation and stabilization leading JNK activation. (Source: BMC Immunology)
Source: BMC Immunology - March 19, 2009 Category: Allergy & Immunology Authors: Ling Zhou, Chunli Yan, Roben G Gieling, Yujiro Kida, Warren L Garner, Wei Li and Yuan-Ping Han Source Type: journals

Anti-idiotypic antibodies: a new approach in prion researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of the present study not only provide an example of the successful production of Ab2 monoclonal antibodies based on a well planned strategy for selection, but should also provide a new experimental approach that is applicable to the field of prion diseases. (Source: BMC Immunology)
Source: BMC Immunology - March 19, 2009 Category: Allergy & Immunology Authors: Anja Colja Venturini, Maja Bresjanac, Tanja Vranac, Simon Koren, Mojca Narat, Mara Popovic and Vladka Curin Serbec Source Type: journals

Identification of conformational epitopes for human IgG on Chemotaxis inhibitory protein of Staphylococcus aureusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Conformational epitopes recognized by human antibodies have been mapped on the CHIPS surface and amino acid residues involved in both antibody and C5aR interaction could be defined. This information has implications for the development of an effective anti-inflammatory agent based on a functional CHIPS molecule with low interaction with human IgG. (Source: BMC Immunology)
Source: BMC Immunology - March 11, 2009 Category: Allergy & Immunology Authors: Erika Gustafsson, Pieter-Jan Haas, Björn Walse, Marcel Hijnen, Christina Furebring, Mats Ohlin, Jos A. G. van Strijp and Kok P. M. van Kessel Source Type: journals

The effects of whole mushrooms during inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data support a model whereby edible mushrooms regulate immunity in vitro. The in vivo effects of edible mushrooms required a challenge with DSS to detect small changes in TNF-α and transient protection from colonic injury. There are modest effects of in vivo consumption of edible mushrooms on induced inflammatory responses. The result is not surprising since it would certainly be harmful to strongly induce or suppress immune function following ingestion of a commonly consumed food. (Source: BMC Immunology)
Source: BMC Immunology - February 20, 2009 Category: Allergy & Immunology Authors: Sanhong Yu, Veronika Weaver, Keith Martin and Margherita T Cantorna Source Type: journals

The effects of whole mushrooms during inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data support a model whereby edible mushrooms regulate immunity in vitro. The in vivo effects of edible mushrooms required a challenge with DSS to detect small changes in TNF-alpha and transient protection from colonic injury. There are modest effects of in vivo consumption of edible mushrooms on induced inflammatory responses. The result is not surprising since it would certainly be harmful to strongly induce or suppress immune function following ingestion of a commonly consumed food. (Source: BMC Immunology)
Source: BMC Immunology - February 20, 2009 Category: Allergy & Immunology Authors: Sanhong Yu, Veronika Weaver, Keith Martin and Margherita T Cantorna Source Type: journals

Dynamics of central and peripheral immunomodulation in a murine glioma modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data provide insight into the kinetics of the immunosuppressive state associated with tumor growth in a murine model of human gliomas. Functional impairment of TAMs occurs relatively late in the course of GBM tumor growth, potentially providing a window of opportunity for therapeutic strategies directed towards preventing their functional impairment. (Source: BMC Immunology)
Source: BMC Immunology - February 18, 2009 Category: Allergy & Immunology Authors: Benjamin C Kennedy, Lisa M Maier, Randy D'Amico, Christopher E Mandigo, Elizabeth J Fontana, Allen Waziri, Marcela C Assanah, Peter Canoll, Richard CE Anderson, David E Anderson and Jeffrey N Bruce Source Type: journals

ER stress affects processing of MHC class I-associated peptidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results demonstrate that ER stress impairs MHC I-peptide presentation, and that it differentially regulates generation of ER- vs. cytosol-derived peptides. Furthermore, this work illustrates how ER stress, a typical feature of infected and malignant cells, can impinge on cues for adaptive immune recognition. (Source: BMC Immunology)
Source: BMC Immunology - February 16, 2009 Category: Allergy & Immunology Authors: Diana P Granados, Pierre-Luc Tanguay, Marie-Pierre Hardy, Etienne Caron, Danielle de Verteuil, Sylvain Meloche and Claude Perreault Source Type: journals

Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study shows that combined TLR2 and TLR4 activation in the context of different antigen sources can induce very distinct molecular profiles in DCs and suggests that the Th1/Th2 polarizing capacity of compounds can be predicted with the molecular signature they induce in DCs. (Source: BMC Immunology)
Source: BMC Immunology - February 4, 2009 Category: Allergy & Immunology Authors: Elly van Riet, Bart Everts, Kim Retra, Marion Phylipsen, Jaap J van Hellemond, Aloysius GM Tielens, Desiree van der Kleij, Franca C Hartgers and Maria Yazdanbakhsh Source Type: journals

Characterization of rag1 mutant zebrafish leukocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study demonstrates that in comparison to wild-type zebrafish, rag1 mutants have a significantly reduced lymphocyte-like cell population that likely includes Non-specific cytotoxic cells (NCC) and NK cells (and lacks functional T and B lymphocytes), a similar macrophage/monocyte population, and a significantly increased neutrophil population. These zebrafish have comparable leukocyte populations to SCID and rag 1 and/or 2 mutant mice, that possess macrophages, natural killer cells and neutrophils, but lack T and B lymphocytes. Rag1 mutant zebrafish will provide the platform for remarkable investigations in ...
Source: BMC Immunology - February 3, 2009 Category: Allergy & Immunology Authors: Lora Petrie-Hanson, Claudia Hohn and Larry Hanson Source Type: journals